“Clareo y Florisea" o la historia de una mentira

La novela “Clareo y Florisea” del novelista Alonso Núñez de Reinoso es considerada la primera novela bizantina española. Apareció en 1552 y ha sido considerada una imitación de la obra “Leucipa y Clitofonte” por la similitud de situaciones y semejanza de historias. Esto hace necesario el planteamiento de la originalidad de la obra desde unos estudios estéticos y críticos más rigurosos.The Novel "Clareo y Florisea" from Alonso Núñez de Reinoso is considered the first Spanish Byzantine novel. It appeared in 1552 and has been considered an imitation of the "Leucippe and Clitophon" work because the similarity of the situations and likeness of stories. This makes necessary to make an approach to the originality of the work since some aesthetic and critical more rigorous studies

El "Auto de los Reyes Magos": consideraciones para una lectura y edición del texto

Las dificultades que ofrecen tanto en su disposición externa como en su análisis interno el primer texto conocido en nuestra tradición dramática --el "Auto de los Reyes Magos"--, han sido básicos para la elaboración de este artículo, que trata de ofrecer una puesta al día sobre esta obra dramática. Por tanto, el autor pasa revista a las opiniones críticas sobre aspectos como la autoría, datación, estructura, fuentes, pensamientos..., al mismo tiempo, el autor propone una nueva lectura del diálogo teatral que nos puede ayudar a entender mejor esta obra.The difficulties that the first-known text in our dramatic tradition —el “Auto de los Reyes Magos”— offer both in its external disposition and in its internal analysis, have been basic for the elaboration of this article which tries to give an up-to-date view about this dramatic work. Therefore the author reviews critical opinions in aspects such as the authorship, dating, structure, sources, meaning..., at the same time the author proposes a new reading of the theatre dialogue which can help us to understand the play better.notPeerReviewe

"El Grao de Valencia"en los orígenes de la dramaturgia barroca

“El Grao de Valencia” (aprox. 1589-1590?) es un trabajo perteneciente al primer período de las obras dramáticas de Lope de Vega aunque pueden encontrarse recursos propios del teatro del siglo XVII. Es además innegable la existencia de algunos errores en la composición y estructura de la obra. Comparando esta comedia con otras obras de Lope, parece experimental o de transición en muchos de los personajes, en gran número de las escenas, en la ausencia del "gracioso", en las descripciones de los personajes. Los temas no están todavía codificados... deberá pasar algún tiempo para que el teatro de Lope alcance la categoría de «teatro nacional» y su esquema dramático sea imitado por el resto de los dramaturgos de su época que se inicia ya en este Lope-preLope.El Grao de Valencia (aproximately 1589-1590?) is a work belonging to the first period of Lope de Vega's dramatic plays. Although, some basic recourses of 17 th century theatre can be found, it is also undeniable the existence of some mistakes in the composition and structure of this play. Comparing this comedy with other Lope's works this seems experimental or transitional in many of the characters, in many scenes, in the absence of "funny", in the descriptions of the characters. Topics are not yet coded ... should spend some time for Lope's theater until it achieves the category of "national theater" and its dramatic scheme was imitated by other playwrights of his time.notPeerReviewe

Complex anatomy difficulting left atrial appendage closure.

Left atrial appendage closure is a useful technique for patients at high thromboembolic risk and contraindications for oral anticoagulation therapy. However, it can be challenging when anatomical difficulties are encountered. We present a unique case of atypical appendage uptake and how we completed the procedure.peer-reviewed409 K

Sequential Colocalization of ERa, PR, and AR Hormone Receptors Using Confocal Microscopy Enables New Insights into Normal Breast and Prostate Tissue and Cancers

Multiplex immunohistochemistry (mIHC) use markers staining different cell populations applying widefield optical microscopy. Resolution is low not resolving subcellular co-localization. We sought to colocalize markers at subcellular level with antibodies validated for clinical diagnosis, including the single secondary antibody (combination of anti-rabbit/mouse-antibodies) used for diagnostic IHC with any primary antibody, and confocal microscopy. We explore colocalization in the nucleus (ColNu) of nuclear hormone receptors (ERa, PR, and AR) along with the baseline marker p63 in paired samples of breast and prostate tissues. We established ColNu mIHCF as a reliable technique easily implemented in a hospital setting. In ERa+ breast cancer, we identified different colocalization patterns (nuclear or cytoplasmatic) with PR and AR on the luminal epithelium. A triple-negative breast-cancer case expressed membrane-only ERa. A PR-only case was double positive PR/p63. In normal prostate, we identified an ERa+/p63+/AR-negative distinct population. All prostate cancer cases characteristically expressed ERa on the apical membrane of the AR+ epithelium. We confirmed this using ERa IHC and needle-core biopsies. ColNu mIHCF is feasible and already revealed a new marker for prostate cancer and identified sub-patterns in breast cancer. It could be useful for pathology as well as for functional studies in normal prostate and breast tissuesThis study has been supported by projects from the State Research Agency (AEI), and Ministry of Science and Innovation, Spain, MINECO-FEDER PID2019-110437RB-I00 (to CVA) and Instituto de Salud Carlos III (ISCIII)-FEDER PI19/01316 (to JMCT). Financial support code: ED431G 2019/02 from the Xunta de Galicia and the European Union (European Regional Development Fund - ERDF) to the Centro singular de Investigación de Galicia accreditation 2019-2022 is gratefully acknowledgedS

