Does the Danube exist? Versions of reality given by various regional climate models and climatological datasets

We present an intercomparison and verification analysis of several regional climate models (RCMs) nested into the same run of the same Atmospheric Global Circulation Model (AGCM) regarding their representation of the statistical properties of the hydrological balance of the Danube river basin for 1961-1990. We also consider the datasets produced by the driving AGCM, from the ECMWF and NCEP-NCAR reanalyses. The hydrological balance is computed by integrating the precipitation and evaporation fields over the area of interest. Large discrepancies exist among RCMs for the monthly climatology as well as for the mean and variability of the annual balances, and only few datasets are consistent with the observed discharge values of the Danube at its Delta, even if the driving AGCM provides itself an excellent estimate. Since the considered approach relies on the mass conservation principle and bypasses the details of the air-land interface modeling, we propose that the atmospheric components of RCMs still face difficulties in representing the water balance even on a relatively large scale. Their reliability on smaller river basins may be even more problematic. Moreover, since for some models the hydrological balance estimates obtained with the runoff fields do not agree with those obtained via precipitation and evaporation, some deficiencies of the land models are also apparent. NCEP-NCAR and ERA-40 reanalyses result to be largely inadequate for representing the hydrology of the Danube river basin, both for the reconstruction of the long-term averages and of the seasonal cycle, and cannot in any sense be used as verification. We suggest that these results should be carefully considered in the perspective of auditing climate models and assessing their ability to simulate future climate changes.Comment: 25 pages 8 figures, 5 table

Are supplements safe? Effects of gallic and ferulic acids on in vitro cell models

Polyphenols display health-promoting properties linked to their biological activities. They are initially absorbed in the small intestine, then they are largely metabolized in the colon, whereupon they are able to exert systemic effects. The health-promoting properties of polyphenols have led to the development of food supplements, which are also largely consumed by healthy people, even if data on their safety are still yet lacking. In the present paper, the content of gallic acid and ferulic acid was analyzed in two supplements, and shown to be higher than the relative contents found in fruit and flour. To evaluate the effects of these phenolic compounds on epithelial intestinal tissue, gallic and ferulic acids were added to a new in vitro model of the intestinal wall at different concentrations. The effects on viability, proliferation and migration of these compounds were respectively tested on three different cell lines (Caco2, L929 and U937), as well as on a tridimensional intestinal model, composed of a mucosal layer and a submucosa with fibroblasts and monocytes. Results indicated that gallic and ferulic acids can exert toxic effects on in vitro cell models at high concentrations, suggesting that an excessive and uncontrolled consumption of polyphenols may induce negative effects on the intestinal wall

Integrating virtual reality and gis tools for geological mapping, data collection and analysis: An example from the metaxa mine, santorini (Greece)

In the present work we highlight the effectiveness of integrating different techniques and tools for better surveying, mapping and collecting data in volcanic areas. We use an Immersive Virtual Reality (IVR) approach for data collection, integrated with Geographic Information System (GIS) analysis in a well-known volcanological site in Santorini (Metaxa mine), a site where volcanic processes influenced the island’s industrial development, especially with regard to pumice mining. Specifically, we have focused on: (i) three-dimensional (3D) high-resolution IVR scenario building, based on Structure from Motion photogrammetry (SfM) modeling; (ii) subsequent geological survey, mapping and data collection using IVR; (iii) data analysis, e.g., calculation of extracted volumes, as well as production of new maps in a GIS environment using input data directly from the IVR survey; and finally, (iv) presentation of new outcomes that highlight the importance of the Metaxa Mine as a key geological and volcanological geosite

Effect of peroxides on spermine transport in rat brain and liver mitochondria.

