Xanthenones: Calixarenes-catalyzed Syntheses, Anticancer Activity And Qsar Studies

An efficient method is proposed for obtaining tetrahydrobenzo[a]xanthene-11-ones and tetrahydro-[1,3]-dioxolo[4,5-b]xanthen-9-ones. The method is based on the use of p-sulfonic acid calix[n]arenes as catalysts under solvent-free conditions. The antiproliferative activity of fifty-nine xanthenones against six human cancer cells was studied. The capacity of all compounds to inhibit cancer cell growth was dependent on the histological origin of the cells. QSAR studies indicate that among compounds derived from β-naphthol the most efficient compounds against glioma (U251) and renal (NCI-H460) cancer cells are those having higher hydrogen bonding donor ability.131132803287Lozano, R., Naghavi, M., Foreman, K., (2013) Lancet, 380, pp. 2095-2128Nakash, O., Levav, I., Aguilar-Gaxiola, S., (2014) Psychooncology, 23, pp. 40-51Chabner, B.A., Roberts, J.T.G., (2005) Nat. Rev. Cancer, 5, pp. 65-72Lambert, R.W., Martin, J.A., Merrett, J.H., Parkes, K.E.B., Thomas, G.J., (1997) CT Int. ApplPoupelin, J.P., Saint-Rut, G., Fussard-Blanpin, O., Narcisse, G., Uchida-Ernouf, G., Lakroix, R., (1978) Eur. J. Med. Chem., 13, pp. 67-71Kumar, A., Sharma, S., Maurya, R.A., Sarkar, J., (2010) J. Comb. Chem., 12, pp. 20-24Hideo, T., Teruomi, J., (1981) Jpn. Patent, p. 56.005.480Banerjee, A., Mukherjee, A.K., (1981) Biotech. Histochem., 56, pp. 83-85Knight, C.G., Stephens, T., (1989) Biochem. J., 258, pp. 683-689Sirkencioglu, O., Talinli, N., Akar, A.J., (1995) Chem. Res., 12, p. 502Ion, R.M., Planner, A., Wiktorowicz, K., Frackowiak, D., (1998) Acta Biochim. Pol., 45, pp. 833-845Heravi, M.M., Alinejhad, H., Bakhtiari, K., Saeedi, M., Oskooie, H.A., Bamoharram, F.F., (2011) Bull. Chem. Soc. Ethiop., 25, pp. 399-406Khurana, J.M., Magoo, D.P., (2009) Tetrahedron Lett., 50, pp. 4777-4780Zhang, Z.-H., Wang, H.-J., Ren, X.-Q., Zhang, Y.-Y., (2009) Monatsh. Chem., 140, pp. 1481-1483Simões, J.B., Da Silva, D.L., De Fátima, A., Fernandes, S.A., (2012) Curr. Org. Chem., 16, pp. 949-971De Fátima, A., Fernandes, S.A., Sabino, A.A., (2009) Curr. Drug Discovery Technol., 6, pp. 151-170Varejão, E.V.V., De Fátima, A., Fernandes, S.A., (2013) Curr. Pharm. Des., 19, pp. 6507-6521Jose, P., Menon, S., (2007) Bioinorg. Chem. Appl., 28, pp. 1-16Da Silva, D.L., Fernandes, S.A., Sabino, A.A., De Fátima, A., (2011) Tetrahedron Lett., 52, pp. 6328-6330Simões, J.B., De Fátima, A., Sabino, A.A., Aquino, F.J.T., Da Silva, D.L., Barbosa, L.C.A., Fernandes, S.A., (2013) Org. Biomol. Chem., 11, pp. 5069-5073Simões, J.B., De Fátima, A., Sabino, A.A., Barbosa, L.C.A., Fernandes, S.A., (2014) RSC Adv., 4, pp. 18612-18615Shimizu, S., Shimada, N., Sasaki, Y., (2006) Green Chem., 8, pp. 608-614Fernandes, S.A., Natalino, R., Gazolla, P.A.R., Da Silva, M.J., Jham, G.N., (2012) Tetrahedron Lett., 53, pp. 1630-1633Monks, A., Scudeiro, D., Skehan, P., Shoemaker, R., Paull, K., Vistica, D., Hose, C., Boyd, M.J., (1991) J. Natl. Cancer Inst., 83, pp. 757-766Xia, B., Ma, W., Zheng, B., Zhang, X., Fan, B., (2008) Eur. J. Med. Chem., 43, pp. 1489-1498Stanton, D.T., Jurs, P.C., (1990) Anal. Chem., 62, p. 2323Stanton, D.T., Egolf, L.M., Jurs, P.C., Hicks, M.G., (1992) J. Chem. Inf. Comput. Sci., 32, p. 306Gutsche, C.D., Dhawan, B., No, K.H., Muthukrishnan, R., (1981) J. Am. Chem. Soc., 103, pp. 3782-3792Casnati, A., Ca, N.D., Sansone, F., Ugozzoli, F., Ungaro, R., (2004) Tetrahedron, 60, pp. 7869-7876Shinkai, S., Araki, K., Tsubaki, T., Some, T., Manabe, O., (1987) J. Chem. Soc., Perkin Trans. 1, pp. 2297-2299Da Silva, D.L., Reis, F.S., Muniz, D.R., Ruiz, A.L.T.G., De Carvalho, J.E., Sabino, A.A., Modolo, L.V., De Fátima, A., (2012) Bioorg. Med.Chem., 20, pp. 2645-2650Pacheco, S.R., Braga, T.C., Da Silva, D.L., Horta, L.P., Reis, F.S., Ruiz, A.L.T.G., De Carvalho, J.E., De Fátima, A., (2013) Med. Chem., 9, pp. 889-896Spartan'06, , Wavefunction, Inc., Irvine, CAStewart, J.J.P., (2007) MOPAC 2007, version 7, , 290 W Stewart Computational Chemistry, Colorado Springs, CODewar, M.J.S., Zoebisch, E.G., Healy, E.F., (1985) J. Am. Chem. Soc., 107, pp. 3902-3909Jensen, F., (2007) Introduction to computational chemistry, , John Wiley & Son Ltd, 2nd ednKatritsky, A.R., Lobanov, V.S., Karelson, M., (1996) CODESSA: Reference ManualVersion 2, , University of Florid

