Clinicopathological study of oral focal mucinosis : a retrospective case series

Oral focal mucinosis (OFM) is a rare soft tissue lesion of unknown etiology that exhibits tumor-like growth. It is considered the oral counterpart of cutaneous focal mucinosis or cutaneous myxoid cyst. This is a retrospective study of oral OFM diagnosed over a period of 42 years at an oral pathology service. Clinical, histopathological and immunohistochemical data were analyzed. Alcian blue staining and S-100 immunohistochemistry were performed. Eleven cases were retrieved (4:1 female-to-male ratio). The mean age was 44 years. The gingiva was the most affected site. The main clinical presentation was sessile or pedunculated lesions of fibrous or hyperplasic appearance, most of them asymptomatic. Positive Alcian blue staining and absence of S-100 protein were observed in all specimens, which supported the histological diagnosis of OFM. Surgical excision was the treatment of choice. Although rare, this study supports the inclusion of OFM in the differential diagnosis of intraoral myxoid lesions

IMPACTO DE DETERMINANTES SOCIAIS NA SAÚDE MENTAL: UMA ANÁLISE DE SAÚDE COLETIVA

Introduction: It seeks to highlight the importance of social determinants of health in relation to the treatment and care of patients with mental disorders. Furthermore, it reports on the changes and how the determinants reflect positively and negatively on this topic, in addition to the evolution that has emerged since past years. Objective: Understand the impacts and the relationship of determinants with the issue of mental health. Methodology: A systematic literature review was carried out covering the years from January 2003 to December 2023 The study was based and guided by the question mentioned throughout the article. Results: The evident role of determinants in the subject of mental health stands out, in addition to showing that the evolution of these determinants can improve and facilitate the development of efficient and appropriate care strategies for patients suffering from some mental illness. Advanced cases can be mitigated gradually. Conclusion: With emphasis on social and economic issues, it is noted that these factors directly affect adherence to treatment and diagnosis for those in need and that even with all the efforts aimed at this topic to this day, an inequality is still seen in the way in which The health system is offered to the population.Introdução: Procura evidenciar a importância das determinantes sociais de saúde em relação ao tratamento e assistência de pacientes com transtornos mentais. Além disso, relata as mudanças e como as determinantes refletem positivamente e negativamente nessa temática, além da evolução que foi surgindo desde anos passados. Objetivo: Compreender os impactos e a relação das determinantes com a temática da saúde mental. Metodologia: Foi realizada uma revisão sistemática de literatura abrangendo os anos de janeiro de 2003 a dezembro de 2023. O estudo teve como base e norteamento a pergunta citada no decorrer do artigo. Resultados: Destaca-se o papel evidente das determinantes no assunto de saúde mental, além de evidenciar que a evolução dessas determinantes podem melhorar e facilitar o desenvolvimento de estratégias de cuidados eficientes e adequadas para pacientes que sofrem de com alguma doença mental Assim, o número avançado de casos podem ser mitigado de forma gradativa. Conclusão: Dando ênfase a questões sociais e econômicas, nota-se que esses fatores afetam diretamente a adesão ao tratamento e diagnóstico aos necessitados e que mesmo com todos os esforços voltados a essa temática até os dias atuais ainda é visto uma desigualdade na forma em como é ofertado o  sistema de saúde a população

COMPLICAÇÕES DE DEISCÊNCIA DOS TECIDOS MOLES PERI-IMPLANTARES: UMA REVISÃO DOS FATORES ASSOCIADOS E FREQUÊNCIA DE OCORRÊNCIA.

