Thin Fisher Zeroes

Biskup et al. [Phys. Rev. Lett. 84 (2000) 4794] have recently suggested that the loci of partition function zeroes can profitably be regarded as phase boundaries in the complex temperature or field planes. We obtain the Fisher zeroes for Ising and Potts models on non-planar (``thin'') regular random graphs using this approach, and note that the locus of Fisher zeroes on a Bethe lattice is identical to the corresponding random graph. Since the number of states appears as a parameter in the Potts solution the limiting locus of chromatic zeroes is also accessible.Comment: 10 pages, 4 figure

Developing a Reduced Gravity Testbed for the Nanoparticle Field Extraction Thruster

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77095/1/AIAA-2009-5194-670.pd

Reduced Gravity Testing of the Nanoparticle Field Extraction Thruster

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77245/1/AIAA-2008-4995-883.pd

The Exo-S probe class starshade mission

Exo-S is a direct imaging space-based mission to discover and characterize exoplanets. With its modest size, Exo-S bridges the gap between census missions like Kepler and a future space-based flagship direct imaging exoplanet mission. With the ability to reach down to Earth-size planets in the habitable zones of nearly two dozen nearby stars, Exo-S is a powerful first step in the search for and identification of Earth-like planets. Compelling science can be returned at the same time as the technological and scientific framework is developed for a larger flagship mission. The Exo-S Science and Technology Definition Team studied two viable starshade-telescope missions for exoplanet direct imaging, targeted to the $1B cost guideline. The first Exo-S mission concept is a starshade and telescope system dedicated to each other for the sole purpose of direct imaging for exoplanets (The "Starshade Dedicated Mission"). The starshade and commercial, 1.1-m diameter telescope co-launch, sharing the same low-cost launch vehicle, conserving cost. The Dedicated mission orbits in a heliocentric, Earth leading, Earth-drift away orbit. The telescope has a conventional instrument package that includes the planet camera, a basic spectrometer, and a guide camera. The second Exo-S mission concept is a starshade that launches separately to rendezvous with an existing on-orbit space telescope (the "Starshade Rendezvous Mission"). The existing telescope adopted for the study is the WFIRST-AFTA (Wide-Field Infrared Survey Telescope Astrophysics Focused Telescope Asset). The WFIRST-AFTA 2.4-m telescope is assumed to have previously launched to a Halo orbit about the Earth-Sun L2 point, away from the gravity gradient of Earth orbit which is unsuitable for formation flying of the starshade and telescope. The impact on WFIRST-AFTA for starshade readiness is minimized; the existing coronagraph instrument performs as the starshade science instrument, while formation guidance is handled by the existing coronagraph focal planes with minimal modification and an added transceiver

Risk Prediction for Epithelial Ovarian Cancer in 11 United States–Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci

Previously developed models for predicting absolute risk of invasive epithelial ovarian cancer have included a limited number of risk factors and have had low discriminatory power (area under the receiver operating characteristic curve (AUC) < 0.60). Because of this, we developed and internally validated a relative risk prediction model that incorporates 17 established epidemiologic risk factors and 17 genome-wide significant single nucleotide polymorphisms (SNPs) using data from 11 case-control studies in the United States (5,793 cases; 9,512 controls) from the Ovarian Cancer Association Consortium (data accrued from 1992 to 2010). We developed a hierarchical logistic regression model for predicting case-control status that included imputation of missing data. We randomly divided the data into an 80% training sample and used the remaining 20% for model evaluation. The AUC for the full model was 0.664. A reduced model without SNPs performed similarly (AUC = 0.649). Both models performed better than a baseline model that included age and study site only (AUC = 0.563). The best predictive power was obtained in the full model among women younger than 50 years of age (AUC = 0.714); however, the addition of SNPs increased the AUC the most for women older than 50 years of age (AUC = 0.638 vs. 0.616). Adapting this improved model to estimate absolute risk and evaluating it in prospective data sets is warranted

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study

In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer.status: publishe

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study

Background: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer. Methods: We employed SNPs with well-established associations with 25(OH)D concentration as instrumental variables for MR: rs7944926 (DHCR7), rs12794714 (CYP2R1) and rs2282679 (GC). We included 31 719 women of European ancestry (10 065 cases, 21 654 controls) from the Ovarian Cancer Association Consortium, who were genotyped using customized Illumina Infinium iSelect (iCOGS) arrays. A two-sample (summary data) MR approach was used and analyses were performed separately for all ovarian cancer (10 065 cases) and for high-grade serous ovarian cancer (4121 cases). Results: The odds ratio for epithelial ovarian cancer risk (10 065 cases) estimated by combining the individual SNP associations using inverse variance weighting was 1.27 (95% confidence interval: 1.06 to 1.51) per 20 nmol/L decrease in 25(OH)D concentration. The estimated odds ratio for high-grade serous epithelial ovarian cancer (4121 cases) was 1.54 (1.19, 2.01). Conclusions: Genetically lowered 25-hydroxyvitamin D concentrations were associated with higher ovarian cancer susceptibility in Europeans. These findings suggest that increasing plasma vitamin D levels may reduce risk of ovarian cancer

Association of vitamin D levels and risk of ovarian cancer:a Mendelian randomization study

Background: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer. Methods: We employed SNPs with well-established associations with 25(OH)D concentration as instrumental variables for MR: rs7944926 (DHCR7), rs12794714 (CYP2R1) and rs2282679 (GC). We included 31 719 women of European ancestry (10 065 cases, 21 654 controls) from the Ovarian Cancer Association Consortium, who were genotyped using customized Illumina Infinium iSelect (iCOGS) arrays. A two-sample (summary data) MR approach was used and analyses were performed separately for all ovarian cancer (10 065 cases) and for high-grade serous ovarian cancer (4121 cases). Results: The odds ratio for epithelial ovarian cancer risk (10 065 cases) estimated by combining the individual SNP associations using inverse variance weighting was 1.27 (95% confidence interval: 1.06 to 1.51) per 20 nmol/L decrease in 25(OH)D concentration. The estimated odds ratio for high-grade serous epithelial ovarian cancer (4121 cases) was 1.54 (1.19, 2.01). Conclusions: Genetically lowered 25-hydroxyvitamin D concentrations were associated with higher ovarian cancer susceptibility in Europeans. These findings suggest that increasing plasma vitamin D levels may reduce risk of ovarian cancer