Dissecting the Mid-Infrared Heart of M83 with JWST

We present a first look at the MRS observations of the nucleus of the spiral galaxy M83, taken with MIRI onboard JWST. The observations show a rich set of emission features from the ionized and warm molecular gas, as well as traces of the dust properties in this highly star forming environment. To begin dissecting the complex processes taking place in this part of the galaxy, we divide the nucleus observations into four different regions. We find that the strength of the emission features appears to strongly vary in all four regions, with the south-east region displaying the weakest features tracing both the dust continuum and ISM properties. Comparison between the cold molecular gas traced by the $^{12}$CO (1-0) transition with ALMA and the H$_2$ 0-0 S(1) transition showed a similar spatial distribution throughout the nucleus. This is in contrast to the distribution of the much warmer H$_2$ emission from the S(7) transition found to be concentrated mainly around the optical nucleus. We modeled the H$_2$ excitation using the rotational emission lines and estimate a total molecular gas mass accounting for the warm H$_2$ component of M($>$50 K)$_{\rm H_{2}}$ = 59.33 ($\pm 4.75$) $\times$ 10$^{6}$ M$_{\odot}$. We compared this value to the total molecular gas mass inferred by probing the cold H$_2$ gas through the $^{12}$CO (1-0) emission, M(CO)$_{\rm H_{2}}$ = 14.99 $\times$ 10$^{6}$ M$_{\odot}$. Our findings indicate that $\sim$75\% of the total molecular gas mass in the core of M83 is contained in the warm H$_2$ component. We also identify [OIV]25.89 $\mu$m and [FeII]25.99 $\mu$m emission (indicative of shocks) in all four nuclear regions with the strongest emission originating from the north-west section. We propose that the diffuse [FeII]25.99 $\mu$m emission is an indication of the combined effects of both the collective supernova explosions and the starbursts themselves.Comment: 13 pages, 3 Tables, 8 Figures, to be submitted to Ap

Multi-phase gas interactions on subarcsec scales in the shocked IGM of Stephan's Quintet with JWST and ALMA

We combine JWST and HST imaging with ALMA~CO(2-1) spectroscopy to study the highly turbulent multi-phase intergalactic medium (IGM) in Stephan's Quintet on 25-150 pc scales. Previous Spitzer observations revealed luminous H$_2$ line cooling across a 45 kpc-long filament, created by a giant shock-wave, following the collision with an intruder galaxy NGC~7318b. We demonstrate that the MIRI/F1000W/F770W filters are dominated by 0-0~S(3)~H$_2$ and a combination of PAH and 0-0~S(5)~H$_2$ emission. They reveal the dissipation of kinetic energy as massive clouds experience collisions, interactions and likely destruction/re-cycling within different phases of the IGM. In one kpc-scaled structure, warm H$_2$ formed a triangular-shaped head and tail of compressed and stripped gas behind a narrow shell of cold H$_2$. In another region, two cold molecular clumps with very different velocities are connected by an arrow-shaped stream of warm, probably shocked, H$_2$ suggesting a cloud-cloud collision is occurring. In both regions, a high warm-to-cold molecular gas fraction indicates that the cold clouds are being disrupted and converted into warm gas. We also map gas associated with an apparently forming dwarf galaxy. We suggest that the primary mechanism for exciting strong mid-IR H$_2$ lines throughout Stephan's Quintet is through a fog of warm gas created by the shattering of denser cold molecular clouds and mixing/recycling in the post-shocked gas. A full picture of the diverse kinematics and excitation of the warm H$_2$ will require future JWST mid-IR spectroscopy. The current observations reveal the rich variety of ways that different gas phases can interact with one another.Comment: Accepted for Publications to ApJ April 10 202

