Systematics of Himerometra (Echinodermata: Crinoidea: Himerometridae) based on morphology and molecular data

One of the most common genera of feather stars found on tropical Indo-western Pacific reefs, Himerometra A.H.Clark, 1907, has previously included six accepted species, distinguished chiefly by variations in the enlarged proximal pinnules. This study examined new and existing specimens using molecular (mtDNA and nuDNA) techniques and morphological characters to revise the genus. Both approaches support placing H. magnipinna and H. martensi as junior synonyms of H. robustipinna. Sequence data for specimens attributed to H. bartschi also place this species as a junior synonym of H. robustipinna, despite some morphological disparity. Himerometra sol is retained as distinct despite morphological congruence with H. robustipinna, because the two known specimens were collected outside the known range of the latter, with no molecular data currently available. Himerometra persica is herein transferred to Heterometra: the type specimens were incorrectly identified. The species treated as valid are redescribed. This study illustrates the importance of re-examining crinoid species boundaries for established taxa without molecular corroboration and demonstrates that diversity in this particular feather star clade might be lower than previously thought

A Multi-wavelength Study of the Host Environment of SMBHB 4C+37.11

4C+37.11, at z=0.055 shows two compact radio nuclei, imaged by VLBI at 7mas separation, making it the closest known resolved super-massive black hole binary (SMBHB). An important question is whether this unique object is young, caught on the way to a gravitational in-spiral and merger, or has `stalled' at 7pc. We describe new radio/optical/X-ray observations of the massive host and its surrounding X-ray halo. These data reveal X-ray/optical channels following the radio outflow and large scale edges in the X-ray halo. These structures are promising targets for further study which should elucidate their relationship to the unique SMBHB core.Comment: To appear in the Astrophysical Journa

Vaccinating sons against HPV: results from a U.S. national survey of parents

PURPOSE: The quadrivalent HPV vaccination was approved for use in males ages 9 to 26 in 2009 and recommended for routine administration in 2011. The purpose of this study was to uncover predictable commonalities amongst parents who chose to vaccinate their 11-17 year old sons against HPV. METHODS: We compiled data from a U.S. national sample of 779 parents with sons 11-17 years old using a web-based survey to gather information about behavioral and sociodemographic factors which predicted receipt of 1 or more HPV vaccine doses based on parental report. Predictors were first modeled individually for univariable associations. Significant predictors (p<0.10) were combined in a multivariable model. RESULTS: In the adjusted model, independent predictors included receipt of flu vaccination, health insurance coverage and sexual health topic discussions with sons. Sons who had received a flu shot in the last two years more frequently received at least one dose of the vaccine (OR 1.82; 95% CI 1.45-2.26). Sons covered by private health insurance had decreased odds of HPV vaccination (OR 0.56 95% CI 0.37-0.83). Lastly, parents who had discussed sexual health topics with their sons were more likely to vaccinate (OR 1.61; 95% CI 1.37-1.89). CONCLUSIONS: Male vaccination rates in the U.S. have increased, but males continue to be under-immunized. Utilization of health care is an important factor in HPV vaccine uptake; therefore, health care providers should use every contact as an opportunity to vaccinate. Communication about sexual health topics may provide a forum for parents and health care providers to have conversations about HPV vaccination as those more comfortable discussing these topics may also be more comfortable discussing HPV vaccination

New Limits on the Low-frequency Radio Transient Sky Using 31 hr of All-sky Data with the OVRO-LWA

We present the results of the first transient survey from the Owens Valley Radio Observatory Long Wavelength Array (OVRO–LWA) using 31 hr of data, in which we place the most constraining limits on the instantaneous transient surface density at timescales of 13 s to a few minutes and at frequencies below 100 MHz. The OVRO–LWA is a dipole array that images the entire viewable hemisphere with 58 MHz of bandwidth from 27 to 84 MHz at 13 s cadence. No transients are detected above a 6.5σ flux density limit of 10.5 Jy, implying an upper limit to the transient surface density of 2.5 × 10⁻⁸ deg⁻² at the shortest timescales probed, which is orders of magnitude deeper than has been achieved at sub-100 MHz frequencies and comparable flux densities to date. The nondetection of transients in the OVRO–LWA survey, particularly at minutes-long timescales, allows us to place further constraints on the rate of the potential population of transients uncovered by Stewart et al. From their transient rate, we expect a detection of 8.4^(+31.8)_(-8.0) events, and the probability of our null detection is 1.9^(+644)_(-1.9) x 10⁻³, ruling out a transient rate >1.4 × 10⁻⁴ days⁻¹ deg⁻² with 95% confidence at a flux density limit of 18.1 Jy, under the assumption of a flat spectrum and wide bandwidth. We discuss the implications of our nondetection for this population and further constraints that can be made on the source spectral index, intrinsic emission bandwidth, and resulting luminosity distribution

