670 research outputs found
Extracting Radial Velocities of A- and B-type Stars from Echelle Spectrograph Calibration Spectra
We present a technique to extract radial velocity measurements from echelle
spectrograph observations of rapidly rotating stars ( km
s). This type of measurement is difficult because the line widths of
such stars are often comparable to the width of a single echelle order. To
compensate for the scarcity of lines and Doppler information content, we have
developed a process that forward-models the observations, fitting the radial
velocity shift of the star for all echelle orders simultaneously with the
echelle blaze function. We use our technique to extract radial velocity
measurements from a sample of rapidly rotating A- and B-type stars used as
calibrator stars observed by the California Planet Survey observations. We
measure absolute radial velocities with a precision ranging from 0.5-2.0 km
s per epoch for more than 100 A- and B-type stars. In our sample of 10
well-sampled stars with radial velocity scatter in excess of their measurement
uncertainties, three of these are single-lined binaries with long observational
baselines. From this subsample, we present detections of two previously unknown
spectroscopic binaries and one known astrometric system. Our technique will be
useful in measuring or placing upper limits on the masses of sub-stellar
companions discovered by wide-field transit surveys, and conducting future
spectroscopic binarity surveys and Galactic space-motion studies of massive
and/or young, rapidly-rotating stars.Comment: Accepted to ApJ
Recommended from our members
Evolution of Hominin Polyunsaturated Fatty Acid Metabolism: From Africa to the New World
The metabolic conversion of dietary omega-3 and omega-6 18 carbon (18C) to long chain (>20 carbon) polyunsaturated fatty acids (LC-PUFAs) is vital for human life. The rate-limiting steps of this process are catalyzed by fatty acid desaturase (FADS) 1 and 2. Therefore, understanding the evolutionary history of the FADS genes is essential to our understanding of hominin evolution. The FADS genes have two haplogroups, ancestral and derived, with the derived haplogroup being associated with more efficient LC-PUFA biosynthesis than the ancestral haplogroup. In addition, there is a complex global distribution of these haplogroups that is suggestive of Neanderthal introgression. We confirm that Native American ancestry is nearly fixed for the ancestral haplogroup, and replicate a positive selection signal in Native Americans. This positive selection potentially continued after the founding of the Americas, although simulations suggest that the timing is dependent on the allele frequency of the ancestral Beringian population. We also find that the Neanderthal FADS haplotype is more closely related to the derived haplogroup and the Denisovan clusters closer to the ancestral haplogroup. Furthermore, the derived haplogroup has a time to the most recent common ancestor of 688,474years before present. These results support an ancient polymorphism, as opposed to Neanderthal introgression, forming in the FADS region during the Pleistocene with possibly differential selection pressures on both haplogroups. The near fixation of the ancestral haplogroup in Native American ancestry calls for future studies to explore the potential health risk of associated low LC-PUFA levels in these populations.Center for Health Related Informatics and Biomaging at the University of Maryland School of Medicine; National Institutes of Health/National Heart, Lung, and Blood Institute [U01 HL72518, HL087698, HL112064]; National Institutes of Health [R01-AT008621]Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Five Planets Transiting a Ninth Magnitude Star
The Kepler mission has revealed a great diversity of planetary systems and
architectures, but most of the planets discovered by Kepler orbit faint stars.
Using new data from the K2 mission, we present the discovery of a five planet
system transiting a bright (V = 8.9, K = 7.7) star called HIP 41378. HIP 41378
is a slightly metal-poor late F-type star with moderate rotation (v sin(i) = 7
km/s) and lies at a distance of 116 +/- 18 from Earth. We find that HIP 41378
hosts two sub-Neptune sized planets orbiting 3.5% outside a 2:1 period
commensurability in 15.6 and 31.7 day orbits. In addition, we detect three
planets which each transit once during the 75 days spanned by K2 observations.