Infrared molecular hydrogen lines in GRB host galaxies

Molecular species, most frequently H_2, are present in a small, but growing, number of gamma-ray burst (GRB) afterglow spectra at redshifts z~2-3, detected through their rest-frame UV absorption lines. In rare cases, lines of vibrationally excited states of H_2 can be detected in the same spectra. The connection between afterglow line-of-sight absorption properties of molecular (and atomic) gas, and the observed behaviour in emission of similar sources at low redshift, is an important test of the suitability of GRB afterglows as general probes of conditions in star formation regions at high redshift. Recently, emission lines of carbon monoxide have been detected in a small sample of GRB host galaxies, at sub-mm wavelengths, but no searches for H_2 in emission have been reported yet. In this paper we perform an exploratory search for rest-frame K band rotation-vibrational transitions of H_2 in emission, observable only in the lowest redshift GRB hosts (z<0.22). Searching the data of four host galaxies, we detect a single significant rotation-vibrational H_2 line candidate, in the host of GRB 031203. Re-analysis of Spitzer mid-infrared spectra of the same GRB host gives a single low significance rotational line candidate. The (limits on) line flux ratios are consistent with those of blue compact dwarf galaxies in the literature. New instrumentation, in particular on the JWST and the ELT, can facilitate a major increase in our understanding of the H_2 properties of nearby GRB hosts, and the relation to H_2 absorption in GRBs at higher redshift.Comment: 7 pages, 4 figures, MNRAS accepte

Biallelic mutations in IRF8 impair human NK cell maturation and function

Human NK cell deficiencies are rare yet result in severe and often fatal disease, particularly as a result of viral susceptibility. NK cells develop from hematopoietic stem cells, and few monogenic errors that specifically interrupt NK cell development have been reported. Here we have described biallelic mutations in IRF8, which encodes an interferon regulatory factor, as a cause of familial NK cell deficiency that results in fatal and severe viral disease. Compound heterozygous or homozygous mutations in IRF8 in 3 unrelated families resulted in a paucity of mature CD56dim NK cells and an increase in the frequency of the immature CD56bright NK cells, and this impairment in terminal maturation was also observed in Irf8–/–, but not Irf8+/–, mice. We then determined that impaired maturation was NK cell intrinsic, and gene expression analysis of human NK cell developmental subsets showed that multiple genes were dysregulated by IRF8 mutation. The phenotype was accompanied by deficient NK cell function and was stable over time. Together, these data indicate that human NK cells require IRF8 for development and functional maturation and that dysregulation of this function results in severe human disease, thereby emphasizing a critical role for NK cells in human antiviral defense

GOALS-JWST: Tracing AGN Feedback on the Star-forming Interstellar Medium in NGC 7469

We present James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI) integral-field spectroscopy of the nearby merging, luminous infrared galaxy, NGC 7469. This galaxy hosts a Seyfert type-1.5 nucleus, a highly ionized outflow, and a bright, circumnuclear star-forming ring, making it an ideal target to study active galactic nucleus (AGN) feedback in the local universe. We take advantage of the high spatial/spectral resolution of JWST/ MIRI to isolate the star-forming regions surrounding the central active nucleus and study the properties of the dust and warm molecular gas on ∼100 pc scales. The starburst ring exhibits prominent polycyclic aromatic hydrocarbon (PAH) emission, with grain sizes and ionization states varying by only ∼30%, and a total star formation rate of 10–30 Me yr−1 derived from fine structure and recombination emission lines. Using pure rotational lines of H2 we detect 1.2 7 107 Me of warm molecular gas at a temperature higher than 200 K in the ring. All PAH bands get significantly weaker toward the central source, where larger and possibly more ionized grains dominate the emission, likely the result of the ionizing radiation and/or the fast wind emerging from the AGN. The small grains and warm molecular gas in the bright regions of the ring however display properties consistent with normal star-forming regions. These observations highlight the power of JWST to probe the inner regions of dusty, rapidly evolving galaxies for signatures of feedback and inform models that seek to explain the coevolution of supermassive black holes and their hosts

Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium

<p>Abstract</p> <p>Background</p> <p><it>Msx1 </it>and <it>Msx2</it>, which belong to the highly conserved <it>Nk </it>family of homeobox genes, display overlapping expression patterns and redundant functions in multiple tissues and organs during vertebrate development. <it>Msx1 </it>and <it>Msx2 </it>have well-documented roles in mediating epithelial-mesenchymal interactions during organogenesis. Given that both <it>Msx1 </it>and <it>Msx2 </it>are crucial downstream effectors of Bmp signaling, we investigated whether <it>Msx1 </it>and <it>Msx2 </it>are required for the Bmp-induced endothelial-mesenchymal transformation (EMT) during atrioventricular (AV) valve formation.</p> <p>Results</p> <p>While both <it>Msx1-/- </it>and <it>Msx2-/- </it>single homozygous mutant mice exhibited normal valve formation, we observed hypoplastic AV cushions and malformed AV valves in <it>Msx1-/-; Msx2-/- </it>mutants, indicating redundant functions of <it>Msx1 </it>and <it>Msx2 </it>during AV valve morphogenesis. In <it>Msx1/2 </it>null mutant AV cushions, we found decreased Bmp2/4 and <it>Notch1 </it>signaling as well as reduced expression of <it>Has2</it>, <it>NFATc1 </it>and <it>Notch1</it>, demonstrating impaired endocardial activation and EMT. Moreover, perturbed expression of chamber-specific genes <it>Anf</it>, <it>Tbx2</it>, <it>Hand1 </it>and <it>Hand2 </it>reveals mispatterning of the <it>Msx1/2 </it>double mutant myocardium and suggests functions of <it>Msx1 </it>and <it>Msx2 </it>in regulating myocardial signals required for remodelling AV valves and maintaining an undifferentiated state of the AV myocardium.</p> <p>Conclusion</p> <p>Our findings demonstrate redundant roles of <it>Msx1 </it>and <it>Msx2 </it>in regulating signals required for development of the AV myocardium and formation of the AV valves.</p

A far-ultraviolet-driven photoevaporation flow observed in a protoplanetary disk.

Most low-mass stars form in stellar clusters that also contain massive stars, which are sources of far-ultraviolet (FUV) radiation. Theoretical models predict that this FUV radiation produces photodissociation regions (PDRs) on the surfaces of protoplanetary disks around low-mass stars, which affects planet formation within the disks. We report James Webb Space Telescope and Atacama Large Millimeter Array observations of a FUV-irradiated protoplanetary disk in the Orion Nebula. Emission lines are detected from the PDR; modeling their kinematics and excitation allowed us to constrain the physical conditions within the gas. We quantified the mass-loss rate induced by the FUV irradiation and found that it is sufficient to remove gas from the disk in less than a million years. This is rapid enough to affect giant planet formation in the disk

PDRs4All IV. An embarrassment of riches: Aromatic infrared bands in the Orion Bar

(Abridged) Mid-infrared observations of photodissociation regions (PDRs) are dominated by strong emission features called aromatic infrared bands (AIBs). The most prominent AIBs are found at 3.3, 6.2, 7.7, 8.6, and 11.2 $\mu$m. The most sensitive, highest-resolution infrared spectral imaging data ever taken of the prototypical PDR, the Orion Bar, have been captured by JWST. We provide an inventory of the AIBs found in the Orion Bar, along with mid-IR template spectra from five distinct regions in the Bar: the molecular PDR, the atomic PDR, and the HII region. We use JWST NIRSpec IFU and MIRI MRS observations of the Orion Bar from the JWST Early Release Science Program, PDRs4All (ID: 1288). We extract five template spectra to represent the morphology and environment of the Orion Bar PDR. The superb sensitivity and the spectral and spatial resolution of these JWST observations reveal many details of the AIB emission and enable an improved characterization of their detailed profile shapes and sub-components. While the spectra are dominated by the well-known AIBs at 3.3, 6.2, 7.7, 8.6, 11.2, and 12.7 $\mu$m, a wealth of weaker features and sub-components are present. We report trends in the widths and relative strengths of AIBs across the five template spectra. These trends yield valuable insight into the photochemical evolution of PAHs, such as the evolution responsible for the shift of 11.2 $\mu$m AIB emission from class B$_{11.2}$ in the molecular PDR to class A$_{11.2}$ in the PDR surface layers. This photochemical evolution is driven by the increased importance of FUV processing in the PDR surface layers, resulting in a "weeding out" of the weakest links of the PAH family in these layers. For now, these JWST observations are consistent with a model in which the underlying PAH family is composed of a few species: the so-called 'grandPAHs'.Comment: 25 pages, 10 figures, to appear in A&