First experience in operating the population of the condition databases for the CMS experiment

Reliable population of the condition databases is critical for the correct operation of the online selection as well as of the offline reconstruction and analysis of data. We will describe here the system put in place in the CMS experiment to populate the database and make condition data promptly available both online for the high-level trigger and offline for reconstruction. The system, designed for high flexibility to cope with very different data sources, uses POOL-ORA technology in order to store data in an object format that best matches the object oriented paradigm for \texttt{C++} programming language used in the CMS offline software. In order to ensure consistency among the various subdetectors, a dedicated package, PopCon (Populator of Condition Objects), is used to store data online. The data are then automatically streamed to the offline database hence immediately accessible offline worldwide. This mechanism was intensively used during 2008 in the test-runs with cosmic rays. The experience of this first months of operation will be discussed in detail.Comment: 15 pages, submitter to JOP, CHEP0

Medicines information and adherence in HIV/AIDS patients

Background: Providing written medicines information is being legislated in an increasing number of countries worldwide, with the patient information leaflet (PIL) being the most widely used method for conveying health information. The impact of providing such information on adherence to therapy is reportedly unpredictable. Therapy for human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) and related opportunistic infections usually involves polytherapy and complex regimens, both of which are risk factors for non-adherence. The objective of this study was to assess the impact of medicines information on adherence to chronic co-trimoxazole therapy in low-literate HIV/AIDS patients. Methods: Two different PILs were designed for co-trimoxazole tablets and were available in both English and isiXhosa. Participants were randomly allocated to a control group (receiving no PIL), group A (receiving a 'complex PIL') and group B (receiving a 'simple PIL' incorporating pictograms). At the first interview, demographic data were collected and the time, date and day that the participant would take his/her first tablet of the month's course was also documented. In a follow-up interview adherence to therapy was assessed using two methods; self-report and tablet count. Results: The medicines information materials incorporating simple text and pictograms resulted in significantly improved adherence to therapy in the short term, whereas a non-significant increase in adherence was associated with the availability of the more complex information. This was shown by both the self-reported assessment as well as the tablet count. Conclusion: This research suggests that appropriately designed written material can have a positive impact in improving adherence and, together with verbal consultation, are essential for enabling patients to make appropriate decisions about their medicine taking

Unicore — From project results to production grids

The UNICORE Grid-technology provides a seamless, secure and intuitive access to distributed Grid resources. In this paper we present the recent evolution from project results to production Grids. At the beginning UNICORE was developed as a prototype software in two projects funded by the German research ministry (BMBF). Over the following years, in various European-funded projects, UNICORE evolved to a full-grown and well-tested Grid middleware system, which today is used in daily production at many supercomputing centers worldwide. Beyond this production usage, the UNICORE technology serves as a solid basis in many European and International research projects, which use existing UNICORE components to implement advanced features, high level services, and support for applications from a growing range of domains. In order to foster these ongoing developments, UNICORE is available as open source under BSD licence at SourceForge, where new releases are published on a regular basis. This paper is a review of the UNICORE achievements so far and gives a glimpse on the UNICORE roadmap.Comment: 21 pages, 3 figure