EXPRESSION OF AUTOPHAGY AND NECROPTOSIS MARKERS IN BLADDER CARCINOMA IN MICE

Cilj istraživanja: Istražiti postoji li povećan izražaj gena za p62, Beclin 1, LC3A, Atg5 i Ripk3f u tumorskom tkivu u odnosu na zdravo tkivo mokraćnog mjehura miša. Materijali i metode: Eksperimentalno istraživanje provedeno je u Laboratoriju za istraživanje raka Medicinskog fakulteta u Splitu. Miševi C57BL/6J divljeg tipa (wt) stari 6 do 8 tjedana podijeljeni su u 3 eksperimentalne skupine, netretiranu kontrolnu skupinu, ispitivanu skupinu podvrgnutu akutnom tretmanu i ispitivanu skupinu podvrgnutu kroničnom tretmanu. Ispitivane skupine izložene su kemikaliji N-butil-N-(4-hidroksibutil) nitrozaminu (BBN-u) u vodi za piće sa svrhom indukcije tumora mokraćnog mjehura. Akutna skupina miševa bila je izložena 0,05% BBN-u tijekom 2 tjedna, dok je skupina kroničnih miševa BBN-u (0,05%) bila izložena 12 tjedana. Životinje su žrtvovane 2 tjedna (skupina akutnih) i 20 tjedana (skupina kroničnih) nakon početka tretmana. Iz uzoraka je izolirana mRNA, nakon čega je prevedena u cDNA koja je služila kao predložak za qRT-PCR. Kao standard za genski izražaj korišten je gen za aktin. Rezultati: Izražaj gena za p62, Beclin 1, LC3A i Atg5 nije promijenjen u akutnoj skupini u odnosu na kontrolnu netretiranu skupinu. Izražaj gena za Ripk3f statistički je značajno povećan u akutnoj skupini u odnosu na kontrolnu (p<0,0001), kao i u kroničnoj skupini u odnosu na kontrolnu (p<0,001). Zaključak: Geni za autofagijske proteine p62, Beclin 1, LC3A i Atg5 nemaju značajno povišen izražaj u tumorima mokraćnog mjehura miša. Izražaj gena za Ripk2f statistički značajno je povećan te ukazuje na važnost uloge nekroptoze u patogenezi tumora mokraćnog mjehura.Objectives: To determine expression of autophagy related genes p62, Beclin 1, LC3A and Atg5, as well as gene expression of necroptosis related gene Ripk3f, in bladder carcinoma compared to healthy bladder tissue of mice. Materials and methods: Experimental research was conducted at Laboratory for cancer research at University of Split School of Medicine. Wild type C57BL/6J mice 6-8 weeks old were divided into 3 groups: untreated control group, experimental group that undergone acute treatment and experimental group that undergone chronic treatment. Experimental groups were exposed to a chemical carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) administered in drinking water, in order to induce bladder carcinoma. Acute experimental group was exposed to BBN (0.05%) during 2 weeks, while the chronic experimental group was exposed to BBN (0.05%) during 12 weeks. Mice were sacrificed 2 and 20 weeks after commencement of treatment. RNA was isolated from tissue samples and then converted into cDNA by reverse transcription. cDNA was used as a template for qRT-PCR reaction. Actin gene was used as a housekeeping control. Results: Expression of p62, Beclin 1, LC3A and Atg5 was not changed in acute experimental group compared to nontreated control group. Ripk3f expression was significantly increased in both acute and chronic experimental groups compared to nontreated control group (p<0.0001; p<0.001). Conclusion: Expression of autophagy related genes p62, Beclin 1, LC3A and Atg5 is not significantly increased in bladder carcinoma in mice. Significantly increased expression of Ripk3f gene suggests that necroptosis plays an important role in pathogenesis of bladder cancer

