Prenatal determinants of physical activity and cardiorespiratory fitness in adolescence - Northern Finland Birth Cohort 1986 study

Background: Lower levels of physical activity and cardiorespiratory fitness are key risk factors of chronic adult diseases. Physical activity and cardiorespiratory fitness are predicted by birth weight, but the underlying parental and pregnancy-related factors remain largely unknown. We examined how prenatal determinants are associated with physical activity and cardiorespiratory fitness in adolescence. Methods: Of the 16-year-old members of the population-based Northern Finland Birth Cohort 1986 (NFBC 1986), 6682 singletons with no major physical disability reported their amount of physical activity outside school hours, and 4706 completed a submaximal cycle ergometer test assessing cardiorespiratory fitness. Physical activity was expressed as metabolic equivalent hours per week (METh/week) and cardiorespiratory fitness as peak oxygen uptake (ml center dot kg(-1)center dot min(-1)). Prenatal determinants included birth weight, length of gestation, mother's and father's body mass index (BMI), maternal gestational diabetes mellitus (GDM), and maternal hypertension and smoking during pregnancy. Data were analyzed by multiple linear regression. Results: A higher birth weight and longer length of gestation predicted lower levels of physical activity and cardiorespiratory fitness at 16 years, although the association between length of gestation and physical activity was inverse U-shaped. Mother's or father's overweight or obesity before pregnancy were associated with lower levels of their offspring's physical activity and fitness in adolescence. Adjusting for maternal pregnancy disorders and the adolescent's own BMI attenuated the associations with the mother's but not the father's overweight/obesity. Furthermore, maternal GDM predicted lower cardiorespiratory fitness. Conclusions: A high birth weight and parental overweight/obesity are associated with lower levels of both physical activity and cardiorespiratory fitness in adolescence, while maternal GDM and longer length of gestation are associated with lower cardiorespiratory fitness. Both long and short lengths of gestation predict low physical activity.Peer reviewe

Balancing profitability of energy production, societal impacts and biodiversity in offshore wind farm design

The global demand for renewable energy is on the rise. Expansion of onshore wind energy is in many parts of the world limited by societal acceptance, and also ecological impacts are a concern. Here, pragmatic methods are developed for the integration of high-dimensional spatial data in offshore wind energy planning. Over 150 spatial data layers are created, which either oppose or support offshore wind energy development, and represent ecological, societal, and economic factors. The method is tested in Finland, where interest in developing offshore wind energy is growing. Analyses were done using a spatial prioritization approach, originally developed for the prioritization of high dimensional ecological data, and rarely used in planning offshore wind energy. When all criteria are integrated, it is possible to find a balanced solution where offshore wind farms cause little disturbance to biodiversity and society, while at the same time yielding high profitability for wind energy production. Earlier proposed areas for offshore wind farms were also evaluated. They were generally well suited for wind power, with the exception of a couple of areas with comparatively high environmental impacts. As an outcome, new areas well suited for large scale wind power deployment were recognized, where construction costs would be moderate and disturbance to biodiversity, marine industries and people limited. A novel tradeoff visualization method was also developed for the conflicts and synergies of offshore energy deployment, which could ease the dialogue between different stakeholders in a spatial planning context. Overall, this study provides a generic and transparent approach for well-informed analysis of offshore wind energy development potential when conflict resolution between biodiversity, societal factors and economic profits is needed. The proposed approach is replicable elsewhere in the world. It is also structurally suitable for the planning of impact avoidance and conflict resolution in the context of other forms of construction or resource extraction.Peer reviewe

Preterm birth and subsequent timing of pubertal growth, menarche, and voice break

Background: We evaluated pubertal growth and pubertal timing of participants born preterm compared to those born at term. Methods: In the ESTER Preterm Birth Study, we collected growth data and measured final height of men/women born very or moderately preterm (<34 gestational weeks, n = 52/55), late preterm (34–<37 weeks, 94/106), and term (≥37 weeks, 131/151), resulting in median 9 measurements at ≥6 years. Timing of menarche or voice break was self-reported. Peak height velocity (PHV, cm/year) and age at PHV (years) were compared with SuperImposition by Translation And Rotation (SITAR) model (sexes separately). Results: Age at PHV (years) and PHV (cm/year) were similar in all gestational age groups. Compared to term controls, insignificant differences in age at PHV were 0.1 (95% CI: −0.2 to 0.4) years/0.2 (−0.1 to 0.4) for very or moderately/late preterm born men and −0.0 (−0.3 to 0.3)/−0.0 (−0.3 to 0.2) for women, respectively. Being born small for gestational age was not associated with pubertal growth. Age at menarche or voice break was similar in all the gestational age groups. Conclusions: Timing of pubertal growth and age at menarche or voice break were similar in participants born preterm and at term

Preterm birth and subsequent timing of pubertal growth, menarche, and voice break

