TiO2-Supported Re as a General and Chemoselective Heterogeneous Catalyst for Hydrogenation of Carboxylic Acids to Alcohols

TiO2-supported Re, Re/TiO2, was found to promote selective hydrogenation of carboxylic acids having aromatic and aliphatic moieties to the corresponding alcohols. Re/TiO2 showed superior results compared to other transition-metal-loaded TiO2 and supported Re catalysts for selective hydrogenation of 3-phenylpropionic acid. 3phenylpropanol was produced in 97% yield under mild conditions (5 MPa H-2 at 140 degrees C). Contrary to typical heterogeneous catalysts, Re/TiO2 does not lead to the formation of dearomatized byproducts. The catalyst is recyclable and shows a wide substrate scope in the synthesis of alcohols (22 examples; up to 97% isolated yield)

One-Pot Selective Catalytic Synthesis of Pyrrolidone Derivatives from Ethyl Levulinate and Nitro Compounds

This is the peer reviewed version of the following article: Vidal, Juan D, Climent Olmedo, María José, Corma Canós, Avelino, Concepción Heydorn, Patricia, Iborra Chornet, Sara. (2017). One-Pot Selective Catalytic Synthesis of Pyrrolidone Derivatives from Ethyl Levulinate and Nitro Compounds .ChemSusChem, 10, 1, 119-128, which has been published in final form at http://doi.org/10.1002/cssc.201601333. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.[EN] N-substituted 5-methyl-2-pyrrolidones were prepared in a one-pot process starting from ethyl levulinate and nitro compounds in the presence of a nanosized Pt-based catalyst. Pt supported on TiO2 nanotubes (Pt/TiO2-NT) catalyzed the synthesis of N-substituted 5-methyl-2-pyrrolidones through a cascade process involving the reduction of nitro compounds, formation of the intermediary imine, hydrogenation, and subsequent cyclization. A bifunctional metal acid system was a suitable catalyst for the process. Pt supported on TiO2 showed lower catalytic activity than Pt/TiO2-NT owing to the strong adsorption of nitro compounds during the first reaction step that poisoned the acidic sites and strongly decreased the rate of amination and cyclization. However, Pt/TiO2-NT with milder acid sites was less affected by the adsorption of nitro compounds and the full cascade process could proceed. The results indicate that the prepared Pt/TiO2-NT is a chemoselective and reusable catalyst that can be applied to the synthesis of a variety of N-substituted 5-methyl-2-pyrrolidones starting from nitro compounds with excellent yields in absence of an additional organic solvent under mild reaction conditions.Financial support by Consolider-Ingenio 2010 (Project Multicat), Spanish MICINN Project (CTQ-2015-67592-P), Generalitat Valenciana (Prometeo Program) and Program Severo Ochoa is gratefully acknowledged.Vidal, JD.; Climent Olmedo, MJ.; Corma Canós, A.; Concepción Heydorn, P.; Iborra Chornet, S. (2017). One-Pot Selective Catalytic Synthesis of Pyrrolidone Derivatives from Ethyl Levulinate and Nitro Compounds. ChemSusChem. 10(1):119-128. https://doi.org/10.1002/cssc.201601333S119128101Vispute, T. P., Zhang, H., Sanna, A., Xiao, R., & Huber, G. W. (2010). Renewable Chemical Commodity Feedstocks from Integrated Catalytic Processing of Pyrolysis Oils. Science, 330(6008), 1222-1227. doi:10.1126/science.1194218Climent, M. J., Corma, A., & Iborra, S. (2014). Conversion of biomass platform molecules into fuel additives and liquid hydrocarbon fuels. Green Chemistry, 16(2), 516. doi:10.1039/c3gc41492bCorma, A., Iborra, S., & Velty, A. (2007). Chemical Routes for the Transformation of Biomass into Chemicals. Chemical Reviews, 107(6), 2411-2502. doi:10.1021/cr050989dCliment, M. J., Corma, A., & Iborra, S. (2011). Converting carbohydrates to bulk chemicals and fine chemicals over heterogeneous catalysts. Green Chemistry, 13(3), 520. doi:10.1039/c0gc00639dGallezot, P. (2012). Conversion of biomass to selected chemical products. Chem. Soc. Rev., 41(4), 1538-1558. doi:10.1039/c1cs15147aTop Value Added Chemicals from Biomass. Results of Screening for Potential Candidates from Sugars and Synthesis Gas, Vol. 1 2004 http://www.nrel.gov/docs/fy04osti/35523.pdfBozell, J. J., & Petersen, G. R. (2010). 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ChemSusChem, 4(11), 1578-1581. doi:10.1002/cssc.201100344Ortiz-Cervantes, C., Flores-Alamo, M., & García, J. J. (2016). Synthesis of pyrrolidones and quinolines from the known biomass feedstock levulinic acid and amines. Tetrahedron Letters, 57(7), 766-771. doi:10.1016/j.tetlet.2016.01.018Du, X.-L., He, L., Zhao, S., Liu, Y.-M., Cao, Y., He, H.-Y., & Fan, K.-N. (2011). Hydrogen-Independent Reductive Transformation of Carbohydrate Biomass into γ-Valerolactone and Pyrrolidone Derivatives with Supported Gold Catalysts. Angewandte Chemie International Edition, 50(34), 7815-7819. doi:10.1002/anie.201100102Du, X.-L., He, L., Zhao, S., Liu, Y.-M., Cao, Y., He, H.-Y., & Fan, K.-N. (2011). Hydrogen-Independent Reductive Transformation of Carbohydrate Biomass into γ-Valerolactone and Pyrrolidone Derivatives with Supported Gold Catalysts. Angewandte Chemie, 123(34), 7961-7965. doi:10.1002/ange.201100102Wei, Y., Wang, C., Jiang, X., Xue, D., Liu, Z.-T., & Xiao, J. (2014). 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Genome-wide association study for systemic lupus erythematosus in an egyptian population