One planet is Neptune sized in a likely ~160 day orbit, one is sub-Saturn sized
likely in a ~130 day orbit, and one is a Jupiter sized planet in a likely ~1
year orbit. We show that these estimates for the orbital periods can be made
more precise by taking into account dynamical stability considerations. We also
calculate the distribution of stellar reflex velocities expected for this
system, and show that it provides a good target for future radial velocity
observations. If a precise orbital period can be determined for the outer
Jovian planet through future observations, it will be an excellent candidate
for follow-up transit observations to study its atmosphere and measure its
oblateness.Comment: Accepted by ApJL. 12 pages, 6 figures, 2 table
Orbiter escape pole
A Shuttle type of aircraft (10) with an escape hatch (12) has an arcuately shaped pole housing (16) attachable to an interior wall and ceiling with its open end adjacent to the escape hatch. The pole housing 16 contains a telescopically arranged and arcuately shaped primary pole member (22) and extension pole member (23) which are guided by roller assemblies (30,35). The extension pole member (23) is slidable and extendable relative to the primary pole member (22). For actuation, a spring actuated system includes a spring (52) in the pole housing. A locking member (90) engages both pole members (22,23) through notch portions (85,86) in the pole members. The locking member selectively releases the extension pole member (23) and the primary pole member (22). An internal one-way clutch or anti-return mechanism prevents retraction of the extension pole member from an extended position. Shock absorbers (54)(150,152) are for absoring the energy of the springs. A manual backup deployment system is provided which includes a canted ring (104) biased by a spring member (108). A lever member (100) with a slot and pin connection (102) permits the mechanical manipulation of the canted ring to move the primary pole member. The ring (104) also prevents retraction of the main pole. The crew escape mechanism includes a magazine (60) and a number of lanyards (62), each lanyard being mounted by a roller loop (68) over the primary pole member (22). The strap on the roller loop has stitching for controlled release, a protection sheath (74) to prevent tangling and a hook member (69) for attachment to a crew harness
Derivation of the Blackbody Radiation Spectrum from a Natural Maximum-Entropy Principle Involving Casimir Energies and Zero-Point Radiation
By numerical calculation, the Planck spectrum with zero-point radiation is
shown to satisfy a natural maximum-entropy principle whereas alternative
choices of spectra do not. Specifically, if we consider a set of
conducting-walled boxes, each with a partition placed at a different location
in the box, so that across the collection of boxes the partitions are uniformly
spaced across the volume, then the Planck spectrum correspond to that spectrum
of random radiation (having constant energy kT per normal mode at low
frequencies and zero-point energy (1/2)hw per normal mode at high frequencies)
which gives maximum uniformity across the collection of boxes for the radiation
energy per box. The analysis involves Casimir energies and zero-point radiation
which do not usually appear in thermodynamic analyses. For simplicity, the
analysis is presented for waves in one space dimension.Comment: 11 page
Evidence for Reionization at z ~ 6: Detection of a Gunn-Peterson Trough in a z=6.28 Quasar
We present moderate resolution Keck spectroscopy of quasars at z=5.82, 5.99
and 6.28, discovered by the Sloan Digital Sky Survey (SDSS). We find that the
Ly Alpha absorption in the spectra of these quasars evolves strongly with
redshift. To z~5.7, the Ly Alpha absorption evolves as expected from an
extrapolation from lower redshifts. However, in the highest redshift object,
SDSSp J103027.10+052455.0 (z=6.28), the average transmitted flux is
0.0038+-0.0026 times that of the continuum level over 8450 A < lambda < 8710 A
(5.95<z(abs)<6.16), consistent with zero flux. Thus the flux level drops by a
factor of >150, and is consistent with zero flux in the Ly Alpha forest region
immediately blueward of the Ly Alpha emission line, compared with a drop by a
factor of ~10 at z(abs)~5.3. A similar break is seen at Ly Beta; because of the
decreased oscillator strength of this transition, this allows us to put a
considerably stronger limit, tau(eff) > 20, on the optical depth to Ly Alpha
absorption at z=6.
