Deep extragalactic visible legacy survey (DEVILS):Evolution of the σsFR-M relation and implications for self-regulated star formation

We present the evolution of the star formation dispersion–stellar mass relation ( σSFR –M ) in the DEVILS D10 region using new measurements derived using the PROSPECT spectral energy distribution fitting code. We find that σSFR –M shows the characteristic ‘U-shape’ at intermediate stellar masses from 0.1 < z < 0.7 for a number of metrics, including using the deconvolved intrinsic dispersion. A physical interpretation of this relation is the combination of stochastic star formation and stellar feedback causing large scatter at low stellar masses and AGN feedback causing asymmetric scatter at high stellar masses. As such, the shape of this distribution and its evolution encodes detailed information about the astrophysical processes affecting star formation, feedback and the lifecycle of galaxies. We find that the stellar mass that the minimum σSFR occurs evolves linearly with redshift, moving to higher stellar masses with increasing lookback time and traces the turno v er in the star-forming sequence. This minimum σSFR point is also found to occur at a fixed specific star formation rate (sSFR) at all epochs (sSFR ∼10 −9.6 Gyr −1 ). The physical interpretation of this is that there exists a maximum sSFR at which galaxies can internally self-regulate on the tight sequence of star formation. At higher sSFRs, stochastic stellar processes begin to cause galaxies to be pushed both above and below the star-forming sequence leading to increased SFR dispersion. As the Universe evolves, a higher fraction of galaxies will drop below this sSFR threshold, causing the dispersion of the low stellar mass end of the star-forming sequence to decrease with time

Viral Retinitis following Intraocular or Periocular Corticosteroid Administration: A Case Series and Comprehensive Review of the Literature.

Abstract Purpose: To describe viral retinitis following intravitreal and periocular corticosteroid administration. Methods: Retrospective case series and comprehensive literature review. Results: We analyzed 5 unreported and 25 previously published cases of viral retinitis following local corticosteroid administration. Causes of retinitis included 23 CMV (76.7%), 5 HSV (16.7%), and 1 each VZV and unspecified (3.3%). Two of 22 tested patients (9.1%) were HIV positive. Twenty-one of 30 (70.0%) cases followed one or more intravitreal injections of triamcinolone acetonide (TA), 4 (13.3%) after one or more posterior sub-Tenon injections of TA, 3 (10.0%) after placement of a 0.59-mg fluocinolone acetonide implant (Retisert), and 1 (3.3%) each after an anterior subconjunctival injection of TA (together with IVTA), an anterior chamber injection, and an anterior sub-Tenon injection. Mean time from most recent corticosteroid administration to development of retinitis was 4.2 months (median 3.8; range 0.25-13.0). Twelve patients (40.0%) had type II diabetes mellitus. Treatments used included systemic antiviral agents (26/30, 86.7%), intravitreal antiviral injections (20/30, 66.7%), and ganciclovir intravitreal implants (4/30, 13.3%). Conclusions: Viral retinitis may develop or reactivate following intraocular or periocular corticosteroid administration. Average time to development of retinitis was 4 months, and CMV was the most frequently observed agent. Diabetes was a frequent co-morbidity and several patients with uveitis who developed retinitis were also receiving systemic immunosuppressive therapy

The Relationship Between Function and Disease Activity as Measured by the HAQ and DAS28 Varies Over Time and by Rheumatoid Factor Status in Early Inflammatory Arthritis (EIA). Results from the CATCH Cohort§

Objective: To investigate the relationship between function and disease activity in early inflammatory arthritis (EIA). Methods: Canadian Early Arthritis Cohort (CATCH) (n=1143) is a multi-site EIA cohort. Correlations between the Health Assessment Questionnaire Disability Index (HAQ) and DAS28 were done at every 3 months for the first year and then at 18 and 24 months. We also investigated the relationship between HAQ and DAS28 by age (<65 versus ≥65) and RF (positive vs negative). Results: Mean HAQ and DAS28 scores were highest at the initial visit with HAQ decreasing over 24 months from a baseline of 0.94 to 0.40 and DAS28 scores decreasing from 4.54 to 2.29. All correlations between HAQ and DAS28 were significant at all time points (p<0.01). The correlations between HAQ and DAS28 were variable over time. The strongest correlation between HAQ and DAS28 occurred at initial visit (most DMARD naive) (n=1,143) and 18 months (r=0.57, n=321) and 24 months (r=0.59, n=214). The baseline correlation between HAQ and DAS28 was significantly different than correlations obtained at 3, 6, and 12 months (p=0.02, 0.01, and 0.01, respectively). Age did not change the association between HAQ and DAS28 {<65 years old (r=0.50, n=868) versus ≥65 (r=0.48, n=254), p=0.49}. The correlation between HAQ and DAS28 was stronger with RF+ patients (r=0.63, n=636) vs RF negative (r=0.47, n=477), p=0.0043 Conclusion: Over 2 years in EIA, HAQ and DAS both improved; correlations at time points were different over 2 years and RF status affected the correlations

