Quasiparticle tunnelling and field-dependent critical current in 2212-BSCCO

Intrinsic c-axis tunnelling in the superconducting state has been measured in zero and finite fields in small mesa structures fabricated on the surface of 2212-BSCCO single crystals. The temperature dependence of the zero-field critical current and quasi-particle conductance is related to microscopic d-wave models in the presence of impurity scattering. The strong field dependence of the c-axis critical current provides information on the correlation of flux pancakes across adjacent superconducting bi-layers. An instability in the IV characteristics is observed below 20K, which accounts for the apparent drop in critical current at low temperatures previously reported

Intrinsic c-axis transport in 2212-BSCCO

We describe two experimental approaches to circumvent the problem of self-heating in IV measurements on small mesa samples of 2212-BSCCO. Simultaneous dc and temperature measurements have been performed, allowing corrections for heating to be made. Short pulse measurements have also been made, where the IV characteristics and the mesa temperature can be measured on a $\mu$s time-scale enabling intrinsic IV characteristics to be derived, even in the presence of appreciable self-heating. Self-heating leads to an appreciable depression of the apparent energy gap and also accounts, in major part, for the s-shaped characteristics often reported at high currents. By correcting for the temperature rise, we derive the intrinsic temperature dependence of the tunnelling characteristics for crystals with a range of doping. Results are compared with recent theoretical models for c-axis transport in d-wave superconductors

Interlayer tunnelling in Bi2Sr2CaCu2O8+d single crystals

We present measurements of the intrinsic quasi-particle conductivity along the c-axis of 2212-BSCCO single-crystal mesa structures in the superconducting and normal states. Direct measurement of the mesa temperature enables corrections to be made for self-heating and permits the acquisition of reliable I-V characteristics over a wide range of temperatures and voltages. Unlike a conventional superconductor, there is no evidence for any change in the quasiparticle conductivity at Tc, consistent with precursor pairing of electrons in the normal state. At low temperatures the initial low-voltage linear conductivity exhibits a T2 dependence, approaching a limiting value at zero temperature

Photocatalytic CO2 reduction using well-defined metal sites on nanostructured surfaces

Carbon dioxide’s (CO2) presence as a greenhouse gas has increased drastically as industry expands across the globe. The utilization of this waste product as a resource is crucial in completing its carbon cycle with fossil fuels. Unfortunately, CO2 is thermodynamically stable due favorable entropy as a gas and enthalpically stable linear carbonyls. Nature can convert this waste product to a resource via photosynthesis where CO2 is converted into sugars. Metal catalysts have been developed to mimic photosynthesis with promising results in CO2 to fuel conversion by using sunlight as an energy source. Homogeneous catalysts have been studied extensively, but they suffer from poor stability under photochemical conditions. Heterogeneous catalysts also have been previously studied due to their stability and low cost but they lack catalytic efficiency. Promising multi-functional catalysts have been developed recently, but there is a lack of understanding on the mechanism of CO2 reduction for these systems. In Chapter I, an introduction to CO2 reduction is provided along with examples of catalysts that have been studied previously in the literature. Multiple types of catalysts are include homogeneous, heterogeneous and hybrid. Hybrid rhenium (Re) catalysts are discussed as well and further explained in Chapter II, where ligand derivatization and surface linkages are optimized for enhanced CO2 reduction. The effects of structural changes and surface attachment are investigated, and infrared studies demonstrate the importance of ligand derivatization on catalysis. Chapter III investigates a different hybrid system where cobalt macrocycles are deposited onto mesoporous silica surfaces. The photocatalytic properties of different macrocyclic ligands are studied. A conjugated macrocycle is introduced for visible light absorption and steric effect. Additionally, each catalyst was heated to see how the changes in surface conformations affect the selectivity of CO2 reduction. Heterogeneous catalysts are investigated in Chapter IV where cobalt is deposited as an oxide on silica and mesoporous silica surfaces. Macrocyclic ligands are added during photocatalysis to observe possible in situ formation of an active catalytic species. Loadings of cobalt are also varied to study the effect of larger or smaller cobalt sites on the surface. Chapter V expands upon heterogeneous catalysts with Cu and Sn deposited on a commercially available semiconductor, P25 TiO2. Surface CO adsorption is studied via infrared studies to help understand their role in CO2 reduction. Additionally, oxygen vacancies on TiO2 are studied for each sample for their role in the catalytic mechanism

System for fast time-resolved measurements of c-axis quasiparticle conductivity in intrinsic Josephson junctions of 2212-BSCCO

A wide-band cryogenic ampli¯er measurement system for time-resolved 4-point VI-characteristic measurements on Bi2Sr2CaCu2O8+± mesa structures is described. We present measurements which demonstrate the importance of self-heating on » 50 ns time scales. Such heating is likely to have been very signi¯cant in many previously published measurements, where the reported nonlinear VI characteristics have been used to derive superconducting energy gaps

1RXS J232953.9+062814: A Dwarf Nova with a 64-minute Orbital Period and a Conspicuous Secondary Star

