Principia relativa : la figure T de l'Art de Raymond Lulle

Cet article investigue la figure T de l'Art de Raymond Lulle. C'est une figure principale de chaque variante majeure de l'Art par laquelle Lulle utilise universellement la relation lorsqu'il aborde les sujets généraux de son Art quaternaire ou ternaire. La relation s'y établit graduellement entre tous les sujets de l'Art de Lulle qui composent une échelle de créatures jusqu'à l'être suprême. Il se peut que Lulle s'y inspire de la figure du Crucifix sous le signe de laquelle Lulle conçoit tout genre de relation au moyen des principes relatifs. Le prédicament de la relation ne se prédique que des sujets créés. Il ne se prédique pas de Dieu dont Lulle exclut quelques principes relatifs -contrariété, majorité, minorité- qui se prédiquent bien des étants créés. C'est le propos immédiat de notre exposition de comprendre comment la figure T des principes relatifs de l'Art de Lulle illustre doctrinalement la relation en tant qu'instrument transcendantal qui s'avère universellement utile à la prédication de l'ensemble des dignités qui sont tant absolument que relativement prédicables.This article examines the figure T of Ramon Lull's Art. It is a main figure of each of the major versions of the Art by means of which Lull universally introduces the relation when addressing the general subjects of his quaternary or ternary Art. The relationship gradually establishes itself between all the subjects of Lull's Art which compose a scale of creatures up to the Supreme Being. Lull may be inspired by the figure of the Crucifix, under the sign of which Lull conceives all kinds of relations by means of relative principles. The predicament of the relation is predicated only of the created subjects. It is not predicated of God from whom Lull excludes some relative principles - contradiction, majority, minority - which are predicated of the created beings. It is the purpose of our exposition to understand how the figure T of the relative principles of Lull's Art doctrinally illustrates the relation as a transcendental instrument which proves universally useful for the predication of all the dignities which are both absolutely and relatively predicable

Le premier Art de Raymond Lulle

La genealogía de las variantes del Arte de Ramón Llull sigue siendo cuestionable. La pregunta principal de esta genealogía no está definitivamente resuelta por la historiografía del Arte luliano. Este artículo investiga la constitución doctrinal del primer Arte por el cual Llull construyó su Arte de la contemplación de Dios, que está por delante de la mayoría de las variantes del Arte cuaternario en el inicio de su actividad. El primer Arte de Llull es una gran enciclopedia contemplativa, inaugurando el método de los principios del Arte en los que Llull contempla a Dios antes que cualquier ser de la escala de las criaturas. Es un Arte de la contemplación en Dios que fue inventado en primer lugar por Llull al comienzo de su Arte cuaternario. El primer Arte de Llull incluye conjuntamente teología y fi losofía en un solo Arte de la contemplación de DiosThe genealogy of the variants of Ramon Lull’s Art presents unresolved questions that cannot be settled by the current historiography. This article investigates the doctrinal foundation of the fi rst Art on which Lull built his Art of Contemplation of God, as this fi rst Art is an early work that precedes most variants of the quaternary Art. The fi rst Art is a contemplative encyclopedia that inaugurates the method of the principles of Art by means of which Lull contemplates God as above all creatures in the chain of being. It includes both theology and philosophy in a single Art of contemplatio

Minimally invasive treatments for disk hernia

Interventional Radiology Department, University Hospital, Bucharest, Romania, “Carol Davila” University, Neurosurgery Clinic, University Hospital, Bucharest, Romania, Neurosurgery Clinic, University Hospital, Bucharest, Romania, “Carol Davila” University, Radiology and Medical Imaging Clinic, University Hospital, Bucharest, Romania, Al VIII-lea Congres Naţional de Ortopedie și Traumatologie cu participare internaţională 12-14 octombrie 2016Background and purpose: Low back pain (LBP) is one of the common reasons for people to seek treatment from a physician, especially in modern society. We present the indications, technique, complications, etc. of the different minimally invasive interventions. Methods: A multitude of therapies are available to treat disc herniation, ranging from conserva-tive methods (medication and physical therapy) to minimally invasive (chemonucleolysis, O₂-O₃ therapy, mechanical nucleoplasty, intradiscal electrothermal therapy, etc) and surgery. Results: We present our experience of 10 years in minimally invasive interventions with common indications, results, complications, tips and tricks, etc. Conclusions: Percutaneous disk interventions are an alternative therapy situated between medical treatment and spinal surgery. Patients selection is very important and lead to the successful of the intervention