A new class of Cu/ZnO catalysts derived from zincian georgeite precursors prepared by co-precipitation

Zincian georgeite, an amorphous copper-zinc hydroxycarbonate, has been prepared by co-precipitation using acetate salts and ammonium carbonate. Incorporation of zinc into the georgeite phase and mild ageing conditions inhibits crystallisation into zincian malachite or aurichalcite. This zincian georgeite precursor was used to prepare a Cu/ZnO catalyst, which exhibits a superior performance to a zincian malachite derived catalyst for methanol synthesis and the low temperature water-gas shift (LTS) reaction. Furthermore, the enhanced LTS activity and stability in comparison to that of a commercial Cu/ZnO/Al2O3 catalyst, indicates that the addition of alumina as a stabiliser may not be required for the zincian georgeite derived Cu/ZnO catalyst. The enhanced performance is partly attributed to the exclusion of alkali metals from the synthesis procedure, which are known to act as catalyst poisons. The effect of residual sodium on the microstructural properties of the catalyst precursor was investigated further with preparations using sodium carbonate

MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria

MPV17 is a mitochondrial inner membrane protein whose dysfunction causes mitochondrial DNA abnormalities and disease by an unknown mechanism. Perturbations of deoxynucleoside triphosphate (dNTP) pools are a recognized cause of mitochondrial genomic instability; therefore, we determined DNA copy number and dNTP levels in mitochondria of two models of MPV17 deficiency. In Mpv17 ablated mice, liver mitochondria showed substantial decreases in the levels of dGTP and dTTP and severe mitochondrial DNA depletion, whereas the dNTP pool was not significantly altered in kidney and brain mitochondria that had near normal levels of DNA. The shortage of mitochondrial dNTPs in Mpv17-/- liver slows the DNA replication in the organelle, as evidenced by the elevated level of replication intermediates. Quiescent fibroblasts of MPV17-mutant patients recapitulate key features of the primary affected tissue of the Mpv17-/- mice, displaying virtual absence of the protein, decreased dNTP levels and mitochondrial DNA depletion. Notably, the mitochondrial DNA loss in the patients’ quiescent fibroblasts was prevented and rescued by deoxynucleoside supplementation. Thus, our study establishes dNTP insufficiency in the mitochondria as the cause of mitochondrial DNA depletion in MPV17 deficiency, and identifies deoxynucleoside supplementation as a potential therapeutic strategy for MPV17-related disease. Moreover, changes in the expression of factors involved in mitochondrial deoxynucleotide homeostasis indicate a remodeling of nucleotide metabolism in MPV17 disease models, which suggests mitochondria lacking functional MPV17 have a restricted purine mitochondrial salvage pathway

The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer.

The androgen receptor (AR) is the dominant growth factor in prostate cancer (PCa). Therefore, understanding how ARs regulate the human transcriptome is of paramount importance. The early effects of castration on human PCa have not previously been studied 27 patients medically castrated with degarelix 7 d before radical prostatectomy. We used mass spectrometry, immunohistochemistry, and gene expression array (validated by reverse transcription-polymerase chain reaction) to compare resected tumour with matched, controlled, untreated PCa tissue. All patients had levels of serum androgen, with reduced levels of intraprostatic androgen at prostatectomy. We observed differential expression of known androgen-regulated genes (TMPRSS2, KLK3, CAMKK2, FKBP5). We identified 749 genes downregulated and 908 genes upregulated following castration. AR regulation of α-methylacyl-CoA racemase expression and three other genes (FAM129A, RAB27A, and KIAA0101) was confirmed. Upregulation of oestrogen receptor 1 (ESR1) expression was observed in malignant epithelia and was associated with differential expression of ESR1-regulated genes and correlated with proliferation (Ki-67 expression).We thank CRUK, The NIHR, The Academy of Medical Sciences(RG:63397) and the National Cancer Research Prostate Cancer: Mechanisms of Progression and Treatment (ProMPT) collaborative (G0500966/75466), Hutchison Whampoa Limited, the Human Research Tissue Bank (Addenbrooke’s Hospital, supported by the NIHR Cambridge BRC), and Cancer Research UK