Developing Communication and Organization Skills: The ELITE Life Skills Reflective Practice Intervention

The aim of the current study was to evaluate the ELITE intervention as a method of increasing the perceived use of communication and organization skills in young people. The participants were three male field hockey players and two female tennis players from a British university. We used a series of single subject, multiple baselines, with minimal meaningful harm and benefit criteria and SMDall effect sizes to evaluate the ELITE intervention. The results revealed no meaningful harm from participating in the program, and the tennis players showed meaningful benefits. SMDall effect sizes all demonstrated that the intervention had a positive effect. Post intervention interviews indicated that participants valued the targeted life skills, and the program was enjoyable. Implications of this study suggest that scholars and practitioners can use the ELITE intervention to increase life skills in young people

Personal qualities of effective Sport Psychologists: Coping with organisational demands in high performance sport

The purpose of the current study was to explore colleagues’ perspectives of the personal qualities of effective sport psychologists and how these qualities enable practitioners to address the organisational demands they face within their work. Semi-structured interviews were conducted with sport physicians (N = 6) and coaches (N = 7). Data analysis identified three main themes: understanding high performance sport environments and cultures, the wider organisational role in high performance sport, and working with support staff in high performance sport. This study provides insight into the wider organisational role of sport psychology in high performance sport and the personal qualities that are fundamental to effective service delivery in this environment. Suggestions are offered regarding how education and training could better prepare practitioners for addressing organisational demands within their role, by developing trainees’ awareness of their personal qualities and providing them with the opportunity to critically explore these qualities in the context of applied sport psychology practice

Stories of Critical Moments Contributing to the Development of Applied Sport Psychology Practitioners

Accepted author manuscript version reprinted, by permission, from The Sport Psychologist, 2020 (ahead of print). © Human Kinetics, Inc.This study explored the stories of critical moments experienced by applied sport psychology practitioners. The 13 recruited practitioners (eight male and five female) were in different stages of their development (trainee, neophyte, and experienced) and were asked to tell one story about a critical moment that significantly contributed to their development as applied practitioners. Narrative analysis was used to explore the stories of critical moments. Four distinct narrative structures were evident; Re-birth, Rags to Riches, Tragedy, and The Quest. There was one consistent narrative feature that supported these plots: critical moments contribute towards an alignment between a practitioner’s beliefs and behaviour, which supports the development of a congruent philosophy of practice and the environment they choose to work within. We recommend future research, such as the use of narrative analysis to explore alternative narrative structures and the investigation of successful and unsuccessful consultancy experiences

Exercise-induced laryngeal obstruction (EILO) in athletes: a narrative review by a subgroup of the IOC Consensus on 'acute respiratory illness in the athlete'

Exercise-induced laryngeal obstruction (EILO) is caused by paradoxical inspiratory adduction of laryngeal structures during exercise. EILO is an important cause of upper airway dysfunction in young individuals and athletes, can impair exercise performance and mimic lower airway dysfunction, such as asthma and/or exercise-induced bronchoconstriction. Over the past two decades, there has been considerable progress in the recognition and assessment of EILO in sports medicine. EILO is a highly prevalent cause of unexplained dyspnoea and wheeze in athletes. The preferred diagnostic approach is continuous visualisation of the larynx (via laryngoscopy) during high-intensity exercise. Recent data suggest that EILO consists of different subtypes, possibly caused via different mechanisms. Several therapeutic interventions for EILO are now in widespread use, but to date, no randomised clinical trials have been performed to assess their efficacy or inform robust management strategies. The aim of this review is to provide a state-of-the-art overview of EILO and guidance for clinicians evaluating and treating suspected cases of EILO in athletes. Specifically, this review examines the pathophysiology of EILO, outlines a diagnostic approach and presents current therapeutic algorithms. The key unmet needs and future priorities for research in this area are also covered.publishedVersio

Gene Expression Signatures of Peripheral Blood Mononuclear Cells during the Early Post-Transplant Period in Patients Developing Cardiac Allograft Vasculopathy