Sudden unexpected death in an adolescent with epilepsy: All roads lead to the heart?

The incidence of sudden unexpected death in epilepsy (SUDEP) has been estimated from 0.5-1.4/1,000 person-years in people with treated epilepsy, and 9/1,000 person-years in candidates for epilepsy surgery. Potential risk factors for SUDEP include: age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure type and winter temperatures. The arrythmogenic side-effect of antiepileptic drugs and seizures may increase the risk of SUDEP. In this report, we describe a patient with prolonged post-ictal tachycardia in EEG video recordings with a typical case of SUDEP: a 16-year-old boy with medically intractable complex partial seizures. Magnetic resonance imaging revealed left mesial temporal sclerosis. During non-invasive video-EEG monitoring, the patient presented a post-ictal heart rate increased for five hours. Two months after video-EEG, he died from SUDEP during a tonic-clonic secondary generalized seizure. The possibility of cardiac involvement in the pathogenesis of SUDEP has been suggested by many studies. Evaluation of this patient with EEG-video monitoring, including measurement of heart rate, contributed to an identification of ictal tachycardia that may have played a role in the SUDEP. Premature mortality seems to be increased in patients with epilepsy, and cardiac abnormalities may be a possible cause of SUDEP. (Cardiol J 2011; 18, 2: 194-196)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)INCT/MCTConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Sao Paulo, Ctr Cirurgia Epilepsia, Dept Neurociencias & Ciencias Comportamento, Fac Med Ribeirao Preto,Ctr Cirurgia Epilepsia CIR, BR-14048900 Sao Paulo, BrazilUniv Fed Sao Paulo, Disciplina Neurol Expt, Escola Paulista Med UNIFESP EPM, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Fisiol, Escola Paulista Med UNIFESP EPM, Sao Paulo, BrazilUniv Fed Sao Paulo, Disciplina Neurol Expt, Escola Paulista Med UNIFESP EPM, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Fisiol, Escola Paulista Med UNIFESP EPM, Sao Paulo, BrazilWeb of Scienc

Proteomic Analysis of Cattle Tick Rhipicephalus (Boophilus) microplus Saliva: A Comparison between Partially and Fully Engorged Females

The cattle tick Rhipicephalus (Boophilus) microplus is one of the most harmful parasites affecting bovines. Similarly to other hematophagous ectoparasites, R. microplus saliva contains a collection of bioactive compounds that inhibit host defenses against tick feeding activity. Thus, the study of tick salivary components offers opportunities for the development of immunological based tick control methods and medicinal applications. So far, only a few proteins have been identified in cattle tick saliva. The aim of this work was to identify proteins present in R. microplus female tick saliva at different feeding stages. Proteomic analysis of R. microplus saliva allowed identifying peptides corresponding to 187 and 68 tick and bovine proteins, respectively. Our data confirm that (i) R. microplus saliva is complex, and (ii) that there are remarkable differences in saliva composition between partially engorged and fully engorged female ticks. R. microplus saliva is rich mainly in (i) hemelipoproteins and other transporter proteins, (ii) secreted cross-tick species conserved proteins, (iii) lipocalins, (iv) peptidase inhibitors, (v) antimicrobial peptides, (vii) glycine-rich proteins, (viii) housekeeping proteins and (ix) host proteins. This investigation represents the first proteomic study about R. microplus saliva, and reports the most comprehensive Ixodidae tick saliva proteome published to date. Our results improve the understanding of tick salivary modulators of host defense to tick feeding, and provide novel information on the tick-host relationship

