Volume CXX, Number 6, October 25, 2002

3rd Asian Pacific Regional Meeting of the International-Society-for-the-Study-of-Xenobiotics -- MAY 10-12, 2009 -- Bangkok, THAILANDWOS: 000269483300069…Int Soc Study Xenobio

Türkiye ve Avro Bölgesi Arasındaki İkili Ticaretin Analizi: Marshall-Lerner Koşulu Geçerli mi?

Dış ticaretin gelir ve fiyat esnekliklerinin ölçülmesi, özellikle gelişmekte olan ülkelerde ticaret politikasının şekillendirilmesi ve ödemeler dengesinin iyileştirilmesi açısından oldukça önemlidir. Bu noktadan hareketle çalışmanın amacı, önemli ticaret partnerlerimizden oluşan Avro Bölgesi ülkeleri ile yaptığımız ikili ticarette Marshall-Lerner koşulunun analiz edilmesidir. Bu kapsamda, 2004-2017 döneminde Avro Bölgesi ile yaptığımız dış ticaret fonksiyonları panel zaman serilerindeki heterojen eğim katsayılarını tahmin etmek için geliştirilen Genişletilmiş Ortalama Grup (AMG) tahmincisi kullanılarak analiz edilecektir. Elde edilen bulgular, ihracat talebi fiyat esnekliğinin pozitif, ithalat talebi fiyat esnekliğinin ise negatif olduğunu göstermektedir. Ayrıca, Türkiye ve Avro Bölgesi arasındaki ikili ticarette Marshall-Lerner koşulunun geçerli olduğu sonucuna ulaşılmıştır

One-stage operation for hydatid disease of lung and liver: Principles of treatment

AbstractObjective: Hydatid disease is endemic in many countries throughout the world. Although we do not have exact figures, the disease is prevalent in Turkey. A considerable number of patients have additional liver cysts as well. In this study we reviewed our experience with hydatid disease of the lung and liver and discussed the principles of treatment. Methods: From 1971 to 1999, 2509 patients with pulmonary hydatidosis were referred to us, and 485 of them had concomitant liver cysts. Of these, 405 patients had cysts located on the dome of the liver, and they were operated on with phrenotomy through a right thoracotomy. Eighty patients who were found to have concomitant liver cysts in the lower part of the liver were referred to general surgery for a laparotomy. Results: Hydatid cysts located in the lungs were managed by means of cystotomy and capitonnage. For liver cysts, cystotomy and inversion of the cavity with sutures was the surgical method of choice, and a drain was left in place. In case of multiple cysts in the liver, needle aspiration was preferred. Twelve major complications, including excessive biliary drainage and bronchobiliary fistula, occurred in these patients. Conclusions: We believe that management of pulmonary and hepatic cysts simultaneously through the thoracic route is convenient and should be encouraged in patients because this prevents a second operation. Needle aspiration can be applied only for liver cysts. It is absolutely contraindicated in lung hydatid cysts.J Thorac Cardiovasc Surg 2002;124:1212-

Sugar, Invertase Enzyme Activities and Invertase Gene Expression in Different Developmental Stages of Strawberry Fruits

The cultivated strawberry (Fragaria × ananassa) is octoploid (2n = 8x = 56) and has been the focused fruit species of which an increasing number of molecular and genetic research has been conducted in recent years. The aim of this study is to identify the relationships between sucrose metabolism, invertase enzyme activity and gene expression in four different fruit development periods (red, pink, green and white) of two commercially important strawberry varieties ‘Rubygem’ and ‘Fortuna’. The metabolite profiles (glucose, fructose, sucrose and total sugar content) of two varieties were discovered to be extremely similar. The highest amount of total sugar was found in red fruits, while the lowest was obtained from green fruits. Invertase represents one of the key enzymes in sucrose metabolism. The lowest invertase activity was obtained from the green fruits in ‘Rubygem’ and ‘Fortuna’ during four developmental periods. In these varieties, the amount of sucrose was found to be close to glucose and fructose and the lowest amount was detected in green period, while invertase activity was relatively high during red and pink periods and invertase gene expression was determined at high levels in both primers (St-4 and St-6) in the green period. The results of the study indicated that sugar content and invertase activity were positively correlated while enzyme activity and gene expression were negatively correlated. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.FBA-2020-12969Acknowledgments: The authors would like to thank the Cukurova University Scientific Research Projects (Turkey) (FBA-2020-12969) for financial support