Background We evaluated pubertal growth and pubertal timing of participants born preterm compared to those born at term. Methods In the ESTER Preterm Birth Study, we collected growth data and measured final height of men/women born very or moderately preterm (= 37 weeks, 131/151), resulting in median 9 measurements at >= 6 years. Timing of menarche or voice break was self-reported. Peak height velocity (PHV, cm/year) and age at PHV (years) were compared with SuperImposition by Translation And Rotation (SITAR) model (sexes separately). Results Age at PHV (years) and PHV (cm/year) were similar in all gestational age groups. Compared to term controls, insignificant differences in age at PHV were 0.1 (95% CI: -0.2 to 0.4) years/0.2 (-0.1 to 0.4) for very or moderately/late preterm born men and -0.0 (-0.3 to 0.3)/-0.0 (-0.3 to 0.2) for women, respectively. Being born small for gestational age was not associated with pubertal growth. Age at menarche or voice break was similar in all the gestational age groups. Conclusions Timing of pubertal growth and age at menarche or voice break were similar in participants born preterm and at term. Impact Pubertal growth and pubertal timing were similar in preterm and term participants in a relatively large cohort with a wide range of gestational ages. Previous literature indicates that small for gestational age is a risk for early puberty in term born children. This was not shown in preterm children. While our study had limited power for children born very preterm, all children born preterm were not at increased risk for early puberty.Peer reviewe

Premature birth and circadian preference in young adulthood : evidence from two birth cohorts

A preference for eveningness (being a "night owl") and preterm birth ( Circadian preference was measured among 594 young adults (mean age 24.3 years, SD 1.3) from two cohorts: the ESTER study and the Arvo Ylppo Longitudinal Study. We compared 83 participants born early preterm (= 37 weeks, n = 346). We also compared very low birth weight (VLBW, There were no consistent differences across the study groups in sleep midpoint. As compared with those born at term, the mean differences in minutes:seconds and 95% confidence intervals for the sleep midpoint were: early preterm weekdays 11:47 (-834 to 32:08), early preterm weekend 4:14 (-19:45 to 28:13), late preterm weekdays -10:28 (-26:16 to 5:21), and late preterm weekend -1:29 (-20:36 to 17:37). There was no difference in sleep timing between VLBW-participants and controls either. The distribution of chronotype in the MEQ among all participants was 12.4% morningness, 65.4% intermediate, and 22.2% eveningness. The distribution of the subjective chronotype class did not differ between the three gestational age groups (p = 0.98). The linear regression models did not show any influence of gestational age group or VLBW status on the MES (all p > 0.5). We found no consistent differences between adults born early or late preterm and those born at term in circadian preference. The earlier circadian preference previously observed in those born smallest is unlikely to extend across the whole range of preterm birth.Peer reviewe

Accelerometer-Measured Physical Activity and Sedentary Time Differ According to Education Level in Young Adults

This study examined the association of education level with objectively measured physical activity and sedentary time in young adults. Data from the Finnish ESTER study (20092011) (n = 538) was used to examine the association between educational attainment and different subcomponents of physical activity and sedentary time measured using hip-worn accelerometers (ActiGraph GT1M) for seven consecutive days. Overall physical activity, moderate-to-vigorous physical activity (MVPA), light-intensity physical activity and sedentary time were calculated separately for weekdays and weekend days. A latent profile analysis was conducted to identify the different profiles of sedentary time and the subcomponents of physical activity. The educational differences in accelerometer-measured physical activity and sedentary time varied according to the subcomponents of physical activity, and between weekdays and weekend days. A high education level was associated with high MVPA during weekdays and weekend days in both sexes, high sedentary time during weekdays in both sexes, and a low amount of light-intensity physical activity during weekdays in males and during weekdays and weekend days in females. The results indicate different challenges related to unhealthy behaviours in young adults with low and high education: low education is associated with a lack of MVPA, whereas high education is associated with a lack of light-intensity physical activity and high sedentary time especially during weekdays.Peer reviewe

MRAC-Based Nonlinear Disturbance Observer And Its Applications To UAV Control

Unknown disturbances are one of the most critical factors impacting control performances, and the design of globally convergent disturbance observers for estimation of disturbances in real-time plays an important role in improving the performance of control systems. This work presents the design of a novel disturbance observer based on model reference adaptive control to relax the restrictive gain conditions in conventional nonlinear disturbance observer design. The proposed Model Reference Adaptive Control-based Nonlinear Disturbance Observer (MRAC-NDO) features a simple structure with theoretically guaranteed global convergence for estimating unknown disturbances appearing in affine systems. The proposed strategy is applied to unmanned aerial vehicles (UAVs) based on cascaded control incorporated by MRAC-NDO disturbance compensation. Numerical results validate the effectiveness of the proposed solution.</p

Maternal Smoking During Pregnancy and Offspring's Risk for Bone Fracture in Childhood and Adolescence

Peer reviewe