Bryn Mawr Talks: Karen MacAusland Tidmarsh, Undergraduate Dean of Bryn Mawr College (1990-2010)

A volume of talks given by Karen Tidmarsh at Bryn Mawr College and elsewhere between 1990 and 2010, prepared by Richard Hamilton, Jan Trembley, and Harrison Eiteljorg, II, for distribution at the memorial service held at Bryn Mawr College on September 28, 2013.https://repository.brynmawr.edu/bmc_books/1022/thumbnail.jp

‘If the cap fits’? Probation staff and the changing nature of supervision in a Community Rehabilitation Company

This article explores the changing nature of supervision in a Community Rehabilitation Company (CRC) following the Transforming Rehabilitation (TR) reforms to probation services in England and Wales. Based on an ethnographic study of an office within a privately owned CRC, it argues that TR has entrenched long-term trends towards ‘Taylorised’ probation practice. This is to say that qualitative and quantitative changes to the complexion of practitioners’ caseloads since TR reflect a decades-long devaluation of the probation service and its staff. The decision to allocate most qualified practitioners to the National Probation Service means that Case Managers (i.e. probation service officers) now supervise offenders who would historically have been supervised by Senior Case Managers (i.e. probation officers). This loss of expertise has been exacerbated by administrative staff redundancies at the office. The result is an increasingly standardised and fragmented mode of working within the CRC in which the majority of services are now delivered by the voluntary sector

Making, unmaking, remaking: Mapping the boundaries of professional legitimacy, identity and practice in probation in England and Wales

This article maps the (shifting) boundaries of professional legitimacy, identity and practice in probation in England and Wales. Probation established itself in the 20th century as a core institution in the modernist pursuit of offender rehabilitation; however, changing political economic priorities in recent decades have prompted a new consensus that also incorporates mentalities of punitivism, managerialism and risk. With a particular emphasis on the reunification of services after the Transforming Rehabilitation reforms, the article presents a practical and moral case for how the Government’s (re)professionalisation agenda can be developed. It draws upon the sociology of the professions literature to emphasise the service’s ‘interstitiality’ as a professional jurisdiction that operates between different social spheres. The article argues that reunification provides an opportunity to remake the boundaries of professional practice in such a way that people on probation can take ownership of their desistance, while reasserting the service’s internal self-image and external legitimacy

Gender in a ‘caring’ profession: The demographic and cultural dynamics of the feminisation of the probation service in England and Wales

The number of women working in occupations that lay claim to professional status has increased markedly in recent decades, but the speed and extent of the ‘feminisation’ of the probation service in England and Wales render it unique. Such change has occurred against the backdrop of attempts to present the service in more ‘masculine’ terms, to increase punitiveness while maximising its efficiency. This article seeks to move explanations for feminisation beyond gender stereotypes about care work. Drawing on semi-structured interviews with 38 members of staff from across the probation estate, and with particular regard to the unification of services, it explores the demographic and cultural dynamics of feminisation. The article argues that the sustained (and ongoing) devaluation of probation's professional project, pay and working conditions have impacted retention and recruitment in such a way that has filtered into the gender composition of the service

Professionalism, Payment by Results and the Probation Service: A Qualitative Study of the Impact of Marketisation on Professional Autonomy

This article utilises Foucauldian understandings of the sociology of the professions to explore how marketising reforms to probation services in England and Wales, and the implementation of a ‘Payment by Results’ (PbR) mechanism in particular, have impacted professional autonomy. Drawing on an ethnographic study of a probation office within a privately owned Community Rehabilitation Company, it argues that an inability to control the socio-economic organisation of probation work has rendered the service susceptible to challenges to autonomy over technique. PbR was proffered as a means to restore practitioner discretion; however, the article demonstrates that probation staff have been compelled to economise their autonomy, adapting their conduct to conform to market-related forms of accountability. In this sense, it presents the Transforming Rehabilitation reforms to probation as a case study of the impact of marketisation on the autonomy of practitioners working within a public sector profession

