2,253 research outputs found
Transits and secondary eclipses of HD 189733 with Spitzer
We present limits on transit timing variations and secondary eclipse depth
variations at 8 microns with the Spitzer Space Telescope IRAC camera. Due to
the weak limb darkening in the infrared and uninterrupted observing, Spitzer
provides the highest accuracy transit times for this bright system, in
principle providing sensitivity to secondary planets of Mars mass in resonant
orbits. Finally, the transit data provides tighter constraints on the
wavelength- dependent atmospheric absorption by the planet.Comment: 7 pages, 7 figures, submitted to proceedings of IAU Symposium No. 253
"Transiting Planets
Protein-truncating variants in BSN are associated with severe adult-onset 2 obesity, type 2 diabetes and fatty liver disease
Obesity is a major risk factor for many common diseases and has a substantial heritable component. To identify novel genetic determinants, we performed exome-sequence analyses for adult body mass index (BMI) in up to 587,027 individuals. We identified rare, loss-of-function variants in two genes (BSN and APBA1) with effects substantially larger than well-established obesity genes such as MC4R. In contrast to most other obesity-related genes, rare variants in BSN and APBA1 were not associated with normal variation in childhood adiposity. Furthermore, BSN protein-truncating variants (PTVs) magnified the influence of common genetic variants associated with BMI, with a common polygenic score exhibiting an effect twice as large in BSN PTV carriers than non-carriers. Finally, we explored the plasma proteomic signatures of BSN PTV carriers as well as the functional consequences of BSN deletion in human iPSC-derived hypothalamic neurons. Collectively, our findings implicate degenerative processes in synaptic function in the etiology of adult53 onset obesity
Rare coding variants in CHRNB2 reduce the likelihood of smoking
Human genetic studies of smoking behavior have been thus far largely limited to common variants. Studying rare coding variants has the potential to identify drug targets. We performed an exome-wide association study of smoking phenotypes in up to 749,459 individuals and discovered a protective association in CHRNB2, encoding the β2 subunit of the α4β2 nicotine acetylcholine receptor. Rare predicted loss-of-function and likely deleterious missense variants in CHRNB2 in aggregate were associated with a 35% decreased odds for smoking heavily (odds ratio (OR) = 0.65, confidence interval (CI) = 0.56–0.76, P = 1.9 × 10−8). An independent common variant association in the protective direction (rs2072659; OR = 0.96; CI = 0.94–0.98; P = 5.3 × 10−6) was also evident, suggesting an allelic series. Our findings in humans align with decades-old experimental observations in mice that β2 loss abolishes nicotine-mediated neuronal responses and attenuates nicotine self-administration. Our genetic discovery will inspire future drug designs targeting CHRNB2 in the brain for the treatment of nicotine addiction
Follow-up Observations of the Neptune Mass Transiting Extrasolar Planet HAT-P-11b
We have confirmed the existence of the transiting super Neptune extrasolar
planet HAT-P-11b. On May 1, 2009 UT the transit of HAT-P-11b was detected at
the University of Arizona's 1.55m Kuiper Telescope with 1.7 millimag rms
accuracy. We find a central transit time of T_c = 2454952.92534+/-0.00060 BJD;
this transit occurred 80+/-73 seconds sooner than previous measurements (71
orbits in the past) would have predicted. Hence, our transit timing rules out
the presence of any large (>200 s) deviations from the ephemeris of Bakos et
al. (2009). We obtain a slightly more accurate period of
P=4.8878045+/-0.0000043 days. We measure a slightly larger planetary radius of
R_p=0.452+/-0.020 R_J (5.07+/-0.22 R_earth) compared to Bakos and co-workers'
value of 0.422+/-0.014 R_J (4.73+/-0.16 R_earth). Our values confirm that
HAT-P-11b is very similar to GJ 436b (the only other known transiting super
Neptune) in radius and other bulk properties.Comment: accepted to ApJ Letters, 11 pages, 2 figures (see Dittmann et al.
