New zero free regions for the derivatives of the Riemann zeta function

The main aim of this paper is twofold. First we generalize, in a novel way, most of the known non-vanishing results for the derivatives of the Riemann zeta function by establishing the existence of an infinite sequence of regions in the right half-plane where these derivatives cannot have any zeros; and then, in the rare regions of the complex plane that do contain zeros of the k-th derivative of the zeta function, we describe a unexpected phenomenon, which implies great regularities in their zero distributions. In particular, we prove sharp estimates for the number of zeros in each of these new critical strips, and we explain how they converge, in a very precise, periodic fashion, to their central, critical lines, as k increases. This not only shows that the zeros are not randomly scattered to the right of the line Re(s)=1, but that, in many respects, their two-dimensional distribution eventually becomes much simpler and more predictable than the one-dimensional behavior of the zeros of the zeta function on the line Re(s)=1/2

B\'ezoutians and the A1\mathbb{A}^1-degree

We prove that both the local and global $\mathbb{A}^1$-degree of an endomorphism of affine space can be computed in terms of the multivariate B\'ezoutian. In particular, we show that the B\'ezoutian bilinear form, the Scheja--Storch form, and the $\mathbb{A}^1$-degree for complete intersections are isomorphic. Our global theorem generalizes Cazanave's theorem in the univariate case, and our local theorem generalizes Kass--Wickelgren's theorem on EKL forms and the local degree. This result provides an algebraic formula for local and global degrees in motivic homotopy theory.Comment: 30 pages, 3 figures. Corrected author funding attribution. Comments welcome

Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex

BACKGROUND: Mutations in the chromodomain helicase DNA binding protein 7 gene (CHD7) lead to CHARGE syndrome, an autosomal dominant multiple malformation disorder. Proteins involved in chromatin remodeling typically act in multiprotein complexes. We previously demonstrated that a part of human CHD7 interacts with a part of human CHD8, another chromodomain helicase DNA binding protein presumably being involved in the pathogenesis of neurodevelopmental (NDD) and autism spectrum disorders (ASD). Because identification of novel CHD7 and CHD8 interacting partners will provide further insights into the pathogenesis of CHARGE syndrome and ASD/NDD, we searched for additional associated polypeptides using the method of stable isotope labeling by amino acids in cell culture (SILAC) in combination with mass spectrometry. PRINCIPLE FINDINGS: The hitherto uncharacterized FAM124B (Family with sequence similarity 124B) was identified as a potential interaction partner of both CHD7 and CHD8. We confirmed the result by co-immunoprecipitation studies and showed a direct binding to the CHD8 part by direct yeast two hybrid experiments. Furthermore, we characterized FAM124B as a mainly nuclear localized protein with a widespread expression in embryonic and adult mouse tissues. CONCLUSION: Our results demonstrate that FAM124B is a potential interacting partner of a CHD7 and CHD8 containing complex. From the overlapping expression pattern between Chd7 and Fam124B at murine embryonic day E12.5 and the high expression of Fam124B in the developing mouse brain, we conclude that Fam124B is a novel protein possibly involved in the pathogenesis of CHARGE syndrome and neurodevelopmental disorders

A qualidade dos produtos e serviços sob a ética dos usuários : um estudo de caso da Biblioteca de CJ da UFPR

Orientador : Joel Souza e SilvaTrabalho de Conclusão de Curso (especialização) - Universidade Federal do Paraná, Setor de Ciências Sociais Aplicadas, Curso de Especialização em Administração de PessoasInclui referência

Psychological functioning in adolescents referred to specialist gender identity clinics across Europe : a clinical comparison study between four clinics

Adolescents seeking professional help with their gender identity development often present with psychological difficulties. Existing literature on psychological functioning of gender diverse young people is limited and mostly bound to national chart reviews. This study examined the prevalence of psychological functioning and peer relationship problems in adolescents across four European specialist gender services (The Netherlands, Belgium, the UK, and Switzerland), using the Child Behavioural Checklist (CBCL) and the Youth Self-Report (YSR). Differences in psychological functioning and peer relationships were found in gender diverse adolescents across Europe. Overall, emotional and behavioural problems and peer relationship problems were most prevalent in adolescents from the UK, followed by Switzerland and Belgium. The least behavioural and emotional problems and peer relationship problems were reported by adolescents from The Netherlands. Across the four clinics, a similar pattern of gender differences was found. Birth-assigned girls showed more behavioural problems and externalising problems in the clinical range, as reported by their parents. According to self-report, internalising problems in the clinical range were more prevalent in adolescent birth-assigned boys. More research is needed to gain a better understanding of the difference in clinical presentations in gender diverse adolescents and to investigate what contextual factors that may contribute to this

Backscattering Behavior of Vulnerable Road Users Based on High-Resolution RCS Measurements

Automotive radars, along with optical sensors such as cameras or lidars, offer a reliable way of obtaining the 3-D information about the environment. Of particular interest in autonomous driving (AD) is the reliable detection of particularly vulnerable road users (VRUs). Modern radar sensors are able to detect, distinguish, and track targets with high resolution. Relying on that, a backscattering model of complex traffic targets can be generated from the reflected signals of their scattering points (SPs). These models can be employed in the radar channel simulations for verification methods of advanced driver assistance systems. Therefore, in this work, different persons as the most vital VRUs are measured with high radial and high angular resolution. The necessary signal processing steps are explained in detail for the determination of the relevant SPs. Thus, the corresponding radar cross section (RCS) values can be assigned to certain body regions. In addition to real persons, further measurements are compared with a dummy of the corresponding size. Based on the measurement results, not only accurate models of road users can be derived, but also the measurement results can be employed for calculating wave propagation in traffic scenarios. From the measured SPs, the classification of the persons by size and stature is derived

Mutation analysis in a German family identified a new cataract-causing allele in the CRYBB2 gene

The study demonstrates the functional candidate gene analysis in a cataract family of German descent. METHODS: We screened a German family, clinically documented to have congenital cataracts, for mutation in the candidate genes CRYG (A to D) and CRYBB2 through polymerase chain reaction analyses and sequencing. RESULTS: Congenital cataract was first observed in a daughter of healthy parents. Her two children (a boy and a girl) also suffer from congenital cataracts and have been operated within the first weeks of birth. Morphologically, the cataract is characterized as nuclear with an additional ring-shaped cortical opacity. Molecular analysis revealed no causative mutation in any of the CRYG genes. However, sequencing of the exons of the CRYBB2 gene identified a sequence variation in exon 5 (383 A>T) with a substitution of Asp to Val at position 128. All three affected family members revealed this change but it was not observed in any of the unaffected persons of the family. The putative mutation creates a restriction site for the enzyme TaiI. This mutation was checked for in controls of randomly selected DNA samples from ophthalmologically normal individuals from the population-based KORA S4 study (n=96) and no mutation was observed. Moreover, the Asp at position 128 is within a stretch of 12 amino acids, which are highly conserved throughout the animal kingdom. For the mutant protein, the isoelectric point is raised from pH 6.50 to 6.75. Additionally, the random coil structure of the protein between the amino acids 126-139 is interrupted by a short extended strand structure. In addition, this region becomes hydrophobic (from neutral to +1) and the electrostatic potential in the region surrounding the exchanged amino acid alters from a mainly negative potential to an enlarged positive potential. CONCLUSIONS: The D128V mutation segregates only in affected family members and is not seen in representative controls. It represents the first mutation outside exon 6 of the human CRYBB2 gene