4,4′-Di-tert-butyl-2,2′-dipyridinium dichloride

In the title compound, C18H26N2 2+·2Cl−, the complete dication is generated by crystallographic inversion symmetry; both N atoms are protonated and engaged in strong and highly directional N—H⋯Cl hydrogen bonds. Additional weak C—H⋯Cl contacts promote the formation of a tape along ca. [110]. The crystal structure can be described by the parallel packing of these tapes. The crystal studied was a non-merohedral twin with twin law [−1 0 0, 0 −1 0, −0.887 0.179 1] and the final BASF parameter refining to 0.026 (2)

Tris(4,4′-di-tert-butyl-2,2′-bipyridine-κ2 N,N′)molybdenum(II) μ6-oxido-dodeca-μ2-oxido-hexa­oxidohexa­molybdate(VI) acetonitrile tetra­solvate

The asymmetric unit of the title compound, [Mo(C18H24N2)3][Mo6O19]·4CH3CN, comprises an [Mo(di-t-Bu-bipy)3]2+ cation (di-t-Bu-bipy is 4,4′-di-tert-butyl-2,2′-bipyridine), two halves of Lindqvist-type [Mo6O19]2− anions (with each anion completed by the application of a center of inversion) and four acetonitrile solvent mol­ecules. The geometry around the metal atom of the cation resembles a distorted octa­hedron, with each of the three di-t-Bu-bipy ligands being almost planar [deviation from planarity < 6.3 (2)°]. Supra­molecular inter­actions, namely Mo=O⋯π, C N⋯π, C—H⋯O and C—H⋯N, along with electrostatic forces, mediate the crystal packing. Two of the tert-butyl groups are affected by rotational disorder which was modeled over two distinct positions with major site occupancies of 0.707 (9) and 0.769 (8)

Determination of ascorbic acid and acetylsalicylic acid in commercial preparations using an electronic tongue

The electronic tongue is a multi-sensors system used to identify the basic standards of taste, such as sweet, salty, sour and bitter, at levels not detectable by humans. Although the main purpose of electronic tongue is the qualitative analysis, the quantitative analysis of substances in a liquid matrix is also possible, having been the subject of these preliminary studies the application of electronic tongue to pharmaceutical products. In this way, the aim of the current study was the quantitative analysis of ascorbic acid (AA) and acetylsalicylic acid (ASA) in several commercial preparations using an electronic tongue. For that, solutions of standard compounds or of commercial preparations contain ascorbic acid and acetylsalicylic acid were analizes by an electronic tongue. The obtained data were using to determine the concentrations of the solutions thought através do multiple linear regression method. The preliminary tests showed that it is possible to quantify the ascorbic acid in effervescent formulations of vitamin C, using the predictor model obtained by multiple linear regression. In the case of acetylsalicylic acid it was verified that the matrix of the analgesics or antipyretics drugs significantly affect the signs of the electronic tongue. The electronic tongue can be used determined ascorbic acid in effervescent formulations while it is necessary developed more selective sensors to acetylsalicylic acid in order to improve the predictive power of electronic tongue quantification of this compound

4,4′-Di-tert-butyl-2,2′-bipyridine

In the title compound, C18H24N2, the mol­ecular unit adopts a trans conformation around the central C—C bond [N—C—C—N torsion angle of 179.2 (3)°], with the two aromatic rings almost coplanar [dihedral angle of only 0.70 (4)°]. The crystal packing is driven by co-operative contacts involving weak C—H⋯N and C—H⋯π inter­actions, and also the need to fill effectively the available space

1-Hydr­oxy-1,1,3,3,3-penta­phenyl­disiloxane, [Si2O(OH)(Ph)5], at 150 K

In the crystal structure of the title compound, C30H26O2Si2, one Si(Ph)3 residue is bound to another Si(OH)(Ph)2 residue via a nonlinear Si—O—Si bridge. The asymmetric unit is composed of four [Si2O(OH)(Ph)5] molecules. Each pair of adjacent molecules inter­acts via strong and highly directional O—H⋯O hydrogen bonds connecting neighbouring Si—OH units, and via inter-unit O—H⋯π contacts connecting the second hydroxyl groups with adjacent phenyl groups

2-(1H-Pyrazol-3-yl)pyridinium chloride monohydrate

The title organic salt, C8H8N3 +·Cl−·H2O, exhibits a rich hydrogen-bonding network involving all constituent species. The water mol­ecules are engaged in strong O—H⋯Cl inter­actions with the chloride anions, two neighboring protonated 2-(1H-pyrazol-3-yl)pyridinium species inter­act via N—H⋯N bonds with two pyrazole rings. Further, a short and highly directional C—H⋯O inter­action is observed connecting the pyridinium ring to the water mol­ecule of crystallization. Weak C—H⋯Cl and N—H⋯Cl inter­actions contribute to the stabilization of the crystal structure