Lat-1 and glut-1 carrier expression and its prognostic value in gastroenteropancreatic neuroendocrine tumors

Cancer cells develop mechanisms that increase nutrient uptake, including key nutrient carriers, such as amino acid transporter 1 (LAT-1) and glucose transporter 1 (GLUT-1), regulated by the oxygen-sensing Von Hippel Lindau-hypoxia-inducible factor (VHL-HIF) transcriptional pathway. We aimed to analyze these metabolic players in gastroenteropancreatic neuroendocrine tumors (GEP-NET) and correlate them with tumor malignancy and progression. LAT-1, GLUT-1, and pVHL expression was analyzed in 116 GEP-NETs and 48 peritumoral tissue samples by immunohistochemistry. LAT-1 was stably silenced using specific shRNA in the human NET BON cell line. LAT-1 expression was significantly increased in tumor tissue compared to non-tumor tissue in both gastrointestinal (67% vs. 44%) and pancreatic NETs (54% vs. 31%). Similarly, GLUT-1 was substantially elevated in gastrointestinal (74% vs. 19%) and pancreatic (58% vs. 4%) NETs. In contrast, pVHL expression was decreased (85% vs. 58%) in pancreatic NETs. Tumors with metastases at diagnosis displayed increased LAT-1 and GLUT-1 and decreased pVHL expression (p < 0.001). In accordance with these data, silencing LAT-1 curtailed cell proliferation in BON cells. These findings suggest that specific mechanisms that increase nutrient uptake, such as LAT-1 and GLUT-1, are increased in GEP-NETs, whereas pVHL is decreased. These markers might be related to the proliferation and metastatic capacity of these tumors.This work was supported by the following grants: Proyectos de Investigación en Salud (FIS) PIE13-0041, PI16-02091 and PI19-00584 (funded by Instituto de Salud Carlos III), TIRONET2-CM, B2017/BMD-3724 (funded by Comunidad de Madrid), GETNE G1707 and GCI1901 (funded by Grupo Español de Tumores Neuroendocrinos y Endocrinos) and cofinanced by FEDER funds to M.M. Proyectos de Investigación en Salud (FIS) PI19/01316-FEDER (funded by Instituto de Salud Carlos III), given to J.C.T. Grants from the Ministerio de Economia y Competitividad (SAF2016-76815 and SAF2017-90794-REDT), and Fundació La Marato de TV3 (534/C/2016) ceded to J.A

Jerónimo de Contreras y los nueve libros de la "Selva de aventuras". Aproximación al modelo bizantino

La escasa atención que los críticos han prestado a nuestro autor, Jerónimo de Contreras, nos obliga a estudiar uno de sus más importantes trabajos, “Selva de aventuras” que primero apareció en Zaragoza (1565). Después de unos breves detalles biográficos y editoriales que nos muestran el éxito de la obra en su propio tiempo, y perfilando el estado de la cuestión se intenta enfatizar pequeños valores del trabajo de este novelista.The little attention that critics have given to our author, Jeronimo de Contreras, forcing us to study one of his most important works, "Selva de aventuras" which first appeared in Zaragoza (1565). After brief biographical and editorial details that show us the success of the work on its own time, the state of affairs is outlined and attempts to emphasize values ​​of this novelist

“Clareo y Florisea" o la historia de una mentira

La novela “Clareo y Florisea” del novelista Alonso Núñez de Reinoso es considerada la primera novela bizantina española. Apareció en 1552 y ha sido considerada una imitación de la obra “Leucipa y Clitofonte” por la similitud de situaciones y semejanza de historias. Esto hace necesario el planteamiento de la originalidad de la obra desde unos estudios estéticos y críticos más rigurosos.The Novel "Clareo y Florisea" from Alonso Núñez de Reinoso is considered the first Spanish Byzantine novel. It appeared in 1552 and has been considered an imitation of the "Leucippe and Clitophon" work because the similarity of the situations and likeness of stories. This makes necessary to make an approach to the originality of the work since some aesthetic and critical more rigorous studies

Dejó la vieja Celestina fama de hechicera o el tema de la magia en las continuaciones celestinescas

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