Career Decision-Making Profiles of High School Students

Cilj ovog rada bio je ispitati načine donošenja odluka o karijeri kod učenika srednjih škola. Načini donošenja odluka o karijeri opisani su pomoću profila odlučivanja o karijeri, multidimenzionalnog modela kojeg su razvili Gati i sur. (2010), a mjereni su skalom Career Decision-Making Profiles (CDMP). Sudionici istraživanja bili su učenici završnih razreda srednjih strukovnih škola i gimnazija s područja Grada Zagreba i okolice (N=529). Podaci su prikupljeni on-line u sklopu projekta Profesionalni razvoj u adolescenciji: razvoj modela tranzicije karijere adolescenata (Vocational Development in Adolescence: Setting the Adolescent Career Transition Model) Hrvatske zaklade za znanost. U istraživanju je dobivena osmofaktorska struktura CDMP-a, što nije u skladu s nalazima istraživanja Gatija i Levina (2012), koji su pokazali da se u pozadini CDMP-a nalazi 12 faktora. Osmofaktorskom strukturom objašnjeno je 66.77 % varijance manifestnih varijabli. Koeficijenti unutarnje konzistencije pojedinih subskala CDMP-a kreću se u rasponu od .71 do .90 (medijan iznosi .79). Također, u radu se ispitivala mogućnost predviđanja 6 adaptabilnih načina odlučivanja (prikupljanje informacija, lokus kontrole, odugovlačenje, brzina donošenja odluke, ovisnost o drugima i želja za ugađanjem drugima) na temelju seta prediktora. Rezultati pokazuju da su profesionalna zrelost i temeljna samoevaluacija najbolji prediktori, dok je uloga roditeljske i prijateljske podrške u predviđanju načina donošenja odluka o karijeri uglavnom mala i neznačajna. Navedene su moguće implikacije dobivenih rezultata i prijedlozi za buduća istraživanja.The main purpose of this study was to examine career decision-making styles among high school students. Career decision-making styles are described by using career decisionmaking profiles, multidimensional model which is proposed by Gati et al. (2010) and they are measured by the Career Decision-Making Profile (CDMP) scale. Participants were students of final grade in high schools (grammar and vocational schools) from Zagreb and its surroundings (N=529). The data were collected online as a part of the project Vocational Development in Adolescence: Setting the Adolescent Career Transition Model, supported by Croatian Foundation for Science. Results of this study show 8-factor structure of Career Decision-Making Profiles scale, what differs from the results of study Gati i Levin (2012), indicating that there are 12 factors underlying CDMP scale. 8-factor structure of scale explained 66.77 % variance of manifest variables. Coefficients of internal consistency of the CDMP subscales are in the range from .71 to .90 (with median .79). Also, we investigated possibility of prediction of 6 adaptive career decision making styles (information gathering, locus of control, procrastination, speed of making the final decision, dependence on others, desire to please others) based on set of predictors. Vocational maturity and core self-evaluations are the best predictors of career decision-making styles in the high school students’ sample. Role of parental and friends support wasn’t significant in predicting the way students make their career decisions. Possible implications of study results and directions for future research are listed

