INTERGENERATIONAL EXPERIENCE AND ONTOLOGICAL CHANGE

The phenomenological concept of ontological change, or change in self-understanding, is used to structure an analysis of the experiential impact of a college-based, intergenerational service-learning project. The semester-long project aimed to create interpersonal, intergenerational situations in which students (N = 12) could experience for themselves the lack of fit between their inherited assumptions regarding aging and the actual meaning of aging as experienced by elders. Content analysis of students\u27 journals indicated that students experienced four temporally distinct types of experiences during the project. Students entered the project with an understanding as to how they should interact with their companions based on inherited assumptions regarding aging and the elderly (anticipation experiences). In the presence of their companions, however, the students\u27 assumptions were revealed as inappropriate and incapable of adequately guiding them in their interactions (personal-confT.ict experiences). To alleviate the awkwardness experienced in the field, students had to reevaluate their understanding of themselves and their role in their intergenerational relationship and identify changes they could make to improve their intergenerational relationships (reevaluation experiences). Ten of 12 students reported effecting positive changes in their relationships afrer redefining their role vis-a-vis their companions (transposition experiences). Phenomenological theory provides (a) insight into the type of intergenerational relationships conducive to combating ageism and (b) a framework (journal content analysis) for assessing the experiential impact of program participation

The sociological significance of Gadamer\u27s hermeneutics

This study is a social-theoretical analysis of Hans-Georg Gadamer\u27s philosophical hermeneutics. Special attention is paid to Gadamer\u27s analysis of the nature of interpretation, which is based in part on Martin Heidegger\u27s concept of the fore-structure of understanding. This Heideggerian concept, which implies that interpretation cannot proceed without a prior understanding of its object, reappears in Gadamer\u27s work in his notion of the prejudiced condition of interpretation. According to Gadamer, interpretation is prejudiced because it involves the application of preconscious linguistical concepts the truth status of which is assumed during their moment of application. Gadamer rejects a strictly pejorative view of prejudices, however, viewing them as necessary preliminary judgments of meaning that may be true or false. For Gadamer, the task we all face is to experience prejudices consciously by bringing into discourse their tacit semantical content. This process is defined by Gadamer as the experience of hermeneutical reflection, which yields an effective-historical consciousness, a consciousness that is aware of the anterior and meaning-constitutive effect of one\u27s existence within a linguistic tradition. It is argued that Anthony Giddens and Jurgen Habermas fail to understand the meaning of Gadamer\u27s notion of the universality of hermeneutics and consequently fail to grasp the full significance of his hermeneutics for sociology. In the case of Giddens, the implications of Gadamer\u27s hermeneutics are limited to the theoretical realm; in Habermas, the implications are taken to be strictly methodological. It is argued that the sociological significance of Gadamer is topical, as well as theoretical and methodological. This means that Gadamer\u27s hermeneutics may be used to introduce new topics and research questions within sociology. It is proposed that sociologists begin studying the distribution of prejudices across groups and the stratification and differentiation of situational opportunities conductive to hermeneutical reflection. The interpretive-sociological contributions of Max Weber, Alfred Schutz and G. H. Mead are also discussed and contrasted with Gadamer\u27s analysis of the prejudiced nature of interpretation

Real-Time Detection of Optical Transients with RAPTOR

Fast variability of optical objects is an interesting though poorly explored subject in modern astronomy. Real-time data processing and identification of transient celestial events in the images is very important for such study as it allows rapid follow-up with more sensitive instruments. We discuss an approach which we have developed for the RAPTOR project, a pioneering closed-loop system combining real-time transient detection with rapid follow-up. RAPTOR's data processing pipeline is able to identify and localize an optical transient within seconds after the observation. The testing we performed so far have been confirming the effectiveness of our method for the optical transient detection. The software pipeline we have developed for RAPTOR can easily be applied to the data from other experiments.Comment: 10 pages, 7 figures, to appear in SPIE proceedings vol. 484

Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies

BACKGROUND: The high fat, low carbohydrate ketogenic diet (KD) was developed as an alternative to fasting for seizure management. While the mechanisms by which fasting and the KD inhibit seizures remain speculative, alterations in brain energy metabolism are likely involved. We previously showed that caloric restriction (CR) inhibits seizure susceptibility by reducing blood glucose in the epileptic EL mouse, a natural model for human multifactorial idiopathic epilepsy. In this study, we compared the antiepileptic and anticonvulsant efficacy of the KD with that of CR in adult EL mice with active epilepsy. EL mice that experienced at least 15 recurrent complex partial seizures were fed either a standard diet unrestricted (SD-UR) or restricted (SD-R), and either a KD unrestricted (KD-UR) or restricted (KD-R). All mice were fasted for 14 hrs prior to diet initiation. A new experimental design was used where each mouse in the diet-restricted groups served as its own control to achieve a 20–23% body weight reduction. Seizure susceptibility, body weights, and the levels of plasma glucose and β-hydroxybutyrate were measured once/week over a nine-week treatment period. RESULTS: Body weights and blood glucose levels remained high over the testing period in the SD-UR and the KD-UR groups, but were significantly (p < 0.001) reduced in the SD-R and KD-R groups. Plasma β-hydroxybutyrate levels were significantly (p < 0.001) increased in the SD-R and KD-R groups compared to their respective UR groups. Seizure susceptibility remained high in both UR-fed groups throughout the study, but was significantly reduced after three weeks in both R-fed groups. CONCLUSIONS: The results indicate that seizure susceptibility in EL mice is dependent on plasma glucose levels and that seizure control is more associated with the amount than with the origin of dietary calories. Also, CR underlies the antiepileptic and anticonvulsant action of the KD in EL mice. A transition from glucose to ketone bodies for energy is predicted to manage EL epileptic seizures through multiple integrated changes of inhibitory and excitatory neural systems