2009 ApJ 699 L48-L51
Modeling Kepler transit light curves as false positives: Rejection of blend scenarios for Kepler-9, and validation of Kepler-9d, a super-Earth-size planet in a multiple system
Light curves from the Kepler Mission contain valuable information on the
nature of the phenomena producing the transit-like signals. To assist in
exploring the possibility that they are due to an astrophysical false positive,
we describe a procedure (BLENDER) to model the photometry in terms of a "blend"
rather than a planet orbiting a star. A blend may consist of a background or
foreground eclipsing binary (or star-planet pair) whose eclipses are attenuated
by the light of the candidate and possibly other stars within the photometric
aperture. We apply BLENDER to the case of Kepler-9, a target harboring two
previously confirmed Saturn-size planets (Kepler-9b and Kepler-9c) showing
transit timing variations, and an additional shallower signal with a 1.59-day
period suggesting the presence of a super-Earth-size planet. Using BLENDER
together with constraints from other follow-up observations we are able to rule
out all blends for the two deeper signals, and provide independent validation
of their planetary nature. For the shallower signal we rule out a large
fraction of the false positives that might mimic the transits. The false alarm
rate for remaining blends depends in part (and inversely) on the unknown
frequency of small-size planets. Based on several realistic estimates of this
frequency we conclude with very high confidence that this small signal is due
to a super-Earth-size planet (Kepler-9d) in a multiple system, rather than a
false positive. The radius is determined to be 1.64 (+0.19/-0.14) R(Earth), and
current spectroscopic observations are as yet insufficient to establish its
mass.Comment: 20 pages in emulateapj format, including 8 tables and 16 figures. To
appear in ApJ, 1 January 2010. Accepted versio
Shared decision making in patients with low risk chest pain: prospective randomized pragmatic trial.
OBJECTIVE: To compare the effectiveness of shared decision making with usual care in choice of admission for observation and further cardiac testing or for referral for outpatient evaluation in patients with possible acute coronary syndrome.
DESIGN: Multicenter pragmatic parallel randomized controlled trial.
SETTING: Six emergency departments in the United States.
PARTICIPANTS: 898 adults (aged \u3e17 years) with a primary complaint of chest pain who were being considered for admission to an observation unit for cardiac testing (451 were allocated to the decision aid and 447 to usual care), and 361 emergency clinicians (emergency physicians, nurse practitioners, and physician assistants) caring for patients with chest pain.
INTERVENTIONS: Patients were randomly assigned (1:1) by an electronic, web based system to shared decision making facilitated by a decision aid or to usual care. The primary outcome, selected by patient and caregiver advisers, was patient knowledge of their risk for acute coronary syndrome and options for care; secondary outcomes were involvement in the decision to be admitted, proportion of patients admitted for cardiac testing, and the 30 day rate of major adverse cardiac events.
RESULTS: Compared with the usual care arm, patients in the decision aid arm had greater knowledge of their risk for acute coronary syndrome and options for care (questions correct: decision aid, 4.2 v usual care, 3.6; mean difference 0.66, 95% confidence interval 0.46 to 0.86), were more involved in the decision (observing patient involvement scores: decision aid, 18.3 v usual care, 7.9; 10.3, 9.1 to 11.5), and less frequently decided with their clinician to be admitted for cardiac testing (decision aid, 37% v usual care, 52%; absolute difference 15%; P
CONCLUSIONS: Use of a decision aid in patients at low risk for acute coronary syndrome increased patient knowledge about their risk, increased engagement, and safely decreased the rate of admission to an observation unit for cardiac testing.Trial registration ClinicalTrials.gov NCT01969240
Induction of viral mimicry upon loss of DHX9 and ADAR1 in breast cancer cells
UNLABELLED: Detection of viral double-stranded RNA (dsRNA) is an important component of innate immunity. However, many endogenous RNAs containing double-stranded regions can be misrecognized and activate innate immunity. The IFN-inducible ADAR1-p150 suppresses dsRNA sensing, an essential function for adenosine deaminase acting on RNA 1 (ADAR1) in many cancers, including breast. Although ADAR1-p150 has been well established in this role, the functions of the constitutively expressed ADAR1-p110 isoform are less understood. We used proximity labeling to identify putative ADAR1-p110-interacting proteins in breast cancer cell lines. Of the proteins identified, the RNA helicase DHX9 was of particular interest. Knockdown of DHX9 in ADAR1-dependent cell lines caused cell death and activation of the dsRNA sensor PKR. In ADAR1-independent cell lines, combined knockdown of DHX9 and ADAR1, but neither alone, caused activation of multiple dsRNA sensing pathways leading to a viral mimicry phenotype. Together, these results reveal an important role for DHX9 in suppressing dsRNA sensing by multiple pathways.