Determinantes Nacionais e Setoriais da Estrutura de Capital na América Latina

This study identified the role of the national environment (the Macroeconomy, Financial Development and Institutional Quality) and industry characteristics (Munificence, Dynamism, Concentration, Life Cycle, Technological Efficiency Dispersion, Product Quality Dispersion, Customer Bargaining Power and Supplier Bargaining Power) on debt of 612 listed companies from 7 Latin American countries (Argentina, Brazil, Chile, Colombia, Mexico, Peru and Venezuela). For comparison purposes, the analysis is also extended to 847 U.S. companies. The period of study is 1996-2009 and the analysis employed a Hierarchical Linear Model, which controls the effects according to the level of the variables (country, industry, time and firm). The results suggest that Financial Development eases access to external funds and Institutional Quality is negatively related to firm Leverage. The research also finds evidence that institutional quality can promote asymmetrical development between stock markets and credit markets

Records of Mantodea (Insecta) collected with light trap at 45 meters height over an Amazon forest canopy, at ZF-2 nucleus, Manaus, Brazil

Insect collections were carried out monthly from January to December of 2004, during three nights of lunar transition third quarter moon/new moon from 18 p.m. to 6 a.m. They were collected over a vertical white sheet illuminated by a 250 watts mixed light and a 20 watts black light (BL) and black light bulb (BLB) lamps. The light trap was mounted at 45 meters height in a metallic tower of 50 meters height, in a "platô de terra firme", in the Cueiras River basin, in Manaus, Amazonas, Brazil. It was collected 23 species of Mantodea: Chaeteessidae (1 species); Mantoididae (2); Mantidae (15); Thespidae (2) and Acanthopidae (3). Six new species were registered and they will be described opportunely in the following genera: Cardioptera Burmeister, 1838; Phyllovates Kirby, 1904; Pseudovates Saussure, 1869; Stagmomantis Saussure, 1869; Stagmatoptera Burmeister, 1838 and Metilia Stal, 1877. Three species previously recorded to an indetermined Brazilian region are being recorded to Brazilian Amazon: Heterovates pardalina Saussure, 1872; Macromantis ovalifolia (Stoll, 1813) and Photina reticulata (Burmeister, 1838). Four records are new for the Amazonas state: Angela guianensis Rehn, 1906; Photina gracillis Giglio-Tos, 1915; Raptrix perspicua (Fabricius, 1787) and Vates festae Gigio-Tos, 1914. The specimens number collected monthly are presented for each species.Foram realizadas coletas mensais de insetos de janeiro a dezembro de 2004, durante três noites de transição lunar minguante/nova, das 18:00 às 06:00 horas. Os espécimes foram capturados em um lençol iluminado com lâmpada de 250 watts, luz mista de vapor de mercúrio e lâmpada de 20 watts black light (BL) e black light bulb (BLB). A armadilha foi montada a 45 metros de altura numa torre metálica de 50 metros, que ultrapassa a maioria das copas das árvores, num platô de terra firme, na bacia do rio Cuieiras, Manaus, Amazonas, Brasil. Foram coletados 23 espécies de Mantodea, sendo Chaeteessidae (1 espécie); Mantoididae (2); Mantidae (15); Thespidae (2) e Acanthopidae (3). Seis espécies são novas e serão descritas oportunamente nos seguintes gênerosCardioptera Burmeister, 1838, Phyllovates Kirby, 1904, Pseudovates Saussure, 1869, Stagmomantis Saussure, 1869, Stagmatoptera Burmeister, 1838 e Metilia Stal, 1877. Três espécies registradas para o Brasil sem uma região determinada estão sendo registradas para a Amazônia brasileiraHeterovates pardalina Saussure, 1872, Macromantis ovalifolia (Stoll, 1813) e Photina reticulata (Burmeister, 1838). Quatro registros são novos para o estado do AmazonasAngela guianensis Rehn, 1906, Photina gracillis Giglio-Tos, 1915, Raptrix perspicua (Fabricius, 1787) e Vates festae Gigio-Tos, 1914. Os números de indivíduos, em cada coleta mensal, são apresentados para cada espécie