EXPRESSION OF AUTOPHAGY AND NECROPTOSIS MARKERS IN BLADDER CARCINOMA IN MICE

Cilj istraživanja: Istražiti postoji li povećan izražaj gena za p62, Beclin 1, LC3A, Atg5 i Ripk3f u tumorskom tkivu u odnosu na zdravo tkivo mokraćnog mjehura miša. Materijali i metode: Eksperimentalno istraživanje provedeno je u Laboratoriju za istraživanje raka Medicinskog fakulteta u Splitu. Miševi C57BL/6J divljeg tipa (wt) stari 6 do 8 tjedana podijeljeni su u 3 eksperimentalne skupine, netretiranu kontrolnu skupinu, ispitivanu skupinu podvrgnutu akutnom tretmanu i ispitivanu skupinu podvrgnutu kroničnom tretmanu. Ispitivane skupine izložene su kemikaliji N-butil-N-(4-hidroksibutil) nitrozaminu (BBN-u) u vodi za piće sa svrhom indukcije tumora mokraćnog mjehura. Akutna skupina miševa bila je izložena 0,05% BBN-u tijekom 2 tjedna, dok je skupina kroničnih miševa BBN-u (0,05%) bila izložena 12 tjedana. Životinje su žrtvovane 2 tjedna (skupina akutnih) i 20 tjedana (skupina kroničnih) nakon početka tretmana. Iz uzoraka je izolirana mRNA, nakon čega je prevedena u cDNA koja je služila kao predložak za qRT-PCR. Kao standard za genski izražaj korišten je gen za aktin. Rezultati: Izražaj gena za p62, Beclin 1, LC3A i Atg5 nije promijenjen u akutnoj skupini u odnosu na kontrolnu netretiranu skupinu. Izražaj gena za Ripk3f statistički je značajno povećan u akutnoj skupini u odnosu na kontrolnu (p<0,0001), kao i u kroničnoj skupini u odnosu na kontrolnu (p<0,001). Zaključak: Geni za autofagijske proteine p62, Beclin 1, LC3A i Atg5 nemaju značajno povišen izražaj u tumorima mokraćnog mjehura miša. Izražaj gena za Ripk2f statistički značajno je povećan te ukazuje na važnost uloge nekroptoze u patogenezi tumora mokraćnog mjehura.Objectives: To determine expression of autophagy related genes p62, Beclin 1, LC3A and Atg5, as well as gene expression of necroptosis related gene Ripk3f, in bladder carcinoma compared to healthy bladder tissue of mice. Materials and methods: Experimental research was conducted at Laboratory for cancer research at University of Split School of Medicine. Wild type C57BL/6J mice 6-8 weeks old were divided into 3 groups: untreated control group, experimental group that undergone acute treatment and experimental group that undergone chronic treatment. Experimental groups were exposed to a chemical carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) administered in drinking water, in order to induce bladder carcinoma. Acute experimental group was exposed to BBN (0.05%) during 2 weeks, while the chronic experimental group was exposed to BBN (0.05%) during 12 weeks. Mice were sacrificed 2 and 20 weeks after commencement of treatment. RNA was isolated from tissue samples and then converted into cDNA by reverse transcription. cDNA was used as a template for qRT-PCR reaction. Actin gene was used as a housekeeping control. Results: Expression of p62, Beclin 1, LC3A and Atg5 was not changed in acute experimental group compared to nontreated control group. Ripk3f expression was significantly increased in both acute and chronic experimental groups compared to nontreated control group (p<0.0001; p<0.001). Conclusion: Expression of autophagy related genes p62, Beclin 1, LC3A and Atg5 is not significantly increased in bladder carcinoma in mice. Significantly increased expression of Ripk3f gene suggests that necroptosis plays an important role in pathogenesis of bladder cancer

European guidelines for obesity treatment: review

Uvod: Pretilost je složeno stanje povećane tjelesne mase, čija učestalost u populaciji raste. Rizični je čimbenik za kardiovaskularne bolesti, šećernu bolest, arterijsku hipertenziju, neke vrste karcinoma i brojne druge bolesti. Pretilost je veliki javnozdravstveni problem čije je liječenje ograničeno i otežano. Postoje različite smjernice u liječenju pretilosti. Cilj: Pronaći i analizirati europske smjernice u liječenju pretilosti. Metode: Pretražili smo MEDLINE, Google Scholar i Hrčak bazu podataka koristeći ključne riječi kako bi pronašli smjernice za usporedbu. Uspoređivali smo preporuke za promjenu načina života, uporabu lijekova, preporuke za kirurško liječenje te kvalitetu dokaza na kojima su temeljene smjernice. Rezultati: Pronašli smo 6 smjernica koje su ispunjavale kriterije za uključenje u analizu. Sve analizirane smjernice savjetuju trostruki pristup liječenju pretilosti: promjene životnog stila, uporabu lijekova i barijatrijsku kirurgiju, premda se razlikuju u vrijednostima za indikaciju pojedinih intervencija. Zaključak: Ovakvi rezultati ukazuju na važnost standardizacije smjernica. Potrebno je ojačati ulogu obiteljskih liječnika u liječenju pretilosti.Introduction: Obesity is a complex state of increased body fat percentage, with alarmingly growing prevalence. It is a risk factor for cardiovascular disease, diabetes, hypertension, some forms of cancer, and many other diseases. Obesity is a large public health problem, with limited and difficult options for treatment. There are various guidelines for obesity management. Aim: Our task was to find and analyze European guidelines for obesity treatment. Methods: We searched MEDLINE, Google Scholar and Hrčak databases using key words to find guidelines for review. We compared recommendations for lifestyle changes, pharmacotherapy, for surgical therapy and quality of evidence in guideline formation. Results: Six guidelines were included and analyzed in this review. Three-way approach to obesity treatment were recommended in all of them: lifestyle changes, use of medication and bariatric surgery. They differ in values for indicating particular interventions. Conclusion: Results of this article show the importance of guidelines standardization. There is a need for strengthening the role of primary health care practitioners in obesity management