Calculating the energy spectra of magnetic molecules: application of real- and spin-space symmetries

The determination of the energy spectra of small spin systems as for instance given by magnetic molecules is a demanding numerical problem. In this work we review numerical approaches to diagonalize the Heisenberg Hamiltonian that employ symmetries; in particular we focus on the spin-rotational symmetry SU(2) in combination with point-group symmetries. With these methods one is able to block-diagonalize the Hamiltonian and thus to treat spin systems of unprecedented size. In addition it provides a spectroscopic labeling by irreducible representations that is helpful when interpreting transitions induced by Electron Paramagnetic Resonance (EPR), Nuclear Magnetic Resonance (NMR) or Inelastic Neutron Scattering (INS). It is our aim to provide the reader with detailed knowledge on how to set up such a diagonalization scheme.Comment: 29 pages, many figure

Highly efficient catalysis of the Kemp elimination in the cavity of a cubic coordination cage.

The hollow cavities of coordination cages can provide an environment for enzyme-like catalytic reactions of small-molecule guests. Here, we report a new example (catalysis of the Kemp elimination reaction of benzisoxazole with hydroxide to form 2-cyanophenolate) in the cavity of a water-soluble M8L12 coordination cage, with two features of particular interest. First, the rate enhancement is among the largest observed to date: at pD 8.5, the value of kcat/kuncat is 2 × 10(5), due to the accumulation of a high concentration of partially desolvated hydroxide ions around the bound guest arising from ion-pairing with the 16+ cage. Second, the catalysis is based on two orthogonal interactions: (1) hydrophobic binding of benzisoxazole in the cavity and (2) polar binding of hydroxide ions to sites on the cage surface, both of which were established by competition experiments

Angiotensin II for the Treatment of Vasodilatory Shock

BACKGROUND Vasodilatory shock that does not respond to high-dose vasopressors is associated with high mortality. We investigated the effectiveness of angiotensin II for the treatment of patients with this condition. METHODS We randomly assigned patients with vasodilatory shock who were receiving more than 0.2 mu g of norepinephrine per kilogram of body weight per minute or the equivalent dose of another vasopressor to receive infusions of either angiotensin II or placebo. The primary end point was a response with respect to mean arterial pressure at hour 3 after the start of infusion, with response defined as an increase from baseline of at least 10 mm Hg or an increase to at least 75 mm Hg, without an increase in the dose of background vasopressors. RESULTS A total of 344 patients were assigned to one of the two regimens; 321 received a study intervention (163 received angiotensin II, and 158 received placebo) and were included in the analysis. The primary end point was reached by more patients in the angiotensin II group (114 of 163 patients, 69.9%) than in the placebo group (37 of 158 patients, 23.4%) (odds ratio, 7.95; 95% confidence interval [CI], 4.76 to 13.3; P<0.001). At 48 hours, the mean improvement in the cardiovascular Sequential Organ Failure Assessment (SOFA) score (scores range from 0 to 4, with higher scores indicating more severe dysfunction) was greater in the angiotensin II group than in the placebo group (-1.75 vs. -1.28, P = 0.01). Serious adverse events were reported in 60.7% of the patients in the angiotensin II group and in 67.1% in the placebo group. Death by day 28 occurred in 75 of 163 patients (46%) in the angiotensin II group and in 85 of 158 patients (54%) in the placebo group (hazard ratio, 0.78; 95% CI, 0.57 to 1.07; P = 0.12). CONCLUSIONS Angiotensin II effectively increased blood pressure in patients with vasodilatory shock that did not respond to high doses of conventional vasopressors. (Funded by La Jolla Pharmaceutical Company; ATHOS-3 ClinicalTrials.gov number, NCT02338843.)Peer reviewe

Expression and functional activity of nucleoside transporters in human choroid plexus

