In-Flight Cost Index Optimisation Upon Weather Forecast Updates

This paper presents an optimisation framework to compute the altitude and speed profiles of a trajectory in the execution phase of the flight, such that the expected total cost (ETC) of the operation is minimised (i.e., modelling the expected cost of delay and fuel – including arrival uncertainties – at the arrival gate). This is achieved with a two-stage optimisation strategy: a trajectory optimiser that minimises a generalised direct operating cost function, for a given cost index; and an upper-level optimiser, which obtains the best cost index that minimises the ETC. Several case studies are presented for different departure delays, while considering the impact of two different weather forecast updates too: a region with relative high head-winds appearing half way across the flight; and a cold atmosphere scenario, with a tropopause altitude lower than standard conditions

Considering TMA holding uncertinaty into in-flight trajectory optimisation

Aircraft crew are aware of the delay they have experienced at departure. However, uncertainties ahead, and in particular holdings at arrival, can have an impact on the final performance of their operations. When optimising a trajectory the expected cost at the arrival gate should be considered. Consequently, taking into account potential congestion and extra delay at the arrival airspace is paramount to avoid taking sub-optimal decisions at the early stages of the flight. This paper presents a framework to optimise trajectories in the execution phase of the flight considering expected delays at arrival. A flight from Athens (LGAV) to London Heathrow (EGLL) is used as illustrative example, systematically exploring a range of departure delays and expected holdings at arrival

A software engine for multi-criteria decision support in flight management - Use of dynamic cost functions - Architecture and first results

Tactical trajectory optimisation should consider the total expected cost of the flight (fuel and delay). The cost of fuel can be estimated from the expected fuel usage. The cost of delay can be approximated by simple non-linear functions but, we propose a methodology to explicitly consider its different components: passenger related (regulation 261, duty of care, missed connections and soft costs), crew and maintenance, and reactionary costs (delay and curfew). This explicit modelling captures the non-continuous aspects of the cost function, which can significantly impact the optimisation profile, e.g. ensure that missed connections are reduced. The cost of delay, dependent on the arrival time at the gate, can be subject to uncertainties which are inherent (e.g. if a passenger will or not miss a connection) and external (e.g. taxi-in or holding times). Therefore, the optimisation framework should estimate the arrival time to the gate (not the runway) while considering these associated uncertainties. The described architecture models the processes affecting the cost (e.g. considering probabilities of missed connections or explicit propagation of delay) and operational aspects at arrival which impact the realisation of the planned optimised trajectory (holding time, sequencing and merging distance (tromboning), and taxi-in time). The consideration of the operational uncertainties enables the estimation of the probability of achieving the flight on-time performance. All these operational uncertainties are integrated into the cost function producing a total expected cost as a function of arrival to FL100 during the descent at the arrival airport. The trajectory is then optimised in its vertical and speed profile finding the cost index which is expected to minimise the total costs with a simulated annealing framework. The first results presented describe how the cost functions are generated, uncertainties considered and trajectories optimised for a flight in the LEDM-EDDF route

Evidence for an extended critical fluctuation region above the polar ordering transition in LiOsO3_3

Metallic LiOsO$_3$ undergoes a continuous ferroelectric-like structural phase transition below $T_c$ = 140 K to realize a polar metal. To understand the microscopic interactions that drive this transition, we study its critical behavior above $T_c$ via electromechanical coupling - distortions of the lattice induced by short-range dipole-dipole correlations arising from Li off-center displacements. By mapping the full angular distribution of second harmonic electric-quadrupole radiation from LiOsO$_3$ and performing a simplified hyper-polarizable bond model analysis, we uncover subtle symmetry-preserving lattice distortions over a broad temperature range extending from $T_c$ up to around 230 K, characterized by non-uniform changes in the short and long Li-O bond lengths. Such an extended region of critical fluctuations may explain anomalous features reported in specific heat and Raman scattering data, and suggests the presence of competing interactions that are not accounted for in existing theoretical treatments. More broadly, our results showcase how electromechanical effects serve as a probe of critical behavior near inversion symmetry breaking transitions in metals.Comment: 6 pages main text, 4 figures, 10 pages supplementary informatio

Background discrimination capabilities of a heat and ionization germanium cryogenic detector

