Sedimentology and fluvial styles of the uppermost Cretaceous continental deposits of the Austral-Magallanes Basin, Patagonia, Argentina

The sedimentary infill of the Austral-Magallanes Basin since the onset of its foreland stage in the Lago Argentino region is dominated by deep-marine and coastal deposits. However, during the Late Cretaceous the basin accumulated a thick and poorly known continental sedimentary succession, which has received different lithostratigraphic names. The aim of this work is to characterize the here defined Uppermost Cretaceous Continental Deposits (UCCD) from a detailed facies and architectural analysis, as well as the resulting stacking pattern. Seven Facies Associations (FAs) were discriminated in order to define the sedimentary paleoenvironments: FA1, gravelly sheet bodies; FA2, tabular bodies of conglomerates with mud rip-up clasts; FA3, complex tabular sandy bodies; FA4, simple tabular sandy bodies; FA5, tabular bodies of structureless sandstones; FA6, heterolithic deposits; and FA7, fine-grained deposits. Three different fluvial styles were recognized: meandering systems dominated by avulsion and meander abandonment processes (fluvial style a), braided systems (fluvial style b), and meandering systems dominated by overbank flood processes (fluvial style c). The stacking pattern of the FAs allowed to divide the UCCD into two major depositional stages related to the accommodation space vs sediment supply (A/S) ratio. Stage I is characterized by the alternation of fluvial styles a and b, while the Stage II is represented by the alternation of fluvial styles c and b, and the Stage III is characterized entirely by fluvial style c deposits. Although the UCCD are considered as a whole within a framework of low A/S ratio, several high frequency variations were recognized. The Stage I records seven high frequency intervals of which four are characterized by high A/S ratio interrupted by three events of low A/S. While the stage II is represented by six high frequency periods of low A/S ratio and other five high frequency events of high A/S ratio. The Stage II is considered as deposited in a relative higher A/S context in comparison with the Stage I, based on the behavior of the moderate to high sinuosity meander fluvial systems. Finally, the Stage III is represented entirely by a high frequency low A/S ratio event.Fil: Tettamanti, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; ArgentinaFil: Moyano Paz, Damián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; ArgentinaFil: Varela, Augusto Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; Argentina. YPF - Tecnología; ArgentinaFil: Tineo, David. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; ArgentinaFil: Gómez Peral, Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; ArgentinaFil: Poire, Daniel Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; ArgentinaFil: Cereceda, Abril. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; ArgentinaFil: Odino Barreto, Andrea Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; Argentin

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes nuclear and mitochondrial DNA damage, denaturation of intracellular proteins, lipid peroxidation and inflammation. Oxidative or nitrosative stress-mediated injury lead to cardiomyocytes apoptosis or necrosis. The reactive oxygen (ROS) and nitrogen species (RNS) concentration is dependent on their production and on the expression and activity of anti-oxidant enzymes. Polyphenols are a large group of natural compounds ubiquitously expressed in plants, and epidemiological studies have shown associations between a diet rich in polyphenols and the prevention of various ROS-mediated human diseases. Polyphenols reduce cardiomyocytes damage, necrosis, apoptosis, infarct size and improve cardiac function by decreasing oxidative stress-induced production of ROS or RNS. These effects are achieved by the ability of polyphenols to modulate the expression and activity of anti-oxidant enzymes and several signaling pathways involved in cells survival. This report reviews current knowledge on the potential anti-oxidative effects of polyphenols to control the cardiotoxicity induced by ROS and RNS stress

Curaduría de arte y nuevos medios. Tendencias en la exhibición y uso de tecnología electrónica en la curaduría del arte

Esta investigación tuvo como objetivo analizar la inclusión de tecnología en muestras artísticas e instituciones museísticas en el ámbito local e internacional durante los últimos años. La exhibición de Tomás Saraceno “¿Cómo atrapar el universo en una telaraña?” (MAMBA, 2017-18); “Rapsodia Inconclusa”, el envío de Nicola Costantino a la Bienal de Venecia de 2013; El problema del caballo, de Claudia Fontes, representante argentina en la Bienal de Venecia de 2017; la obra Millions de Jorge Caterbetti en el Museo Evita; la muestra del Premio ITAU 2017 en la Casa Nacional del Bicentenario, y a nivel internacional espacios como Atelier des Lumieres (París), MORI Digital Art Museum (Tokio); eventos como Modigliani VR en la TATE (Londres), The Wrong Biennale (online), y aplicaciones en museos como ASK del Brooklyn Museum, o First Look: Artists’ VR del New Museum, entre otros.Además del análisis de estos casos, los investigadores han escrito un artículo teórico sobre la utilización de nuevos medios tecnológicos en la curaduría de arte contemporáneo utilizando los conceptos de pos y trans humanismo. Vinculado a este campo de estudio, durante el primer cuatrimestre de la Maestría en Curaduría de Arte Contemporáneo, se brindó un Seminario optativo sobre Artes Electrónicas, que contribuyó a la reflexión del presente proyecto aportando nuevas referencias teóricas de obras y exposiciones con tecnología. Se entiende que, al ser un campo en expansión y modificación permanente, es muy difícil lograr un perfil acabado con definiciones cerradas y absolutas. No obstante, se logró dar cuenta de un aspecto cada vez más consolidado en la curaduría de arte contemporáneo, generado a partir de la inclusión de nuevas tecnologías en las propuestas artísticas y de diseño curatorial, que constituye un conocimiento fundamental para un curador en la actualidad. Se presentarán, en el transcurso del corriente año, los resultados de la investigación en jornadas, congresos y publicacione

