Barriers and challenges in the prevention, treatment, and rehabilitation of breast cancer patients

Breast cancer is the most common female cancer worldwide. This disease represents one of the main points of public health concern today, aggravating the situation due to the numerous barriers to preventing, treating, and rehabilitation patients affected by this health condition. In this way, this letter to the editor aims to discuss the barriers and challenges in preventing, treating, and rehabilitating breast cancer patients.info:eu-repo/semantics/publishedVersio

Uma inscrição votiva em língua lusitana

Dá-se notícia de um importante achado epigráfico relativo a uma inscrição votiva em língua lusitana onde estão contidas referências a divindades inéditas. Elabora-se uma tentativa de definição dessas divindades

Culture medium pH and growth of brazilian ginseng in vitro cultured plantlets

O presente trabalho objetivou avaliar o efeito do pH do meio de cultivo sobre alguns parâmetros de crescimento da Pfaffia glomerata (Spreng.) Pedersen cultivada in vitro, bem como checar se o crescimento dos explantes altera o pH do meio ao longo do período de cultivo. Foram testados quatro tratamentos constituídos de distintos valores de pH (3,7; 5,0; 6,0 e 7,5) do meio de cultivo. O pH do meio de cultivo foi ajustado antes da inclusão do agar (6g L-1 - Merck) e da autoclavagem. Como fonte de explantes foram utilizadas segmentos nodais de plantas previamente estabelecidas in vitro em meio MS. Dos nove aos 15 dias após a inoculação (DAI) dos segmentos nodais, verificou-se maior número de raízes em pH 6,0 e o menor no pH 7,5. Aos 35 DAI, o comprimento da maior brotação e o número total de segmentos nodais por planta foram maiores em torno de pH 6,0. Aos 35 DAI, observou-se menor crescimento em biomassa de raízes em pH 3,7. Já a parte aérea apresentou menor biomassa em pH 7,5. Aos 35 DAI, a produção de matéria fresca e seca total da plântula foi maior em pH próximo a 6,0. Concluiu-se que valores de pH do meio de cultivo próximos a 6,0, ajustados antes da autoclavagem, são ideais para o crescimento da P. glomerata cultivada in vitro. Também se verificou que o crescimento da plântula modificou significativamente o pH do meio de cultivo.The present research aimed to evaluate the effect of culture medium pH on some growth parameter of Pfaffia glomerata (Spreng.) Pedersen in vitro cultured plantlets, as well as to check whether the explant´s growth alters the culture medium pH. Four treatments consisted of different values (3.7; 5.0; 6.0 and 7.5) of culture medium pH were tested. The culture medium pH was adjusted prior to the addition of agar (6g L-1 - Merck) and autoclaving. Nodal segments from asseptic plants grown in MS medium were used as explants. From 9 to 15 days after inoculation (DAI) of nodal segments, the higher number of roots was obtained at pH 6.0, and the lower at pH 7.5. At 35 DAI, both length of the higher sprout and total number of nodal segments per plantlet were greater at about pH 6.0. At 35 DAI, roots biomass was lower at pH 3.7. On the other hand, shoots biomass was lower at pH 7.5. Fresh and dry matter of the whole plantlet was greater at pH around 6.0. In conclusion, values of culture medium pH near to 6.0, adjusted prior to autoclaving, are ideal for the growth of P. glomerata in vitro cultured plantlets. Moreover, the in vitro growth of plantlet modified significantly the culture medium pH

Complete 5-years time series of combined monthly gravity field models derived from Swarm GPS data