Background. Cardiac allograft vasculopathy (CAV) is a major cause of graft loss and death after heart transplantation. Currently, no diagnostic methods are available during the early post-transplant period to accurately identify patients at risk of CAV. We hypothesized that PBMC gene expression profiles (GEP) can identify patients at risk of CAV. Methods. We retrospectively analyzed a limited set of whole-genome PBMC microarrays from 10 post-transplant patients who did (n = 3) or did not (n = 7) develop advanced grade CAV during their long-term follow-up. We used significance analysis of microarrays to identify differentially expressed genes and High-Throughput GoMiner to assess gene ontology (GO) categories. We corroborated our findings by retrospective analysis of PBMC real-time PCR data from 33 patients. Results. Over 300 genes were differentially expressed (FDR < 5%), and 18 GO-categories including “macrophage activation”, “Interleukin-6 pathway”, “NF-KappaB cascade”, and “response to virus” were enriched by these genes (FDR < 5%). Out of 8 transcripts available for RT-PCR analysis, we confirmed 6 transcripts (75.0%) including FPRL1, S100A9, CXCL10, PRO1073, and MMP9 (P < .05). Conclusion. Our pilot data suggest that GEP of PBMC may become a valuable tool in the evaluation of patients at risk of CAV. Larger prospectively designed studies are needed to corroborate our hypothesis

Game of Stones:feasibility randomised controlled trial of how to engage men with obesity in text message and incentive interventions for weight loss

Objectives To examine the acceptability and feasibility of narrative text messages with or without financial incentives to support weight loss for men. Design Individually randomised three-arm feasibility trial with 12 months’ follow-up. Setting Two sites in Scotland with high levels of disadvantage according to Scottish Index for Multiple Deprivation (SIMD). Participants Men with obesity (n=105) recruited through community outreach and general practitioner registers. Interventions Participants randomised to: (A) narrative text messages plus financial incentive for 12 months (short message service (SMS)+I), (B) narrative text messages for 12 months (SMS only), or (C) waiting list control. Outcomes Acceptability and feasibility of recruitment, retention, intervention components and trial procedures assessed by analysing quantitative and qualitative data at 3, 6 and 12 months. Results 105 men were recruited, 60% from more disadvantaged areas (SIMD quintiles 1 or 2). Retention at 12 months was 74%. Fewer SMS+I participants (64%) completed 12-month assessments compared with SMS only (79%) and control (83%). Narrative texts were acceptable to many men, but some reported negative reactions. No evidence emerged that level of disadvantage was related to acceptability of narrative texts. Eleven SMS+I participants (31%) successfully met or partially met weight loss targets. The cost of the incentive per participant was £81.94 (95% CI £34.59 to £129.30). Incentives were acceptable, but improving health was reported as the key motivator for weight loss. All groups lost weight (SMS+I: −2.51 kg (SD=4.94); SMS only: −1.29 kg (SD=5.03); control: −0.86 kg (SD=5.64) at 12 months). Conclusions This three-arm weight management feasibility trial recruited and retained men from across the socioeconomic spectrum, with the majority from areas of disadvantage, was broadly acceptable to most participants and feasible to deliver

Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness.

BACKGROUND: Numerous pathologies result in multiple-organ failure, which is thought to be a direct consequence of compromised cellular bioenergetic status. Neither the nature of this phenotype nor its relevance to survival are well understood, limiting the efficacy of modern life-support. METHODS: To explore the hypothesis that survival from critical illness relates to changes in cellular bioenergetics, we combined assessment of mitochondrial respiration with metabolomic, lipidomic and redox profiling in skeletal muscle and blood, at multiple timepoints, in 21 critically ill patients and 12 reference patients. RESULTS: We demonstrate an end-organ cellular phenotype in critical illness, characterized by preserved total energetic capacity, greater coupling efficiency and selectively lower capacity for complex I and fatty acid oxidation (FAO)-supported respiration in skeletal muscle, compared to health. In survivors, complex I capacity at 48 h was 27% lower than in non-survivors (p = 0.01), but tended to increase by day 7, with no such recovery observed in non-survivors. By day 7, survivors' FAO enzyme activity was double that of non-survivors (p = 0.048), in whom plasma triacylglycerol accumulated. Increases in both cellular oxidative stress and reductive drive were evident in early critical illness compared to health. Initially, non-survivors demonstrated greater plasma total antioxidant capacity but ultimately higher lipid peroxidation compared to survivors. These alterations were mirrored by greater levels of circulating total free thiol and nitrosated species, consistent with greater reductive stress and vascular inflammation, in non-survivors compared to survivors. In contrast, no clear differences in systemic inflammatory markers were observed between the two groups. CONCLUSION: Critical illness is associated with rapid, specific and coordinated alterations in the cellular respiratory machinery, intermediary metabolism and redox response, with different trajectories in survivors and non-survivors. Unravelling the cellular and molecular foundation of human resilience may enable the development of more effective life-support strategies

Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness.

