Risk-based Security Measure Allocation Against Injection Attacks on Actuators

This article considers the problem of risk-optimal allocation of security measures when the actuators of an uncertain control system are under attack. We consider an adversary injecting false data into the actuator channels. The attack impact is characterized by the maximum performance loss caused by a stealthy adversary with bounded energy. Since the impact is a random variable, due to system uncertainty, we use Conditional Value-at-Risk (CVaR) to characterize the risk associated with the attack. We then consider the problem of allocating the security measures which minimize the risk. We assume that there are only a limited number of security measures available. Under this constraint, we observe that the allocation problem is a mixed-integer optimization problem. Thus we use relaxation techniques to approximate the security allocation problem into a Semi-Definite Program (SDP). We also compare our allocation method $(i)$ across different risk measures: the worst-case measure, the average (nominal) measure, and $(ii)$ across different search algorithms: the exhaustive and the greedy search algorithms. We depict the efficacy of our approach through numerical examples.Comment: Submitted to IEEE Open Journal of Control Systems (OJ-CSYS

Security Allocation in Networked Control Systems under Stealthy Attacks

This paper considers the problem of security allocation in a networked control system under stealthy attacks in which the system is comprised of interconnected subsystems represented by vertices. A malicious adversary selects a single vertex on which to conduct a stealthy data injection attack to maximally disrupt the local performance while remaining undetected. On the other hand, a defender selects several vertices on which to allocate defense resources against the adversary. First, the objectives of the adversary and the defender with uncertain targets are formulated in probabilistic ways, resulting in an expected worst-case impact of stealthy attacks. Next, we provide a graph-theoretic necessary and sufficient condition under which the cost for the defender and the expected worst-case impact of stealthy attacks are bounded. This condition enables the defender to restrict the admissible actions to a subset of available vertex sets. Then, we cast the problem of security allocation in a Stackelberg game-theoretic framework. Finally, the contribution of this paper is highlighted by utilizing the proposed admissible actions of the defender in the context of large-scale networks. A numerical example of a 50-vertex networked control system is presented to validate the obtained results.Comment: 11 pages, 3 figures, and 1 table, journal submissio

Risk Assessment of Stealthy Attacks on Uncertain Control Systems

In this article, we address the problem of risk assessment of stealthy attacks on uncertain control systems. Considering data injection attacks that aim at maximizing impact while remaining undetected, we use the recently proposed output-to-output gain to characterize the risk associated with the impact of attacks under a limited system knowledge attacker. The risk is formulated using a well-established risk metric, namely the maximum expected loss. Under this setups, the risk assessment problem corresponds to an untractable infinite non-convex optimization problem. To address this limitation, we adopt the framework of scenario-based optimization to approximate the infinite non-convex optimization problem by a sampled non-convex optimization problem. Then, based on the framework of dissipative system theory and S-procedure, the sampled non-convex risk assessment problem is formulated as an equivalent convex semi-definite program. Additionally, we derive the necessary and sufficient conditions for the risk to be bounded. Finally, we illustrate the results through numerical simulation of a hydro-turbine power system

A Zero-Sum Game Framework for Optimal Sensor Placement in Uncertain Networked Control Systems under Cyber-Attacks

This paper proposes a game-theoretic approach to address the problem of optimal sensor placement against an adversary in uncertain networked control systems. The problem is formulated as a zero-sum game with two players, namely a malicious adversary and a detector. Given a protected performance vertex, we consider a detector, with uncertain system knowledge, that selects another vertex on which to place a sensor and monitors its output with the aim of detecting the presence of the adversary. On the other hand, the adversary, also with uncertain system knowledge, chooses a single vertex and conducts a cyber-attack on its input. The purpose of the adversary is to drive the attack vertex as to maximally disrupt the protected performance vertex while remaining undetected by the detector. As our first contribution, the game payoff of the above-defined zero-sum game is formulated in terms of the Value-at-Risk of the adversary's impact. However, this game payoff corresponds to an intractable optimization problem. To tackle the problem, we adopt the scenario approach to approximately compute the game payoff. Then, the optimal monitor selection is determined by analyzing the equilibrium of the zero-sum game. The proposed approach is illustrated via a numerical example of a 10-vertex networked control system.Comment: 8 pages, 3 figues, Accepted to the 61st Conference on Decision and Control, Cancun, December 202