The discrimination capabilities of a 70 g heat and ionization Ge bolometer are studied. This first prototype has been used by the EDELWEISS Dark Matter experiment, installed in the Laboratoire Souterrain de Modane, for direct detection of WIMPs. Gamma and neutron calibrations demonstrate that this type of detector is able to reject more than 99.6% of the background while retaining 95% of the signal, provided that the background events distribution is not biased towards the surface of the Ge crystal. However, the 1.17 kg.day of data taken in a relatively important radioactive environment show an extra population slightly overlapping the signal. This background is likely due to interactions of low energy photons or electrons near the surface of the crystal, and is somewhat reduced by applying a higher charge-collecting inverse bias voltage (-6 V instead of -2 V) to the Ge diode. Despite this contamination, more than 98% of the background can be rejected while retaining 50% of the signal. This yields a conservative upper limit of 0.7 event.day^{-1}.kg^{-1}.keV^{-1}_{recoil} at 90% confidence level in the 15-45 keV recoil energy interval; the present sensitivity appears to be limited by the fast ambient neutrons. Upgrades in progress on the installation are summarized.Comment: Submitted to Astroparticle Physics, 14 page

Clinical relevance of monitoring serum levels of adalimumab in patients with rheumatoid arthritis in daily practice

[Objectives]: We aimed to assess the usefulness of measuring serum levels of adalimumab (ADL) and anti-ADL antibodies in 57 patients with rheumatoid arthritis (RA) treated with ADL for at least 3 months in daily practice. [Methods]: All patients received concomitant disease-modifying anti-rheumatic drug (DMARD). Receiver-operator characteristics (ROC) analysis was used to obtain the cut-off value of ADL for low disease activity (DAS28-ESR ≤3.2). [Results]: Anti-ADL antibodies were detected in 4 (7%) patients with a mean (SD) DAS28 score of 4.6 (0.9). Patients with positive anti-ADL antibodies had significantly lower levels of ADL and higher DAS28 scores than those with negative antibodies. Patients with DAS28 ≤3.2 as compared with patients with DAS28 >3.2 showed significantly better SDAI score, higher serum concentrations of ADL and none of them showed anti-ADL antibodies. The cut-off of serum level of ADL for DAS28 11.3 mg/L. Patients in the medium group were closed to clinical remission (median DAS28 2.7) and patients in the high group were on clinical remission (DAS28 2.1). [Conclusion]: Serum levels of ADL should be maintained >4.3 mg/L. In patients with ADL levels >11.3 mg/L, a decrease of the dose of ADL or an increase in the interval between doses may be planned. The presence of anti-ADL antibodies was associated with a loss of clinical efficacy of ADL.Peer Reviewe

Stable mode-locked pulses from mid-infrared semiconductor lasers

We report the unequivocal demonstration of mid-infrared mode-locked pulses from a semiconductor laser. The train of short pulses was generated by actively modulating the current and hence the optical gain in a small section of an edge-emitting quantum cascade laser (QCL). Pulses with pulse duration at full-width-at-half-maximum of about 3 ps and energy of 0.5 pJ were characterized using a second-order interferometric autocorrelation technique based on a nonlinear quantum well infrared photodetector. The mode-locking dynamics in the QCLs was modelled and simulated based on Maxwell-Bloch equations in an open two-level system. We anticipate our results to be a significant step toward a compact, electrically-pumped source generating ultrashort light pulses in the mid-infrared and terahertz spectral ranges.Comment: 26 pages, 4 figure

Event categories in the EDELWEISS WIMP search experiment

Four categories of events have been identified in the EDELWEISS-I dark matter experiment using germanium cryogenic detectors measuring simultaneously charge and heat signals. These categories of events are interpreted as electron and nuclear interactions occurring in the volume of the detector, and electron and nuclear interactions occurring close to the surface of the detectors(10-20 mu-m of the surface). We discuss the hypothesis that low energy surface nuclear recoils,which seem to have been unnoticed by previous WIMP searches, may provide an interpretation of the anomalous events recorded by the UKDMC and Saclay NaI experiments. The present analysis points to the necessity of taking into account surface nuclear and electron recoil interactions for a reliable estimate of background rejection factors.Comment: 11 pages, submitted to Phys. Lett.