Abstract Background Human equilibrative nucleoside transporters (hENTs) 1-3 and human concentrative nucleoside transporters (hCNTs) 1-3 in the human choroid plexus (hCP) play a role in the homeostasis of adenosine and other naturally occurring nucleosides in the brain; in addition, hENT1, hENT2 and hCNT3 mediate membrane transport of nucleoside reverse transcriptase inhibitors that could be used to treat HIV infection, 3'-azido-3'-deoxythymidine, 2'3'-dideoxycytidine and 2'3'-dideoxyinosine. This study aimed to explore the expression levels and functional activities of hENTs 1-3 and hCNTs 1-3 in human choroid plexus. Methods Freshly-isolated pieces of lateral ventricle hCP, removed for various clinical reasons during neurosurgery, were obtained under Local Ethics Committee approval. Quantification of mRNAs that encoded hENTs and hCNTs was performed by the hydrolysis probes-based reverse transcription real time-polymerase chain reaction (RT-qPCR); for each gene of interest and for 18 S ribosomal RNA, which was an endogenous control, the efficiency of PCR reaction (E) and the quantification cycle (Cq) were calculated. The uptake of [3H]inosine by the choroid plexus pieces was investigated to explore the functional activity of hENTs and hCNTs in the hCP. Results RT-qPCR revealed that the mRNA encoding the intracellularly located transporter hENT3 was the most abundant, with E-Cq value being only about 40 fold less that the E-Cq value for 18 S ribosomal RNA; mRNAs encoding hENT1, hENT2 and hCNT3 were much less abundant than mRNA for the hENT3, while mRNAs encoding hCNT1 and hCNT2 were of very low abundance and not detectable. Uptake of [3H]inosine by the CP samples was linear and consisted of an Na+-dependent component, which was probably mediated by hCNT3, and Na+-independent component, mediated by hENTs. The latter component was not sensitive to inhibition by S-(4-nitrobenzyl)-6-thioinosine (NBMPR), when used at a concentration of 0.5 μM, a finding that excluded the involvement of hENT1, but it was very substantially inhibited by 10 μM NBMPR, a finding that suggested the involvement of hENT2 in uptake. Conclusion Transcripts for hENT1-3 and hCNT3 were detected in human CP; mRNA for hENT3, an intracellularly located nucleoside transporter, was the most abundant. Human CP took up radiolabelled inosine by both concentrative and equilibrative processes. Concentrative uptake was probably mediated by hCNT3; the equilibrative uptake was mediated only by hENT2. The hENT1 transport activity was absent, which could suggest either that this protein was absent in the CP cells or that it was confined to the basolateral side of the CP epithelium.</p

Mapping the internal recognition surface of an octanuclear coordination cage using guest libraries

Size and shape criteria for guest binding inside the cavity of an octanuclear cubic coordination cage in water have been established using a new fluorescence displacement assay to quantify guest binding. For aliphatic cyclic ketones of increasing size (from C5 to C11), there is a linear relationship between ΔG for guest binding and the guest’s surface area: the change in ΔG for binding is 0.3 kJ mol–1 Å–2, corresponding to 5 kJ mol–1 for each additional CH2 group in the guest, in good agreement with expectations based on hydrophobic desolvation. The highest association constant is K = 1.2 × 106 M–1 for cycloundecanone, whose volume is approximately 50% of the cavity volume; for larger C12 and C13 cyclic ketones, the association constant progressively decreases as the guests become too large. For a series of C10 aliphatic ketones differing in shape but not size, ΔG for guest binding showed no correlation with surface area. These guests are close to the volume limit of the cavity (cf. Rebek’s 55% rule), so the association constant is sensitive to shape complementarity, with small changes in guest structure resulting in large changes in binding affinity. The most flexible members of this series (linear aliphatic ketones) did not bind, whereas the more preorganized cyclic ketones all have association constants of 104–105 M–1. A crystal structure of the cage·cycloundecanone complex shows that the guest carbonyl oxygen is directed into a binding pocket defined by a convergent set of CH groups, which act as weak hydrogen-bond donors, and also shows close contacts between the exterior surface of the disc-shaped guest and the interior surface of the pseudospherical cage cavity despite the slight mismatch in shape