Live From New York, It\u27s the Fake News! Saturday Night Live and the (Non)Politics of Parody

Though Saturday Night Live\u27s “Weekend Update” has become one of the most iconic of fake news programs, it is remarkably unfocused on either satiric critique or parody of particular news conventions. Instead, the segment has been shaped by a series of hosts who made a name for themselves by developing distinctive comic personalities. In contrast to more politically invested contemporary programs, the genre of fake news on Saturday Night Live has been largely emptied to serve the needs of the larger show, maintaining its status as just topical, hip, and unthreatening enough to attract celebrities and politicians, as well as a mass audience

The Effects of Early Laxative, Diet, and Exercise Education on Postpartum Constipation Prevention

Introduction: Postpartum constipation is a common problem women face after delivery. Vaginal tears, pain medications, hormonal changes, decreased activity, dietary changes, and hemorrhoids can all increase the risk of developing constipation in the postpartum period. Evidence Summary: Constipation can cause pain, discomfort, decreased quality of life, and life-long consequences if left untreated. Nurses have a responsibility to the patient to provide quality care by taking a proactive approach to bowel management. Regular assessment of patient bowel habits and the provision of education on non-pharmacologic and pharmacologic prevention measures are recommended. Gaps: There is a lack of literature specific to constipation in the postpartum population, and the literature lacks specific guidelines for management due to the subjective nature of the problem. Recommendations for Practice: Prevention of constipation is superior to treating the problem after it has already occurred. Discussing prevention interventions with patients on admission and daily thereafter can improve quality of care and potentially reduce constipation related pain and discomfort

ROMANTIC RELATIONSHIPS IN THE CONTEXT OF PARENTING CHILDREN WITH AUTISM

This study examines the impact of raising a child with an autism spectrum disorder on relationship quality using the double ABCX model of adjustment and adaptation. Respondents (N = 126) recruited through Autism Society listervs completed online surveys designed to measure three factors of relationship quality: satisfaction, positive perceptions, and negative perceptions. Results from hierarchical multiple regression models indicate that the double ABCX model accounted for 47% of variance in satisfaction, 72% in positive perceptions, and 50% in negative perceptions, for predicting the quality of couple relationships. Implications for clinicians working with couples are discussed, such as the need for treatment that focuses on stress management and increasing support through affectionate, emotional, tangible, and social interactions

Structure-property correlations in novel spin crossover materials

In complexes where the energy difference between the high and low spin state of the metal is of the order of k(_b)T, temperature can be used to induce a spin crossover transition (SC). In some cases, at very low temperatures, irradiation can induce excitation to a meta-stable high spin state. At low temperatures, this Light-Induced Excited Spin-State Trapped (LIESST) state is generally long lived, enabling structural examination. The results presented herein refer to a wide range of iron(II) spin crossover materials which have been structurally studied in both thermal and light induced states. These fall into three categories; mononuclear, dinuclear and polymeric. The mononuclear complexes studied include FeL[H(_2)B(Pz)(_2)](_2) L = 2,2'-bipyridine (1) and 1,10-phenanthroline (2), of which 2 was found to undergo a change in symmetry in addition to the change in spin state, leading to a novel light induced polymorphism that has not been previously seen. Two dinuclear compounds with step transitions have been examined. While {[N(CN)(_2)](FeBpl)(_2)}(PF(_6))(_3) undergoes a gradual transition, the transitions in [Fe(Btz)(NCS)(_2)](_2)Bpmd are abrupt and the latter also undergoes LIESST but with a rapid relaxation that has not been observed previously with any other technique. While the origin of this relaxation is uncertain, the structure of this excited state has been studied under constant irradiation. The largest structural study of three dimensional SC materials has been carried out, including bimetallic polymers with [Au(CN)(_2)], [Ag(CN)(_2)]-, [Ag(_2)(CN)(_3)]- and [Pd(CN)(_4)](^2-) bridging ligands. These anionic bridges have been shown to enhance cooperativity between iron centres leading to abrupt transitions and hysteresis. These materials have been shown to undergo LIESST, crystalline state allosterism, and thermo-chromism. Such multi-property materials have a high potential for technological applications

Chiral selection in the formation of borates from racemic binaphthols and related diols

A series of racemic or stereochemically labile chiral borate anions based on the 2,2′-biphenol motif was investigated. All borates were homochiral in the solid state, although in some cases the heterochiral diastereomers were computed to be thermodynamically preferred (DFT). The crystallographic preference for the homochiral diastereomer was attributed to its lower bulk, higher molecular symmetry, and the therewith associated better packing ability

