Innovations in energy and climate policy: lessons from Vermont

We ask in this article: how can planners and policymakers replicate Vermont’s energy and climate policies? We begin by explaining the research methods utilized for this article—mainly research interviews with a pool of experts, coupled with a targeted literature review. We then analyze the success of Vermont energy policy across four areas: energy efficiency, renewable energy, the smart grid, and energy governance. The following sections first explain how Vermont accomplished these successes, next identify a number of remaining barriers and elements of Vermont’s approach that may not be replicable, and finally present the article’s conclusions

The Effect of Diffusive and Convective Sodium Balance During Hemodialysis on Interdialytic Weight Gain

Patients with end stage renal disease (ESRD) often require hemodialysis treatments in which blood’s water and dissolved solutes undergo diffusion and convection by exposure to an extracorporeal membrane. The leading cause of death in this population is cardiovascular, and how hemodialysis is prescribed alters total sodium balance, a critical determinant of cardiovascular health. We performed retrospective and prospective analysis of data from patients in the Southwestern Ontario Regional Hemodialysis Program. An increased Dialysate sodium (Dial-Na+) to Pre-dialysis plasma sodium (Pre- Na+) concentration difference (DPNa+) leads to adverse clinical outcomes in hemodialysis patients. The post- to pre-dialysis plasma sodium difference (PPNa+) predicts clinical outcomes equally well as DPNa+ so long as Dial-Na+ is within 3 mmol/L of Pre-Na+. Calculation of DPNa+ requires determination of the Pre-Na+, historically thought to be stable in hemodialysis patients and thus termed “setpoint” (SP). However, we determined that SP is modifiable by hemodialysis prescription. Finally, an equation to predict interdialytic weight gain was created, confirming Dial-Na+, dialysis frequency and duration to be modifiable factors affecting IDWG. Further research is required to validate this equation prospectively, and to determine the impact of changes of SP on cardiovascular morbidity and mortality

Physically optimizing inference

Data is scaling exponentially in fields ranging from genomics to neuroscience to economics. A central question is: can modern machine learning methods be applied to construct predictive models of natural systems like cells and brains based on large data sets? In this paper, we examine how inference is impacted when training data is generated by the statistical behavior of a physical system, and hence outside direct control by the experimentalist. We develop an information-theoretic analysis for the canonical problem of spin-network inference. Our analysis reveals the essential role that the physical properties of the spin network and its environment play in determining the difficulty of the underlying machine learning problem. Specifically, stochastic fluctuations drive a system to explore a range of configurations providing `raw' information for a learning algorithm to construct an accurate model; yet they also blur energetic differences between network states and thereby degrade information. This competition leads spin networks to generically have an intrinsic optimal temperature at which stochastic spin fluctuations provide maximal information for discriminating among competing models, maximizing inference efficiency. We demonstrate a simple active learning protocol that optimizes network temperature to boost inference efficiency and dramatically increases the efficiency of inference on a neural circuit reconstruction task. Our results reveal a fundamental link between physics and information and show how the physical environment can be tuned to optimize the efficiency of machine learning

The virtue politics of Cristoforo Landino’s Disputationes Camaldulenses

The purpose of this thesis is to present a study of the aims, contexts, philosophical basis, and intended praxis of the system of virtue politics in Cristoforo Landino’s Disputationes Camaldulenses, a philosophical dialogue completed in 1474 whose stated aim is to investigate what a republican politician can learn from Plato. Landino presents a programme for the ascent of the soul which involves both the moral virtues, which involve political activity and the purgation of the soul, and the intellectual virtues, which are concerned with the cognition of God and from which one can gain the wisdom to guide and direct the state. Since the best way of life involves the use of each kind of virtue as far as is necessary, Landino grants the statesman the capacity to move between government and detachment from direct civic intervention as desired. I show how Landino’s purpose is, therefore, to justify the exercise of political power in a republic by an individual who does not occupy a governmental role, and in doing so legitimise the position of Lorenzo de’ Medici. My thesis consists of three parts. In the first I outline the political-historical and intellectual contexts for the composition of the Disputationes, situating the work within contemporary humanistic debates about political virtue and the Florentine political currents of the late Quattrocento. The second part of the thesis analyses Landino’s system of virtue politics, its philosophical and psychological underpinning, and how it reconciles Ciceronian republicanism with Platonic perfectionism. In the third part of the thesis I show how the allegory of the Aeneid in the third and fourth books of the Disputationes describes a course of practical ethics which the statesman must undertake if he is to purify himself of vice, attain knowledge of the divine, and impart this wisdom to the state while remaining outside of government

Sustainability of physical exam skills in a resident-led curriculum in a large internal medicine program with competency based medical education

Background: Competency Based Medical Education (CBME) designates physical examination competency as an Entrustable Professional Activity (EPA). Considerable concern persists regarding the increased time burden CBME may place on educators. We developed a novel physical examination curriculum that shifted the burden of physical examination case preparation and performance assessment from faculty to residents. Our first objective was to determine if participation led to sustainable improvements in physical examination skills. The second objective was to determine if resident peer assessment was comparable to faculty assessment.    Methods: We selected physical exam case topics based on the Objectives of Training in the Specialty of Internal Medicine as prescribed by the Royal College of Physicians and Surgeons of Canada. Internal Medicine residents compiled evidence-based physical exam checklists that faculty reviewed before distribution to all learners. Physical exam practice sessions with whole-group demonstration followed by small-group practice sessions were performed weekly. We evaluated this pilot curriculum with a formative OSCE, during which a resident peer and a faculty member simultaneously observed and assessed examinee performance by .Results: Participation in the novel curriculum practice sessions improved OSCE performance (faculty score mean 78.96 vs. 62.50, p<0.05). Peer assessment overestimated faculty scores (76.2 vs. 65.7, p<0.001), but peer and faculty assessments were highly correlated (R2 = 0.73 (95% CI 0.50-0.87).Conclusion: This novel physical examination curriculum leads to sustainable improvement of physical examination skills. Peer assessment correlated well with the gold standard faculty assessment. This resident-led physical examination curriculum enhanced physical examination skills in a CBME environment, with minimal time commitment from faculty members

Higher quality quit-date goal setting enhances quit attempts among quitline callers

INTRODUCTION At tobacco quitlines, coaching and cessation medications are commonly structured around setting a date for making a quit attempt. However, limited literature evaluating this practice suggests that callers do not routinely set quit-date goals. High quality goal setting may increase the frequency of caller quit attempts. In this study, we examine the quality of quit-date goal setting and its association with in-program quit attempts and the timing of callers' first quit attempt. METHODS Using call recordings, we scored the quality of quit-date goal setting among 90 callers enrolled at Arizona Smokers' Helpline between August and December 2017. The primary exposure was quality of quit-date goal setting assessed using the Lorencatto et al. rating scale. Coding reliability was assessed using Cohen's kappa. Multivariable logistic regression was used to examine the association between quality of goal setting and in-program quit attempts (>24 h tobacco free). RESULTS The mean quality goal setting score was 3.1 (range: -3 to 7). Sixty-nine callers (77%) set a quit date and 39 (43%) made a quit attempt. Compared to callers who experienced low-quality goal setting, the adjusted odds of in-program quitting for high quality goal setting was AOR=3.98 (95% CI: 1.55-10.20) and for making a quit attempt within two weeks OR=6.23 (95% CI: 1.52-25.49). CONCLUSIONS Quit-date goal setting is an important element of quitline services and callers benefit from high quality quit-date goal setting. Quitlines should establish quality improvement measures to ensure that coaches are trained to provide high quality quit-date goal setting opportunities to all callers.Arizona Department of Health Services [ADHS11-007339, ADHS16-106672, ADHS13-026130:5]; NIH-NCI Cancer Center [P30 CA023074]Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Comparative efficacy of two Ivermectin Pour-on anthelmintics in beef steers in a commercial feedyard

Generic products generally have a cost advantage for beef producers over brand-name products. Recently, many beef producers have debated whether to utilize generic anthelmintics in cow/calf herds and feeder cattle. If generics are to be justified, the products must be proven to have efficacy similar to the brand-name product. Previous studies have indicated that generic macrocyclic lactones are less effective in controlling gastrointestinal parasites of cattle than the original brand-name products. The objective of this study was to compare the efficacy of Vetrimec (Norbrook Laboratories Limited, Newry, Co. Down, Northern Ireland) pour-on and Ivomec (Merial Animal Health, Duluth, GA) pour-on by utilizing the fecal egg reduction test in newly arrived feedlot steers

Vascular changes in diabetic retinopathy-a longitudinal study in the Nile rat.

