Infección grave por el virus del Chikungunya

 Publicaciones recientes han desafiado la visión convencional sobre la naturaleza benigna de la infección por el virus de Chikungunya (VCHIK). Las manifestaciones clínicas son muy variables y pueden ser graves en algunos casos. Los estudios sugieren que la forma grave de la infección por el VCHIK puede ser asociada con disfunción orgánica múltiple, hepatitis, meningitis, nefritis, encefalitis, dermatitis ampollosa, miocarditis, arritmias cardiacas, entre otras. La fisiopatología subyacente para algunas de las complicaciones de la enfermedad por el VCHIK sigue siendo poco clara. Sin embargo, de acuerdo con las características clínicas de los casos graves o atípicos descritos a la fecha, el desarrollo de complicaciones podría agruparse principalmente en tres categorías: la exacerbación de condiciones médicas subyacentes, el deterioro de un trastorno no reconocido previamente y la respuesta inmunológica inadecuada a la infección. Se ha encontrado asociación entre las manifestaciones graves de la infección, niveles elevados de citoquinas y algunas secuencias genómicas específicas del VCHIK. La inmunoterapia pasiva puede constituir una estrategia eficaz en el tratamiento de individuos expuestos al VCHIK con riesgo de infección grave. Actualmente no existe evidencia clínica que soporte el uso de antivirales en la prevención o tratamiento de la infección por el VCHIK

Axially symmetric Hartree-Fock-Bogoliubov Calculations for Nuclei Near the Drip-Lines

Nuclei far from stability are studied by solving the Hartree-Fock-Bogoliubov (HFB) equations, which describe the self-consistent mean field theory with pairing interaction. Calculations for even-even nuclei are carried out on two-dimensional axially symmetric lattice, in coordinate space. The quasiparticle continuum wavefunctions are considered for energies up to 60 MeV. Nuclei near the drip lines have a strong coupling between weakly bound states and the particle continuum. This method gives a proper description of the ground state properties of such nuclei. High accuracy is achieved by representing the operators and wavefunctions using the technique of basis-splines. The detailed representation of the HFB equations in cylindrical coordinates is discussed. Calculations of observables for nuclei near the neutron drip line are presented to demonstrate the reliability of the method.Comment: 13 pages, 4 figures. Submitted to Physical Review C on 05/08/02. Revised on Dec/0

Trajectories of Symptom Dimensions in Short-Term Response to Antipsychotic Treatment in Patients with a First Episode of Non-Affective Psychosis

Background Trajectory patterns of positive, disorganized and negative dimension symptoms during antipsychotic treatment in drug-naive patients with first-episode psychosis have yet to be examined by using naturalistic data. Method This pragmatic clinical trial randomized 161 drug-naive patients with a first episode of psychosis to olanzapine, risperidone or haloperidol. Patients were assessed with the Scale for the Assessment of Negative Symptoms (SANS) and Positive Symptoms (SAPS) at baseline and at the end of weeks 1, 2, 3, 4 and 6 of antipsychotic treatment. Censored normal models of response trajectories were developed with three dimensions of the SAPS-SANS scores (positive, disorganized and negative) in order to identify the different response trajectories. Diagnosis, cannabis use, duration of untreated psychosis (DUP), smoking and antipsychotic class were examined as possible predictive variables. Results Patients were classified in five groups according to the positive dimension, three groups according to the disorganized dimension and five groups according to the negative dimension. Longer DUPs and cannabis use were associated with higher scores and poorer responses in the positive dimension. Cannabis use was associated with higher scores and poorer responses in the disorganized dimension. Only schizophrenia diagnosis was associated with higher scores and poorer responses in the negative dimension. Conclusions Our results illustrate the heterogeneity of short-term response to antipsychotics in patients with a first episode of psychosis and highlight markedly different patterns of response in the positive, disorganized and negative dimensions. DUP, cannabis use and diagnosis appeared to have a prognostic value in predicting treatment response with different implications for each dimension

Plantas nativas del Norte Argentino : aplicación en el control de bacterias fitopatógenas

