Novo modelo de estadiamento para indicação de cirurgia faríngea em pacientes com apneia obstrutiva do sono,

Introduction: The success of pharyngeal surgery in the treatment of obstructive sleep apnea syndrome depends on the appropriate selection of patients. Objective: To propose a new staging for indication of pharyngeal surgery in obstructive sleep apnea syndrome. Methods: A total of 54 patients undergoing extended tonsillectomy were retrospectively included, divided into six stages. Stage I: patients with palatine tonsils grade 3/4 and modified Mallampati index 1/2; stage II: palatine tonsils 3/4 and modified Mallampati index 3/4; stage III: palatine tonsils 1/2 and modified Mallampati index 1/2; stage IV: palatine tonsils 1/2 and modified Mallampati index 3/4; stage V: body mass index ≥40 kg/m2 with palatine tonsils 3/4 and modified Mallampati index 1, 2, 3, or 4. Stage VI: body mass index ≥40 with palatine tonsils 1/2 and modified Mallampati index 1, 2, 3, or 4. Results: The surgical success rates were 88.9%, 75.0%, 35.7%, 38.5%, and 100.0% in stages I–V. Conclusion: The presence of hypertrophic palatine tonsils was the anatomical factor in common in the most successful stages (I, II, and V), regardless of body mass index. Although the modified Mallampati index classes 3 and 4 reduced the success rate of surgery in patients with hypertrophic tonsils (stage II), the presence of modified Mallampati index classes 1 and 2 did not favor surgical success in patients with normal tonsils (stage III).Introdução: O sucesso da cirurgia faríngea no tratamento da síndrome da apneia obstrutiva do sono (SAOS) depende da adequada seleção de pacientes. Objetivo: Propor um novo estadiamento para indicação de cirurgia faríngea na SAOS. Método: Estudo retrospectivo, onde foram inclusos, 54 pacientes submetidos a amigdalectomia ampliada, divididos em 6 estádios. Estádio I: pacientes com tonsilas palatinas graus 3/4 e índice de Mallampati modificado (IMM) 1/2; Estádio II: tonsilas palatinas 3/4 e IMM 3/4; Estádio III: tonsilas palatinas 1/2 e IMM 1/2; Estádio IV: tonsilas palatinas 1/2 e IMM 3/4; Estádio V: IMC (índice de massa corpórea) ≥ com tonsilas palatinas 3/4 e IMM 1, 2, 3 ou 4. Estádio VI: IMC ≥ kg/m2 com tonsilas palatinas 1 ou 2 e IMM 1, 2, 3, ou 4. Resultados: As taxas de sucesso cirúrgico foram de 88,9%; 75,0%; 35,7%; 38,5% e 100,0% nos estádios I a V. Conclusão: A presença de tonsilas palatinas hipertróficas foi o fator anatômico em comum nos estádios de maior sucesso (I, II e V), independente do IMC. Apesar do IMM classe III e IV diminuir a taxa de sucesso da cirurgia em pacientes com tonsilas hipertróficas (estádio II), a presença de IMM classe I e II não favoreceu o sucesso cirúrgico em pacientes com tonsilas normotróficas (estádio III).Universidade Federal de São Paulo (UNIFESP) Department of OtorhinolaryngologyUniversidade Federal de São Paulo (UNIFESP) Department of PsychobiologyInstituto do Ronco e Apneia de MaringáSão José dos Campos Clínica OpusUNIFESP, Department of OtorhinolaryngologyUNIFESP, Department of PsychobiologySciEL

Frequência de condenações de carcaças com lesões sugestivas de tuberculose bovina em abatedouro-frigorífico em Santo Antônio de Jesus-BA e correlação com casos de tuberculose humana

A tuberculose bovina (TB) é uma doença infecciosa causada pela bactéria Mycobacterium bovis e afeta principalmente o gado, mas também pode infectar outras espécies animais. A tuberculose humana (TH) é uma doença infecciosa e transmissível que afeta principalmente os pulmões humanos. O presente estudo teve como objetivo obter informações sobre a frequência de carcaças condenadas com lesões sugestivas de TB em um abatedouro-frigorífico na cidade de Santo Antônio de Jesus, Bahia, no período de janeiro de 2007 a dezembro de 2016. Além disso, buscou-se verificar estatisticamente a correlação entre a TH e TB nos municípios de origem dos animais abatidos. Os resultados revelaram uma baixa frequência (0,020%) de tuberculose bovina no abatedouro-frigorífico estudado e não foi observada uma correlação positiva significativa (p = 0,312) entre a TB e TH nos parâmetros analisados. O estudo destaca a importância de compreender e controlar a tuberculose bovina e humana, visando melhorar as medidas de prevenção e reduzir os efeitos na saúde pública e na produção agropecuária