Vertebroplasty - minimally invasive treatment for vertebral fractures

Interventional Radiology Department, University Hospital, Bucharest, Romania, “Carol Davila” University, Neurosurgery Clinic, University Hospital, Bucharest, Romania, “Carol Davila” University, Radiology and Medical Imaging Clinic, University Hospital, Bucharest, Romania, Al VIII-lea Congres Naţional de Ortopedie și Traumatologie cu participare internaţională 12-14 octombrie 2016Background and purpose: Vertebral fracture is the most common complication of osteoporosis and sometimes also in osteolytic methastasis, active hemangiomas or multiple myelomas. We present the indications, technique, complications, etc. Methods: Vertebroplasty is the percutaneous placement of polymethylmethacrylate (PMMA) into vertebral compression fractures for relief of pain, performed under fluoroscopic guidance while the exact mechanism of pain relief is unknown, it is believed that the delivery of the ciment into the fracture stabilizes the vertebral body, obtaining an analgesic effect. Results: We present our experience of 14 years in percutaneous vertebroplasty (and kyphoplasty) with common indications, results, complications, new indications, tips and tricks, etc. Conclusions: Vertebroplasty is an alternative to spinal surgery. In experienced centers, percuta-neous vertebroplasty is safe and effective in the treatment of patients with painful vertebral com-pression fractures

New technologies for low-grade glioma surgery

Brain surgery has come far from the primitive methods used thousands of years ago. In the last hundred years alone, we have come across countless breakthroughs like the invention of bipolar coagulation, the surgical microscope, microsurgical techniques and a large variety of surgical instruments. The latest years have brought us neuro-navigation, intra-operative imaging techniques and brain activity monitoring. Low-grade glioma surgery, in particular, has taken advantage a lot from all these new methods, bringing great benefits for the patients: the safe extent of resection has grown progressively and tumours located in eloquent areas that were thought until recently to be inoperable, have started to be removed in safe conditions. The purpose of this paper is to present these new technologies as a recap for neurosurgical professionals

Hidrotermička sinteza cirkonijevih nanoprahova i tankih prevlaka

The synthesis of nano-powders was accomplished using different physical, mechanical and chemical methods. Hydrothermal processes have been recently reported as a very attractive route in the synthesis of both zirconia powders and films. The present paper presents some aspects of the microstructural evolution of zirconia nanomaterials obtained via hydrothermal process starting from soluble peroxide precursors.Sinteza nanoprahova izvršena je uporabom raznih fizičkih, mehaničkih i kemijskih metoda. Od nedavno se o hidrotermičkom procesu govori kao o vrlo atra-ktivnom načinu sinteze cirkonijevog praha i tanke prevlake. Ovaj rad predstavlja neke aspekte mikrostrukturalne evolucije cirkonijevih materijala dobivene hidrotermičkim procesom koji počinje s topljivim početnim peroksidnim materijalom

Case report: Tackling the complexities of an extremely premature newborn with intrauterine growth restriction and congenital metabolic disorders through a multidisciplinary approach

Background and objectivesThe premature birth of a newborn can present a complex challenge for healthcare providers, particularly in cases of extreme prematurity combined with intrauterine growth restriction and multiple metabolic deficiencies. In this report, we aim to shed light on the difficulties and considerations involved in the management of such a case. In addition, our study is aimed to raise awareness of the importance of a multidisciplinary team in managing an extreme premature case with multiple comorbidities.Case presentation and main findingsWe present the case of a 28-week premature female newborn with very low birth weight (660 g, percentile <10%) and intrauterine growth restriction. She was born through emergency cesarean delivery due to maternal Hemolysis, Elevated Liver enzymes, and Low Platelet count (HELLP) syndrome and had a high-risk pregnancy (spontaneous twin pregnancy, with one fetus stopping development at 16 weeks and maternal hypertension). In the first hours of life, she presented with persistent hypoglycemia requiring progressive glucose supplementation up to 16 g/kg/day to maintain normal blood glucose levels. The baby then showed favorable progress. However, from days 24 to 25, hypoglycemia recurred and did not respond to glucose boluses or supplementation in both intravenous and oral feeds, leading to the suspicion of a congenital metabolic disorder. Endocrine and metabolic screenings led to suspicion of primary carnitine deficiency and a deficiency in hepatic form of carnitine-palmitoyltransferase type I (CPT1) on the second screening.Conclusion and clinical implicationsThe study highlights rare metabolic anomalies that can be due to both organ and system immaturity and delayed enteral feeding and excessive use of antibiotics. The clinical implications of this study emphasize the need for careful monitoring and comprehensive care of premature infants to prevent and manage potential metabolic abnormalities by neonatal metabolic screening

