5 research outputs found
Speelveld en strijdtoneel
REDE uitgesproken bij de openbare aanvaarding van het ambt van gewoon hoogleraar in de dermatologie en venerologie aan de faculteit der geneeskunde aan de Erasmus Universiteit Rotterdam op woensdag 25 mei 198
Estrogen-Containing Oral Contraceptives Are Associated With Polycystic Liver Disease Severity in Premenopausal Patients
The association between estrogen-containing oral contraceptives and history of pregnancies with disease severity in women with polycystic liver disease (PLD) is unclear. We performed a cross-sectional cohort study to assess this association by selecting female patients with PLD of which imaging was available prior to any liver volume-reducing therapy. Patients received a questionnaire to collect detailed information on estrogen use and pregnancies. Preplanned subgroup analyses were performed on premenopausal and postmenopausal patients. The questionnaire was returned by 287 of 360 selected patients (80%). There was no significant association between estrogen-containing oral contraceptives and height-adjusted total liver volume (hTLV) in the total group (PÂ =Â 0.06) and postmenopausal subgroup (PÂ =Â 0.7). By contrast, each year of exposure corresponds with a 1.45% higher hTLV (PÂ =Â 0.02) in the premenopausal subgroup, equivalent to a 15.5% higher hTLV for every 10Â years of use. Pregnancy duration was not associated with hTLV. In conclusion, patients with PLD should avoid exogenous estrogens.status: publishe