We present spectroscopy and time-series photometry of the newly discovered dwarf nova 1RXS J232953.9+062814. Photometry in superoutburst reveals a superhump with a period of 66.06(6) minutes. The low state spectrum shows Balmer and HeI emission on a blue continuum, and in addition shows a rich absorption spectrum of type K4 +- 2. The absorption velocity is modulated sinusoidally at P_orb = 64.176(5) min, with semi-amplitude K = 348(4) km/s. The low-state light curve is double-humped at this period, and phased as expected for ellipsoidal variations. The absorption strength does not vary appreciably around the orbit. The orbital period is shorter than any other cataclysmic variable save for a handful of helium-star systems and V485 Centauri (59 minutes). The secondary is much hotter than main sequence stars of similar mass, but is well-matched by helium-enriched models, indicating that the secondary evolved from a more massive progenitor. A preliminary calculation in which a 1.2 solar-mass star begins mass transfer near the end of H burning matches this system's characteristics remarkably well.Comment: accepted to Astrophysical Journal Letters; 14 pages, 3 eps figures + 1 jpg greyscale figur

Pan-cancer deconvolution of cellular composition identifies molecular correlates of antitumour immunity and checkpoint blockade response

The nature and extent of immune cell infiltration into solid tumours are key determinants of therapeutic response. Here, using a novel DNA methylation-based approach to tumour cell fraction deconvolution, we report the integrated analysis of tumour composition and genomics across a wide spectrum of solid cancers. Initially studying head and neck squamous cell carcinoma, we identify two distinct tumour subgroups: ‘immune hot’ and ‘immune cold’, which display differing prognosis, mutation burden, cytokine signalling, cytolytic activity, and oncogenic driver events. We demonstrate the existence of such tumour subgroups pan-cancer, link clonal-neoantigen burden to hot tumours, and show that transcriptional signatures of hot tumours are selectively engaged in immunotherapy responders. We also find that treatment-naive hot tumours are markedly enriched for known immune-resistance genomic alterations and define a catalogue of novel and known mediators of active antitumour immunity, deriving biomarkers and potential targets for precision immunotherapy

MicroRNA Signatures in Tumor Tissue Related to Angiogenesis in Non-Small Cell Lung Cancer

BACKGROUND: Angiogenesis is regarded as a hallmark in cancer development, and anti-angiogenic treatment is presently used in non-small cell lung cancer (NSCLC) patients. MicroRNAs (miRs) are small non-coding, endogenous, single stranded RNAs that regulate gene expression. In this study we aimed to identify significantly altered miRs related to angiogenesis in NSCLC. METHODS: From a large cohort of 335 NSCLC patients, paraffin-embedded samples from 10 patients with a short disease specific survival (DSS), 10 with a long DSS and 10 normal controls were analyzed. The miRs were quantified by microarray hybridization and selected miRs were validated by real-time qPCR. The impacts of different pathways, including angiogenesis, were evaluated by Gene Set Enrichment Analysis (GSEA) derived from Protein ANalysis THrough Evolutionary Relationship (PANTHER). One of the most interesting candidate markers, miR-155, was validated by in situ hybridization (ISH) in the total cohort (n = 335) and correlation analyses with several well-known angiogenic markers were done. RESULTS: 128 miRs were significantly up- or down-regulated; normal versus long DSS (n = 68) and/or normal versus short DSS (n = 63) and/or long versus short DSS (n = 37). The pathway analysis indicates angiogenesis-related miRs to be involved in NSCLC. There were strong significant correlations between the array hybridization and qPCR validation data. The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r = 0.17, P = 0.002), though most prominent in the subgroup with nodal metastasis (r = 0.34, P<0.001). CONCLUSIONS: Several angiogenesis-related miRs are significantly altered in NSCLC. Further studies to understand their biological functions and explore their clinical relevance are warranted

Sexual Segregation and Flexible Mating Patterns in Temperate Bats

Social structure evolves from a trade-off between the costs and benefits of group-living, which are in turn dependent upon the distribution of key resources such as food and shelter. Males and females, or juveniles and adults, may have different priorities when selecting habitat due to differences in physiological or behavioural imperatives, leading to complex patterns in group composition. We studied social structure and mating behaviour in the insectivorous bat Myotis daubentonii along an altitudinal gradient, combining field studies with molecular genetics. With increasing altitude the proportion of males in summer roosts increased and only males were present in the highest roosts. With increasing altitude environmental temperature decreased, nightly variation in temperature increased, and bat foraging activity decreased, supporting the hypothesis that the harsher, high elevation sites cannot support breeding females. We found that offspring in female-dominated lowland roosts had a very high probability of being fathered by bats caught during autumn swarming at hibernation sites, in contrast to those in intermediate roosts, which had a high probability of being fathered by males sharing the nursery roost with the females. Whilst females normally appear to exclude males from nursery colonies, for those in marginal habitats, one explanation for the presence of males is that the thermoregulatory benefits to the females may outweigh disadvantages, such as competition for food, and give some males an opportunity to increase their breeding success. We suggest that the environment, and its effects on resource distribution, thus determine social structure, which in turn determines the mating pattern that has evolved

Adaptive Evolution of the Myo6 Gene in Old World Fruit Bats (Family: Pteropodidae)

PMCID: PMC3631194This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited