Dirhodium(II) Tetraacetamidate 1

International audienc

Human Muscle Progenitor Cells Displayed Immunosuppressive Effect through Galectin-1 and Semaphorin-3A

In human skeletal muscle, myoblasts represent the main population of myogenic progenitors. We previously showed that, beside their myogenic differentiation capacities, myoblasts also differentiate towards osteogenic and chondrogenic lineages, some properties generally considered being hallmarks of mesenchymal stem cells (MSCs). MSCs are also characterized by their immunosuppressive potential, through cell-cell contacts and soluble factors, including prostaglandin E-2 (PGE-2), transforming growth factor-β1 (TGF-β1), interleukine-10, or indoleamine 2,3-dioxygenase. We and others also reported that Galectin-1 (Gal-1) and Semaphorin-3A (Sema-3A) were involved in MSCs-mediated immunosuppression. Here, we show that human myoblasts induce a significant and dose-dependant proliferation inhibition, independently of PGE-2 and TGF-β1. Our experiments revealed that myoblasts, in culture or in situ in human muscles, expressed and secreted Gal-1 and Sema-3A. Furthermore, myoblasts immunosuppressive functions were reverted by using blocking antibodies against Gal-1 or Sema-3A. Together, these results demonstrate an unsuspected immunosuppressive effect of myoblasts that may open new therapeutic perspectives

Distributed vs. semi-distributed simulations of snowpack dynamics in alpine areas: case study in the upper Arve catchment, French Alps, 1989–2015

We evaluated distributed and semi-distributed modeling approaches to simulating the spatial and temporal evolution of snow and ice over an extended mountain catchment, using the Crocus snowpack model. The distributed approach simulated the snowpack dynamics on a 250-m grid, enabling inclusion of terrain shadowing effects. The semi-distributed approach simulated the snowpack dynamics for discrete topographic classes characterized by elevation range, aspect, and slope. This provided a categorical simulation that was subsequently spatially re-projected over the 250-m grid used for the distributed simulations. The study area (the upper Arve catchment, western Alps, France) is characterized by complex topography, including steep slopes, an extensive glaciated area, and snow cover throughout the year. Simulations were carried out for the period 1989–2015 using the SAFRAN meteorological forcing system. The simulations were compared using four observation datasets including point snow depth measurements, seasonal and annual glacier surface mass balance, snow covered area evolution based on optical satellite sensors, and the annual equilibrium-line altitude of glacier zones, derived from satellite images. The results showed that in both approaches the Crocus snowpack model effectively reproduced the snowpack distribution over the study period. Slightly better results were obtained using the distributed approach because it included the effects of shadows and terrain characteristics

Are nettle fibers produced on metal-contaminated lands suitable for composite applications?

This work assesses the potential of nettle (Urtica dioica L.) fibers produced on contaminated lands for composite applications. The nettles studied in this work grew spontaneously and in a prevalent manner in poplar short rotation coppice planted for the phytomanagement of a land contaminated by traces of metals. Results show that the contaminant contents in nettle bast fibers are low: only traces were mea-sured. It makes it possible to consider this biomass for material use. The measured matter yield is lower than those obtained with traditional fiber crops cultivated in Europe on agricultural lands but the tensile properties of the bast fibers are equal to or better than those of hemp and flax, making spontaneous nettle an interesting supplement to traditional European fiber crops for composite applications

Native stinging nettle (Urtica dioica L.) growing spontaneously under short rotation coppice for phytomanagement of trace element contaminated soils: Fibre yield, processability and quality

This work assesses the potential of stinging nettle (Urtica dioica L.) growing on trace element contaminated soils to produce fibres for material applications. The nettles studied in this work grew spontaneously and dominated the vegetation cover in poplar short rotation coppices planted for the phytomanagement of lands contaminated by trace elements. Two sites were studied, contaminated by Hg for the first one and a mix of As, Cd, Pb and Zn for the second one. Results show that, for the considered soils, the contaminant contents in nettle bast fibres were at low levels, comparable to those collected at unpolluted control areas. It makes it possible to consider this biomass for material use. The measured matter yield was lower than those obtained with traditional fibre crops cultivated in Europe on agricultural lands. However, the tensile properties of the bast fibres mechanically extracted without field retting or prior alkaline treatment were equal to or better than those of industrial hemp and flax, making spontaneous nettles an interesting supplement to traditional European fibre crops for material applications

An approach for particle sinking velocity measurements in the 3–400 μm size range and considerations on the effect of temperature on sinking rates

The flux of organic particles below the mixed layer is one major pathway of carbon from the surface into the deep ocean. The magnitude of this export flux depends on two major processes—remineralization rates and sinking velocities. Here, we present an efficient method to measure sinking velocities of particles in the size range from approximately 3–400 μm by means of video microscopy (FlowCAM®). The method allows rapid measurement and automated analysis of mixed samples and was tested with polystyrene beads, different phytoplankton species, and sediment trap material. Sinking velocities of polystyrene beads were close to theoretical values calculated from Stokes’ Law. Sinking velocities of the investigated phytoplankton species were in reasonable agreement with published literature values and sinking velocities of material collected in sediment trap increased with particle size. Temperature had a strong effect on sinking velocities due to its influence on seawater viscosity and density. An increase in 9 °C led to a measured increase in sinking velocities of ~40 %. According to this temperature effect, an average temperature increase in 2 °C as projected for the sea surface by the end of this century could increase sinking velocities by about 6 % which might have feedbacks on carbon export into the deep ocean

Carbene-Mediated C-H Bond Functionalization: a Sweet Perspective

International audienc

Functionalization of Sugars by Carberne Insertion: Access to Ketopyranosides of Biological Interest

National audienc

Carbene-mediated functionalization of the anomeric C-H bond of carbohydrates: synthetic developments and mechanistic aspects

National audienc