This is a clear detection of a complete Gunn-Peterson trough, caused by
neutral hydrogen in the intergalactic medium. Even a small neutral hydrogen
fraction in the intergalactic medium would result in an undetectable flux in
the Ly Alpha forest region. Therefore, the existence of the Gunn-Peterson
trough by itself does not indicate that the quasar is observed prior to the
reionization epoch. However, the fast evolution of the mean absorption in these
high-redshift quasars suggests that the mean ionizing background along the line
of sight to this quasar has declined significantly from z~5 to 6, and the
universe is approaching the reionization epoch at z~6.Comment: Revised version (2001 Sep 4) accepted by the Astronomical Journal
(minor changes
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate
ADAM10 and ADAM17 have been shown to contribute to the acquired drug resistance of HER2-positive breast cancer in response to trastuzumab. The majority of ADAM10 and ADAM17 inhibitor development has been focused on the discovery of compounds that bind the active site zinc, however, in recent years, there has been a shift from active site to secondary substrate binding site (exosite) inhibitor discovery in order to identify non-zinc-binding molecules. In the present work a glycosylated, exosite-binding substrate of ADAM10 and ADAM17 was utilized to screen 370,276 compounds from the MLPCN collection. As a result of this uHTS effort, a selective, time-dependent, non-zinc-binding inhibitor of ADAM10 with Ki = 883 nM was discovered. This compound exhibited low cell toxicity and was able to selectively inhibit shedding of known ADAM10 substrates in several cell-based models. We hypothesize that differential glycosylation of these cognate substrates is the source of selectivity of our novel inhibitor. The data indicate that this novel inhibitor can be used as an in vitro and, potentially, in vivo, probe of ADAM10 activity. Additionally, results of the present and prior studies strongly suggest that glycosylated substrate are applicable as screening agents for discovery of selective ADAM probes and therapeutics
High-Redshift Quasars Found in Sloan Digital Sky Survey Commissioning Data IV: Luminosity Function from the Fall Equatorial Stripe Sampl
This is the fourth paper in a series aimed at finding high-redshift quasars
from five-color imaging data taken along the Celestial Equator by the SDSS.
during its commissioning phase. In this paper, we use the color-selected sample
of 39 luminous high-redshift quasars presented in Paper III to derive the
evolution of the quasar luminosity function over the range of 3.6<z<5.0, and
-27.5<M_1450<-25.5 (Omega=1, H_0=50 km s^-1 Mpc^-1). We use the selection
function derived in Paper III to correct for sample incompleteness. The
luminosity function is estimated using three different methods: (1) the 1/V_a
estimator; (2) a maximum likelihood solution, assuming that the density of
quasars depends exponentially on redshift and as a power law in luminosity and
(3) Lynden-Bell's non-parametric C^- estimator. All three methods give
consistent results. The luminous quasar density decreases by a factor of ~ 6
from z=3.5 to z=5.0, consistent with the decline seen from several previous
optical surveys at z<4.5. The luminosity function follows psi(L) ~ L^{-2.5} for
z~4 at the bright end, significantly flatter than the bright end luminosity
function psi(L) \propto L^{-3.5} found in previous studies for z<3, suggesting
that the shape of the quasar luminosity function evolves with redshift as well,
and that the quasar evolution from z=2 to 5 cannot be described as pure
luminosity evolution. Possible selection biases and the effect of dust
extinction on the redshift evolution of the quasar density are also discussed.Comment: AJ accepted, with minor change
Identifying key drivers of the impact of an HIV cure intervention in sub-Saharan Africa
BACKGROUND: The properties required of an intervention that results in eradication or control of HIV in absence of antiretroviral therapy (ART-free viral suppression) to make it cost-effective in low income settings are unknown. METHODS: We used a model of HIV and ART to investigate the effect of introducing an ART-free viral suppression intervention in 2022 in an example country of Zimbabwe. We assumed that the intervention (cost: 300 million (8.7% saving). An intervention of this efficacy costing anything up to $1400 is likely to be cost-effective in this setting. CONCLUSION: Interventions aimed at curing HIV have the potential to improve overall disease burden and to reduce costs. Given the effectiveness and cost of ART, such interventions would have to be inexpensive and highly effective
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