New advances in leukaemia immunotherapy by the use of Chimeric Artificial Antigen Receptors (CARs): state of the art and perspectives for the near future

Leukaemia immunotherapy represents a fascinating and promising field of translational research, particularly as an integrative approach of bone marrow transplantation. Adoptive immunotherapy by the use of donor-derived expanded leukaemia-specific T cells has showed some kind of clinical response, but the major advance is nowadays represented by gene manipulation of donor immune cells, so that they acquire strict specificity towards the tumour target and potent lytic activity, followed by significant proliferation, increased survival and possibly anti-tumour memory state. This is achieved by gene insertion of Chimeric T-cell Antigen Receptors (CARs), which are artificial molecules containing antibody-derived fragments (to bind the specific target), joined with potent signalling T-Cell Receptor (TCR)-derived domains that activate the manipulated cells. This review will discuss the main application of this approach particularly focusing on the paediatric setting, raising advantages and disadvantages and discussing relevant perspectives of use in the nearest future

Sedimentology of the shallow marine deposits of the Calafate Formation during the Maastrichtian transgression at Lago Argentino, Austral-Magallanes basin, Argentina

The Maastrichtian shallow marine deposits exposed at the south margin of the Lago Argentino within the Austral-Magallanes Basin are known as the Calafate Formation. In order to interpret the depositional systems and reconstruct the sequence stratigraphic architecture for this unit at its type locality (Cerro Calafate), we acquire new data from seven stratigraphic sections. We recognized six facies associations (FA-1 to FA-6) corresponding to shallow marine deposits, which are organized vertically displaying a transition from shallower to deeper conditions, representing a ~90 m thick transgressive succession. The Calafate Formation deposits are differentiated into a lower wave-dominated coast (FA1, FA2 and FA3) and an upper tide-dominated coast (FA4, FA5 and FA6), each marked by the dominance of wave and tidal sedimentary processes, respectively. The Calafate Formation overlies the fluvial deposits of the Chorrillo Formation by a transgressive surface (TS), which is overlaid by a transgressive marine succession characterized by a retrogradational stacking pattern. The latter is finally covered by offshore transition marine deposits marking a progressive deepening of the depositional system that culminates with the maximum flooding surface (MFS). From here, an aggradational stacking pattern dominates the upper sandstones of the unit representing the highstand systems tract (HST), which is interpreted to be the cause of short-term periods when the accommodation space rate was nearly equaled to the sediment supply rate during the Maastrichtian.Centro de Investigaciones Geológica

Sedimentology of the shallow marine deposits of the Calafate Formation during the Maastrichtian transgression at Lago Argentino, Austral-Magallanes basin, Argentina

The Maastrichtian shallow marine deposits exposed at the south margin of the Lago Argentino within the Austral-Magallanes Basin are known as the Calafate Formation. In order to interpret the depositional systems and reconstruct the sequence stratigraphic architecture for this unit at its type locality (Cerro Calafate), we acquire new data from seven stratigraphic sections. We recognized six facies associations (FA-1 to FA-6) corresponding to shallow marine deposits, which are organized vertically displaying a transition from shallower to deeper conditions, representing a ~90 m thick transgressive succession. The Calafate Formation deposits are differentiated into a lower wave-dominated coast (FA1, FA2 and FA3) and an upper tide-dominated coast (FA4, FA5 and FA6), each marked by the dominance of wave and tidal sedimentary processes, respectively. The Calafate Formation overlies the fluvial deposits of the Chorrillo Formation by a transgressive surface (TS), which is overlaid by a transgressive marine succession characterized by a retrogradational stacking pattern. The latter is finally covered by offshore transition marine deposits marking a progressive deepening of the depositional system that culminates with the maximum flooding surface (MFS). From here, an aggradational stacking pattern dominates the upper sandstones of the unit representing the highstand systems tract (HST), which is interpreted to be the cause of short-term periods when the accommodation space rate was nearly equaled to the sediment supply rate during the Maastrichtian.Centro de Investigaciones Geológica

Sedimentology of the shallow marine deposits of the Calafate Formation during the Maastrichtian transgression at Lago Argentino, Austral-Magallanes basin, Argentina

The Maastrichtian shallow marine deposits exposed at the south margin of the Lago Argentino within the Austral-Magallanes Basin are known as the Calafate Formation. In order to interpret the depositional systems and reconstruct the sequence stratigraphic architecture for this unit at its type locality (Cerro Calafate), we acquire new data from seven stratigraphic sections. We recognized six facies associations (FA-1 to FA-6) corresponding to shallow marine deposits, which are organized vertically displaying a transition from shallower to deeper conditions, representing a ~90 m thick transgressive succession. The Calafate Formation deposits are differentiated into a lower wave-dominated coast (FA1, FA2 and FA3) and an upper tide-dominated coast (FA4, FA5 and FA6), each marked by the dominance of wave and tidal sedimentary processes, respectively. The Calafate Formation overlies the fluvial deposits of the Chorrillo Formation by a transgressive surface (TS), which is overlaid by a transgressive marine succession characterized by a retrogradational stacking pattern. The latter is finally covered by offshore transition marine deposits marking a progressive deepening of the depositional system that culminates with the maximum flooding surface (MFS). From here, an aggradational stacking pattern dominates the upper sandstones of the unit representing the highstand systems tract (HST), which is interpreted to be the cause of short-term periods when the accommodation space rate was nearly equaled to the sediment supply rate during the Maastrichtian.Centro de Investigaciones Geológica

Action observation and motor imagery in performance of complex movements: Evidence from EEG and kinematics analysis

Motor imagery (MI) and action observation (AO) are considered effective cognitive tools for motor learning, but little work directly compared their cortical activation correlate in relation with subsequent performance. We compared AO and MI in promoting early learning of a complex four-limb, hand?foot coordination task, using electroencephalographic (EEG) and kinematic analysis. Thirty healthy subjects were randomly assigned into three groups to perform a training period in which AO watched a video of the task, MI had to imagine it, and Control (C) was involved in a distracting computation task. Subjects were then asked to actually perform the motor task with kinematic measurement of error time with respect to the correct motor performance. EEG was recorded during baseline, training and task execution, with task-related power (TRPow) calculation for sensorimotor (alpha and beta) rhythms reactive with respect to rest. During training, the AO group had a stronger alpha desynchronization than the MI and C over frontocentral and bilateral parietal areas. However, during task execution, AO group had greater beta synchronization over bilateral parietal regions than MI and C groups. This beta synchrony furthermore demonstrated the strongest association with kinematic errors, which was also significantly lower in AO than in MI. These data suggest that sensorimotor activation elicited by action observation enhanced motor learning according to motor performance, corresponding to a more efficient activation of cortical resources during task execution. Action observation may be more effective than motor imagery in promoting early learning of a new complex coordination task

Rehabilitation of COVID-19 patients

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Cambios en el uso del suelo entre agricultura y ganadería en un establecimiento típico en General Pinto, pradera pampeana, Argentina, analizado con programación lineal

Ras, Cristina Helena. Universidad de Buenos Aires. Facultad de Agronomía. Buenos Aires, Argentina.Marra, Rita María Andrea. Universidad de Buenos Aires. Facultad de Agronomía. Buenos Aires, Argentina.Abram Tettamanti, María Florencia. Universidad de Buenos Aires. Facultad de Agronomía. Buenos Aires, Argentina.151-163General Pinto, igual que otras zonas de la pampa argentina, en los 90, incorporó la siembra directa como herramienta para la producción agrícola, permitiendo una gran expansión de superficie dedicada a cultivos anuales. Este proceso afectó la actividad de engorde bovino reduciendo notablemente la superficie dedicada a la misma. Actualmente, las mejoras en las relaciones de los precios y las tecnologías de producción ganadera cambiaron esta situación incentivando a los productores a reincorporar pasturas para la terminación de novillos en algunas tierras. Este trabajo analiza, mediante programación lineal, la integración agrícola-ganadera de los establecimientos de esta zona y concluye que la optimización del resultado económico teórico se logra aumentando la superficie dedicada a ganadería. Las limitantes para volver a los sistemas de producción ganaderos son; las restricciones financieras, las infraestructuras ganaderas deterioradas por el desuso, la falta de entrenamiento adecuado del personal y las exigencias de gerenciamiento adicional que estos sistemas requieren