Factors Influencing Interdisciplinary Research and Industry-Academia Collaborations at Six European Universities: A Qualitative Study

The introduction of interdisciplinarity and industry-academia collaborations (IAC) into higher education institutions (HEIs) and curricula as tools for promoting sustainable development has been debated both in academic and non-academic contexts. While overall rising trends in the acceptance of interdisciplinarity and IAC exist, research has stressed difficulty in implementation and practices. We conducted eight focus groups at six European Universities (members of the SEA-EU alliance) and analysed the transcripts using Braun and Clarke's reflexive thematic approach to qualitative analysis in order to develop themes on barriers and facilitators to both conducting interdisciplinarity and IAC, as well as the inclusion of university students in interdisciplinary research. We observed that the main barriers to IR and IAC and the inclusion of students in such activities include traditional HEI structures focused on single-discipline approaches, a lack of joint platforms for IR and IAC, and academic differences (publication outcome differences, academic background). Likewise, a lack of funding (especially for early career researchers), employability (for students willing to do a research career), and a lack of validation by HEIs for researchers conducting IR and IAC are major barriers. To IDR- and IAC-related activities, a top-down approach is needed to restructure HEIs and make them more accommodating to both students and staff willing to conduct IR and IAC activities, thus refocusing them towards sustainability

Addressing challenges when applying GRADE to public health guidelines: a scoping review protocol and pilot analysis

This is a protocol for a scoping review that aims to determine how guideline authors using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach have addressed previously identified challenges related to public health. The Joanna Briggs Institute (JBI) methodology for scoping reviews will be followed. We will search and screen titles of guidelines for all languages published in 2013−2021 in: the GIN library, BIGG database, Epistemonikos GRADE guidelines repository, GRADEpro Database, MAGICapp, NICE and WHO websites. Two reviewers will independently screen full texts of the documents identified. The following information will be extracted: methods used for identifying different stakeholders and incorporating their perspectives; methods for identification and prioritization of non-health outcomes; methods for determining thresholds for decision-making; methods for incorporating and grading evidence from non-randomized studies; methods for addressing concerns with conditional recommendations in public health; methods for reaching consensus; additional methodological concerns; and any modifications made to GRADE. A combination of directed content analysis and descriptive statistics will be used for data analysis, and the findings presented narratively in a tabular and graphical form. In this protocol, we present the pilot results from 13 identified eligible guidelines issued between January and August 2021. We will publish the full review results when they become available