Reuse of treated domestic sewage for biquinho pepper cultivation

This study aimed to evaluate the reuse of treated domestic sewage in biquinho pepper (Capsicum chinense L.) cultivation under different irrigation regimes. The experiment was carried out in a greenhouse, in a randomised block design with a 3 x 4 factorial scheme, with four replications. Forty-eight pepper plants were subjected to three treated domestic sewage concentrations (0, 50, and 100%) and four irrigation depths (75, 100, 125, and 150% of the crop evapotranspiration - ETc). Data for ETc estimation were obtained from an automatic meteorological station, which was installed in the greenhouse. The results showed that irrigation depths corresponding to 125 and 150% of the ETc at a concentration of 100% treated domestic sewage resulted in higher plants. Moreover, longer fruits were obtained when plants were subjected to 100% ETc at 100% treated domestic sewage. The studied irrigation depths influenced pepper fruit total weight and yield. No treated domestic sewage concentrations significantly influenced the variables analysed. Treated domestic sewage reuse can constitute an alternative for quality water saving and for chemical fertilisation of biquinho pepper crop. Highlights: The growing of beak pepper with domestic sewage treated can bring benefits in terms of providing nutrients to the crops; Adequate levels of water replacement with domestic sewage treated may promote good crop development. The use of treated domestic sewage can be an alternative to reduce the use of better quality water and chemical fertilization in the growing of beak pepper. Reduction of environmental impact may be possible with the replacement of chemical fertilizer by domestic sewage treated in the growing of beak pepper.This study aimed to evaluate the reuse of treated domestic sewage in biquinho pepper (Capsicum chinense L.) cultivation under different irrigation regimes. The experiment was carried out in a greenhouse, in a randomised block design with a 3 x 4 factorial scheme, with four replications. Forty-eight pepper plants were subjected to three treated domestic sewage concentrations (0, 50, and 100%) and four irrigation depths (75, 100, 125, and 150% of the crop evapotranspiration - ETc). Data for ETc estimation were obtained from an automatic meteorological station, which was installed in the greenhouse. The results showed that irrigation depths corresponding to 125 and 150% of the ETc at a concentration of 100% treated domestic sewage resulted in higher plants. Moreover, longer fruits were obtained when plants were subjected to 100% ETc at 100% treated domestic sewage. The studied irrigation depths influenced pepper fruit total weight and yield. No treated domestic sewage concentrations significantly influenced the variables analysed. Treated domestic sewage reuse can constitute an alternative for quality water saving and for chemical fertilisation of biquinho pepper crop. Highlights: The growing of beak pepper with domestic sewage treated can bring benefits in terms of providing nutrients to the crops; Adequate levels of water replacement with domestic sewage treated may promote good crop development. The use of treated domestic sewage can be an alternative to reduce the use of better quality water and chemical fertilization in the growing of beak pepper. Reduction of environmental impact may be possible with the replacement of chemical fertilizer by domestic sewage treated in the growing of beak pepper

Hepatite aguda grave por uso de anabolizante concomitante à infecção pelo vírus hepatite A: relato de caso

Hepatite aguda grave é uma síndrome clinica que pode evoluir para hepatite aguda fulminante com a instalação de insuficiência hepática. Suas principais causas incluem o uso de substâncias hepatotóxicas e infecções virais e sua apresentação clínica inicia-se, na maioria das vezes, de forma inespecífica com sintomas análogos ao quadro gripal, sendo necessários dados da anamnese e epidemiologia para direcionar a investigação. O objetivo do trabalho é relatar e discutir um caso de hepatite aguda grave, cuja etiologia é multifatorial, uma vez que coexistem o uso de anabolizante, terapia antirretroviral (TARV) e anti-inflamatórios ao quadro de hepatite A. O paciente relatado é um homem de 30 anos, em uso de TARV, que iniciou com sintomatologia inespecifica, evoluiu com o aparecimento de icterícia e aumento dos níveis de transaminas e bilirrubina, quadro indicativo de hepatite. Além da presença de IgM positivo para hepatite A, o paciente relatou uso de anabolizantes em associação à TARV. A conduta tomada foi a suspensão de ambas substâncias hepatotóxicas e acompanhamento dos níveis de transaminases, a partir da qual observou-se melhora progressiva até resolução do quadro. Portanto, concluiu tratar-se de uma lesão hepática aguda por associação medicamentosa e viral, não sendo possível a determinação exata do fator causal ou desencadeante

Early hematopoietic stem cell transplantation in a patient with severe mucopolysaccharidosis II : 7 years follow-up