Las enfermedades bacterianas generan pérdidas económicas importantes en los cultivos. En la actualidad se aplican en forma preventiva compuestos cúpricos para disminuir a incidencia de las mismas. El noroeste argentino posee una enorme biodiversidad en sus plantas medicinales que constituyen una potencial fuente de nuevos metabolitos bioactivos. En este contexto, el objetivo del trabajo fue identificar y cuantificar la actividad antibacteriana de extractos de plantas nativas del noroeste argentino sobre bacterias fitopatógenas de importancia agrícola. Para ello se recolectaron partes aéreas de plantas nativas del noroeste argentino. Hojas y tallos de Aspidosperma quebracho-blanco, Schinus fasciculatus, S. gracilipes, Amphilophium cynanchoides y Tecoma stans fueron separados y extraídos con solventes de polaridad creciente para obtener extractos de diclorometano (fCH2Cl2), acetato de etilo (fAcEt) y metanol (fMeOH), respectivamente. Entre los treinta extractos analizados solo los fAcEt a partir de hojas y tallos de S. fasciculatus inhibieron a las cinco cepas bacterianas ensayadas, Pseudomonas syringae pv tomato Pseudomonas corrugata, Xanthomonas campestres pv vesicatoria, Erwinia carotovora var carotovora y Agrobacterium tumefaciens (CI50 = 0.9 mg/ml). Se identificaron y cuantificó la ctividad antibacteriana de tres componentes de estos extractos: kaempferol (CIM= 250 μg/ml, CECT 124 y 472; CIM=500 μg/ml, CECT 126 y 792), quercetina (CIM = 1000 μg/ml, CECT 124, 126 y 792; CIM= 2000 ppm, CECT 472) y agathisflavona (CIM = 2000 μg/ml; CECT 126 y 792). El extracto fAcEt de S. fasciculatus y los flavonoides mostraron efectos sinérgicos y aditivos en las cepas bacterianas en combinación con kocideFil: Terán Baptista, Zareath P. . Université de Paris.Fil: Kritsanida, Marina. Université de Paris.Fil: Grougnetb, Raphael . Université de Paris.Fil: Sampietro, Diego A. . Université de Paris

Coordinate-Space Hartree-Fock-Bogoliubov Description of Superfluid Fermi Systems

Properties of strongly interacting, two-component finite Fermi systems are discussed within the recently developed coordinate-space Hartree-Fock-Bogoliubov (HFB) code {\hfbax}. Two illustrative examples are presented: (i) weakly bound deformed Mg isotopes, and (ii) spin-polarized atomic condensates in a strongly deformed harmonic trap.Comment: 4 pages, 2 figures, ENAM 2008 conference proceedings (EPJA

Pinto Bean Cultivars Blackfoot, Nez Perce, and Twin Falls

Pinto bean (Phaseolus vulgaris L.) cultivars ‘Blackfoot’ (Reg. No. CV-316, PI 680632), ‘Nez Perce’ (Reg. No. CV-317, PI 680633), and ‘Twin Falls’ (Reg. No. CV-318, PI 680634) were developed at the University of Idaho, Kimberly Research and Extension Center in collaboration with researchers in Colorado, Nebraska, and Washington. Blackfoot and Nez Perce are sister cultivars derived from the same bulk population, UIP35 (USPT-CBB-1/3/‘Othello’/‘UI 906’//‘Topaz’/‘Buster’). Twin Falls was selected from the bulk population UIP40 (USPT-CBB-1/3/CO12650/USPT-ANT-1//Othello/ABL15). The F8 of both population bulks and checks were yield tested in the Western Regional Bean Trial in 2014 and 2015 and in the Cooperative Dry Bean Nursery in 2015. The three cultivars were yield tested in Idaho in 2015. They were also yield tested across nine production environments in Colorado, Idaho, Nebraska, and Washington in 2016. Blackfoot, Nez Perce, and Twin Falls are the first indeterminate erect Type II growth habit pinto bean cultivars resistant to Bean common mosaic virus (an aphid-vectored potyvirus) and bean rust developed at University of Idaho. Blackfoot has a compact Type IIA growth habit and produces little or no vine (i.e., elongated terminal axis with intertwined internodes that help the plant climb when provided support). In contrast, Nez Perce is tall and produces medium to long vines, with a Type IIB growth habit. Blackfoot has a mean maturity of 85 d and Nez Perce 95 d in southern Idaho. Twin Falls is a full-season cultivar (≥100 d) and relatively tall, with very small or no vines for climbing. The three cultivars have relatively smaller seed (100−1 seeds) than early-maturity pinto ‘Othello’ (≥35 g 100−1 seeds) in the Pacific Northwest

Large-Scale Self-Consistent Nuclear Mass Calculations

The program of systematic large-scale self-consistent nuclear mass calculations that is based on the nuclear density functional theory represents a rich scientific agenda that is closely aligned with the main research directions in modern nuclear structure and astrophysics, especially the radioactive nuclear beam physics. The quest for the microscopic understanding of the phenomenon of nuclear binding represents, in fact, a number of fundamental and crucial questions of the quantum many-body problem, including the proper treatment of correlations and dynamics in the presence of symmetry breaking. Recent advances and open problems in the field of nuclear mass calculations are presented and discussed.Comment: 21 pages, 5 figures, submitted to International Journal of Mass Spectrometr

Life Cycle Analysis of the panela agroindustry: Intensification for its development

The research made it possible to identify sensitive environmental factors generated in all the operations carried out in an intensified panela agroindustry for the purposes of diversification, productivity, quality and safety. Results of the Environmental Impact Assessment (EIA), according to the Life Cycle Analysis (LCA) methodology show that in all impact categories, the industrial stage of the production of honey, panela and sugar, cause greater environmental impact, being the two latter the most representative. However, according to the Ecuadorian environmental legislation, the impacts of the panela agroindustry are considered to be moderate and cataloged type II, therefore it does not require intensive corrective practices. However, it requires preventive actions aimed to mitigate impacts, considering that it is a subsector of the sugar cane industry that is present as production units throughout the country, where there are favorable conditions for the cultivation of sugar cane