The effects of complexity, accuracy, and fluency on communicative adequacy in oral task performance

Communicative adequacy is a key construct in second language research, as the primary goal of most language learners is to communicate successfully in real-world situations. Nevertheless, little is known about what linguistic features contribute to communicatively adequate speech. This study fills this gap by investigating the extent to which complexity, accuracy, and fluency (CAF) predict adequacy, and whether proficiency and task type moderate these relationships. In all, 20 native speakers and 80 second language users from four proficiency levels performed five tasks. Speech samples were rated for adequacy and coded for a range of CAF indices. Filled pause frequency, a feature of breakdown fluency, emerged as the strongest predictor of adequacy. Predictors with significant but smaller effects included indices of all three CAF dimensions: linguistic complexity (lexical diversity, overall syntactic complexity, syntactic complexity by subordination, and frequency of conjoined clauses), accuracy (general accuracy and accuracy of connectors), and fluency (silent pause frequency and speed fluency). For advanced speakers, incidence of false starts also emerged as predicting communicatively adequate speech. Task type did not influence the link between linguistic features and adequacy

Balancing engagement and neutrality in technology assessment

Should technology assessment take a stance – when, on what, and how? How to deal with its neutrality paradigm in times of anti-democratic tendencies

Value capture from low embodied emissions of buildings - A business model innovation perspective

The transition to a society with low emissions has led to several intensives for decreasing operational energy and the environmental impact of buildings. The embodied impacts from manufacturing materials have been shown to increase in relative importance as the operational energy efficiency has increased. Several case studies have shown various technical solutions which can reduce embodied carbon emissions. But is this reduction good for business? There are several building projects that have achieved low embodied emissions, but these are often in segments of premium private clients or green public procurement where additional motivation such as reputation and long-term viability is in place. However, with the transition to a low emission society, there is a need to include all types of building markets. This study aims to find business model innovation opportunities with reduced embodied emissions in building projects where the clients have low motivation beyond reducing costs. The approach is through action research with a Norwegian contractor seeking new opportunities while keeping the main competitive advantage. The research starts with a case that could reduce overall greenhouse gas emissions, and includes the potential savings from green loans to find potentials to capture value from reducing emissions. The results show that criteria exist for green loans based on reducing operational and embodied emissions. Future studies are however need to make an integrated assessment on the potential value captured from these green loans.</p

Women in strange trousers

Poem.Author biography: Josh McDonald is a writer, musician, and storyteller. He is currently writing his third novel. [2008]This episode of our podcast features three runners-up in the Voice-only poetry category of our 2007 Audio Competition. In 'The Golden lesson,' second runner-up Susan Somers-Willet gives an engaging performance of a poem rich in painterly image and metaphor, a poem both complex in its ideas, and visceral in its textures. The third runner-up of the Voice-only poetry category is Eric Torgersen with 'Taking tickets.' The poem defies easy classification--but we're sure you'll find this voice-driven poem, with its quirky character, entertaining. And we conclude with the fourth runner-up, Josh McDonald's 'Women in strange trousers,' a prose poem about females attired in an assortment of odd apparel--Publisher's Web siteAuthor biography: Susan B.A. Somers-Willett is the author of two books of poetry, Quiver and Roam, and a book of criticism, The Cultural politics of slam poetry : race, identity, and the performance of popular verse in America. Her honors include the Ann Stanford Poetry Prize and the Robert Frost Foundation Poetry Award. Raised in New Orleans, she teaches English and Creative Writing at Montclair State University in New Jersey. [2010]Author biography: Eric Torgersen, Professor of English, Central Michigan University, has published two chapbooks and three full-length books of poetry, one book of fiction (a novella), and the biographical/critical study Dear Friend: Rainer Maria Rilke and Paula Modersohn-Becker, Northwestern UP. [2008]The golden lesson / Susan Somers-Willet -- Taking tickets / Eric Torgersen -- Women in strange trousers / Josh McDonald

Influenza A(H1N1) infection and severe cardiac dysfunction in adults: A case series

