Utjecaj udjela botritiziranih bobica grožđa na aromu vina Amarone

The aim of this study is to evaluate the impact of Botrytis cinerea, a noble rot, on the aroma components of Amarone, a dry red wine produced from withered grapes. A comparative analysis of wines obtained from manually selected healthy and botrytized grapes was done. Aroma analysis revealed that most compounds varied significantly according to the percentage of botrytized berries utilized. Botrytized wines contained less fatty acids and more fruity acetates than healthy wines. A positive correlation between the content of N-(3-methylbutyl)acetamide, sherry lactone and an unidentified compound and the level of fungal infection was also observed. The results indicate that noble rot can significantly modify important aroma components of Amarone wine.Svrha je ovoga rada bila procijeniti utjecaj plemenite plijesni Botrytis cinerea na sastojke arome suhoga crvenog vina Amarone, proizvedenog iz prosušenoga grožđa. Uspoređen je sastav vina dobivenog od ručno probranih zdravih i botritiziranih bobica grožđa, pa je utvrđeno da većina sastojaka arome bitno ovisi o udjelu navedenih bobica. Botritizirana vina sadrže manje masnih kiselina i više voćnih acetata od vina dobivenih od zdravoga grožđa. Opažena je pozitivna korelacija udjela N-(3-metilbutil)acetamida, laktona iz sherryja i neidentificiranog spoja te jačine gljivične infekcije. Rezultati pokazuju da plemenita plijesan bitno utječe na udjel glavnih sastojaka arome vina Amarone

Pensare come una laguna. Verso un contratto di area umida per la laguna nord di Venezia

Il progetto Interreg Italia-Croazia CREW - Coordinated Wetland Management in Italy-Croatia cross-border region, si pone come obiettivo principale la tutela della biodiversità delle aree umide costiere nella regione adriatica tra Italia e Croazia, attraverso lo sviluppo di strumenti innovativi di governance partecipata, quale il Contratto di Area Umida. l’Università Iuav di Venezia, leader partner del progetto, ha scelto di occuparsi della Laguna di Venezia, area umida di grande rilevanza storica, culturale, economica ed ambientale a livello europeo e mediterraneo. Promuovendo la centralità dei soggetti territoriali (amministrazioni locali, comunità, associazioni e singoli) ma anche dei soggetti ‘diversamente animati’ (flora e fauna), il Contratto per la Laguna nord di Venezia si propone di affrontare la gestione delle aree umide superando i confini amministrativi e guardando agli ecosistemi nel loro complesso

Thalidomide-dexamethasone as induction therapy before autologous stem cell transplantation in patients with newly diagnosed multiple myeloma and renal insufficiency.

The aim of this study was to evaluate the efficacy and the toxicity of thalidomide-dexamethasone (Thal-Dex) as induction therapy before autologous peripheral blood stem cell (PBSC) transplantation in patients with newly diagnosed multiple myeloma (MM) with renal insufficiency. The study included 31 patients with a baseline creatinine clearance value ≤50 mL/min, 7 of whom required chronic hemodialysis. Patients received 4 months of Thal-Dex, followed by PBSC collection and subsequent transplantation. After induction, a partial response (PR) or greater was obtained in 23 patients (74%), including 8 (26%) who achieved a very good PR. Renal function improved more frequently in patients achieving a PR or greater (82%, vs 37% in patients achieving less than a PR; P = .04). Twenty-six patients underwent PBSC mobilization; in 17 of these patients (65%), >4 × 10 6 CD34 + cells/kg were collected. Double autologous transplantation was performed in 15 patients, and a single autologous transplantation was performed in 7 patients. After a median of 32 months of follow-up, median event-free survival was 30 months, and median survival was not determined. According to our data, Thal-Dex is effective and safe in patients with newly diagnosed MM and renal insufficiency. Given the relationship between recovery of renal function and response to induction treatment, more intensive Thal + bortezomib regimens could be explored to rescue higher numbers of patients

ECMO for COVID-19 patients in Europe and Israel

Since March 15th, 2020, 177 centres from Europe and Israel have joined the study, routinely reporting on the ECMO support they provide to COVID-19 patients. The mean annual number of cases treated with ECMO in the participating centres before the pandemic (2019) was 55. The number of COVID-19 patients has increased rapidly each week reaching 1531 treated patients as of September 14th. The greatest number of cases has been reported from France (n = 385), UK (n = 193), Germany (n = 176), Spain (n = 166), and Italy (n = 136) .The mean age of treated patients was 52.6 years (range 16–80), 79% were male. The ECMO configuration used was VV in 91% of cases, VA in 5% and other in 4%. The mean PaO2 before ECMO implantation was 65 mmHg. The mean duration of ECMO support thus far has been 18 days and the mean ICU length of stay of these patients was 33 days. As of the 14th September, overall 841 patients have been weaned from ECMO support, 601 died during ECMO support, 71 died after withdrawal of ECMO, 79 are still receiving ECMO support and for 10 patients status n.a. . Our preliminary data suggest that patients placed on ECMO with severe refractory respiratory or cardiac failure secondary to COVID-19 have a reasonable (55%) chance of survival. Further extensive data analysis is expected to provide invaluable information on the demographics, severity of illness, indications and different ECMO management strategies in these patients