Genetic relatedness among quince (<i>Cydonia oblonga</i> Miller) accessions from Turkey using amplified fragment length polymorphisms

Among fruit species cultivated in Turkey, quince shows a great deal of morphological variability and adaptability to the various environments. We attempted to study genetic relationships among 40 quince accessions using amplified fragment length polymorphisms (AFLPs) for future breeding programs. The accessions were previously characterized based on their pomological and yield characteristics and then the best ones were planted in a single collection in Ataturk Central Horticultural Research Institute, Yalova, Turkey. Six AFLP primer combinations generated a total of 746 bands, 493 of which were polymorphic (66.1%). Resolving powers of the AFLP primers ranged from 48.0 to 99.6 making a total of 421.5. Unweighted Pair Group Method with Arithmetic Average (UPGMA) clustering of the accessions showed three major clusters and ‘SapancaEsme’ and ‘Esme-3’ were the closest accessions with 95% similarity. Our study indicated that there is a high level of genetic diversity among quince accessions in Turkey and the results of this study can be used for future cultivar breeding programs in quince

SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors

Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This study was investigated inhibition potentials of recently synthesized disubstituted tacrines derivatives on going our research against AChE, BChE and carbonic anhydrase cyctosolic (hCA I and H) enzymes to explore the Structure activity relationship (SAR). Methods: Inhibitory activities of tested compounds against AChE and BChE were measured by spectrophotometric method, developed by Ellman et al. Furthermore, the disubstituted tacrines were determined as inhibitors of two physiologically relevant CA isoforms, the cytosolic hCA I and H by an esterase assay method. Results: The silyl, thiomethyl and cyano substituted seven membered hydrocycle tacrines (9, 11 and 14) significantly inhibited AChE, compared with starting compound 3 (6,8-dibromo-2,3,4,5-teytrahydro-1H-cyclohepta[1,2-b] quinoline) and reference compounds, galantamine and tacrine, while methoxy substituted seven membered hydrocycle tacrine derivative 10 showed selective inhibition against BChE (IC50 = 563 nM). Interestingly, disubstituted tacrines displayed higher or parallel inhibition to galantamine. Additionally, all these tacrine analogues were recorded to be powerful inhibitor compounds of the cytosolic isoenzyme hCA I with K-i in the range of 43.81-471.67 nM, as well as a moderate selectivity toward hCA II isoenzyme with K-i in the range from 87.14 to 614.68 nM compared with AZA, as standard. Conclusion: The disubstituted seven membered hydrocycle tacrine analogues 9-12 and 14 may have promising anti Alzhemier drug candidate and dibromo six membered hydrocycle 2 and dibromo seven membered hydrocycle 3 derivatives may be novel hCA I and II enzyme inhibitors

Chemical Characterization Of 64 Propolis Samples From Hakkari, Turkey

Propolis is a resinous substance produced by honey bees from various plants they visit. Sixty-four propolis samples were collected from different localities of four districts (Merkez, Yiiksekova, Semdinli, and Qukurca) in Hakkari territory. Ethanol extracts of the propolis samples were prepared, and their chemical contents were determined by gas chromatography-mass spectroscopy (GC-MS). Flavonoids were generally found in a high concentration in Semdinli samples of Turkey. Twenty-seven coumarins were identified in the 28 propolis samples among studied 64 ones. Except suberosin, the coumarins were never reported before in any propolis sample with Turkish origin. The propolis samples belonging to Yuksekova were found to be richer in coumarins than the others, and the most richest one among the Yfiksekova apiaries, was found to be Akocak sample (Y2) with 41.99% total yield, followed by Akcall sample (Y5) (30.86%). This is a first comprehensive and original report about the chemical profile of propolis samples from Hakkari. The propolis samples from Hakkari exhibited a chemical content rich in flavonoids including coumarins and furocoumarins.WoSScopu