Using early life stages of marine animals to screen the toxicity of priority hazardous and noxious substances

This study provides toxicity values for early life stages (ELS) of two phylogenetically distinct marine animal taxa, the sea urchin (Paracentrotus lividus), a deuterostome invertebrate, and the turbot (Scophthalmus maximus), a vertebrate (teleost), when challenged by six hazardous and noxious substances (HNS): aniline, butyl acrylate, m-cresol, cyclohexylbenzene, hexane and trichloroethylene. The aim of the study was to provide preliminary information on toxic effects of representative and relevant priority HNS to assess the risk posed by spills to marine habitats and therefore improve preparedness and the response at the operational level. Selection criteria to include each compound in the study were (1) inclusion in the HASREP (2005) list; (2) presence on the priority list established by Neuparth et al. (2011); (3) paucity of toxicological data (TOXnet and ECOTOX) for marine organisms; (4) behaviour in the water according to the categories defined by the European Behaviour classification system (GESAMP 2002), by selecting compounds with different behaviours in water; and (5) physicochemical and toxicological properties, where available, in order to anticipate the most toxic compounds. Aniline and m-cresol were the most toxic compounds with no observed apical effect concentration (NOAEC) values for sea urchin ranging between 0.01 and 0.1 mg/L, followed by butyl acrylate and cyclohexylbenzene with NOAECs ranging between 0.1 and 1.0 mg/L and trichloroethylene with NOAEC values that were in the range between 1 and 10 mg/L, reflecting their behaviour in water, mostly vapour pressure, but also solubility and log Kow. Hexane was toxic only for turbot embryos, due to its neurotoxic effects, and not for sea urchin larvae, at concentrations in the range between 1 and 10 mg/L. The concentrations tested were of the same order of magnitude for both species, and it was observed that sea urchin embryos (length of the longest arm) are more sensitive than turbot eggs larvae (hatching and cumulative mortality rates) to the HNS tested (except hexane). For this specific compound, concentrations up to 70 mg/L were tested in sea urchin larvae and no effects were observed on the length of the larvae. Both tests were found to be complementary depending on behaviour in water and toxicity target of the compounds analysed.info:eu-repo/semantics/publishedVersio

Atom lithography using MRI-type feature placement

We demonstrate the use of frequency-encoded light masks in neutral atom lithography. We demonstrate that multiple features can be patterned across a monotonic potential gradient. Features as narrow as 0.9 microns are fabricated on silicon substrates with a metastable argon beam. Internal state manipulation with such a mask enables continuously adjustable feature positions and feature densities not limited by the optical wavelength, unlike previous light masks.Comment: 4 pages, 4 figure

Biodegradation of the herbicide mecoprop-p with soil depth and its relationship with class III tfdA genes

Mecoprop-p [(R)-2-(4-chloro-2-methylphenoxy) propanoic acid) is widely used 37 in agriculture and poses an environmental concern because of its susceptibility to leach 38 from soil to water. We investigated the effect of soil depth on mecoprop-p 39 biodegradation and its relationship with the number and diversity of tfdA related genes, 40 which are the most widely known genes involved in degradation of the 41 phenoxyalkanoic acid group of herbicides by bacteria. Mecoprop-p half-life (DT50) was 42 approximately 12 days in soil sampled from <30 cm depth, and increased progressively 43 with soil depth, reaching over 84 days at 70-80 cm. In sub-soil there was a lag period of 44 between 23 and 34 days prior to a phase of rapid degradation. No lag phase occurred in 45 top-soil samples prior to the onset of degradation. The maximum degradation rate was 46 the same in top-soil and sub-soil samples. Although diverse tfdAα and tfdA genes were 47 present prior to mecoprop-p degradation, real time PCR revealed that degradation was 48 associated with proliferation of tfdA genes. The number of tfdA genes and the most 49 probable number of mecoprop-p degrading organisms in soil prior to mecoprop-p 50 addition were below the limit of quantification and detection respectively. Melting 51 curves from the real time PCR analysis showed that prior to mecoprop-p degradation 52 both class I and class III tfdA genes were present in top- and sub-soil samples. However 53 at all soil depths only tfdA class III genes proliferated during degradation. Denaturing 54 gradient gel electrophoresis confirmed that class III tfdA genes were associated with 55 mecoprop-p degradation. Degradation was not associated with the induction of novel 56 tfdA genes in top- or sub-soil samples, and there were no apparent differences in tfdA 57 gene diversity with soil depth prior to or following degradation