Since 2013, the Swarm satellite constellation has allowed us to observe the Earth's large-scale mass transport processes. We present the nearly complete time series of monthly gravity field models derived from the data collected by Swarm?s GPS receivers, from December 2013 to September 2018. These models are the result of the combination of four individual solutions, produced by the Astronomical Institute of the University of Bern, the Astronomical Institute of the Czech Academy of Sciences, the Institute of Geodesy of the Graz University of Technology and the School of Earth Sciences of the Ohio State University, each considering a different gravity field estimation approach. The combination is done at the level of normal equations, with weights derived from Variance Component Estimation, much like what was done by the European Gravity Service for Improved Emergency Management (EGSIEM) initiative. We illustrate the geophysical signal captured by Swarm's GPS receivers over large hydrological basins, the errors represented by the variability of the models over the oceans and the agreement with GRACE and GRACE- FO. All analyses span the GRACE/GRACE-FO gap, to illustrate the importance of the Swarm satellites to bridge the absence of low-low satellite-to-satellite tracking data

Tratamento do carcinoma pulmonar de não pequenas células, doença avançada, com erlotinib em segunda e terceira linhas. A propósito de dois casos clínicos

AbstractAgents that inhibit the activity of cell membrane receptor tyrosine kinases, such as the human epidermal growth factor receptor (EGFR) have been an attractive target because EGFR is expressed by 80% of NSCLC. Erlotinib as monotherapy in the treatment of NSCLC after failure of at least one prior chemotherapy regimen, prolonged survival and improved quality of life, although modest response rate. Women, Asiens, patients with Adenocarcinoma and never smokers, were more likely than other patients to have a response to erlotinib. This is the group of patients that most commonly have an EGFR mutation. The authors describe two cases, with important control of symptoms and increased time to progression, independently o response rate (stable disease or partial response).Rev Port Pneumol 2008; XIV (Supl 3): S53-S6

+ Idade + Saúde – Programa de exercício físico regular para idosos

O número de idosos irá quase triplicar até 2050, e com isso, promover estratégias um envelhecimento ativo a nível mundial são fundamentais. Com isso, no município de Bragança, Norte de Portuga, foi criado o + idade + saúde, um programa de exercício físico regular, do Instituto Politécnico de Bragança (IPB). Objetivo: Promover a saúde física e mental de idosos por meio de exercício físico regular, além de servir de campo para investigações a nível de mestrado e doutoramento. Objetivos: Avaliar, prescrever e orientar a prática de exercício físico adotado para idosos. Métodos: A amostra toral é composta por um grupo de 90 homens e mulheres idosos, que treinam 3 vezes por semana, de 09:00 às 10:00, com duração de 50 minutos cada sessão, sendo divididos em dois grupos, o grupo A (n =30, treino multicomponente, TMC), e o grupo B (n =30, treino intervalado de alta intensidade, HIIT), e grupo de controlo de idosos fisicamente inativos (n =30). Será avaliada a aptidão funcional através do Functional Fitness Test: a força e a resistência dos membros superiores (MS) e inferiores (MI), a flexibilidade dos MI e MS, a agilidade e o equilíbrio dinâmico, a resistência aeróbia; a composição corporal; nível de atividade física, a qualidade de vida, a qualidade do sono, e os índices de solidão dos idosos. Resultados esperados: Esperamos que o treino HIIT (grupo B) surta efeitos maiores e significativos na capacidade funcional, qualidade de vida e bem-estar, e qualidade do sono dos idosos.info:eu-repo/semantics/publishedVersio

Primeiro registro de Platyembia tessellata Ross, 2003 (Embioptera: Anisembiidae) para o estado de Rondônia, Brasil