EXPRESSION OF AUTOPHAGY AND NECROPTOSIS MARKERS IN BLADDER CARCINOMA IN MICE

Cilj istraživanja: Istražiti postoji li povećan izražaj gena za p62, Beclin 1, LC3A, Atg5 i Ripk3f u tumorskom tkivu u odnosu na zdravo tkivo mokraćnog mjehura miša. Materijali i metode: Eksperimentalno istraživanje provedeno je u Laboratoriju za istraživanje raka Medicinskog fakulteta u Splitu. Miševi C57BL/6J divljeg tipa (wt) stari 6 do 8 tjedana podijeljeni su u 3 eksperimentalne skupine, netretiranu kontrolnu skupinu, ispitivanu skupinu podvrgnutu akutnom tretmanu i ispitivanu skupinu podvrgnutu kroničnom tretmanu. Ispitivane skupine izložene su kemikaliji N-butil-N-(4-hidroksibutil) nitrozaminu (BBN-u) u vodi za piće sa svrhom indukcije tumora mokraćnog mjehura. Akutna skupina miševa bila je izložena 0,05% BBN-u tijekom 2 tjedna, dok je skupina kroničnih miševa BBN-u (0,05%) bila izložena 12 tjedana. Životinje su žrtvovane 2 tjedna (skupina akutnih) i 20 tjedana (skupina kroničnih) nakon početka tretmana. Iz uzoraka je izolirana mRNA, nakon čega je prevedena u cDNA koja je služila kao predložak za qRT-PCR. Kao standard za genski izražaj korišten je gen za aktin. Rezultati: Izražaj gena za p62, Beclin 1, LC3A i Atg5 nije promijenjen u akutnoj skupini u odnosu na kontrolnu netretiranu skupinu. Izražaj gena za Ripk3f statistički je značajno povećan u akutnoj skupini u odnosu na kontrolnu (p<0,0001), kao i u kroničnoj skupini u odnosu na kontrolnu (p<0,001). Zaključak: Geni za autofagijske proteine p62, Beclin 1, LC3A i Atg5 nemaju značajno povišen izražaj u tumorima mokraćnog mjehura miša. Izražaj gena za Ripk2f statistički značajno je povećan te ukazuje na važnost uloge nekroptoze u patogenezi tumora mokraćnog mjehura.Objectives: To determine expression of autophagy related genes p62, Beclin 1, LC3A and Atg5, as well as gene expression of necroptosis related gene Ripk3f, in bladder carcinoma compared to healthy bladder tissue of mice. Materials and methods: Experimental research was conducted at Laboratory for cancer research at University of Split School of Medicine. Wild type C57BL/6J mice 6-8 weeks old were divided into 3 groups: untreated control group, experimental group that undergone acute treatment and experimental group that undergone chronic treatment. Experimental groups were exposed to a chemical carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) administered in drinking water, in order to induce bladder carcinoma. Acute experimental group was exposed to BBN (0.05%) during 2 weeks, while the chronic experimental group was exposed to BBN (0.05%) during 12 weeks. Mice were sacrificed 2 and 20 weeks after commencement of treatment. RNA was isolated from tissue samples and then converted into cDNA by reverse transcription. cDNA was used as a template for qRT-PCR reaction. Actin gene was used as a housekeeping control. Results: Expression of p62, Beclin 1, LC3A and Atg5 was not changed in acute experimental group compared to nontreated control group. Ripk3f expression was significantly increased in both acute and chronic experimental groups compared to nontreated control group (p<0.0001; p<0.001). Conclusion: Expression of autophagy related genes p62, Beclin 1, LC3A and Atg5 is not significantly increased in bladder carcinoma in mice. Significantly increased expression of Ripk3f gene suggests that necroptosis plays an important role in pathogenesis of bladder cancer

COMPLETENESS OF REPORTING AND QUALITY OF EVIDENCE IN CLINICAL PRACTICE GUIDELINES

Ciljevi: Istraživanja opisana u ovoj disertaciji imaju za cilj dati odgovore na pitanja o trenutnom stanju smjernica za kliničku praksu u Republici Hrvatskoj i Europi, o učinkovitosti alata, smjernica za izvještavanje, u procjeni kliničkih smjernica, te o učinkovitosti edukacije o pristupu procjeni dokaza koji stoje iza preporuka u kliničkim smjernicama. Metode: Dva istraživanja o smjernicama za kliničku praksu i smjernicama za izvještavanje bila su presječnog ustroja, na kohorti hrvatskih smjernica za kliničku praksu i odgovarajućih smjernica europskih profesionalnih društava. U istraživanju o različitim edukacijskim pristupima za podučavanje GRADE pristupa procjeni dokaza, korišten je randomizirani kontrolirani dizajn. Rezultati: Kliničke smjernice u Republici Hrvatskoj, kao i one u Europi, imale su nedostatne razine izvještavanja u nekim od ključnih dijelova smjernica, poglavito o prijenosu dokaza u kliničke preporuke. Smjernice za izvještavanje, RIGHT i AGREE Reporting dale su dosljedno slične rezultate kada se koriste za procjenu objavljenih kliničkih smjernica, a njihov sadržaj se tematski preklapao. Edukacija budućih korisnika smjernica o uporabi i razumijevanju koncepata GRADE pristupu procjene dokaza bila je učinkovita i uživo i putem mrežne edukacije. Ipak, pojedini elementi edukacije, poput procjene rizika pristranosti, imali su bolje rezultate pri edukaciji uživo. Zaključak: Pri izradi smjernica za kliničku praksu, autori bi trebali koristiti alate za izvještavanje, kako bi ostvarili napredak u transparentnosti i jasnoći smjernica. S obzirom na kraći format i veću sukladnost s objavljenim i trenutno korištenim smjernicama, RIGHT bi mogao biti prikladniji alat za korisnike kliničkih smjernica. Kako bi se poboljšala sinteza dokaza u smjernicama za kliničku praksu, edukacija o GRADE pristupu procjeni dokaza mogla bi biti jednako učinkovita uživo i putem mrežne edukacije.Aims: Studies described in this doctoral thesis aimed to assess the level of transparency of contemporary clinical practice guidelines in Croatia and Europe, and to assess efficacy and content of reporting guidelines aimed at clinical practice guidelines. Also, online and face-to-face methods of teaching GRADE approach for evidence assessment were compared. Methods: Two studies on clinical practice guidelines and reporting guidelines were cross sectional studeis on a cohort of Croatian and European guidelines, and the study on delivery modes of GRADE education was a randomised controlled trial. Results: Croatian clinical practice guidelines, as well as their European counterparts, had insufficient levels of reporting in some of the crucial parts of their methodology, primarily in translating evidence into recommendations. Reporting guidelines RIGHT and AGREE Reporting gave consistently similar results when applied to clinical practice guidelines for reporting evaluation, and had overlapping content. Education of GRADE approach is overall effective both online and face-to-face. However, some aspects, such as risk of bias assessment, had better results when taught face-to-face. Conclusion: Authors of clinical practice guidelines should use reporting guidelines to improve transparency and clarity of recommendations. Due to shorter format, overlapping content, and greater adherence to currently used clinical practice guidelines, RIGHT reporting guideline might be a better option for guideline consumers. To improve evidence synthesis necessary for creating clinical practice guidelines, traning in GRADE approach could be equally effective online and face-to-face