Biologic Therapy for HLA-B27-associated Ocular Disorders

The treatment of articular and extra-articular manifestations associated with HLA-B27 has undergone dramatic changes over the past two decades, mainly as a consequence of the introduction of biologic agents and in particular anti-tumor necrosis factor α (anti-TNFα) agents. Uveitis is known to be the most frequent extra-articular feature in HLA-B27-associated spondyloarthritides. Topical corticosteroids and cycloplegic agents remain the cornerstones of treatment. However, biologic therapy may be effective in the management of refractory or recurrent forms of uveitis. This review gives an update on the management of HLA-B27-associated ocular disorders with biologics, including anti-TNFα agents and non-anti-TNFα biologic modifier drugs. There is an emerging role for newer biologics targeting interleukin-12/23 and interleukin-17 for the treatment of spondyloarthritides but data on their efficacy on anterior uveitis are sparse

Measuring Black Hole Spin in OJ287

We model the binary black hole system OJ287 as a spinning primary and a non-spinning secondary. It is assumed that the primary has an accretion disk which is impacted by the secondary at specific times. These times are identified as major outbursts in the light curve of OJ287. This identification allows an exact solution of the orbit, with very tight error limits. Nine outbursts from both the historical photographic records as well as from recent photometric measurements have been used as fixed points of the solution: 1913, 1947, 1957, 1973, 1983, 1984, 1995, 2005 and 2007 outbursts. This allows the determination of eight parameters of the orbit. Most interesting of these are the primary mass of $1.84\cdot 10^{10} M_\odot$, the secondary mass $1.46\cdot 10^{8} M_\odot$, major axis precession rate $39^\circ.1$ per period, and the eccentricity of the orbit 0.70. The dimensionless spin parameter is $0.28\:\pm\:0.01$ (1 sigma). The last parameter will be more tightly constrained in 2015 when the next outburst is due. The outburst should begin on 15 December 2015 if the spin value is in the middle of this range, on 3 January 2016 if the spin is 0.25, and on 26 November 2015 if the spin is 0.31. We have also tested the possibility that the quadrupole term in the Post Newtonian equations of motion does not exactly follow Einstein's theory: a parameter $q$ is introduced as one of the 8 parameters. Its value is within 30% (1 sigma) of the Einstein's value $q = 1$. This supports the $no-hair theorem$ of black holes within the achievable precision. We have also measured the loss of orbital energy due to gravitational waves. The loss rate is found to agree with Einstein's value with the accuracy of 2% (1 sigma).Comment: 12 pages, 4 figures, IAU26

Numerical evolutions of nonlinear r-modes in neutron stars

Nonlinear evolution of the gravitational radiation (GR) driven instability in the r-modes of neutron stars is studied by full numerical 3D hydrodynamical simulations. The growth of the r-mode instability is found to be limited by the formation of shocks and breaking waves when the dimensionless amplitude of the mode grows to about three in value. This maximum mode amplitude is shown by numerical tests to be rather insensitive to the strength of the GR driving force. Upper limits on the strengths of possible nonlinear mode--mode coupling are inferred. Previously unpublished details of the numerical techniques used are presented, and the results of numerous calibration runs are discussed.Comment: RevTeX 4, 17 pages, 26 figures. Slightly revised. To be published in PRD (April 2002

The ZEPLIN II dark matter detector: data acquisition system and data reduction

ZEPLIN-II is a two-phase (liquid/gas) xenon dark matter detector searching for WIMP-nucleon interactions. In this paper we describe the data acquisition system used to record the data from ZEPLIN-II and the reduction procedures which parameterise the data for subsequent analysis.Comment: 11 pages, 10 figure

Learning and Action Alliance framework to facilitate stakeholder collaboration and social learning in urban flood risk management

Flood and water management governance may be enhanced through partnership working, intra- and cross-organisational collaborations, and wide stakeholder participation. Nonetheless, barriers associated with ineffective communication, fragmented responsibilities and ‘siloed thinking’ restrict open dialogue and discussion. The Learning and Action Alliance (LAA) framework may help overcome these barriers by enabling effective engagement through social learning, and facilitating targeted actions needed to deliver innovative solutions to environmental problems. By increasing the adaptive capacity of decision-makers and participants, social learning through LAAs may lead to concerted action and sustained processes of behavioural change. In this paper, we evaluate the LAA framework as a catalyst for change that supports collaborative working and facilitates transition to more sustainable flood risk management. We use a case study in Newcastle-upon-Tyne, UK, to demonstrate how the LAA framework brought together disparate City stakeholders to co-produce new knowledge, negotiate innovative actions and, ultimately, work towards implementing a new vision for sustainable urban flood risk management. The shared vision of Newcastle as a ‘Blue-Green City’ that emerged is founded on a strong platform for social learning which increased organisations’ and individuals’ capacities to manage differences in perspectives and behaviours, reframe knowledge, and make collective decisions based on negotiation and conflict resolution. Broad recommendations based on lessons learned from the Newcastle LAA are presented to aid other cities and regions in establishing and running social learning platforms

The ZEPLIN II dark matter detector: data acquisition system and data reduction

ZEPLIN-II is a two-phase (liquid/gas) xenon dark matter detector searching for WIMP-nucleon interactions. In this paper we describe the data acquisition system used to record the data from ZEPLIN-II and the reduction procedures which parameterise the data for subsequent analysis.Comment: 11 pages, 10 figure

Time-Independent Gravitational Fields

This article reviews, from a global point of view, rigorous results on time independent spacetimes. Throughout attention is confined to isolated bodies at rest or in uniform rotation in an otherwise empty universe. The discussion starts from first principles and is, as much as possible, self-contained.Comment: 47 pages, LaTeX, uses Springer cl2emult styl