Trapping x‐ray radiation damage from homolytic Se–C bond cleavage in BnSeSeBn crystals (Bn=benzyl, CH2C6H5)

Irradiation of dibenzyl diselenide BnSeSeBn with X-ray or UV-light cleaves the Se-C and the Se-Se bonds, inducing stable and metastable radical states. They are inevitably important to all natural and life sciences. Structural changes due to X-ray-induced Se-C bond-cleavage could be pin-pointed in various high-resolution X-ray diffraction experiments for the first time. Extended DFT methods were applied to characterize the solid-state structure and support the refinement of the observed residuals as contributions from the BnSeSe • radical species. The X-ray or UV-irradiated crystalline samples of BnSeSeBn were characterized by solid-state EPR. This paper provides insight that in the course of X-ray structure analysis of selenium compounds not only organo-selenide radicals like RSe • may occur, but also organo diselenide BnSeSe • radicals and organic radicals R • are generated, particularly important to know in structural biology

Trends and Regional Differences in Breastfeeding in Germany From 1871 To 1937

This article describes trends and regional differences in breastfeeding within Germany from 1870 to 1937. Sharp regional differences in both the in cidence and duration of breastfeeding are present around 1910. There is a com plex pattern of trends in infant-feeding practices. Breastfeeding declined in urban areas between the late nineteenth century and the first World War. A strong nationwide resurgence in the incidence of breastfeeding occurred between the two world wars, accompanied by a decline in the average duration of breastfeeding. By 1937, the formerly great regional differences in breastfeeding had nearly dis appeared. The article also discusses social, economic, cultural, and historical variables affecting infant-feeding practices, including local breastfeeding customs, a national infant welfare campaign, and allowances to nursing mothers.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67272/2/10.1177_036319908501000203.pd

Communicative competence as a basis for the creative interaction of the professional (vocational-technical) education institution's subjects: the special course for the audience members of the advanced training classes of professional education administra

Матеріали спецкурсу присвячено проблемі комунікативної компетентності керівників, новопризначених керівників та педагогічних працівників обласних навчально-(науково)-методичних центрів (кабінетів), закладів професійної (професійно-технічної) освіти для удосконалення власного досвіду та педагогічної майстерності. Зміст спецкурсу спрямовано на розвиток комунікативної взаємодії суб’єктів освітнього процесу, професійно-особистісного розвитку педагогічних кадрів. Спецкурс підготовлений для слухачів курсів підвищення кваліфікації керівних та педагогічних кадрів професійної (професійно-технічної) освіти у Центральному інституті післядипломної освіти ДВНЗ «Університет менеджменту освіти».The materials of special course are devoted to the problem of communicative competence of managers, newly appointed managers and pedagogical workers of regional educational (scientific) -methodic centers (offices), institutions of professional (vocational-technical) education for improving their own experience and pedagogical skills. The content of the special course aims to develop the communicative interaction between the subjects of the educational process, professional and personal development of teaching staff. The special course has been developed for management and pedagogical staff of vocational (vocational-technical) education refresher training at the Central Institute of Postgraduate Education "University of Education Management"

A História da Alimentação: balizas historiográficas

Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domínio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crítico da historiografia brasileira sobre o tema

Consolidated data modeling of health services research data with the entity-attribute-value model and data vault

Distributed and heterogeneous data must be integrated for health services research in a way, which is open to new requirements and easily expandable for new data sources. For data integration in the health services research domain, mainly data warehouses have been used that model data either as a dimensional or an entity-attribute-value (EAV) model. However, these data models are either not flexible enough or lack data management capabilities, which makes longitudinal data analyses more difficult. We have extended the EAV approach with data vault modelling and hereby modelled the data structures of the hospital quality reports by the Gemeinsamer Bundesauschuss (G-BA) and integrated data from the years 2011 to 2015 accordingly. This makes it possible to historicise metadata of features, in particular those of quality indicators, and establishes a high degree of extensibility towards new heterogeneous data sources. The proposed approach allows a free selection of the abstraction level for the entities to be modelled, so that a completely generic EAV model with historicised metadata can be created.Für die Versorgungsforschung ist wichtig, dass verteilte und heterogene Daten so integriert werden, dass sie offen für neue Analyse-Anforderungen und leicht um neue Datenquellen erweiterbar sind. Für die Integration von Versorgungsdaten werden bislang hauptsächlich Data-Warehouses eingesetzt, die Daten dimensional oder als Entity-Attribute-Value-Struktur (EAV) modellieren. Diese Datenmodelle sind jedoch entweder unflexibel oder weisen ein zu geringes Maß an Datenorganisation auf, was longitudinale Analysen erschwert. Wir haben den EAV-Ansatz um die Data-Vault-Modellierung ergänzt und damit die Datenstrukturen der Krankenhaus-Qualitätsberichte des Gemeinsamen Bundesausschusses (G-BA) modelliert sowie die Daten der Jahre 2011 bis 2015 integriert. Dies ermöglicht eine Historisierung der Metadaten für Merkmale, insbesondere der Qualitätsindikatoren, sowie ein hohes Maß an Erweiterbarkeit gegenüber neuen heterogenen Datenquellen. Der vorgeschlagene Ansatz erlaubt es, den Abstraktionsgrad für die zu modellierenden Entitäten frei zu wählen, so dass auch ein vollständig generisches EAV-Modell mit historisierten Metadaten erstellt werden kann

Business informatics and medical informatics - what are the foundations of these disciplines and how are they related?

Business informatics and medical informatics adopt and adapt methods and knowledge from computer science and further develop appropriate methods for the particular needs in their application domains. A panel discussion at the 2018 conference of the German Society for Medical Informatics, Biometry and Epidemiology (GMDS) analyzed the relationship between business informatics, medical informatics and computer science. Five questions guided the discussion: What are the basic goals of these disciplines? To what extent does practical application of results shape the disciplines? Do medicine and economy demand for particular methods in informatics and computer science? How important is foundation by theory and evidence? Can the disciplines learn from each other? The analysis made clear that business informatics, medical informatics and computer science would gain profit from a more systematic mutual exchange. The "Learning Healthcare System" could provide a useful framework.Wirtschaftsinformatik und Medizinische Informatik gehören zu den sogenannten Bindestrich-Informatik-Fächern, die sich mit der Anwendung der Methoden und Erkenntnisse der Informatik, aber auch mit der Weiterentwicklung solcher Methoden und Erkenntnisse für gewisse Anwendungsgebiete befassen. Auf einer Podiumsdiskussion der Jahrestagung 2018 der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS) wurde für Wirtschaftsinformatik, Medizinische Informatik und Informatik analysiert wie sie zueinander stehen. Die Analyse erfolgte anhand von fünf Fragen: Welche grundlegenden Ziele bestimmen die jeweilige wissenschaftliche Arbeit? Wie ist der Praxisbezug ausgeprägt? Inwieweit sind Besonderheiten von Medizin bzw. Ökonomie prägend für die jeweilige wissenschaftliche Arbeit? Welche Rolle spielen Theoriefundierung und Evidenz? Was können Wirtschaftsinformatik und Informatik von Medizinischer Informatik und Medizin lernen - und umgekehrt? Die Analyse zeigt, dass die drei Disziplinen von einem systematischen wechselseitigen Austausch profitieren können. Das "Lernende Gesundheitssystem" bietet Ansätze für einen entsprechenden Rahmen