Bubble population growth and gas release from packed beds of AW500 ion exchange pellets

This paper explores the phenomenon of in situ generated gas retention within densely packed cylindrical ion-exchange pellets. Initially, discrete element method (DEM) simulations were used to identify pertinent contact packing parameters, rigorously validated through packing experiments. Calibrated values for dynamic and static friction, and the coefficient of restitution were found in ranges of 0.8–1.0, 0–0.2, and 0–0.2, respectively, with the importance of dynamic friction highlighted. The DEM validation process achieved a packing fraction that exhibited < 4 % deviation from experimental data, with some cylinder alignment observed near the column base. Additionally, laboratory-scale gas generation tests were conducted to replicate the retention of hydrogen within densely packed beds, achieved through the decomposition of hydrogen peroxide. X-ray computed tomography was then used to quantify bubble population size and growth within the beds. Experiments suggested a dynamic bed retention gas fraction of ∼7 %, which was produced within the first 30 min of generation. In parallel, CT imaging of the bubble populations indicated that large bubbles become less spherical over time, likely from pore invasion, partial cavity expansion and secondary coalescence. These mechanisms led to bubbles located in the upper portion of the bed being more likely to be released buoyantly, compared to those situated in the bed's lower regions. Overall, results indicate that the pore network channels within the pellet beds are large enough to achieve relatively steady gas release. These dynamics reduce the risk of sudden hydrogen rollover occurring industrially, particularly within the specialised context of nuclear waste management

Adjunctive Volasertib in Patients With Acute Myeloid Leukemia not Eligible for Standard Induction Therapy : A Randomized, Phase 3 Trial

In this phase 3 trial, older patients with acute myeloid leukemia ineligible for intensive chemotherapy were randomized 2:1 to receive the polo-like kinase inhibitor, volasertib (V; 350 mg intravenous on days 1 and 15 in 4-wk cycles), combined with low-dose cytarabine (LDAC; 20 mg subcutaneous, twice daily, days 1-10; n = 444), or LDAC plus placebo (P; n = 222). Primary endpoint was objective response rate (ORR); key secondary endpoint was overall survival (OS). Primary ORR analysis at recruitment completion included patients randomized >= 5 months beforehand; ORR was 25.2% for V+LDAC and 16.8% for P+LDAC (n = 371; odds ratio 1.66 [95% confidence interval (CI), 0.95-2.89]; P = 0.071). At final analysis (>= 574 OS events), median OS was 5.6 months for V+LDAC and 6.5 months for P+LDAC (n = 666; hazard ratio 0.97 [95% CI, 0.8-1.2]; P = 0.757). The most common adverse events (AEs) were infections/infestations (grouped term; V+LDAC, 81.3%; P+LDAC, 63.5%) and febrile neutropenia (V+LDAC, 60.4%; P+LDAC, 29.3%). Fatal AEs occurred in 31.2% with V+LDAC versus 18.0% with P+LDAC, most commonly infections/infestations (V+LDAC, 17.1%; P+LDAC, 6.3%). Lack of OS benefit with V+LDAC versus P+LDAC may reflect increased early mortality with V+LDAC from myelosuppression and infections.Peer reviewe

SNUPN deficiency causes a recessive muscular dystrophy due to RNA mis-splicing and ECM dysregulation

SNURPORTIN-1, encoded by SNUPN, plays a central role in the nuclear import of spliceosomal small nuclear ribonucleoproteins. However, its physiological function remains unexplored. In this study, we investigate 18 children from 15 unrelated families who present with atypical muscular dystrophy and neurological defects. Nine hypomorphic SNUPN biallelic variants, predominantly clustered in the last coding exon, are ascertained to segregate with the disease. We demonstrate that mutant SPN1 failed to oligomerize leading to cytoplasmic aggregation in patients’ primary fibroblasts and CRISPR/Cas9-mediated mutant cell lines. Additionally, mutant nuclei exhibit defective spliceosomal maturation and breakdown of Cajal bodies. Transcriptome analyses reveal splicing and mRNA expression dysregulation, particularly in sarcolemmal components, causing disruption of cytoskeletal organization in mutant cells and patient muscle tissues. Our findings establish SNUPN deficiency as the genetic etiology of a previously unrecognized subtype of muscular dystrophy and provide robust evidence of the role of SPN1 for muscle homeostasis