Zusammenfassung: HINTERGRUND: Während die virale Myokarditis und das Herzversagen anerkannte und gefürchtete Komplikationen einer saisonalen Influenza A Infektion sind, liegen bislang nur wenig Informationen über ein durch das 2009 Influenza A(H1N1) Virus induziertes Herzversagen vor. METHODEN UND HAUPTERGEBNISSE: Diese Fallsammlung fasst den Krankheitsverlauf von vier Patienten mit 2009 Influenza A(H1N1) Infektion zusammen, welche an unserer Klinik im Zeitraum von November 2009 bis September 2010 behandelt wurden. Alle Patienten präsentierten sich mit einer schweren kardialen Funktionsstörung (akutes Herzversagen, kardiogener Schock oder Herzkreislaufstillstand im Rahmen eines Kammerflimmerns) als das führende Symptom einer Influenza A(H1N1) Infektion. Zwei Patienten waren mit hoher Wahrscheinlichkeit kardial vorerkrankt, und drei benötigten eine Katecholamintherapie, um die hämodynamische Funktion zu stabilisieren. Mit Ausnahme eines Patienten der vor der Diagnosestellung der Influenza A(H1N1) Infektion verstarb, wurden alle Patienten mit einer antiviralen Therapie mit Oseltamivir und supportiver Intensivtherapie behandelt. Ein Acute Respiratory Distress Syndrom infolge der Influenza A(H1N1) Infektion trat bei einem Patienten auf. Die Herzfunktion normalisierte sich bei zwei Patienten und war bei einem Patienten noch bei Krankenhausentlassung eingeschränkt. SCHLUSSFOLGERUNG: Eine Influenza A(H1N1) Infektion kann mit einer schweren kardialen Funktionseinschränkung assoziiert sein. Diese kann sich sogar als führendes klinisches Symptom darstellen. Während einer Influenza Pandemie kann eine genaue Anamneseerhebung Grippeähnliche Symptome hervorbringen und sollte auch bei kritisch kranken Patienten mit akutem Herzversagen eine Diagnostik auf H1N1 Infektion veranlasse

Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy

Cellular responses to DNA damage involve distinct DNA repair pathways, such as mismatch repair (MMR) and base excision repair (BER). Using Caenorhabditis elegans as a model system, we present genetic and molecular evidence of a mechanistic link between processing of DNA damage and activation of autophagy. Here we show that the BER AP endonucleases APN-1 and EXO-3 function in the same pathway as MMR, to elicit DNA-directed toxicity in response to 5-fluorouracil, a mainstay of systemic adjuvant treatment of solid cancers. Immunohistochemical analyses suggest that EXO-3 generates the DNA nicks required for MMR activation. Processing of DNA damage via this pathway, in which both BER and MMR enzymes are required, leads to induction of autophagy in C. elegans and human cells. Hence, our data show that MMR- and AP endonuclease-dependent processing of 5-fluorouracil-induced DNA damage leads to checkpoint activation and induction of autophagy, whose hyperactivation contributes to cell death. © 2013 Macmillan Publishers Limited. All rights reserved

Dissolved noble gases and stable isotopes as tracers of preferential fluid flow along faults in the Lower Rhine Embayment, Germany

Groundwater in shallow unconsolidated sedimentary aquifers close to the Bornheim fault in the Lower Rhine Embayment (LRE), Germany, has relatively low δ2H and δ18O values in comparison to regional modern groundwater recharge, and 4He concentrations up to 1.7 × 10−4 cm3 (STP) g–1 ± 2.2 % which is approximately four orders of magnitude higher than expected due to solubility equilibrium with the atmosphere. Groundwater age dating based on estimated in situ production and terrigenic flux of helium provides a groundwater residence time of ∼107 years. Although fluid exchange between the deep basal aquifer system and the upper aquifer layers is generally impeded by confining clay layers and lignite, this study’s geochemical data suggest, for the first time, that deep circulating fluids penetrate shallow aquifers in the locality of fault zones, implying  that sub-vertical fluid flow occurs along faults in the LRE. However, large hydraulic-head gradients observed across many faults suggest that they act as barriers to lateral groundwater flow. Therefore, the geochemical data reported here also substantiate a conduit-barrier model of fault-zone hydrogeology in unconsolidated sedimentary deposits, as well as corroborating the concept that faults in unconsolidated aquifer systems can act as loci for hydraulic connectivity between deep and shallow aquifers. The implications of fluid flow along faults in sedimentary basins worldwide are far reaching and of particular concern for carbon capture and storage (CCS) programmes, impacts of deep shale gas recovery for shallow groundwater aquifers, and nuclear waste storage sites where fault zones could act as potential leakage pathways for hazardous fluids

Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study

INTRODUCTION: Despite the key role of hemodynamic goals, there are few data addressing the question as to which hemodynamic variables are associated with outcome or should be targeted in cardiogenic shock patients. The aim of this study was to investigate the association between hemodynamic variables and cardiogenic shock mortality. METHODS: Medical records and the patient data management system of a multidisciplinary intensive care unit (ICU) were reviewed for patients admitted because of cardiogenic shock. In all patients, the hourly variable time integral of hemodynamic variables during the first 24 hours after ICU admission was calculated. If hemodynamic variables were associated with 28-day mortality, the hourly variable time integral of drops below clinically relevant threshold levels was computed. Regression models and receiver operator characteristic analyses were calculated. All statistical models were adjusted for age, admission year, mean catecholamine doses and the Simplified Acute Physiology Score II (excluding hemodynamic counts) in order to account for the influence of age, changes in therapies during the observation period, the severity of cardiovascular failure and the severity of the underlying disease on 28-day mortality. RESULTS: One-hundred and nineteen patients were included. Cardiac index (CI) (P = 0.01) and cardiac power index (CPI) (P = 0.03) were the only hemodynamic variables separately associated with mortality. The hourly time integral of CI drops 0.05). The hourly time integral of CPI drops 0.05). CONCLUSIONS: During the first 24 hours after intensive care unit admission, CI and CPI are the most important hemodynamic variables separately associated with 28-day mortality in patients with cardiogenic shock. A CI of 3 L/min/m2 and a CPI of 0.8 W/m2 were most predictive of 28-day mortality. Since our results must be considered hypothesis-generating, randomized controlled trials are required to evaluate whether targeting these levels as early resuscitation endpoints can improve mortality in cardiogenic shock

Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial

INTRODUCTION: It is unclear to which level mean arterial blood pressure (MAP) should be increased during septic shock in order to improve outcome. In this study we investigated the association between MAP values of 70 mmHg or higher, vasopressor load, 28-day mortality and disease-related events in septic shock. METHODS: This is a post hoc analysis of data of the control group of a multicenter trial and includes 290 septic shock patients in whom a mean MAP > or = 70 mmHg could be maintained during shock. Demographic and clinical data, MAP, vasopressor requirements during the shock period, disease-related events and 28-day mortality were documented. Logistic regression models adjusted for the geographic region of the study center, age, presence of chronic arterial hypertension, simplified acute physiology score (SAPS) II and the mean vasopressor load during the shock period was calculated to investigate the association between MAP or MAP quartiles > or = 70 mmHg and mortality or the frequency and occurrence of disease-related events. RESULTS: There was no association between MAP or MAP quartiles and mortality or the occurrence of disease-related events. These associations were not influenced by age or pre-existent arterial hypertension (all P > 0.05). The mean vasopressor load was associated with mortality (relative risk (RR), 1.83; confidence interval (CI) 95%, 1.4-2.38; P 70 mmHg by augmenting vasopressor dosages may increase mortality. Future trials are needed to identify the lowest acceptable MAP level to ensure tissue perfusion and avoid unnecessary high catecholamine infusions

Cochlea-inspired tonotopic resonators

The cochlea has long been the subject of investigation in various research fields due to its intriguing spiral architecture and unique sensing characteristics. One of its most interesting features is tonotopy, the abil- ity to sense acoustic waves at different spatial locations based on their frequency content. In this work, we propose a novel design for a tonotopic resonator, based on a cochlea-inspired spiral, which can dis- criminate the frequency content of elastic waves without the use of sub-wavelength resonators. The structure is the result of an optimization process to obtain a uniform distribution of displacement max- ima along its centreline for frequencies spanning nearly two-decades, while maintaining a compact design. Numerical simulations are performed to demonstrate the concept and experimental measure- ments to validate it on a 3D printed structure. The resulting frequency-dependent distribution is also shown to be a viable means to discriminate signals with various frequency components. We also show that for appropriate parameter ranges, the tonotopic behaviour can be inverted, i.e., lower frequencies can be made to concentrate in narrower regions, as happens in the real cochlea. The harnessed tonotopic features can be used as a fundamental principle to design structures with applications in areas such as non-destructive testing and vibration attenuation