Yes, construction cost, time and scope are important, but there is more: a new action plan for infrastructure success

Purpose: During the planning and delivery, iron triangle criteria, are essential for internal stakeholders (e.g. owner, sponsors and delivery company), mostly ignoring external stakeholders such as local communities (often perceived as inconvenient) or end users. In the medium-long term, infrastructure cost and benefit are far more important for external stakeholders and the environment. Design/methodology/approach: The iron triangle criteria, i.e. delivering on time, budget and quality/scope, is the traditional perspective to assess the success of infrastructure projects. Delivering on cost and time is significant, but particularly for infrastructure, there are more relevant success criteria. The authors argue which criteria are important, and explain why. Findings: The authors challenge the traditional view of judging projects based on respecting time, budget and quality/scope. The authors explain that discussing the social value and contribution to achieving the UN Sustainable Development Goals (SDGs) is extremely relevant. Crucially these metrics keep changing, even after the project is terminated. Originality/value: The authors provide a new seven-step action plan for decision-makers to improve infrastructure provision by reflecting on SDGs and engaging with external stakeholders, particularly minorities and the weaker members of their communities. Such an action plan is focused on the cost and value for different stakeholders on different timeframes and progress toward social value and achieving SDGs

Planck Low Frequency Instrument: Beam Patterns

The Low Frequency Instrument on board the ESA Planck satellite is coupled to the Planck 1.5 meter off-axis dual reflector telescope by an array of 27 corrugated feed horns operating at 30, 44, 70, and 100 GHz. We briefly present here a detailed study of the optical interface devoted to optimize the angular resolution (10 arcmin at 100 GHz as a goal) and at the same time to minimize all the systematics coming from the sidelobes of the radiation pattern. Through optical simulations, we provide shapes, locations on the sky, angular resolutions, and polarization properties of each beam.Comment: On behalf of the Planck collaboration. 3 pages, 1 figure. Article published in the Proceedings of the 2K1BC Experimental Cosmology at millimetre wavelength

Dynamic validation of the Planck/LFI thermal model

The Low Frequency Instrument (LFI) is an array of cryogenically cooled radiometers on board the Planck satellite, designed to measure the temperature and polarization anisotropies of the cosmic microwave backgrond (CMB) at 30, 44 and 70 GHz. The thermal requirements of the LFI, and in particular the stringent limits to acceptable thermal fluctuations in the 20 K focal plane, are a critical element to achieve the instrument scientific performance. Thermal tests were carried out as part of the on-ground calibration campaign at various stages of instrument integration. In this paper we describe the results and analysis of the tests on the LFI flight model (FM) performed at Thales Laboratories in Milan (Italy) during 2006, with the purpose of experimentally sampling the thermal transfer functions and consequently validating the numerical thermal model describing the dynamic response of the LFI focal plane. This model has been used extensively to assess the ability of LFI to achieve its scientific goals: its validation is therefore extremely important in the context of the Planck mission. Our analysis shows that the measured thermal properties of the instrument show a thermal damping level better than predicted, therefore further reducing the expected systematic effect induced in the LFI maps. We then propose an explanation of the increased damping in terms of non-ideal thermal contacts.Comment: Planck LFI technical papers published by JINST: http://www.iop.org/EJ/journal/-page=extra.proc5/1748-022

Analysis of 3 years of data from the gravitational wave detectors EXPLORER and NAUTILUS

We performed a search for short gravitational wave bursts using about 3 years of data of the resonant bar detectors Nautilus and Explorer. Two types of analysis were performed: a search for coincidences with a low background of accidentals (0.1 over the entire period), and the calculation of upper limits on the rate of gravitational wave bursts. Here we give a detailed account of the methodology and we report the results: a null search for coincident events and an upper limit that improves over all previous limits from resonant antennas, and is competitive, in the range h_rss ~1E-19, with limits from interferometric detectors. Some new methodological features are introduced that have proven successful in the upper limits evaluation.Comment: 12 pages, 12 figure

Structure and Dynamics of RNA Guanine Quadruplexes in SARS-CoV-2 Genome. Original Strategies against Emerging Viruses

Guanine quadruplex (G4) structures in the viral genome have a key role in modulating viruses' biological activity. While several DNA G4 structures have been experimentally resolved, RNA G4s are definitely less explored. We report the first calculated G4 structure of the RG-1 RNA sequence of SARS-CoV-2 genome, obtained by using a multiscale approach combining quantum and classical molecular modeling and corroborated by the excellent agreement between the corresponding calculated and experimental circular dichroism spectra. We prove the stability of the RG-1 G4 arrangement as well as its interaction with G4 ligands potentially inhibiting viral protein translation