Design of multiplicative watermarking against covert attacks

This paper addresses the design of an active cyberattack detection architecture based on multiplicative watermarking, allowing for detection of covert attacks. We propose an optimal design problem, relying on the so-called output-to-output l2-gain, which characterizes the maximum gain between the residual output of a detection scheme and some performance output. Although optimal, this control problem is non-convex. Hence, we propose an algorithm to design the watermarking filters by solving the problem suboptimally via LMIs. We show that, against covert attacks, the output-to-output l2-gain is unbounded without watermarking, and we provide a sufficient condition for boundedness in the presence of watermarks.Comment: 6 page conference paper accepted to the 60th IEEE Conference on Decision and Contro

Hydrogen peroxide production regulates the mitochondrial function in insulin resistant muscle cells: Effect of catalase overexpression

AbstractThe mitochondrial redox state plays a central role in the link between mitochondrial overloading and insulin resistance. However, the mechanism by which the ROS induce insulin resistance in skeletal muscle cells is not completely understood. We examined the association between mitochondrial function and H2O2 production in insulin resistant cells. Our hypothesis is that the low mitochondrial oxygen consumption leads to elevated ROS production by a mechanism associated with reduced PGC1α transcription and low content of phosphorylated CREB. The cells were transfected with either the encoded sequence for catalase overexpression or the specific siRNA for catalase inhibition. After transfection, myotubes were incubated with palmitic acid (500μM) and the insulin response, as well as mitochondrial function and fatty acid metabolism, was determined. The low mitochondrial oxygen consumption led to elevated ROS production by a mechanism associated with β-oxidation of fatty acids. Rotenone was observed to reduce the ratio of ROS production. The elevated H2O2 production markedly decreased the PGC1α transcription, an effect that was accompanied by a reduced phosphorylation of Akt and CREB. The catalase transfection prevented the reduction in the phosphorylated level of Akt and upregulated the levels of phosphorylated CREB. The mitochondrial function was elevated and H2O2 production reduced, thus increasing the insulin sensitivity. The catalase overexpression improved mitochondrial respiration protecting the cells from fatty acid-induced, insulin resistance. This effect indicates that control of hydrogen peroxide production regulates the mitochondrial respiration preventing the insulin resistance in skeletal muscle cells by a mechanism associated with CREB phosphorylation and β-oxidation of fatty acids

Portuguese Football Federation consensus statement 2020: nutrition and performance in football

Nutrition is an undeniable part of promoting health and performance among football (soccer) players. Nevertheless, nutritional strategies adopted in elite football can vary significantly depending on culture, habit and practical constraints and might not always be supported by scientific evidence. Therefore, a group of 28 Portuguese experts on sports nutrition, sports science and sports medicine sought to discuss current practices in the elite football landscape and review the existing evidence on nutritional strategies to be applied when supporting football players. Starting from understanding football's physical and physiological demands, five different moments were identified: preparing to play, match-day, recovery after matches, between matches and during injury or rehabilitation periods. When applicable, specificities of nutritional support to young athletes and female players were also addressed. The result is a set of practical recommendations that gathered consensus among involved experts, highlighting carbohydrates periodisation, hydration and conscious use of dietary supplements.info:eu-repo/semantics/publishedVersio

The Portuguese Society of Rheumatology position paper on the use of biosimilars

Biotechnological drugs have become a fundamental resource for the treatment of rheumatic patients. Patent expiry of some of these drugs created the opportunity for biopharmaceutical manufacturers to develop biosimilar drugs intended to be as efficacious as the originator product but with a lower cost to healthcare systems. Due to the complex manufacturing process and highly intricate structure of biologicals, a biosimilar can never be an exact copy of its reference product. Consequently, regulatory authorities issued strict preclinical and clinical guidelines to ensure safety and efficacy equivalence and, in September 2013, the biosimilar of infliximab was the first biosimilar monoclonal antibody to be authorized for use in the European Union. The current document is a position statement of the "Sociedade Portuguesa de Reumatologia" (Portuguese Society of Rheumatology) on the use of biosimilar drugs in rheumatic diseases. Two systematic literature reviews were performed, one concerning clinical trials and the other one concerning international position papers on biosimilars. The results were presented and discussed in a national meeting and a final position document was discussed, written and approved by Portuguese rheumatologists. Briefly, this position statement is contrary to automatic substitution of the originator by the biosimilar, defends either a different INN or the prescription by brand name, supports that switching between biosimilars and the originator molecule should be done after at least 6 months of treatment and based on the attending physician decision and after adequate patient information, recommends the registration of all biosimilar treated patients in Reuma.pt for efficacy, safety and immunogenicity surveillance, following the strategy already ongoing for originators, and opposes to extrapolation of indications approved to the originator to completely different diseases and/or age groups without adequate pre-clinical, safety or efficacy data.info:eu-repo/semantics/publishedVersio