Modelling human choices: MADeM and decision‑making

Research supported by FAPESP 2015/50122-0 and DFG-GRTK 1740/2. RP and AR are also part of the Research, Innovation and Dissemination Center for Neuromathematics FAPESP grant (2013/07699-0). RP is supported by a FAPESP scholarship (2013/25667-8). ACR is partially supported by a CNPq fellowship (grant 306251/2014-0)

An idea of lagoon heritage : territorial preservation between speculation and civic rights

The notion of heritage has long been used within the rhetoric of territorial promotion concerning Venice, which describes its value in relation to historical data, and supports investments and consumption linked to the experience of typicality. The same notion is adopted to support safeguarding and protection operations, in the awareness of the fragility that characterises the city and the lagoon context it is part of. The observation of the Venetian lagoon offers, in this regard, a privileged space of investigation that allows to examine the changing trends related to the patrimonialization of places and the (narrative and financial) speculation to which they are exposed. At the same time, it makes it possible to recognise an opposite tension that operates to protect the landscape and its resources, starting from the idea of common good. This latter tendency recognises in the practices of non-proprietary custody an important element for the safeguarding of territorial rights. The experience of Interreg Crew-Wetland Contract for the Northern Lagoon of Venice, provides an opportunity to rethink the promotion of the lagoon as a shared process, in the awareness that the territory can be experienced and enjoyed outside of the processes of museification, spectacularization, and marketization already widely investigated

Laguna Futuri : Esperienze e progetti dal territorio veneziano

Forse esistono tante lagune di Venezia quanti sono i progetti che l’hanno interessata nel corso dei suoi mille anni di storia. Sia le grandi pianificazioni sia le minute hanno costruito spazi reali e immaginari alla ricerca di un equilibrio tra opposti: la terra e l’acqua, la natura e l’uomo, la necessità di regolazione e gli effetti imprevedibili dei cambiamenti climatici. È sul futuro, o per meglio dire sui molteplici futuri di questo territorio che il volume si interroga, e lo fa raccontando la prima esperienza partecipata di un Contratto di Area Umida per la Laguna Nord di Venezia. Le esperienze, le testimonianze e le riflessioni che ne derivano forniscono prospettive originali per guardare questi luoghi e riconoscerne non solo i mutamenti fisici e spaziali ma anche quelli propri dell’immaginario di chi li vive quotidianamente. Un complesso eterogeneo di informazioni, temi e confronti, descritti e mappati sotto forma di atlante eclettico, compone così un vero e proprio lessico lagunare

Partecipare a distanza. Il Contratto di Area Umida per la Laguna Nord di Venezia durante Covid-19

Il “Contratto di Area Umida” per la laguna nord di Venezia, parte del progetto Interreg CREW, offre l’occasione di riflettere sul valore attribuito ai territori in trasformazione, specie quando essi sono sottoposti a pressioni antropiche e naturali che ne mettono a repentaglio il ruolo ecosistemico. Svoltosi in piena epoca pandemica, il progetto ha sperimentato la necessità di innovare un approccio alla partecipazione tradizionalmente legato ad attività svolte in presenza. Questo ha favorito una diversa valutazione delle caratteristiche del territorio e la rielaborazione critica delle sue qualità e mancanze. Il paper propone di leggere l’esperienza di coinvolgimento degli attori locali nel processo di formazione del Contratto, confrontandolo con le pratiche di attivazione dei Living e Policy Lab. La lettura analizza le innovazioni come parte del processo di co-creazione materiale e politica che prevede la partecipazione di comunità diverse alla discussione di problemi sociali e territoriali complessi

An ordered probit model for seismic intensity data

Seismic intensity, measured through the Mercalli–Cancani–Sieberg (MCS) scale, provides an assessment of ground shaking level deduced from building damages, any natural environment changes and from any observed effects or feelings. Generally, moving away from the earthquake epicentre, the effects are lower but intensities may vary in space, as there could be areas that amplify or reduce the shaking depending on the earthquake source geometry, geological features and local factors. Currently, the Istituto Nazionale di Geofisica e Vulcanologia analyzes, for each seismic event, intensity data collected through the online macroseismic questionnaire available at the web-page www.haisentitoilterremoto.it. Questionnaire responses are aggregated at the municipality level and analyzed to obtain an intensity defined on an ordinal categorical scale. The main aim of this work is to model macroseismic attenuation and obtain an intensity prediction equation which describes the decay of macroseismic intensity as a function of the magnitude and distance from the hypocentre. To do this we employ an ordered probit model, assuming that the intensity response variable is related through the link probit function to some predictors. Differently from what it is commonly done in the macroseismic literature, this approach takes properly into account the qualitative and ordinal nature of the macroseismic intensity as defined on the MCS scale. Using Markov chain Monte Carlo methods, we estimate the posterior probability of the intensity at each site. Moreover, by comparing observed and estimated intensities we are able to detect anomalous areas in terms of residuals. This kind of information can be useful for a better assessment of seismic risk and for promoting effective policies to reduce major damages.Published1593–16024T. Sismologia, geofisica e geologia per l'ingegneria sismicaJCR Journa