The polyamine spermine is transported into the matrix of various types of mitochondria by a specific uniporter system identified as a protein channel. This mechanism is regulated by the membrane potential; other regulatory effectors are unknown. This study analyzes the transport of spermine in the presence of peroxides in both isolated rat liver and brain mitochondria, in order to evaluate the involvement of the redox state in this mechanism, and to compare its effect in both types of mitochondria. In liver mitochondria peroxides are able to inhibit spermine transport. This effect is indicative of redox regulation by the transporter, probably due to the presence of critical thiol groups along the transport pathway, or in close association with it, with different accessibility for the peroxides and performing different functions. In brain mitochondria, peroxides have several effects, supporting the hypothesis of a different regulation of spermine transport. The fact that peroxovanadate can inhibit tyrosine phosphatases in brain mitochondria suggests that mitochondrial spermine transport is regulated by tyrosine phosphorylation in this organ. In this regard, the evaluation of spermine transport in the presence of Src inhibitors suggests the involvement of Src family kinases in this process. It is possible that phosphorylation sites for Src kinases are present in the channel pathway and have an inhibitory effect on spermine transport under regulation by Src kinases. The results of this study suggest that the activity of the spermine transporter probably depends on the redox and/or tyrosine phosphorylation state of mitochondria, and that its regulation may be different in distinct organs

First line chemotherapy with planned sequential administration of gemcitabine followed by docetaxel in elderly advanced non-small-cell lung cancer patients: a multicenter phase II study

This multicenter phase II study evaluated, in chemonaive patients with stage IIIB–IV NSCLC, age ⩾70 and with a performance status 0–2, the activity, efficacy and tolerability of planned sequential administration of gemcitabine 1200 mg m−2 on days 1 and 8 every 3 weeks for three courses followed by three cycles of docetaxel 37.5 mg m−2 on days 1 and 8 every 3 weeks, provided there was no evidence of disease progression. A total of 56 patients entered the study. According to intention-to-treat analysis, the objective response rate was 16.0% (95% CI 7.6–28.3%); 23 patients (41.0%) had stable disease and 24 patients (43%) had progressive disease. Five patients who had a stable disease after three courses of gemcitabine obtained a conversion to partial response by docetaxel. Median time to progression was 4.8 months (95% CI 3.6–6.0 months) and median duration of survival was 8.0 months (95% CI 5.6–10.5 months). The 1-year survival rate was 34%. No grade 4 haematological toxicity was observed and grade 3 neutropenia and thrombocytopenia were reported in 5.4 and 3.6% of the patients, respectively. Grade 3/4 mucositis and grade 3 diarrhoea, both occurred in 3.6% of the patients and grade 3 asthenia was observed in 9% of patients. One patient reported a grade 4 skin toxicity. No treatment-related deaths occurred. Sequential gemcitabine and docetaxel is a well-tolerated and effective regimen in elderly advanced NSCLC patients

53pimmune related adverse events correlate with clinical outcomes in non small cell lung cancer nsclc patients treated with nivolumab in the italian expanded access programme

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Adopciones: el circuito institucional de las prácticas de la obediencia

El artículo aborda ejes claves que vertebran el proyecto de investigación “No lo quiero tener más, lo vengo a devolver. Características de los circuitos burocráticos-administrativos en el proceso de las adopciones tramitadas a través del Consejo Provincial del Menor en el período 1973 a 1983 bajo el régimen de la Ley 19.134”. Es parte de un estudio más amplio sobre el funcionamiento de una institución paradigmática en materia de infancia en la Provincia de Entre Ríos, como lo es el ex Consejo Provincial del Menor (actual Consejo Provincial del Niño, el Adolescente y la Familia) durante el período coincidente con la apropiación criminal de niños en la Argentina perpetrada sistemáticamente por el estado bajo la última dictadura cívico-militar. El propósito es vincular analítica y reflexivamente las prácticas descriptas y registradas en los Legajos de cada niño/a y la construcción de la categoría “abandono” material y moral con la que se declarara el estado de adoptabilidad, permitiendo observar la trama por la que los circuitos burocráticos administrativos se constituyen en normalizantes, de allí la importancia en indagar las prácticas administrativas-institucionales, que definieron la politicidad específica de la infancia en situación de adopción