47 research outputs found
ΠΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ ΡΠΌΡΠ½ΠΎ-Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ° ΠΌΡΠΊΡΠΎΠ±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΡ Ρ ΠΆΡΠ½ΠΎΠΊ Π· ΡΡΠ·Π½ΠΈΠΌΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ ΠΏΠΎΠ»ΡΠΏΡΠ² Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΡΡ
ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 58 ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΠΏΠΎΠ»ΠΈΠΏΠ°ΠΌΠΈ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΡ. ΠΡΡΠ²Π»Π΅Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ
ΠΏΠ΅ΠΉΠ·Π°ΠΆΠ°, Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΠΌ ΠΏΠΎΠ»ΠΈΠΏΠΎΠ² ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΡ.
ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ» Π²ΡΠ΄Π΅Π»ΠΈΡΡ Π³ΡΡΠΏΠΏΡ ΡΠΈΡΠΊΠ° ΠΏΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΠΎΠ»ΠΈΠΏΠΎΠ² ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΡ. ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ
ΠΏΠΎΠ»ΠΈΠΏ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΡ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡ Π½Π΅ ΠΊΠ°ΠΊ ΠΌΠ΅ΡΡΠ½ΡΠΉ ΠΏΡΠΎΡΠ΅ΡΡ, Π° ΠΊΠ°ΠΊ ΡΠ΅Π°ΠΊΡΠΈΡ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΡ Π² ΠΎΡΠ²Π΅Ρ Π½Π°
ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ Π³ΠΎΠΌΠ΅ΠΎΡΡΠ°Π·Π°, ΡΡΠΎ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΡΡΠΈΡΡΠ²Π°ΡΡ ΠΏΡΠΈ Π²ΡΠ±ΠΎΡΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΡ
Π΄Π°Π½Π½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ58 women with endometrial polyps were investigated. Specific microflora and hormonal and immune status
depending on the morphological forms of endometrial polyps were found. The analysis performed allowed to
allocate risk groups according to development of endometrial polyp. It was shown that endometrial polyp shall be
considered as endometrial reaction in response to hormonal and immune homeostasis disorder, rather than local
process. This should be borne in mind when choosing treatment for this patholog
Alignment of CanMEDS-based Undergraduate and Postgraduate Pharmacy Curricula in The Netherlands
In this article the design of three master programs (MSc in Pharmacy) and two postgraduate specialization programs for community or hospital pharmacist is described. After a preceding BSc in Pharmacy, these programs cover the full pharmacy education capacity for pharmacists in primary and secondary health care in the Netherlands. All programs use the CanMEDS framework, adapted to pharmacy education and specialization, which facilitates the horizontal integration of pharmacists' professional development with other health care professions in the country. Moreover, it is illustrated that crossing the boundary from formal (university) education to experiential (workplace) education is eased by a gradual change in time spent in these two educational environments and by the use of comparable monitoring, feedback, and authentic assessment instruments. A reflection on the curricula, based on the principles of theIntegrative Pedagogy Modeland theSelf-determination Theory, suggests that the alignment of these educational programs facilitates the development of professional expertise and professional identity of Dutch pharmacists
Translating Pharmacogenomics: Challenges on the Road to the Clinic
Pharmacogenomics is one of the first clinical applications of the postgenomic era. It promises personalized medicine rather than the established βone size fits allβ approach to drugs and dosages. The expected reduction in trial and error should ultimately lead to more efficient and safer drug therapy. In recent years, commercially available pharmacogenomic tests have been approved by the Food and Drug Administration (FDA), but their application in patient care remains very limited. More generally, the implementation of pharmacogenomics in routine clinical practice presents significant challenges. This article presents specific clinical examples of such challenges and discusses how obstacles to implementation of pharmacogenomic testing can be addressed
Coumarin anticoagulants and co-trimoxazole: avoid the combination rather than manage the interaction
OBJECTIVE: The objective of our study was to examine the management of the interaction between acenocoumarol or phenprocoumon and several antibiotics by anticoagulation clinics and to compare the consequences of this interaction on users of co-trimoxazole with those for users of other antibiotics. METHODS: A follow-up study was conducted at four anticoagulation clinics in The Netherlands. Data on measurements of the International Normalised Ratio (INR), application of a preventive dose reduction (PDR) of the coumarin anticoagulant, fever and time within or outside the therapeutic INR range were collected. RESULTS: The study cohort consisted of 326 subjects. A PDR was given more often to users of co-trimoxazole PDR than to users of other antibiotics. The PDR in co-trimoxazole users resulted in a significantly reduced risk of both moderate overanticoagulation (INR >4.5) and severe overanticoagulation (INR >6.0) compared with no PDR, with odds ratios (ORs) of 0.06 [95% confidence interval (CI): 0.01-0.51] and 0.09 (95% CI: 0.01-0.92), respectively. In co-trimoxazole users without PDR, the risk of overanticoagulation was significantly increased compared with users of other antibiotics. All co-trimoxazole users spent significantly more time under the therapeutic INR range during the first 6 weeks after the course than users of other antibiotics. CONCLUSION: PDR is effective in preventing overanticoagulation in co-trimoxazole users, but results in a significantly prolonged period of underanticoagulation after the course. Avoidance of concomitant use of co-trimoxazole with acenocoumarol or phenprocoumon seems to be a safer approach than management of the interaction between these drugs