BACKGROUND: Numerous pathologies result in multiple-organ failure, which is thought to be a direct consequence of compromised cellular bioenergetic status. Neither the nature of this phenotype nor its relevance to survival are well understood, limiting the efficacy of modern life-support. METHODS: To explore the hypothesis that survival from critical illness relates to changes in cellular bioenergetics, we combined assessment of mitochondrial respiration with metabolomic, lipidomic and redox profiling in skeletal muscle and blood, at multiple timepoints, in 21 critically ill patients and 12 reference patients. RESULTS: We demonstrate an end-organ cellular phenotype in critical illness, characterized by preserved total energetic capacity, greater coupling efficiency and selectively lower capacity for complex I and fatty acid oxidation (FAO)-supported respiration in skeletal muscle, compared to health. In survivors, complex I capacity at 48 h was 27% lower than in non-survivors (p = 0.01), but tended to increase by day 7, with no such recovery observed in non-survivors. By day 7, survivors' FAO enzyme activity was double that of non-survivors (p = 0.048), in whom plasma triacylglycerol accumulated. Increases in both cellular oxidative stress and reductive drive were evident in early critical illness compared to health. Initially, non-survivors demonstrated greater plasma total antioxidant capacity but ultimately higher lipid peroxidation compared to survivors. These alterations were mirrored by greater levels of circulating total free thiol and nitrosated species, consistent with greater reductive stress and vascular inflammation, in non-survivors compared to survivors. In contrast, no clear differences in systemic inflammatory markers were observed between the two groups. CONCLUSION: Critical illness is associated with rapid, specific and coordinated alterations in the cellular respiratory machinery, intermediary metabolism and redox response, with different trajectories in survivors and non-survivors. Unravelling the cellular and molecular foundation of human resilience may enable the development of more effective life-support strategies.MRC, Evelyn Trust, Intensive Care Society, Royal Free Charit

An Ancient Metal-Poor Population in M32, and Halo Satellite Accretion in M31, Identified by RR Lyrae Stars

We present time-series photometry of two fields near M32 using archival observations from ACS/WFC onboard HST. One field is centered about 2 arcmin from M32 while the other is located 15 arcmin to the southeast of M31. We identify a total of 1139 RR Lyrae variables of which 821 are ab-type and 318 are c-type. In the field near M32, we find a radial gradient in the density of RR Lyraes relative to the center of M32. This gradient is consistent with the surface brightness profile of M32 suggesting that a significant number of the RR Lyraes in this region belong to M32. This provides further confirmation that M32 contains an ancient stellar population formed around the same time as the oldest population in M31 and the Milky Way. The RR Lyrae stars in M32 exhibit a mean metal abundance of [Fe/H] ~ -1.42 +/- 0.02, which is ~15 times lower than the metal abundance of the overall M32 stellar population. Moreover, the abundance of RR Lyrae stars normalized to the luminosity of M32 in the field analyzed further indicates that the ancient metal-poor population in M32 represents only a very minor component of this galaxy, consistent with the 1% to 4.5% in mass inferred from the CMD analysis of Monachesi et al. In the other field, we find unprecedented evidence for two populations of RR Lyraes in M31 as shown by two distinct sequences among the ab-type variables in the Bailey Diagram. When interpreted in terms of metal abundance, one population exhibits a peak at [Fe/H] ~ -1.3 and the other is at [Fe/H] ~ -1.9. One possible interpretation of this result is that the more metal-rich population represents the dominant M31 halo, while the metal-poorer group could be a disrupted dwarf satellite galaxy orbiting M31. If true, this represents a further indication that the formation of the M31 spheroid has been significantly influenced by the merger and accretion of dwarf galaxy satellites. [abridged]Comment: 22 pages, 17 figures, accepted for publication in the MNRA