SIGNIFICANCE: These findings implicate DHX9 as a suppressor of dsRNA sensing. In some cell lines, loss of DHX9 alone is sufficient to cause activation of dsRNA sensing pathways, while in other cell lines DHX9 functions redundantly with ADAR1 to suppress pathway activation
Confirmation of SBS 1150+599A As An Extremely Metal-Poor Planetary Nebula
SBS 1150+599A is a blue stellar object at high galactic latitude discovered
in the Second Byurakan Survey. New high-resolution images of SBS 1150+599A are
presented, demonstrating that it is very likely to be an old planetary nebula
in the galactic halo, as suggested by Tovmassian et al (2001). An H-alpha image
taken with the WIYN 3.5-m telescope and its "tip/tilt" module reveals the
diameter of the nebula to be 9.2", comparable to that estimated from spectra by
Tovmassian et al. Lower limits to the central star temperature were derived
using the Zanstra hydrogen and helium methods to determine that the star's
effective temperature must be > 68,000K and that the nebula is optically thin.
New spectra from the MMT and FLWO telescopes are presented, revealing the
presence of strong [Ne V] lambda 3425, indicating that the central star
temperature must be > 100,000K. With the revised diameter, new central star
temperature, and an improved central star luminosity, we can constrain
photoionization models for the nebula significantly better than before. Because
the emission-line data set is sparse, the models are still not conclusive.
Nevertheless, we confirm that this nebula is an extremely metal-poor planetary
nebula, having a value for O/H that is less than 1/100 solar, and possibly as
low as 1/500 solar.Comment: 19 pages, 6 figures. Accepted for publication in the Astronomical
Journa
Revised Stellar Properties of Kepler Targets for the Quarter 1-16 Transit Detection Run
We present revised properties for 196,468 stars observed by the NASA Kepler
Mission and used in the analysis of Quarter 1-16 (Q1-Q16) data to detect and
characterize transiting exoplanets. The catalog is based on a compilation of
literature values for atmospheric properties (temperature, surface gravity, and
metallicity) derived from different observational techniques (photometry,
spectroscopy, asteroseismology, and exoplanet transits), which were then
homogeneously fitted to a grid of Dartmouth stellar isochrones. We use
broadband photometry and asteroseismology to characterize 11,532 Kepler targets
which were previously unclassified in the Kepler Input Catalog (KIC). We report
the detection of oscillations in 2,762 of these targets, classifying them as
giant stars and increasing the number of known oscillating giant stars observed
by Kepler by ~20% to a total of ~15,500 stars. Typical uncertainties in derived
radii and masses are ~40% and ~20%, respectively, for stars with photometric
constraints only, and 5-15% and ~10% for stars based on spectroscopy and/or
asteroseismology, although these uncertainties vary strongly with spectral type
and luminosity class. A comparison with the Q1-Q12 catalog shows a systematic
decrease in radii for M dwarfs, while radii for K dwarfs decrease or increase
depending on the Q1-Q12 provenance (KIC or Yonsei-Yale isochrones). Radii of
F-G dwarfs are on average unchanged, with the exception of newly identified
giants. The Q1-Q16 star properties catalog is a first step towards an improved
characterization of all Kepler targets to support planet occurrence studies.Comment: 20 pages, 14 figures, 5 tables; accepted for publication in ApJS;
electronic versions of Tables 4 and 5 are available as ancillary files (see
sidebar on the right), and an interactive version of Table 5 is available at
the NASA Exoplanet Archive (http://exoplanetarchive.ipac.caltech.edu/
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