Cavity solitons in vertical-cavity surface-emitting lasers

We investigate a control of the motion of localized structures of light by means of delay feedback in the transverse section of a broad area nonlinear optical system. The delayed feedback is found to induce a spontaneous motion of a solitary localized structure that is stationary and stable in the absence of feedback. We focus our analysis on an experimentally relevant system namely the Vertical-Cavity Surface-Emitting Laser (VCSEL). In the absence of the delay feedback we present experimental evidence of stationary localized structures in a 80 $\mu$m aperture VCSEL. The spontaneous formation of localized structures takes place above the lasing threshold and under optical injection. Then, we consider the effect of the time-delayed optical feedback and investigate analytically the role of the phase of the feedback and the carrier lifetime on the self-mobility properties of the localized structures. We show that these two parameters affect strongly the space time dynamics of two-dimensional localized structures. We derive an analytical formula for the threshold associated with drift instability of localized structures and a normal form equation describing the slow time evolution of the speed of the moving structure.Comment: 7 pages, 5 figure

OMEGAPIX: 3D integrated circuit prototype dedicated to the ATLAS upgrade Super LHC pixel project

In late 2008, an international consortium for development of vertically integrated (3D) readout electronics was created to explore features available from this technology. In this paper, the OMEGAPIX circuit is presented. It is the first front-end ASIC prototype designed at LAL in 3D technology. It has been submitted on May 2009. At first, a short reminder of 3D technology is presented. Then the IC design is explained: analogue tier, digital tier and testability

Theoretical and experimental study of polarization switching in longwavelength VCSELs subject to parallel optical injection

We report a theoretical and experimental analysis of the polarization switching found in a single-transverse mode VCSEL when subject to parallel optical injection. We have found a novel situation in which injection locking of the parallel polarization and excitation of the free-running orthogonal polarization of the VCSEL are simultaneously obtained. Analytical expressions for the power of both linear polarizations in the previous steady state are determined. We show that considering two linear polarization modes in a model of a VCSEL subject to parallel optical injection leads to simpler expressions than those found for a VCSEL with only a single linear polarization. We show that the power emitted in both linear polarizations depend linearly on the injected power. The stability region of this solution is measured in the plane injected power versus frequency detuning.This work has been funded by the Ministerio de Economía y Competitividad, Spain under project TEC2015-65212-C3-1-P and cofinanced by FEDER funds

Duplications of the critical Rubinstein-Taybi deletion region on chromosome 16p13.3 cause a novel recognisable syndrome

Background The introduction of molecular karyotyping technologies facilitated the identification of specific genetic disorders associated with imbalances of certain genomic regions. A detailed phenotypic delineation of interstitial 16p13.3 duplications is hampered by the scarcity of such patients. Objectives To delineate the phenotypic spectrum associated with interstitial 16p13.3 duplications, and perform a genotype-phenotype analysis. Results The present report describes the genotypic and phenotypic delineation of nine submicroscopic interstitial 16p13.3 duplications. The critically duplicated region encompasses a single gene, CREBBP, which is mutated or deleted in Rubinstein-Taybi syndrome. In 10 out of the 12 hitherto described probands, the duplication arose de novo. Conclusions Interstitial 16p13.3 duplications have a recognizable phenotype, characterized by normal to moderately retarded mental development, normal growth, mild arthrogryposis, frequently small and proximally implanted thumbs and characteristic facial features. Occasionally, developmental defects of the heart, genitalia, palate or the eyes are observed. The frequent de novo occurrence of 16p13.3 duplications demonstrates the reduced reproductive fitness associated with this genotype. Inheritance of the duplication from a clinically normal parent in two cases indicates that the associated phenotype is incompletely penetrant

A progress report of the IFCC Committee for Standardization of Thyroid Function Tests

BACKGROUND: The IFCC Committee for Standardization of Thyroid Function Tests aims at equivalence of laboratory test results for free thyroxine (FT4) and thyrotropin (TSH). OBJECTIVES: This report describes the phase III method comparison study with clinical samples representing a broad spectrum of thyroid disease. The objective was to expand the feasibility work and explore the impact of standardization/harmonization in the clinically relevant concentration range. METHODS: Two sets of serum samples (74 for FT4, 94 for TSH) were obtained in a clinical setting. Eight manufacturers participated in the study (with 13 FT4 and 14 TSH assays). Targets for FT4 were set by the international conventional reference measurement procedure of the IFCC; those for TSH were based on the all-procedure trimmed mean. The manufacturers recalibrated their assays against these targets. RESULTS: All FT4 assays were negatively biased in the mid- to high concentration range, with a maximum interassay discrepancy of approximately 30%. However, in the low range, the maximum deviation was approximately 90%. For TSH, interassay comparability was reasonable in the mid-concentration range, but worse in the pathophysiological ranges. Recalibration was able to eliminate the interassay differences, so that the remaining dispersion of the data was nearly entirely due to within-assay random error components. The impact of recalibration on the numerical results was particularly high for FT4. CONCLUSIONS: Standardization and harmonization of FT4 and TSH measurements is feasible from a technical point of view. Because of the impact on the numerical values, the implementation needs careful preparation with the stakeholders

Deterministic polarization chaos from a laser diode

Fifty years after the invention of the laser diode and fourty years after the report of the butterfly effect - i.e. the unpredictability of deterministic chaos, it is said that a laser diode behaves like a damped nonlinear oscillator. Hence no chaos can be generated unless with additional forcing or parameter modulation. Here we report the first counter-example of a free-running laser diode generating chaos. The underlying physics is a nonlinear coupling between two elliptically polarized modes in a vertical-cavity surface-emitting laser. We identify chaos in experimental time-series and show theoretically the bifurcations leading to single- and double-scroll attractors with characteristics similar to Lorenz chaos. The reported polarization chaos resembles at first sight a noise-driven mode hopping but shows opposite statistical properties. Our findings open up new research areas that combine the high speed performances of microcavity lasers with controllable and integrated sources of optical chaos.Comment: 13 pages, 5 figure

Необъяснимая боль после тотального эндопротезирования коленного сустава

Although total knee arthroplasty (TKA) improves function and reduces pain for the large majority of the patients, a few continue to have pain and require investigation. The causes of dysfunction and pain after total knee arthroplasty can be described as intrinsic (intra-articular) or extrinsic (extra-articular) sources of pain. For the majority of the cases, following a complete evaluation protocol, the cause of pain can be identified and a specific treatment can be applied, however occasionally there remains a group of patients with unexplained pain whose management is difficult. It was our hypothesis that revising a TKA without pre-operative diagnosis of the failure is not worth. Therefore, the aimed of this review was to: 1) analyse the results of revision TKA for unexplained pain, and 2) described the potential solutions for an alternative conservative management of the painful TKA.Несмотря на то, что тотальная артропластика коленного сустава приводит к улучшению функции и уменьшению болевого синдрома у подавляющего большинства пациентов, ряд больных после операции продолжают испытывать болевые ощущения. Причины боли и нарушения функции после эндопротезирования могут быть обусловлены как внутрисуставными, так внесуставными факторами. Системный подход к обследованию таких пациентов чаще всего позволяет установить источник боли и провести соответствующее лечение. Тем не менее, существует небольшая группа пациентов с необъяснимой болью, лечение которых является крайне сложной клинической задачей. Нами выдвинута гипотеза, что без четкого понимания причины неудачи первичного вмешательства проведение ревизионного эндопротезирования таким пациентам не показано. В данном обзоре литературы проведён анализ результатов реэндопротезированя коленного сустава, выполненных пациентам с необъяснимой болью и описаны возможные варианты консервативных подходов к лечению этой категории больных