E3 Ligase Identified by Differential Display (EDD) Enhances Cell Survival and Cisplatin Resistance in Epithelial Ovarian Cancer and Oral Squamous Cell Carcinoma

EDD (E3-ubiquitin ligase identified by Differential Display) is an E3 ubiquitin ligase that is overexpressed in ovarian cancer, but is rare in benign and borderline tumors. EDD is also overexpressed in recurrent, platinum-resistant ovarian cancers and is associated with a two-fold increased risk of disease recurrence and death in ovarian cancer patients, suggesting a role in tumor survival and/or platinum resistance. EDD knockdown by siRNA induced apoptosis in A2780ip2, OVCAR5, and ES-2 ovarian cancer cells, correlating with a loss of the anti-apoptotic protein Mcl-1 through a GSK-3β-independent mechanism. Transient knockdown of EDD or Mcl-1 induced comparable levels of apoptosis in A2780ip2 and ES-2 cells. Stable overexpression of Mcl-1 protected cells from apoptosis following EDD knockdown, accompanied by a loss of endogenous, but not exogenous, Mcl-1 protein, indicating that EDD may regulate Mcl-1 synthesis. Indeed, EDD knockdown induced a 1.87-fold decrease in Mcl-1 mRNA and EDD transfection enhanced murine Mcl-1 promoter driven luciferase expression five-fold. To separate EDD survival and potential cisplatin resistance functions, we generated EDD shRNA stable cell lines that could survive initial EDD knockdown and demonstrated that these cells were four- to 21-fold more sensitive to cisplatin. Moreover, transient EDD overexpression in COS-7 cells was sufficient to promote cisplatin resistance 2.4-fold, dependent upon its E3 ligase activity. In vivo, mouse intraperitoneal ES-2 and A2780ip2 xenograft experiments showed that mice treated with EDD siRNA by nanoliposomal delivery (DOPC) along with cisplatin had significantly less tumor burden than those treated with control siRNA/DOPC alone (ES-2, 77.9% reduction, p=0.004; A2780ip2, 75.9% reduction, p=0.042) or control siRNA/DOPC with cisplatin in ES-2 (64.4% reduction, p=0.035), with a trend in A2780ip2 (60.3% reduction, p=0.168). These results identify EDD as a dual regulator of cell survival and cisplatin resistance and suggest EDD is a therapeutic target for ovarian cancer. Additionally, edd is overamplified in oral squamous cell carcinoma of the tongue. Preliminary results in this carcinoma indicate similar roles of EDD in regulating cellular survival and cisplatin resistance as demonstrated in ovarian cancer

The Effect of Enhanced Visualization Instruction on First Grade Students\u27 Scores on the North Carolina Standard Course Assessment

Visualization was once thought to be an important skill for professions only related to engineering, but due to the realization of concurrent design and the fast pace of technology, it is now desirable in other professions as well. The importance of learning basic knowledge of geometrical concepts has a greater impact than it did prior to the 21st century. This study\u27s purpose was to test the effect of enhanced visualization instruction on the visualization skills measured by the North Carolina standard course test for first grade students. This quasi-experimental study was conducted using the non-randomized subjects, non-equivalent control group design. Nine elementary classrooms with a total of 157 students participated. The standard end of course test scores of the participants were analyzed using a two-way ANCOVA to establish whether a significant difference existed among the sample means based on instructional delivery method and gender and instructional delivery method and race. A pre-test was used to control for differences between groups. A Tukey\u27s HSD test was used to evaluate multiple comparisons for delivery method. Results indicated that instructional delivery had a significant effect on post-test scores. Participants who took part in a classroom with instruction enhanced by multimedia or manipulatives scored higher than those who received instruction without any enhancements. Participants who received instruction with both multimedia and manipulatives had the highest scores. Gender and race were not significant factors in the students\u27 success. Discussion of further research is also incorporated

Methyl 6-amino-6-oxohexanoate

The title compound, C7H13NO3, adopts an approximately planar conformation. The torsion angles in the aliphatic chain between the carbonyl group C atoms range from 172.97 (14) to 179.38 (14)° and the r.m.s. deviation of all non-H atoms is 0.059 Å. The crystal packing is dominated by two strong N—H⋯O hydrogen bonds involving the amide groups and forming R 2 2(8) rings and C(4) chains. Overall, a two-dimensional network parallel to (100) is formed. A weak inter­molecular C—H⋯O inter­action is also present