Systemic lupus erythematosus (SLE) susceptibility has a strong genetic component. Genome-wide association studies (GWAS) across trans-ancestral populations show both common and distinct genetic variants of susceptibility across European and Asian ancestries, while many other ethnic populations remain underexplored. We conducted the first SLE GWAS on Egyptians–an admixed North African/Middle Eastern population–using 537 patients and 883 controls. To identify novel susceptibility loci and replicate previously known loci, we performed imputation-based association analysis with 6,382,276 SNPs while accounting for individual admixture. We validated the association analysis using adaptive permutation tests (n = 109). We identified a novel genome-wide significant locus near IRS1/miR-5702 (Pcorrected = 1.98 × 10−8) and eight novel suggestive loci (Pcorrected 0.8) with lead SNPs from four suggestive loci (ARMC9, DIAPH3, IFLDT1, and ENTPD3) were associated with differential gene expression (3.5 × 10−95 < p < 1.0 × 10−2) across diverse tissues. These loci are involved in cellular proliferation and invasion—pathways prominent in lupus and nephritis. Our study highlights the utility of GWAS in an admixed Egyptian population for delineating new genetic associations and for understanding SLE pathogenesis

Sur Quelques Modes D\u27hypertrophie Chez Les V\ue9g\ue9taux

Volume: 4Start Page: 649End Page: 65

Rapport De Sur L\u27herborisation Faite, Le 10 Juin, Aun Bois De La Moure Et Au Port Jun\ue9nal, Et Dirig\ue9e par MM. Chatin Et Touchy

Volume: 4Start Page: 592End Page: 59

Auf Erfahrung gegründete Unterweisung wie Gutsbesizzer, Pachter und Landleute ihre Haus- und Feldwirthschaft besser benuzzen und wohlhabender und reicher werden können : In drei Theilen

[Ferdinand Christian Touchy]Vorlageform der Veröffentlichungsangabe: Leipzig in Commission in der Sommerschen Buchhandlung