COMPOSIÇÃO CORPORAL, APTIDÃO FÍSICA E QUALIDADE DE VIDA EM MULHERES JOVENS EM EXERCÍCIOS NO MINI-TRAMPOLIM

Este estudo verificou os efeitos da prática de exercício no mini-trampolim em solo em intervenção de 16semanas, com três sessões semanais de 45 minutos cada, sobre a composição corporal (percentual de gordura, peso,densidade corporal, índice de massa corpórea e perímetros de cintura e quadril e suas relações), aptidão física (força eresistência de membros inferiores, flexibilidade, resistência abdominal, condição cardiorrespiratória) e qualidade devida em 26 mulheres entre 19 e 28 anos de idade (média de 22,88 À 2,56) em estudo de grupo único com avaliaçõesinicial e final. Os resultados apontaram, de forma estatisticamente significativa, melhoria nas variáveis: valores decintura pélvica e relação desta com o quadril, força de membros inferiores, flexibilidade, resistência muscular abdominale de membros inferiores e condição cardiorrespiratória. Diante destes achados, conclui-se que o exercício no minitrampolimem solo foi eficiente em diversas capacidades físicas, enquanto os valores obtidos independem da composiçãocorporal e qualidade de vida

Programa de seguimento protocolado de doentes com insuficiência cardíaca : impacto no prognóstico e na qualidade de vida

© 2020 Sociedade Portuguesa de Cardiologia. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license.Introduction: Heart failure is associated with high rates of readmission and mortality, and there is a need for measures to improve outcomes. This study aims to assess the impact of the implementation of a protocol-based follow-up program for heart failure patients on readmission and mortality rates and quality of life. Methods: A quasi-experimental study was performed, with a prospective registry of 50 consecutive patients discharged after hospitalization for acute heart failure. The study group was followed by a cardiologist at days 7-10 and the first, third, sixth and 12th month after discharge, with predefined procedures. The control group consisted of patients hospitalized for heart failure prior to implementation of the program and followed on a routine basis. Results: No significant differences were observed between the two groups regarding mean age (67.1±11.2 vs. 65.8±13.4 years, p=0.5), NYHA functional class (p=0.37), or median left ventricular ejection fraction (27% [19.8-35.3] vs. 29% [23.5-40]; p=0.23) at discharge. Mean follow-up after discharge was similar (11±5.3 vs. 10.9±5.5 months, p=0.81). The protocol-based follow-up program was associated with a significant reduction in allcause readmission (26% vs. 60%, p=0.003), heart failure readmission (16% vs. 36%, p=0.032), and mortality (4% vs. 20%, p=0.044). In the study group there was a significant improvement in all quality of life measures (p<0.001). Conclusion: A protocol-based follow-up program for patients with heart failure led to a signif-icant reduction in readmission and mortality rates, and was associated with better quality of life.info:eu-repo/semantics/publishedVersio

Subtractive phage display selection from canine visceral leishmaniasis identifies novel epitopes that mimic leishmania infantum antigens with potential serodiagnosis applications

Visceral leishmaniasis (VL) is a zoonotic disease that is endemic to Brazil, where dogs are the main domestic parasite reservoirs, and the percentages of infected dogs living in regions where canine VL (CVL) is endemic have ranged from 10% to 62%. Despite technological advances, some problems have been reported with CVL serodiagnosis. The present study describes a sequential subtractive selection through phage display technology from polyclonal antibodies of negative and positive sera that resulted in the identification of potential bacteriophage-fused peptides that were highly sensitive and specific to antibodies of CVL. A negative selection was performed in which phage clones were adhered to purified IgGs from healthy and Trypanosoma cruzi-infected dogs to eliminate cross-reactive phages. The remaining supernatant nonadhered phages were submitted to positive selection against IgG from the blood serum of dogs that were infected with Leishmania infantum. Phage clones that adhered to purified IgGs from the CVL-infected serum samples were selected. Eighteen clones were identified and their reactivities tested by a phage enzyme-linked immunosorbent assay (phage-ELISA) against the serum samples from infected dogs (n 31) compared to those from vaccinated dogs (n 21), experimentally infected dogs with cross-reactive parasites (n 23), and healthy controls (n 17). Eight clones presented sensitivity, specificity, and positive and negative predictive values of 100%, and they showed no crossreactivity with T. cruzi- or Ehrlichia canis-infected dogs or with dogs vaccinated with two different commercial CVL vaccines in Brazil. Our study identified eight mimotopes of L. infantum antigens with 100% accuracy for CVL serodiagnosis. The use of these mimotopes by phage-ELISA proved to be an excellent assay that was reproducible, simple, fast, and inexpensive, and it can be applied in CVL-monitoring programsThis work was supported by grants from the Pró-Reitoria de Pesquisa of UFMG (supported 03/2013), the Instituto Nacional de Ciência e Tecnologia em Nano-Biofarmacêutica (INCT Nano-Biofar), Rede Nanobiotec/Brasil-UFU (CAPES), PRONEX-FAPEMIG (APQ-01019- 09), FAPEMIG (APQ-00496-11 and APQ-00819-12), and CNPq (APQ- 472090/2011-9 and APQ-482976/2012-8). E.A.F.C. and L.R.G. are recipients of grants from CNPq. M.A.C.-F. is the recipient of a grant from FAPEMIG/CAPE