Multiwavelength Study on Solar and Interplanetary Origins of the Strongest Geomagnetic Storm of Solar Cycle 23

We study the solar sources of an intense geomagnetic storm of solar cycle 23 that occurred on 20 November 2003, based on ground- and space-based multiwavelength observations. The coronal mass ejections (CMEs) responsible for the above geomagnetic storm originated from the super-active region NOAA 10501. We investigate the H-alpha observations of the flare events made with a 15 cm solar tower telescope at ARIES, Nainital, India. The propagation characteristics of the CMEs have been derived from the three-dimensional images of the solar wind (i.e., density and speed) obtained from the interplanetary scintillation data, supplemented with other ground- and space-based measurements. The TRACE, SXI and H-alpha observations revealed two successive ejections (of speeds ~350 and ~100 km/s), originating from the same filament channel, which were associated with two high speed CMEs (~1223 and ~1660 km/s, respectively). These two ejections generated propagating fast shock waves (i.e., fast drifting type II radio bursts) in the corona. The interaction of these CMEs along the Sun-Earth line has led to the severity of the storm. According to our investigation, the interplanetary medium consisted of two merging magnetic clouds (MCs) that preserved their identity during their propagation. These magnetic clouds made the interplanetary magnetic field (IMF) southward for a long time, which reconnected with the geomagnetic field, resulting the super-storm (Dst_peak=-472 nT) on the Earth.Comment: 24 pages, 16 figures, Accepted for publication in Solar Physic

Relativistic Electron Shock Drift Acceleration in Low Mach Number Galaxy Cluster Shocks

An extreme case of electron shock drift acceleration in low Mach number collisionless shocks is investigated as a plausible mechanism of initial acceleration of relativistic electrons in large-scale shocks in galaxy clusters where upstream plasma temperature is of the order of 10 keV and a degree of magnetization is not too small. One-dimensional electromagnetic full particle simulations reveal that, even though a shock is rather moderate, a part of thermal incoming electrons are accelerated and reflected through relativistic shock drift acceleration and form a local nonthermal population just upstream of the shock. The accelerated electrons can self-generate local coherent waves and further be back-scattered toward the shock by those waves. This may be a scenario for the first stage of the electron shock acceleration occurring at the large-scale shocks in galaxy clusters such as CIZA J2242.8+5301 which has well defined radio relics.Comment: 26 pages, 10 figures, accepted for publication in Ap

Mini-magnetospheres above the lunar surface and the formation of lunar swirls

In this paper we present in-situ satellite data, theory and laboratory validation that show how small scale collisionless shocks and mini-magnetospheres can form on the electron inertial scale length. The resulting retardation and deflection of the solar wind ions could be responsible for the unusual "lunar swirl" patterns seen on the surface of the Moon.Comment: 5 pages, 5 figure

Improved estimation of glomerular filtration rate (GFR) by comparison of eGFRcystatin C and eGFRcreatinine

Objective. GFR-prediction equations based upon cystatin C and creatinine have better diagnostic performance in estimating GFR than equations based upon only one of the two markers. The present work concerns in what way a comparison between separate estimations of GFR based upon cystatin C (eGFR(cystatin C)) or creatinine (eGFR(creatinine)) can be used to evaluate the diagnostic performance of a combined cystatin C-and creatinine-based estimation of GFR. Methods. The difference between eGFR(cystatin C) and eGFR(creatinine) was compared with measured GFR (iohexol clearance) and a combined cystatin C- and creatinine-based estimation of GFR in a Swedish-Caucasian cohort of 857 adult patients. Results. A difference between eGFR(cystatin C) and eGFR(creatinine) of >= 40% indicated a markedly reduced diagnostic performance of the combined cystatin C- and creatinine-based estimation of GFR. Conclusion. Comparison of the agreement between eGFR(cystatin C) and eGFR(creatinine) can be used to evaluate the diagnostic performance of combined cystatin C-and creatinine-based estimations of GFR. If 'threshold values' for discordance are exceeded, it must be considered whether the clinical context requires the use of an invasive gold standard method to measure GFR. In some clinical contexts either creatinine or cystatin C are known to be invalidated as markers of GFR and in these situations the use of only the cystatin C-or the creatinine-based GFR estimate should be considered when the 'threshold values' are exceeded