Career Decision-Making Profiles of High School Students

Cilj ovog rada bio je ispitati načine donošenja odluka o karijeri kod učenika srednjih škola. Načini donošenja odluka o karijeri opisani su pomoću profila odlučivanja o karijeri, multidimenzionalnog modela kojeg su razvili Gati i sur. (2010), a mjereni su skalom Career Decision-Making Profiles (CDMP). Sudionici istraživanja bili su učenici završnih razreda srednjih strukovnih škola i gimnazija s područja Grada Zagreba i okolice (N=529). Podaci su prikupljeni on-line u sklopu projekta Profesionalni razvoj u adolescenciji: razvoj modela tranzicije karijere adolescenata (Vocational Development in Adolescence: Setting the Adolescent Career Transition Model) Hrvatske zaklade za znanost. U istraživanju je dobivena osmofaktorska struktura CDMP-a, što nije u skladu s nalazima istraživanja Gatija i Levina (2012), koji su pokazali da se u pozadini CDMP-a nalazi 12 faktora. Osmofaktorskom strukturom objašnjeno je 66.77 % varijance manifestnih varijabli. Koeficijenti unutarnje konzistencije pojedinih subskala CDMP-a kreću se u rasponu od .71 do .90 (medijan iznosi .79). Također, u radu se ispitivala mogućnost predviđanja 6 adaptabilnih načina odlučivanja (prikupljanje informacija, lokus kontrole, odugovlačenje, brzina donošenja odluke, ovisnost o drugima i želja za ugađanjem drugima) na temelju seta prediktora. Rezultati pokazuju da su profesionalna zrelost i temeljna samoevaluacija najbolji prediktori, dok je uloga roditeljske i prijateljske podrške u predviđanju načina donošenja odluka o karijeri uglavnom mala i neznačajna. Navedene su moguće implikacije dobivenih rezultata i prijedlozi za buduća istraživanja.The main purpose of this study was to examine career decision-making styles among high school students. Career decision-making styles are described by using career decisionmaking profiles, multidimensional model which is proposed by Gati et al. (2010) and they are measured by the Career Decision-Making Profile (CDMP) scale. Participants were students of final grade in high schools (grammar and vocational schools) from Zagreb and its surroundings (N=529). The data were collected online as a part of the project Vocational Development in Adolescence: Setting the Adolescent Career Transition Model, supported by Croatian Foundation for Science. Results of this study show 8-factor structure of Career Decision-Making Profiles scale, what differs from the results of study Gati i Levin (2012), indicating that there are 12 factors underlying CDMP scale. 8-factor structure of scale explained 66.77 % variance of manifest variables. Coefficients of internal consistency of the CDMP subscales are in the range from .71 to .90 (with median .79). Also, we investigated possibility of prediction of 6 adaptive career decision making styles (information gathering, locus of control, procrastination, speed of making the final decision, dependence on others, desire to please others) based on set of predictors. Vocational maturity and core self-evaluations are the best predictors of career decision-making styles in the high school students’ sample. Role of parental and friends support wasn’t significant in predicting the way students make their career decisions. Possible implications of study results and directions for future research are listed