Generation of Cosmological Seed Magnetic Fields from Inflation with Cutoff

Inflation has the potential to seed the galactic magnetic fields observed today. However, there is an obstacle to the amplification of the quantum fluctuations of the electromagnetic field during inflation: namely the conformal invariance of electromagnetic theory on a conformally flat underlying geometry. As the existence of a preferred minimal length breaks the conformal invariance of the background geometry, it is plausible that this effect could generate some electromagnetic field amplification. We show that this scenario is equivalent to endowing the photon with a large negative mass during inflation. This effective mass is negligibly small in a radiation and matter dominated universe. Depending on the value of the free parameter of the theory, we show that the seed required by the dynamo mechanism can be generated. We also show that this mechanism can produce the requisite galactic magnetic field without resorting to a dynamo mechanism.Comment: Latex, 16 pages, 2 figures, 4 references added, minor corrections; v4: more references added, boundary term written in a covariant form, discussion regarding other gauge fields added, submitted to PRD; v5: matched with the published versio

Two-photon final states in peripheral heavy ion collisions

We discuss processes leading to two photon final states in peripheral heavy ion collisions at RHIC. Due to the large photon luminosity we show that the continuum subprocess $\gamma \gamma \to \gamma \gamma$ can be observed with a large number of events. We study this reaction when it is intermediated by a resonance made of quarks or gluons and discuss its interplay with the continuum process, verifying that in several cases the resonant process ovewhelms the continuum one. It is also investigated the possibility of observing a scalar resonance (the $\sigma$ meson) in this process. Assuming for the $\sigma$ the mass and total decay width values recently reported by the E791 Collaboration we show that RHIC may detect this particle in its two photon decay mode if its partial photonic decay width is of the order of the ones discussed in the literature.Comment: 10 pages, 8 figure

Probing For New Physics and Detecting non linear vacuum QED effects using gravitational wave interferometer antennas

Low energy non linear QED effects in vacuum have been predicted since 1936 and have been subject of research for many decades. Two main schemes have been proposed for such a 'first' detection: measurements of ellipticity acquired by a linearly polarized beam of light passing through a magnetic field and direct light-light scattering. The study of the propagation of light through an external field can also be used to probe for new physics such as the existence of axion-like particles and millicharged particles. Their existence in nature would cause the index of refraction of vacuum to be different from unity in the presence of an external field and dependent of the polarization direction of the light propagating. The major achievement of reaching the project sensitivities in gravitational wave interferometers such as LIGO an VIRGO has opened the possibility of using such instruments for the detection of QED corrections in electrodynamics and for probing new physics at very low energies. In this paper we discuss the difference between direct birefringence measurements and index of refraction measurements. We propose an almost parasitic implementation of an external magnetic field along the arms of the VIRGO interferometer and discuss the advantage of this choice in comparison to a previously proposed configuration based on shorter prototype interferometers which we believe is inadequate. Considering the design sensitivity in the strain, for the near future VIRGO+ interferometer, of $h<2\cdot10^{-23} \frac{1}{\sqrt{\rm Hz}}$ in the range 40 Hz $- 400$ Hz leads to a variable dipole magnet configuration at a frequency above 20 Hz such that $B^{2}D \ge 13000$ T$^{2}$m/$\sqrt{\rm Hz}$ for a `first' vacuum non linear QED detection

On the pion electroproduction amplitude

We analyze amplitudes for the pion electroproduction on proton derived from Lagrangians based on the local chiral SU(2) x SU(2) symmetries. We show that such amplitudes do contain information on the nucleon axial form factor F_A in both soft and hard pion regimes. This result invalidates recent Haberzettl's claim that the pion electroproduction at threshold cannot be used to extract any information regarding F_A.Comment: 14 pages, 6 figures, revised version, accepted for publication in Phys. Rev.

Elastic and Raman scattering of 9.0 and 11.4 MeV photons from Au, Dy and In

Monoenergetic photons between 8.8 and 11.4 MeV were scattered elastically and in elastically (Raman) from natural targets of Au, Dy and In.15 new cross sections were measured. Evidence is presented for a slight deformation in the 197Au nucleus, generally believed to be spherical. It is predicted, on the basis of these measurements, that the Giant Dipole Resonance of Dy is very similar to that of 160Gd. A narrow isolated resonance at 9.0 MeV is observed in In.Comment: 31 pages, 11 figure

Chromosome-scale genome assembly of the brown anole (Anolis sagrei), an emerging model species

