26 research outputs found
Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study
Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk
Lawson criterion for ignition exceeded in an inertial fusion experiment
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37Â MJ of fusion for 1.92Â MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion
Na-29: Defining the edge of the island of inversion for Z=11
The low-energy level structure of the exotic Na isotopes
28
;
29
Na
has been investigated through
-delayed
spectroscopy. The
N
20
isotones for
Z
10
â
12
are considered to belong to the ââisland
of inversionââ where intruder configurations dominate the ground state wave function. However, it is an
open question as to where and how the transition from normal to intruder dominated configurations
happens in an isotopic chain. The present work, which presents the first detailed spectroscopy of
28
;
29
Na
,
clearly demonstrates that such a transition in the Na isotopes occurs between
28
Na
(
N
17
) and
29
Na
(
N
18
), supporting the smaller
N
20
shell gap in neutron-rich
sd
shell nuclei. The evidence for
inverted shell structure is found in
-decay branching ratios, intruder dominated spectroscopy of low-
lying states, and shell model analysis.status: publishe
Lowest excitations in Ti-56 and the predicted N=34 shell closure
Recent experimental characterization of the subshell closure at
N
32
in the Ca, Ti, and Cr isotones
has stimulated shell-model calculations that indicated the possibility that the
N
34
isotones of these
same elements could exhibit characteristics of a shell closure, namely, a high energy for the first excited
2
level. To that end, we have studied the decay of
56
Sc
produced in fragmentation reactions and
identified new
rays in the daughter
N
34
isotone
56
Ti
. The first
2
level is found at an energy of
1127 keV
, well below the expected position that would indicate the presence of an
N
34
shell closure
in
56
Ti
.status: publishe
Structure of neutron-rich odd-mass127,129,131in populated in the decay of127,129,131Cd
New level structures are proposed for neutron-rich127,129,131In populated in the decay of127,129,131Cd. No evidence for the presence of 1-particle- 2-hole intruder structures in the neutron-rich In isotopes is observed
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection.
Aicardi-GoutiĂšres syndrome (AGS) is an autosomal recessive neurological disorder, the clinical and immunological features of which parallel those of congenital viral infection. Here we define the composition of the human ribonuclease H2 enzyme complex and show that AGS can result from mutations in the genes encoding any one of its three subunits. Our findings demonstrate a role for ribonuclease H in human neurological disease and suggest an unanticipated relationship between ribonuclease H2 and the antiviral immune response that warrants further investigation
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-GoutiĂšres syndrome and mimic congenital viral brain infection.
Aicardi-GoutiĂšres syndrome (AGS) is an autosomal recessive neurological disorder, the clinical and immunological features of which parallel those of congenital viral infection. Here we define the composition of the human ribonuclease H2 enzyme complex and show that AGS can result from mutations in the genes encoding any one of its three subunits. Our findings demonstrate a role for ribonuclease H in human neurological disease and suggest an unanticipated relationship between ribonuclease H2 and the antiviral immune response that warrants further investigation