Effect of cosmic rays on the resonant gravitational wave detector NAUTILUS at temperature T=1.5 K

The interaction between cosmic rays and the gravitational wave bar detector NAUTILUS is experimentally studied with the aluminum bar at temperature of T=1.5 K. The results are compared with those obtained in the previous runs when the bar was at T=0.14 K. The results of the run at T = 1.5 K are in agreement with the thermo-acoustic model; no large signals at unexpected rate are noticed, unlike the data taken in the run at T = 0.14 K. The observations suggest a larger efficiency in the mechanism of conversion of the particle energy into vibrational mode energy when the aluminum bar is in the superconductive status.Comment: 7 pages, 3 figures, 2 tables. Accepted by Physics Letters

Increasing the bandwidth of resonant gravitational antennas: The case of Explorer

Resonant gravitational wave detectors with an observation bandwidth of tens of hertz are a reality: the antenna Explorer, operated at CERN by the ROG collaboration, has been upgraded with a new read-out. In this new configuration, it exhibits an unprecedented useful bandwidth: in over 55 Hz about its frequency of operation of 919 Hz the spectral sensitivity is better than 10^{-20} /sqrt(Hz) . We describe the detector and its sensitivity and discuss the foreseable upgrades to even larger bandwidths.Comment: 4 pages- 4 figures Acceted for publication on Physical Review Letter

Thermal susceptibility of the Planck-LFI receivers

This paper is part of the Prelaunch status LFI papers published on JINST: http://www.iop.org/EJ/journal/-page=extra.proc5/jinst . This paper describes the impact of the Planck Low Frequency Instrument front end physical temperature fluctuations on the output signal. The origin of thermal instabilities in the instrument are discussed, and an analytical model of their propagation and impact on the receivers signal is described. The experimental test setup dedicated to evaluate these effects during the instrument ground calibration is reported together with data analysis methods. Finally, main results obtained are discussed and compared to the requirements.Comment: This is an author-created, un-copyedited version of an article accepted for publication in Journal of Instrumentation. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at 10.1088/1748-0221/4/12/T1201

Effect of Fourier filters in removing periodic systematic effects from CMB data

We consider the application of high-pass Fourier filters to remove periodic systematic fluctuations from full-sky survey CMB datasets. We compare the filter performance with destriping codes commonly used to remove the effect of residual 1/f noise from timelines. As a realistic working case, we use simulations of the typical Planck scanning strategy and Planck Low Frequency Instrument noise performance, with spurious periodic fluctuations that mimic a typical thermal disturbance. We show that the application of Fourier high-pass filters in chunks always requires subsequent normalisation of induced offsets by means of destriping. For a complex signal containing all the astrophysical and instrumental components, the result obtained by applying filter and destriping in series is comparable to the result obtained by destriping only, which makes the usefulness of Fourier filters questionable for removing this kind of effects.Comment: 10 pages, 8 figures, published in Astronomy & Astrophysic

Antiproliferative properties and g-quadruplex-binding of symmetrical naphtho[1,2-b:8,7-b’]dithiophene derivatives

Background: G-quadruplex (G4) forming sequences are recurrent in telomeres and promoter regions of several protooncogenes. In normal cells, the transient arrangements of DNA in G-tetrads may regulate replication, transcription, and translation processes. Tumors are character-ized by uncontrolled cell growth and tissue invasiveness and some of them are possibly mediated by gene expression involving G-quadruplexes. The stabilization of G-quadruplex sequences with small molecules is considered a promising strategy in anticancer targeted therapy. Methods: Molecular virtual screening allowed us identifying novel symmetric bifunctionalized naphtho[1,2-b:8,7-b’]dithiophene ligands as interesting candidates targeting h-Telo and c-MYC G-quadruplexes. A set of unexplored naphtho-dithiophene derivatives has been synthesized and biologically tested through in vitro antiproliferative assays and spectroscopic experiments in solution. Results: The analysis of biological and spectroscopic data highlighted noteworthy cytotoxic effects on HeLa cancer cell line (GI50 in the low µM range), but weak interactions with G-quadruplex c-MYC promoter. Conclusions: The new series of naphtho[1,2-b:8,7-b’]dithiophene derivatives, bearing the pharmacophoric assump-tions necessary to stabilize G-quadruplexes, have been designed and successfully synthesized. The interesting antiproliferative results supported by computer aided rational approaches suggest that these studies are a significant starting point for a lead optimization process and the isolation of a more efficacious set of G-quadruplexes stabilizers