The Use of Rank Transformation and Multiple Regression Analysis in Estimating Residential Property Values With A Small Sample

Conventional multiple regression analysis which has been used in estimating residential property values typically relies upon cardinal data. This paper argues that appraisal theory requires the appraiser to rank the comparables from best to worst and use a regression technique which can be applied to ordinal data. The rank regression procedure illustrated here was successfully used on small sample sizes, and did not violate the critical assumptions underlying conventional multiple regression. The results indicate that the rank regression technique illustrated here is more theoretically correct than conventional multiple regression and produces a better model with more accurate price estimates.

A Procedure for Uncovering Acceptable and Nonacceptable Mortgage Applications through Discriminant Analysis Using Ranked Data

The procedure developed in this paper uses a less biased statistical technique than conventional discriminant analysis and parallels the ranking procedure used by loan officers. A variety of univariate and multivariate statistical procedures as well as comprehensive validation methods are used to develop a "best" model. The resulting model provides more accurate classification than other studies have shown, without violating federal law regarding discrimination.

Factors that Influence the Intention to Pirate Software and Media

intention toward digital piracy, ethical behavior, theory of planned behavior, moral obligation,

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

Extracellular regulated kinase 5 (ERK5) signalling has been implicated in driving a number of cellular phenotypes including endothelial cell angiogenesis and tumour cell motility. Novel ERK5 inhibitors were identified using high throughput screening, with a series of pyrrole-2-carboxamides substituted at the 4-position with an aroyl group being found to exhibit IC 50 values in the micromolar range, but having no selectivity against p38α MAP kinase. Truncation of the N-substituent marginally enhanced potency (∼3-fold) against ERK5, but importantly attenuated inhibition of p38α. Systematic variation of the substituents on the aroyl group led to the selective inhibitor 4-(2-bromo-6-fluorobenzoyl)-N-(pyridin-3-yl)-1H-pyrrole-2-carboxamide (IC 50 0.82 μM for ERK5; IC 50 > 120 μM for p38α). The crystal structure (PDB 5O7I) of this compound in complex with ERK5 has been solved. This compound was orally bioavailable and inhibited bFGF-driven Matrigel plug angiogenesis and tumour xenograft growth. The selective ERK5 inhibitor described herein provides a lead for further development into a tool compound for more extensive studies seeking to examine the role of ERK5 signalling in cancer and other diseases