Mucopolysaccharidosis type II (MPS II - Hunter syndrome) is an X-linked lysosomal storage disorder caused by a deficiency in the enzyme iduronate-2 sulfatase (I2S), leading to the accumulation of the glycosaminoglycans, affecting multiple organs and systems. Enzyme replacement therapy does not cross the blood brain barrier, limiting results in neurological forms of the disease. Another option of treatment for severe MPS, hematopoietic stem cell transplantation (HSCT) has become the treatment of choice for the severe form of MPS type I, since it can preserve neurocognition when performed early in the course of the disease. To date, only few studies have examined the long-term outcomes of HSCT in patients with MPS II. We describe the seven-year follow-up of a prenatally diagnosed MPS II boy with positive family history of severe MPS form, submitted to HSCT with umbilical cord blood cells at 70 days of age. Engraftment after 30 days revealed mixed chimerism with 79% donor cells; after 7 years engraftment remains at 80%. I2S activity 30 days post-transplant was low in plasma and normal in leukocytes and the same pattern is observed to date. At age 7 years growth charts are normal and he is very healthy, although mild signs of dysostosis multiplex are present, as well as hearing loss. The neuropsychological evaluation (Wechsler Intelligence Scale for Children - Fourth Edition - WISC-IV), disclosed an IQ of 47. Despite this low measured IQ, the patient continues to show improvements in cognitive, language and motor skills, being quite functional. We believe that HSCT is a therapeutic option for MPS II patients with the severe phenotype, as it could preserve neurocognition or even halt neurodegeneration, provided strict selection criteria are followed

Caracterização do processo de rigor mortis em músculos de equinos e maciez da carne

Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorResumo disponível para download. Documento em papel (78 f.)disponível na Biblioteca da Faculdade de Veterinária da Universidade Federal Fluminense - BFV/UFF - T617.6007 R696 E-mail: [email protected] - Tel: (21) 2629-9552/9553 para consulta local, solicitação de cópia através de comutação bibliográfica (SCAD/COMUT) ou empréstimo entre bibliotecas

Hematological studies in pacas under captive conditions

ABSTRACT. Stradiotti C.G.P., Lopes G.L., Stradiotti Júnior D., Cóser A.C., Rangel C.C., Rodrigues T.F. & Almeida F.M. [Hematological studies in pacas under captive conditions.] Estudos hematológicos em pacas sob condições de cativeiro. Revista Brasileira de Medicina Veterinária, 37(3):227-232, 2015. Programa de Pós-Graduação em Reprodução e Nutrição Animal, Universidade Federal do Espírito Santo, Rua Alto Universitário, s/n, Bairro Guararema, Alegre, ES 29500-000, Brasil. E-mail: [email protected] This study was conducted aiming to evaluate the hematologic aspects both in the red series (eritrogram) and the white series (leucogram) of the Agouti paca species reared in captivity conditions and to verify possible differences related to animal sexes. To this study 11 adult animals (six females and five males) were used, adopting the completely randomized design. Collect of blood samples and the hematologic analysis were done with no stress to the animals. Results showed that blood elements of the eritrogram had no effect over the sex, except to the hematocrit that presented higher values to the males. In the leukocyte analysis, monocytes and eosinophils were different statistically when related to the sex, both with higher values to the females

Brazilian Journal of OTORHINOLARYNGOLOGY New clinical staging for pharyngeal surgery in obstructive sleep apnea patients ଝ,ଝଝ New clinical staging for pharyngeal surgery 491 PALAVRAS-CHAVE

Abstract Introduction: The success of pharyngeal surgery in the treatment of obstructive sleep apnea syndrome depends on the appropriate selection of patients. Objective: To propose a new staging for indication of pharyngeal surgery in obstructive sleep apnea syndrome. Methods: A total of 54 patients undergoing extended tonsillectomy were retrospectively included, divided into six stages. Stage I: patients with palatine tonsils grade 3/4 and modified Mallampati index 1/2; stage II: palatine tonsils 3/4 and modified Mallampati index 3/4; stage III: palatine tonsils 1/2 and modified Mallampati index 1/2; stage IV: palatine tonsils 1/2 and modified Mallampati index 3/4; stage V: body mass index ≥40 kg/m 2 with palatine tonsils 3/4 and modified Mallampati index 1, 2, 3, or 4. Stage VI: body mass index ≥40 with palatine tonsils 1/2 and modified Mallampati index 1, 2, 3, or 4. Conclusão: A presença de tonsilas palatinas hipertróficas foi o fator anatômico em comum nos estádios de maior sucesso (I, II e V), independente do IMC. Apesar do IMM classe III e IV diminuir a taxa de sucesso da cirurgia em pacientes com tonsilas hipertróficas (estádio II), a presença de IMM classe I e II não favoreceu o sucesso cirúrgico em pacientes com tonsilas normotróficas (estádio III). PALAVRAS-CHAV