  Given the importance of associated factors and the need for appropriate preventive strategies, this study aims to review the existing literature on complications of peri-implant soft tissue dehiscence, analyzing the associated factors and frequency of occurrence. From this review, we intend to provide a solid scientific basis for the implementation of clinical practices that minimize the incidence of this complication and improve the results of treatments with dental implants. The results of this review emphasize the importance of a multifaceted approach to preventing and managing peri-implant soft tissue dehiscence. The quality of the gingival tissues, the surgical technique, the type and positioning of the implant, the patient's oral hygiene, and rigorous post-operative care are crucial determinants. Furthermore, systemic and environmental factors, the biocompatibility of implant materials, and the surgeon's experience play significant roles. Multidisciplinary collaboration and technological advances emerge as important allies to improve clinical results. Therefore, careful assessment and detailed planning are essential to reduce complications and ensure the long-term success of dental implants, promoting a better quality of life for patients.Diante da importância dos fatores associados e da necessidade de estratégias preventivas adequadas, este estudo tem como objetivo revisar a literatura existente sobre as complicações de deiscência dos tecidos moles peri-implantares, analisando os fatores associados e a frequência de ocorrência. A partir dessa revisão, pretende-se fornecer uma base científica sólida para a implementação de práticas clínicas que minimizem a incidência dessa complicação e melhorem os resultados dos tratamentos com implantes dentários. Os resultados desta revisão enfatizam a importância de uma abordagem multifacetada para prevenir e gerenciar a deiscência dos tecidos moles peri-implantares. A qualidade dos tecidos gengivais, a técnica cirúrgica, o tipo e o posicionamento do implante, a higiene bucal do paciente, e os cuidados pós-operatórios rigorosos são determinantes cruciais. Além disso, fatores sistêmicos e ambientais, a biocompatibilidade dos materiais dos implantes, e a experiência do cirurgião desempenham papéis significativos. A colaboração multidisciplinar e os avanços tecnológicos emergem como aliados importantes para melhorar os resultados clínicos. Portanto, uma avaliação cuidadosa e um planejamento detalhado são essenciais para reduzir as complicações e garantir o sucesso a longo prazo dos implantes dentários, promovendo uma melhor qualidade de vida para os pacientes

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Perspectivas atuais sobre o uso de psilocibina no manejo da depressão resistente: revisão sistemática

A depressão resistente ao tratamento é um desafio global, impactando negativamente a qualidade de vida dos pacientes. Nesse contexto, a psilocibina, um composto psicodélico presente em certos cogumelos, desperta interesse como possível intervenção terapêutica. Seu potencial para influenciar positivamente o humor e a cognição, através da ativação dos receptores de serotonina no cérebro, sugere uma nova abordagem no tratamento da depressão resistente. Este estudo busca analisar as perspectivas atuais sobre o uso da psilocibina nesse contexto, destacando a necessidade de mais pesquisas sobre seus efeitos e segurança para sua integração clínica. Este estudo, baseado em uma revisão sistemática da literatura científica, abrange o período de 2016 a 2024, utilizando as bases de dados PubMed (Medline), Cochrane Library e Scientific Electronic Library Online (SciELO). No primeiro estudo, os efeitos agudos da psilocibina foram detectáveis de 30 a 60 minutos após a administração, atingindo o pico em 2 a 3 horas e diminuindo após pelo menos 6 horas. A substância foi bem tolerada, com eventos adversos leves e transitórios. Houve uma redução significativa nos sintomas depressivos, ansiedade e anedonia após o tratamento com doses altas. O segundo estudo envolveu 233 participantes distribuídos em grupos de doses diferentes. Houve uma redução significativa nos sintomas depressivos após o tratamento, com doses mais altas apresentando uma diferença estatisticamente maior em comparação com a dose mais baixa e o grupo de controle. Eventos adversos, como dor de cabeça e náusea, foram comuns entre os participantes. O terceiro estudo abordou as perspectivas futuras para o tratamento com psilocibina para depressão resistente. Recomendações incluíram equilibrar o tempo dos pacientes e terapeutas, aumentar gradualmente a intensidade das sessões e integrar a terapia sustentada ao tratamento. O envolvimento de pacientes experientes e estudos naturalísticos adicionais foi destacado como importante para abordagens mais personalizadas. Em resumo, a psilocibina mostra potencial como tratamento para a depressão resistente, com redução significativa dos sintomas depressivos e boa tolerabilidade. No entanto, são necessárias mais pesquisas para confirmar sua eficácia e segurança, destacando a importância de estudos adicionais e ensaios clínicos controlados

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost