The Toxicity of plant material, Drimia Altissima (Urginea Altissima), Against the Field Rat, Arvicanthis Abyssinicus: A potential non-synthetic rodenticide

Background: Rodents are important pests of public health and agricultural importance, capable of transmitting diseases to humans and causing crop damage. The present rodent control strategy depends primarily on synthetic rodenticides, which are highly toxic, affect non-target species, and are expensive. Naturally produced organic pesticides may be more desirable as they are less toxic to non-target animals and are  economically sustainable.Objective: The objective of the study is to explore the toxicity and palatability of the bulbs of Drimia altissima against the field rat, Arvicanthis abyssincus with the aim of developing locally based organic rodenticides.Method: This is a laboratory study for evaluating the toxicity of D. altissimia bait against the field rat, Arvicanthis abyssincus. In the study, field rats were randomly assigned to treatment and control groups. The treatment groups received different concentrations of D. altissimia poison bait prepared in the lab. The control groups received the plain bait. Mortality was recorded during the test period.Results: Of the treatment groups, 80%-100% of the rats receiving the poison bait died, while none of the rats offered a choice between the plain bait and the poisoned bait died. It is estimated that 8% of the powdered bulb would produce 50% mortality.Conclusion: The powdered bulb of D. altissima resulted in rat mortality in the test but not in the control group. The liberation of the toxic substance from the poisoned bait might have been slowed by the presence of the plain bait in the choice test. The result of this study suggests that further work is needed for understanding the toxicological properties of the active agents in the bulb

A multiple-imputation-based approach to sensitivity analyses and effectiveness assessments in longitudinal clinical trials.

It is important to understand the effects of a drug as actually taken (effectiveness) and when taken as directed (efficacy). The primary objective of this investigation was to assess the statistical performance of a method referred to as placebo multiple imputation (pMI) as an estimator of effectiveness and as a worst reasonable case sensitivity analysis in assessing efficacy. The pMI method assumes the statistical behavior of placebo- and drug-treated patients after dropout is the statistical behavior of placebo-treated patients. Thus, in the effectiveness context, pMI assumes no pharmacological benefit of the drug after dropout. In the efficacy context, pMI is a specific form of a missing not at random analysis expected to yield a conservative estimate of efficacy. In a simulation study with 18 scenarios, the pMI approach generally provided unbiased estimates of effectiveness and conservative estimates of efficacy. However, the confidence interval coverage was consistently greater than the nominal coverage rate. In contrast, last and baseline observation carried forward (LOCF and BOCF) were conservative in some scenarios and anti-conservative in others with respect to efficacy and effectiveness. As expected, direct likelihood (DL) and standard multiple imputation (MI) yielded unbiased estimates of efficacy and tended to overestimate effectiveness in those scenarios where a drug effect existed. However, in scenarios with no drug effect, and therefore where the true values for both efficacy and effectiveness were zero, DL and MI yielded unbiased estimates of efficacy and effectiveness

Empowerment and Tech Adoption: Introducing the Treadle Pump Triggers Farmers’ Innovation in Eastern Ethiopia

In 2013, thirty-eight treadle pumps (TPs) were installed as low-cost technology introduction for small-scale irrigation in eastern Ethiopia. This pilot project also trained six farmers on tube well excavation, as well as the installation and maintenance of pumps. In June 2015, researchers visited nine of the thirty-eight TP villages and found only two TPs functioning as originally installed. The rest were replaced with a new technology developed by the trained farmers. Farmers, empowered by training, gained more control in developing technology options tailored to local needs and conditions of their communities. Adopters of the new technology stated that the limited water output and high labor demand of the conventional TP did not optimally fulfil their irrigation water requirements. The new technology had spread quickly to more than one hundred households due to three key factors. First, farmers’ innovative modifications of the initial excavation technique addressed the discharge limitations of the conventional TP by excavating boreholes with wider diameter. Second, local ownership of the new technology, including skills used in well drilling and manufacturing excavation implements, made the modified irrigation technology affordable and accessible to the majority of households. Third, this innovation spread organically without any external support, confirming its sustainability

Photoperiod-dependent developmental reprogramming of the transcriptional response to seawater entry in Atlantic salmon (Salmo salar)

Acknowledgments We would like to extend our thanks the skilled employees at TARS, and to Dr. Chandra S. Ravuri who assisted with sample processing. Funding We thank The Research Council of Norway for funding (project number 241016).Peer reviewedPublisher PD

EC11-101 Spring Seed Guide

Welcome to the 2011 Spring Seed Guide. Corn, soybean, sorghum, and alfalfa are included in this seed guide. This circular is a progress report of variety trials conducted by personnel of the Agronomy Department, West Central, and Northeast Extension Centers, and their associated agricultural laboratories and the associates of the University of Wyoming at SAREC

Goltz syndrome (focal dermal hypoplasia) with unilateral ocular, cutaneous and skeletal features: case report

<p>Abstract</p> <p>Background</p> <p>Goltz syndrome or focal dermal hypoplasia (FDH) is an uncommon multisystem disorder. Herein, we report a typical case of FDH with unilateral ocular, cutaneous and skeletal features.</p> <p>Case Presentation</p> <p>a 4-year-old girl presented with microphthalmos and iris coloboma of the left eye, facial asymmetry, and a low-set protruding ear. Cutaneous changes included hypopigmented atrophic macules on the left side of the face, chest, abdomen and limbs. Characteristic lobster claw deformity of left hand and oligodactyly and syndactyly of left foot were present.</p> <p>Conclusions</p> <p>FDH usually affects both sides of the body. This case represents the unusual unilateral manifestation of the syndrome.</p

Patterns of domestication in the Ethiopian oil-seed crop noug (Guizotia abyssinica)

Noug (Guizotia abyssinica) is a semidomesticated oil-seed crop, which is primarily cultivated in Ethiopia. Unlike its closest crop relative, sunflower, noug has small seeds, small flowering heads, many branches, many flowering heads, and indeterminate flowering, and it shatters in the field. Here, we conducted common garden studies and microsatellite analyses of genetic variation to test whether high levels of crop–wild gene flow and/or unfavorable phenotypic correlations have hindered noug domestication. With the exception of one population, analyses of microsatellite variation failed to detect substantial recent admixture between noug and its wild progenitor. Likewise, only very weak correlations were found between seed mass and the number or size of flowering heads. Thus, noug's ‘atypical’ domestication syndrome does not seem to be a consequence of recent introgression or unfavorable phenotypic correlations. Nonetheless, our data do reveal evidence of local adaptation of noug cultivars to different precipitation regimes, as well as high levels of phenotypic plasticity, which may permit reasonable yields under diverse environmental conditions. Why noug has not been fully domesticated remains a mystery, but perhaps early farmers selected for resilience to episodic drought or untended environments rather than larger seeds. Domestication may also have been slowed by noug's outcrossing mating syste

C—H⋯π packing inter­actions in 2-[5,5-bis­(4-benzyl­oxyphen­yl)-3-cyano-4-methyl-2,5-dihydro­furan-2-yl­idene]malononitrile

The title mol­ecule, C35H25N3O3, packs utilizing C—H⋯π attractive inter­actions causing the identical 4-benzyl­oxyphenyl groups to pack with different conformational angles. This difference is consistent with the variable inter­planar dihedral angles found in closely related structures

Mixed-effects height prediction model for Juniperus procera trees from a Dry Afromontane Forest in Ethiopia.

Tree height is a crucial variable in forestry science. In the current study, an accurate height prediction model for Juniperus procera Hochst. ex Endl. trees were developed, using a nonlinear mixed-effects modeling approach on 1215 observations from 101 randomly established plots in the Chilimo Dry Afromontane Forest in Ethiopia. After comparing 14 nonlinear models, the most appropriate base model was selected and expanded as a mixed-effects model, using the sample plot as a grouping factor, and adding stand-level variables to increase the model’s prediction ability. Using a completely independent dataset of observations, the best sampling alternative for calibration was determined using goodness-of-fit criteria. Our findings revealed that the Michaelis–Menten model outperformed the other models, while the expansion to the mixed-effects model significantly improved the height prediction. On the other hand, incorporating the quadratic mean diameter and the stem density slightly improved the model’s prediction ability. The fixed-effects of the selected model can also be used to predict the mean height of Juniperus procera trees as a marginal solution. The calibration response revealed that a systematic selection of the three largest-diameter trees at the plot level is the most effective for random effect estimation across new plots or stands