Embioptera is one of the less studied insect groups. About 400 species have been recorded worldwide, but in Brazil, where five families have been reported to occur, the group is still poorly known. The Amazon is particularly important, insofar as it harbors a great biodiversity, although many species from its entomofauna remain unreported. We report here, for the first time, the occurrence of Platyembia tessellata Ross, 2003 in Rondônia state, northern Brazil. Specimens were collected from a tree trunk near the Jaci Paraná river. An adult male was identified based on its terminalia morphology, following the species original description.Os embiópteros constituem um dos grupos de insetos menos estudados atualmente. São registradas mais de 390 espécies no mundo todo e são pouco conhecidos no Brasil, onde ocorrem quatro famílias. A Amazônia é especialmente importante pois abriga uma grande biodiversidade e muitas espécies da entomofauna carecem de registro. O objetivo deste estudo é registrar a primeira ocorrência de Platyembia tessellata Ross, 2003 para o Estado de Rondônia, Brasil. As coletas foram realizadas em tronco de árvore próxima ao Rio Jaci Paraná. A identificação com base na morfologia da genitália de um macho adulto foi realizada de acordo com a descrição original da espécie. Os resultados mostram uma população brasileira da espécie sendo aqui registrada apenas pela segunda vez após a descoberta de Ross em 2003

The impact of multicomponent exercise protocols order on the maximum voluntary contraction of older women

The aim of this study was to evaluate the impact of exercise order in multicomponent training (MCT) on the maximum voluntary contraction (MVC) of older women. A total of 91 older women, ranging in age from 60 to 85 years, were randomly assigned to either Group A or Group B. Group A performed a warm up followed by aerobic training and resistance training, whereas Group B followed a warm up followed by resistance training and aerobic training. A control group (CG) did not engage in any exercise interventions. Statistical analysis was conducted using one-way ANOVA for between-group comparisons, and ANOVA was used for repeated measures. The results revealed that Group A demonstrated significant increases in MVC for knee extensors (KEs) between M1 and M3 (p < 0.001) and between M2 and M3 (p < 0.001). Similarly, Group A exhibited significant increases in MVC for knee flexors (KFs) between M1 and M3 (p = 0.001) and between M2 and M3 (p < 0.001). Both Group A and Group B demonstrated significant increases in MVC for elbow flexors (EFs) between M1 and M3 (p < 0.001). Furthermore, Group B showed a significant increase in hand grip strength (HGS) between M1 and M3 (p < 0.001). Overall, the findings suggest that initiating MCT with aerobic training followed by resistance training is the most effective approach for improving muscle strength in older women.This research was funded by national funds via the Portuguese Foundation for Science and Technology. I.P.: grant number UIDB/04748/2020 and grant number UID/04045/2020info:eu-repo/semantics/publishedVersio

The effectiveness of pilates training interventions on older adults’ balance: a systematic review and meta-analysis of randomized controlled trials

Pilates training intervention programs have gained attention as a potential approach to enhancing balance in older adults, thereby reducing the risk of falls. In light of these considerations, this systematic review and meta-analysis aimed to critically evaluate the existing evidence and determine the effect of Pilates training intervention programs on older adults’ balance. Materials and Methods: The literature was searched through the PubMed, Web of Science, and Scopus databases from inception until July 2023. The primary keywords used for the literature search included “elderly” or “older adults” and “pilates training” and “balance”. Results: The systematic review through qualitative analysis showed robust evidence about the efficacy of Pilates intervention programs in improving older adults’ balance. The pooled meta-analysis of static and dynamic balance showed that eight (53%) out of a total fifteen analyzed interventions presented a significant effect of Pilates in improving the participants’ balance, without between-study heterogeneity. In addition, the meta-analysis regarding dynamic balance showed that six (67%) out of nine analyzed interventions presented a significant effect of Pilates in improving the participants’ balance, without heterogeneity between studies. Similarly, the meta-analysis regarding static balance showed that four (50%) out of eight analyzed studies presented significant effects on the older adults’ balance, where moderate between-study heterogeneity was found. Sensitivity analysis showed that three studies reduced the between-study heterogeneity (19, 17.6, and 17%), regressing from moderate to low heterogeneity, p < 0.05. Conclusions: This systematic review and meta-analysis underscores the potential of Pilates training as a valuable intervention to enhance balance in the elderly populationThis work is supported by national funding through the Portuguese Foundation for Science and Technology, I.P., under the project UIDB/04045/2020.info:eu-repo/semantics/publishedVersio