Rapid technological improvements are democratizing access to high quality, chromosome-scale genome assemblies. No longer the domain of only the most highly studied model organisms, now non-traditional and emerging model species can be genome-enabled using a combination of sequencing technologies and assembly software. Consequently, old ideas built on sparse sampling across the tree of life have recently been amended in the face of genomic data drawn from a growing number of high-quality reference genomes. Arguably the most valuable are those long-studied species for which much is already known about their biology; what many term emerging model species. Here, we report a highly complete chromosome-scale genome assembly for the brown anole, Anolis sagrei – a lizard species widely studied across a variety of disciplines and for which a high-quality reference genome was long overdue. This assembly exceeds the vast majority of existing reptile and snake genomes in contiguity (N50 = 253.6 Mb) and annotation completeness. Through the analysis of this genome and population resequence data, we examine the history of repetitive element accumulation, identify the X chromosome, and propose a hypothesis for the evolutionary history of fusions between autosomes and the X that led to the sex chromosomes of A. sagrei

SYMBIOmatics: Synergies in Medical Informatics and Bioinformatics – exploring current scientific literature for emerging topics

Background: The SYMBIOmatics Specific Support Action (SSA) is "an information gathering and dissemination activity" that seeks "to identify synergies between the bioinformatics and the medical informatics" domain to improve collaborative progress between both domains (ref. to http://www.symbiomatics.org). As part of the project experts in both research fields will be identified and approached through a survey. To provide input to the survey, the scientific literature was analysed to extract topics relevant to both medical informatics and bioinformatics. Results: This paper presents results ofa systematic analysis of the scientific literature from medical informatics research and bioinformatics research. In the analysis pairs of words (bigrams) from the leading bioinformatics and medical informatics journals have been used as indication of existing and emerging technologies and topics over the period 2000-2005 ("recent") and 1990-1990 ("past"). We identified emerging topics that were equally important to bioinformatics and medical informatics in recent years such as microarray experiments, ontologies, open source, text mining and support vector machines. Emerging topics that evolved only in bioinformatics were system biology, protein interaction networks and statistical methods for microarray analyses, whereas emerging topics in medical informatics were grid technology and tissue microarrays. Conclusion: We conclude that although both fields have their own specific domains of interest, they share common technological developments that tend to be initiated by new developments in biotechnology and computer science

Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset

Purpose: To evaluate the efficacy of a single intravitreal injection of rAAV2/2-ND4 in subjects with visual loss from Leber hereditary optic neuropathy (LHON). Design: RESCUE is a multicenter, randomized, double-masked, sham-controlled, phase 3 clinical trial. Participants: Subjects with the m.11778G&gt;A mitochondrial DNA mutation and vision loss ≤6 months from onset in 1 or both eyes were included. Methods: Each subject's right eye was randomly assigned (1:1) to treatment with rAAV2/2-ND4 (single injection of 9 × 1010 viral genomes in 90 μl) or to sham injection. The left eye received the treatment not allocated to the right eye. Main Outcome Measures: The primary end point was the difference of the change from baseline in best-corrected visual acuity (BCVA) between rAAV2/2-ND4–treated and sham-treated eyes at week 48. Other outcome measures included contrast sensitivity, Humphrey visual field perimetry, retinal anatomic measures, and quality of life. Follow-up extended to week 96. Results: Efficacy analysis included 38 subjects. Mean age was 36.8 years, and 82% were male. Mean duration of vision loss at time of treatment was 3.6 months and 3.9 months in the rAAV2/2-ND4–treated eyes and sham-treated eyes, respectively. Mean baseline logarithm of the minimum angle of resolution (logMAR) BCVA (standard deviation) was 1.31 (0.52) in rAAV2/2-ND4–treated eyes and 1.26 (0.62) in sham-treated eyes, with a range from −0.20 to 2.51. At week 48, the difference of the change in BCVA from baseline between rAAV2/2-ND4–treated and sham-treated eyes was −0.01 logMAR (P = 0.89); the primary end point of a −0.3 logMAR (15-letter) difference was not met. The mean BCVA for both groups deteriorated over the initial weeks, reaching the worst levels at week 24, followed by a plateau phase until week 48, and then an improvement of +10 and +9 Early Treatment Diabetic Retinopathy Study letters equivalent from the plateau level in the rAAV2/2-ND4–treated and sham-treated eyes, respectively. Conclusions: At 96 weeks after unilateral injection of rAAV2/2-ND4, LHON subjects carrying the m.11778G&gt;A mutation treated within 6 months after vision loss achieved comparable visual outcomes in the injected and uninjected eyes