1,088 research outputs found
Treatment of calibration uncertainty in multi-baseline cross-correlation searches for gravitational waves
Uncertainty in the calibration of gravitational wave (GW) detector data leads to systematic errors, which must be accounted for in setting limits on the strength of GW signals. When cross-correlation measurements are made using data from a pair of instruments, as in searches for a stochastic GW background, the calibration uncertainties of the individual instruments can be combined into an uncertainty associated with the pair. With the advent of multi-baseline GW observation (e.g., networks consisting of multiple detectors such as the LIGO observatories and Virgo), a more sophisticated treatment is called for. We have described how the correlations between calibration factors associated with different pairs can be taken into account by marginalizing over the uncertainty associated with each instrument
Gravitational waves from Sco X-1: A comparison of search methods and prospects for detection with advanced detectors
The low-mass X-ray binary Scorpius X-1 (Sco X-1) is potentially the most
luminous source of continuous gravitational-wave radiation for interferometers
such as LIGO and Virgo. For low-mass X-ray binaries this radiation would be
sustained by active accretion of matter from its binary companion. With the
Advanced Detector Era fast approaching, work is underway to develop an array of
robust tools for maximizing the science and detection potential of Sco X-1. We
describe the plans and progress of a project designed to compare the numerous
independent search algorithms currently available. We employ a mock-data
challenge in which the search pipelines are tested for their relative
proficiencies in parameter estimation, computational efficiency, robust- ness,
and most importantly, search sensitivity. The mock-data challenge data contains
an ensemble of 50 Scorpius X-1 (Sco X-1) type signals, simulated within a
frequency band of 50-1500 Hz. Simulated detector noise was generated assuming
the expected best strain sensitivity of Advanced LIGO and Advanced VIRGO ( Hz). A distribution of signal amplitudes was then
chosen so as to allow a useful comparison of search methodologies. A factor of
2 in strain separates the quietest detected signal, at
strain, from the torque-balance limit at a spin frequency of 300 Hz, although
this limit could range from (25 Hz) to (750 Hz) depending on the unknown frequency of Sco X-1. With future
improvements to the search algorithms and using advanced detector data, our
expectations for probing below the theoretical torque-balance strain limit are
optimistic.Comment: 33 pages, 11 figure
Detectability of eccentric compact binary coalescences with advanced gravitational-wave detectors
Compact binary coalescences are a promising source of gravitational waves for second-generation interferometric gravitational-wave detectors such as advanced LIGO and advanced Virgo. While most binaries are expected to possess circular orbits, some may be eccentric, for example, if they are formed through dynamical capture. Eccentric orbits can create difficulty for matched filtering searches due to the challenges of creating effective template banks to detect these signals. In previous work, we showed how seedless clustering can be used to detect low-mass (M_totalâ€10M_â) compact binary coalescences for both spinning and eccentric systems, assuming a circular post-Newtonian expansion. Here, we describe a parametrization that is designed to maximize sensitivity to low-eccentricity (0â€Î”â€0.6) systems, derived from the analytic equations. We show that this parametrization provides a robust and computationally efficient method for detecting eccentric low-mass compact binaries. Based on these results, we conclude that advanced detectors will have a chance of detecting eccentric binaries if optimistic models prove true. However, a null observation is unlikely to firmly rule out models of eccentric binary populations
Searching for prompt signatures of nearby core-collapse supernovae by a joint analysis of neutrino and gravitational-wave data
We discuss the science motivations and prospects for a joint analysis of
gravitational-wave (GW) and low-energy neutrino data to search for prompt
signals from nearby supernovae (SNe). Both gravitational-wave and low-energy
neutrinos are expected to be produced in the innermost region of a
core-collapse supernova, and a search for coincident signals would probe the
processes which power a supernova explosion. It is estimated that the current
generation of neutrino and gravitational-wave detectors would be sensitive to
Galactic core-collapse supernovae, and would also be able to detect
electromagnetically dark SNe. A joint GW-neutrino search would enable
improvements to searches by way of lower detection thresholds, larger distance
range, better live-time coverage by a network of GW and neutrino detectors, and
increased significance of candidate detections. A close collaboration between
the GW and neutrino communities for such a search will thus go far toward
realizing a much sought-after astrophysics goal of detecting the next nearby
supernova.Comment: 10 pages, 3 figures. To appear in Class. Quantum Gra
Mathematical Modelling of Optical Coherence Tomography
In this chapter a general mathematical model of Optical Coherence Tomography
(OCT) is presented on the basis of the electromagnetic theory. OCT produces
high resolution images of the inner structure of biological tissues. Images are
obtained by measuring the time delay and the intensity of the backscattered
light from the sample considering also the coherence properties of light. The
scattering problem is considered for a weakly scattering medium located far
enough from the detector. The inverse problem is to reconstruct the
susceptibility of the medium given the measurements for different positions of
the mirror. Different approaches are addressed depending on the different
assumptions made about the optical properties of the sample. This procedure is
applied to a full field OCT system and an extension to standard (time and
frequency domain) OCT is briefly presented.Comment: 28 pages, 5 figures, book chapte
Antibiotic use among 8-month-old children in Malmö, Sweden â in relation to child characteristics and parental sociodemographic, psychosocial and lifestyle factors
In the county of Scania, Sweden, antibiotic use among small children is among the highest in the country. The aim of this study was to investigate the associations between antibiotic use among 8-month-old children in Malmö and characteristics of the child as well as parental sociodemographic characteristics, lifestyle factors, and psychosocial support.
The study was a population-based cross-sectional survey. The study population consisted of children who visited the Child Health Care (CHC) centres in Malmö for their 8-month health checkup during 2003â2006 and whose parents answered a self-administered questionnaire (n = 7266 children). The questionnaire was distributed to parents of children registered with the CHC and invited for an 8-month checkup during the study period.
The odds of using antibiotics increased as parental educational level decreased. Using high educational level as a reference group, low maternal educational level was associated with an increased antibiotic use for the child, odds ratio (OR) = 1.61 (95% CI: 1.34â1.93). Furthermore, children whose parents were born outside Sweden showed higher antibiotic use, OR = 1.43 (95% CI: 1.24â1.65), in comparison with children whose parents were born in Sweden. Exposure to environmental smoking, parental experience of economic stress, and a low level of emotional support increased the odds for antibiotic use. Boys had higher odds of use of antibiotics than girls, OR = 1.40 (95% CI: 1.25â1.57). Having a low birth weight, having an allergy and having siblings also increased the odds for early antibiotic use, while breastfeeding seemed to have a protective role.
Conclusion
There were clear associations between parental factors such as sociodemographic, psychosocial and lifestyle factors and antibiotic use at this early stage of life. Several characteristics of the child also affected the use of antibiotics
Astrocytic Ion Dynamics: Implications for Potassium Buffering and Liquid Flow
We review modeling of astrocyte ion dynamics with a specific focus on the
implications of so-called spatial potassium buffering, where excess potassium
in the extracellular space (ECS) is transported away to prevent pathological
neural spiking. The recently introduced Kirchoff-Nernst-Planck (KNP) scheme for
modeling ion dynamics in astrocytes (and brain tissue in general) is outlined
and used to study such spatial buffering. We next describe how the ion dynamics
of astrocytes may regulate microscopic liquid flow by osmotic effects and how
such microscopic flow can be linked to whole-brain macroscopic flow. We thus
include the key elements in a putative multiscale theory with astrocytes
linking neural activity on a microscopic scale to macroscopic fluid flow.Comment: 27 pages, 7 figure
In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae
Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is a Gram-negative bacterium that represents the main cause of porcine pleuropneumonia in pigs, causing significant economic losses to the livestock industry worldwide. A. pleuropneumoniae, as the majority of Gram-negative bacteria, excrete vesicles from its outer membrane (OM), accordingly defined as outer membrane vesicles (OMVs). Thanks to their antigenic similarity to the OM, OMVs have emerged as a promising tool in vaccinology. In this study we describe the in vivo testing of several vaccine prototypes for the prevention of infection by all known A. pleuropneumoniae serotypes. Previously identified vaccine candidates, the recombinant proteins ApfA and VacJ, administered individually or in various combinations with the OMVs, were employed as vaccination strategies. Our data show that the addition of the OMVs in the vaccine formulations significantly increased the specific IgG titer against both ApfA and VacJ in the immunized animals, confirming the previously postulated potential of the OMVs as adjuvant. Unfortunately, the antibody response raised did not translate into an effective protection against A. pleuropneumoniae infection, as none of the immunized groups following challenge showed a significantly lower degree of lesions than the controls. Interestingly, quite the opposite was true, as the animals with the highest IgG titers were also the ones bearing the most extensive lesions in their lungs. These results shed new light on A. pleuropneumoniae pathogenicity, suggesting that antibody-mediated cytotoxicity from the host immune response may play a central role in the development of the lesions typically associated with A. pleuropneumoniae infections
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