Diabetic retinopathy is the most common microvascular complication of diabetes and is a major cause of blindness, but an understanding of the pathogenesis of the disease has been hampered by a lack of accurate animal models. Here, we explore the dynamics of retinal cellular changes in the Nile rat (Arvicanthis niloticus), a carbohydrate-sensitive model for type 2 diabetes. The early retinal changes in diabetic Nile rats included increased acellular capillaries and loss of pericytes that correlated linearly with the duration of diabetes. These vascular changes occurred in the presence of microglial infiltration but in the absence of retinal ganglion cell loss. After a prolonged duration of diabetes, the Nile rat also exhibits a spectrum of retinal lesions commonly seen in the human condition including vascular leakage, capillary non-perfusion, and neovascularization. Our longitudinal study documents a range and progression of retinal lesions in the diabetic Nile rat remarkably similar to those observed in human diabetic retinopathy, and suggests that this model will be valuable in identifying new therapeutic strategies

Not Just Asking Questions: Effects of Implicit and Explicit Conspiracy Information About Vaccines and Genetic Modification

This is the author accepted manuscript. The final version is available from Taylor & Francis (Routledge) via the DOI in this record.While conspiracy ideation has attracted overdue attention from social scientists in recent years, little work focuses on how different pro-conspiracy messages affect the take-up of conspiracy beliefs. In this study, we compare the effect of explicit and implicit conspiracy cues on the adoption of conspiracy beliefs. We also examine whether corrective information can undo conspiracy cues, and whether there are differences in the effectiveness of corrective information based on whether a respondent received an explicit or implicit conspiracy cue. We examine these questions using a real-world but low-salience conspiracy theory concerning Zika, GM mosquitoes, and vaccines. Using a preregistered experiment (N = 1018: https://osf.io/hj2pw/), we find that both explicit and implicit conspiracy cues increase conspiracy beliefs, but in both cases corrections are generally effective. We also find reception of an explicit conspiracy cue and its correction is conditional on feelings toward the media and pharmaceutical companies. Finally, we find that examining open-ended conspiracy belief items reveals similar patterns, but with a few key differences. These findings have implications for how news media cover controversial public health issues going forward.European Research Counci

Evaluating differences in the clinical impact of a free online weight loss programme, a resource-intensive commercial weight loss programme and an active control condition: a parallel randomised controlled trial

Background: Finding effective intervention strategies to combat rising obesity levels could significantly reduce the burden that obesity and associated non-communicable diseases places on both individuals and the National Health Service. Methods: In this parallel randomised-controlled trial, 76 participants who are overweight or obese (50 female) were given free access to a fitness centre for the duration of the 12-week intervention and randomised to one of three interventions. The commercial intervention, the Healthy Weight Programme, (HWP, n = 25, 10/15 men/women) consisted of twelve 1-h nutrition coaching sessions with a nutritionist delivered as a mixture of group and 1 to 1 sessions. In addition, twice-weekly exercise sessions (24 in total) were delivered by personal trainers for 12 weeks. The NHS intervention (n = 25, 8/17 men/women) consisted of following an entirely self-managed 12-week online NHS resource. The GYM intervention (n = 26, 8/18 men/women) received no guidance or formal intervention. All participants were provided with a gym induction for safety and both the NHS and GYM participants were familiarised with ACSM physical activity guidelines by way of a hand-out. Results: The overall follow-up rate was 83%. Body mass was significantly reduced at post-intervention in all groups (HWP: N = 18, − 5.17 ± 4.22 kg, NHS: N = 21–4.19 ± 5.49 kg; GYM: N = 24–1.17 ± 3.00 kg; p < 0.001) with greater reductions observed in HWP and NHS groups compared to GYM (p < 0.05). Out with body mass and BMI, there were no additional statistically significant time x intervention interaction effects. Conclusions: This is the first study to evaluate the efficacy of both a free online NHS self-help weight-loss tool and a commercial weight loss programme that provides face-to-face nutritional support and supervised exercise. The findings suggest that both interventions are superior to an active control condition with regard to eliciting short-term weight-loss. Trial registration: ISRCTN Registry - ISRCTN31489026. Prospectively registered: 27/07/16