Optimal Control of the Landau-de Gennes Model of Nematic Liquid Crystals

We present an analysis and numerical study of an optimal control problem for the Landau-de Gennes (LdG) model of nematic liquid crystals (LCs), which is a crucial component in modern technology. They exhibit long range orientational order in their nematic phase, which is represented by a tensor-valued (spatial) order parameter $Q = Q(x)$. Equilibrium LC states correspond to $Q$ functions that (locally) minimize an LdG energy functional. Thus, we consider an $L^2$-gradient flow of the LdG energy that allows for finding local minimizers and leads to a semi-linear parabolic PDE, for which we develop an optimal control framework. We then derive several a priori estimates for the forward problem, including continuity in space-time, that allow us to prove existence of optimal boundary and external ``force'' controls and to derive optimality conditions through the use of an adjoint equation. Next, we present a simple finite element scheme for the LdG model and a straightforward optimization algorithm. We illustrate optimization of LC states through numerical experiments in two and three dimensions that seek to place LC defects (where $Q(x) = 0$) in desired locations, which is desirable in applications.Comment: 26 pages, 9 figure

Taming the Pion Cloud of the Nucleon

We present a light-front determination of the pionic contribution to the nucleon self-energy, $\Sigma_\pi$, to second-order in pion-baryon coupling constants that allows the pion-nucleon vertex function to be treated in a model-independent manner constrained by experiment. The pion mass $\mu$ dependence of $\Sigma_\pi$ is consistent with chiral perturbation theory results for small values of $\mu$ and is also linearly dependent on $\mu$ for larger values, in accord with the results of lattice QCD calculations. The derivative of $\Sigma_\pi$ with respect to $\mu^2$ yields the dominant contribution to the pion content, which is consistent with the $\bar{d}-\bar{u}$ difference observed experimentally in the violation of the Gottfried sum rule.Comment: 11 pages, 3 figure

Evaluation of a Brazilian fuel alcohol yeast strain for Scotch whisky fermentations

Traditionally, distilling companies in Scotland have employed a very limited number of yeast strains in the production of alcohol for Scotch whiskies. Recent changes such as the decline in availability of brewers’ yeast as a secondary yeast strain and the availability of yeast in different formats (e.g., dried and cream yeast as alternatives to compressed yeast) have promoted interest in alternative Scotch whisky distilling yeasts. In previous work, we investigated different strains of yeasts, specifically Brazilian yeasts which had been isolated from and used in fuel alcohol distilleries. One of the Brazilian yeasts (CAT 1) showed a comparable fermentation performance and superior stress tolerance compared with a standard commercial Scotch whisky distilling yeast (M Type). The Brazilian CAT 1 yeast isolate was further assessed in laboratory scale fermentations and subsequent new make spirit was subjected to sensory analyses. The spirits produced using the Brazilian strain had acceptable flavour profiles and exhibited no sensory characteristics that were atypical of Scotch whisky new make spirit. This study highlights the potential of exploiting yeast biodiversity in traditional Scotch whisky distillery fermentation processes

Flight Determination of the Static Longitudinal Stability Boundaries of the Bell X-5 Research Airplane with 59 Deg Sweepback

During the flight program on the Bell X-5 airplane with 59 deg sweepback to determine the practical Mach number and normal-force coefficient limits of this configuration, a reduction in static longitudinal stability was encountered in maneuvering flight. A determination of the boundary for reduction of longitudinal stability extending to a Mach number of 0.98 is presented in this paper. A reduction of static longitudinal stability existed for all elevator and all stabilizer-executed maneuvers. The reduction of stability existed for maneuvers executed with elevator near a normal-force coefficient of 0.6 for a Mach number range of about 0.31 to 0.76. Above a Mach number of 0.76 the normal-force coefficient for reduction of stability gradually decreased to a value of 0.2 at a Mach number of 0.98. For stabilizer-executed maneuvers the stability boundary was the same as for elevator maneuvers up to a Mach number of 0.88. Above this Mach number the reduction of stability occurred at slightly higher normal-force coefficients decreasing from about 0.51 at a Mach number of 0.92 to a value of 0.311 at a Mach number of 0.97. The airplane has been flown to a Mach number of 1.04 at a normal-force coefficient of about 0.15 without encountering any reduction of stability. The pilot did not consider the reduction of stability to be dangerous at altitudes above 30,000 feet; however, precise flight was impossible. At angles of attack above that at which the reduction of longitudinal stability occurred, directional instability and aileron control overbalance were encountered

Experimental investigation of a 4 and 1/2 stage turbine with very high stage loading factor. 2: Turbine performance

The experimental test program results of a 4 1/2-stage turbine with a very high stage loading factor are presented. A four-stage turbine was tested with and without outlet turning vanes. The 4 1/2-stage turbine achieved a design point total-to-total efficiency of 0.853. The outlet turning vane design point performance was 0.4 percent of the overall 4 1/2-stage turbine efficiency. Tests were conducted at various levels of Reynolds number and indicated decreases in turbine efficiency and equivalent weight flow with decreasing Reynolds number

Food Preference and Demand in a Ramp Task in Guinea Pigs (Cavia porcellus)

Guinea pigs (Cavia porcellus) are popular pets and used as laboratory animals, however, their dietary preferences are under-studied. It is important for guinea pig owners and carers to increase the opportunity for good animal welfare by providing personalized and enriching dietary options. Thus, this study aimed to assess the use of paired-stimulus and multiple-stimulus-without-replacement preference assessments to determine the food preferences of seven male guinea pigs and test the validity of the methods by testing the demand for the most- and least preferred foods as reinforcers for climbing an elevated ramp. Generally, the preference assessments identified the same foods as the most preferred for each guinea pig, but not the least preferred foods. Guinea pigs climbed up to the steepest angle for both most and least preferred foods, but a non-linear least squares regression and demand analysis indicated faster climbing and inelastic demand for most preferred foods compared to slower climbing and elastic demand for least preferred foods. Both preference assessment methods were valid in identifying a preferred food, however, the multiple-stimulus-without-replacement assessment was more efficient to conduct. High-preference foods such as parsley and dandelion are recommended as future training reinforcers for guinea pigs and as foods to consider using as enrichment in captive guinea pig systems to encourage good welfare.&nbsp

Scaling law for the electromagnetic form factors of the proton

The violation of the scaling law for the electric and magnetic form factors of the proton are examined within the cloudy bag model. The suppression of the ratio of the electric and magnetic form factors is natural in the bag model. The pion cloud plays a moderate role in understanding the recent data from TJNAF.Comment: 8 pages, REVTeX, 2 figures include

Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila

Apolipoprotein D (ApoD) expression increases in several neurological disorders and in spinal cord injury. We provide a report of a physiological role for human ApoD (hApoD): Flies overexpressing hApoD are long-lived and protected against stress conditions associated with aging and neurodegeneration, including hyperoxia, dietary paraquat, and heat stress. We show that the fly ortholog, Glial Lazarillo, is strongly up-regulated in response to these extrinsic stresses and also can protect in vitro-cultured cells in situations modeling Alzheimer's disease (AD) and Parkinson's disease (PD). In adult flies, hApoD overexpression reduces age-associated lipid peroxide accumulation, suggesting a proximal mechanism of action. Similar data obtained in the mouse [Ganfornina, M.D., et al., (2008) Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress. Aging Cell 10.1111/j.1474-9726.2008.00395.] as well as in plants (Charron et al., personal communication) suggest that ApoD and its orthologs play an evolutionarily conserved role in response to stress, possibly managing or preventing lipid peroxidation

Cost of thoracic endovascular aortic repair versus open repair and implications for the US health care system

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