Blood Protein Binding of Cyclosporine in Transplant Patients

The objective of this study was to compare the binding of cyclosporine to blood proteins between four healthy subjects and five liver and eight renal transplant patients. Fresh heparinized blood was obtained, to which sufficient quantities of tritium-labelled cyclosporine and unlabelled cyclosporine were added to blood samples or red blood cell (RBC) suspensions. Concentrations of cyclosporine in whole blood, plasma, RBC suspension, and phosphate buffer were estimated by liquid scintigraphy. The blood:plasma ratio of cyclosporine in transplant patients was significantly lower (P < .05) than that in healthy volunteers. The RBC:buffer ratio, a measure of affinity of RBCs for cyclosporine, was highest in those with liver transplants and lowest in those with kidney transplants. The unbound fraction of cyclosporine in plasma was less in transplant patients than in healthy volunteers. The results of this study indicate that there are differences in blood protein binding of cyclosporine between transplant patients that may contribute to the differences in the pharmacokinetics and pharmacodynamics of this drug

Position scientifique de la France dans le monde 2000-2015 (La)

Ce rapport analyse le positionnement scientifique de la France depuis 2000, en s’appuyant essentiellement sur des données bibliométriques. Se concentrant sur la France et certaines de ses problématiques spécifiques, il offre un traitement approfondi de ses données et prend en compte les publications de l’ensemble des acteurs de la recherche en  France.

Le "Mastery learning" : une voie pour l'apprentissage et la réussite rapport de recherche faite au Département des techniques informatiques du Cégep André-Laurendeau /

Également disponible en version papierTitre de l'écran-titre (visionné le 5 déc. 2009)Bibliogr

A case study on graphically modelling and detecting knowledge mobility risks

As the world continues to increasingly depend on a knowledge economy, companies are realising that their most valuable asset is knowledge held by their employees. This asset is hard to track, manage and retain especially in a situation where employees are free to job-hop for better pay after providing a few weeks’ notice to their employers. In previous work we have defined the concept of knowledge risk, and presented a graph-based approach for detecting it. In this paper, we present the results of a case study which employs knowledge graphs in the context of four software development teams.peer-reviewe

A constraint programming approach to the hospitals/residents problem

An instance I of the Hospitals/Residents problem (HR) involves a set of residents (graduating medical students) and a set of hospitals, where each hospital has a given capacity. The residents have preferences for the hospitals, as do hospitals for residents. A solution of I is a &lt;i&gt;stable matching&lt;/i&gt;, which is an assignment of residents to hospitals that respects the capacity conditions and preference lists in a precise way. In this paper we present constraint encodings for HR that give rise to important structural properties. We also present a computational study using both randomly-generated and real-world instances. We provide additional motivation for our models by indicating how side constraints can be added easily in order to solve hard variants of HR

Cratering Experiments on the Self Armoring of Coarse-Grained Granular Targets

Recently published crater statistics on the small asteroids 25143 Itokawa and 433 Eros show a significant depletion of craters below approx. 100 m in diameter. Possible mechanisms that were brought up to explain this lack of craters were seismic crater erasure and self armoring of a coarse, boulder covered asteroid surface. While seismic shaking has been studied in this context, the concept of armoring lacks a deeper inspection and an experimental ground truth. We therefore present cratering experiments of glass bead projectiles impacting into granular glass bead targets, where the grain sizes of projectile and target are in a similar range. The impact velocities are in the range of 200 to 300 m/s. We find that craters become fainter and irregular shaped as soon as the target grains are larger than the projectile sizes and that granular craters rarely form when the size ratio between projectile and target grain is around 1:10 or smaller. In that case, we observe a formation of a strength determined crater in the first struck target grain instead. We present a simple model based on the transfer of momentum from the projectile to this first target grain, which is capable to explain our results with only a single free parameter, which is moreover well determined by previous experiments. Based on estimates of typical projectile size and boulder size on Itokawa and Eros, given that our results are representative also for km/s impact velocities, armoring should play an important role for their evolution.Comment: accepted for publication in Icaur

Exploring the link between test suite quality and automatic specification inference

While no one doubts the importance of correct and complete specifications, many industrial systems still do not have formal specifications written out — and even when they do, it is hard to check their correctness and completeness. This work explores the possibility of using an invariant extraction tool such as Daikon to automatically infer specifications from available test suites with the idea of aiding software engineers to improve the specifications by having another version to compare to. Given that our initial experiments did not produce satisfactory results, in this paper we explore which test suite attributes influence the quality of the inferred specification. Following further study, we found that instruction, branch and method coverage are correlated to high recall values, reaching up to 97.93%.peer-reviewe