3D pic simulations of collisionless shocks at lunar magnetic anomalies and their role in forming lunar swirls

The authors would like to thank the Science and Technology Facilities Council for fundamental physics and computing resources that were provided by funding from STFC’s Scientific Computing Department, and would like to thank the European Research Council (ERC 2010 AdG Grant 267841) and FCT (Portugal) grants SFRH/BD/75558/2010 for support.Investigation of the lunar crustal magnetic anomalies offers a comprehensive long-term data set of observations of small-scale magnetic fields and their interaction with the solar wind. In this paper a review of the observations of lunar mini-magnetospheres is compared quantifiably with theoretical kinetic-scale plasma physics and 3D particle-in-cell simulations. The aim of this paper is to provide a complete picture of all the aspects of the phenomena and to show how the observations from all the different and international missions interrelate. The analysis shows that the simulations are consistent with the formation of miniature (smaller than the ion Larmor orbit) collisionless shocks and miniature magnetospheric cavities, which has not been demonstrated previously. The simulations reproduce the finesse and form of the differential proton patterns that are believed to be responsible for the creation of both the "lunar swirls" and "dark lanes." Using a mature plasma physics code like OSIRIS allows us, for the first time, to make a side-by-side comparison between model and space observations. This is shown for all of the key plasma parameters observed to date by spacecraft, including the spectral imaging data of the lunar swirls. The analysis of miniature magnetic structures offers insight into multi-scale mechanisms and kinetic-scale aspects of planetary magnetospheres.Publisher PDFPeer reviewe

Relativistic Laser-Matter Interaction and Relativistic Laboratory Astrophysics

The paper is devoted to the prospects of using the laser radiation interaction with plasmas in the laboratory relativistic astrophysics context. We discuss the dimensionless parameters characterizing the processes in the laser and astrophysical plasmas and emphasize a similarity between the laser and astrophysical plasmas in the ultrarelativistic energy limit. In particular, we address basic mechanisms of the charged particle acceleration, the collisionless shock wave and magnetic reconnection and vortex dynamics properties relevant to the problem of ultrarelativistic particle acceleration.Comment: 58 pages, 19 figure

ANCA-associated vasculitis.

The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group of disorders involving severe, systemic, small-vessel vasculitis and are characterized by the development of autoantibodies to the neutrophil proteins leukocyte proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA). The three AAV subgroups, namely granulomatosis with polyangiitis (GPA), microscopic polyangiitis and eosinophilic GPA (EGPA), are defined according to clinical features. However, genetic and other clinical findings suggest that these clinical syndromes may be better classified as PR3-positive AAV (PR3-AAV), MPO-positive AAV (MPO-AAV) and, for EGPA, by the presence or absence of ANCA (ANCA+ or ANCA-, respectively). Although any tissue can be involved in AAV, the upper and lower respiratory tract and kidneys are most commonly and severely affected. AAVs have a complex and unique pathogenesis, with evidence for a loss of tolerance to neutrophil proteins, which leads to ANCA-mediated neutrophil activation, recruitment and injury, with effector T cells also involved. Without therapy, prognosis is poor but treatments, typically immunosuppressants, have improved survival, albeit with considerable morbidity from glucocorticoids and other immunosuppressive medications. Current challenges include improving the measures of disease activity and risk of relapse, uncertainty about optimal therapy duration and a need for targeted therapies with fewer adverse effects. Meeting these challenges requires a more detailed knowledge of the fundamental biology of AAV as well as cooperative international research and clinical trials with meaningful input from patients