72 research outputs found
Gene expression and nucleotide composition are associated with genic methylation level in Oryza sativa
Background
The methylation of cytosines at CpG dinucleotides, which plays an important role in gene expression regulation, is one of the most studied epigenetic modifications. Thus far, the detection of DNA methylation has been determined mostly by experimental methods, which are not only prone to bench effects and artifacts but are also time-consuming, expensive, and cannot be easily scaled up to many samples. It is therefore useful to develop computational prediction methods for DNA methylation. Our previous studies highlighted the existence of correlations between the GC content of the third codon position (GC3), methylation, and gene expression. We thus designed a model to predict methylation in Oryza sativa based on genomic sequence features and gene expression data.
Results
We first derive equations to describe the relationship between gene methylation levels, GC3, expression, length, and other gene compositional features. We next assess gene compositional features involving sixmers and their association with methylation levels and other gene level properties. By applying our sixmer-based approach on rice gene expression data we show that it can accurately predict methylation (Pearson’s correlation coefficient r = 0.79) for the majority (79%) of the genes. Matlab code with our model is included.
Conclusions
Gene expression variation can be used as predictors of gene methylation levels
COVID-19-associated coagulopathy in children and adolescents
The pandemic of the new coronavirus infection COVID-19 in 2020 has become the main health problem across the globe. A special characteristic of the SARSCoV-2 virus is tropism to the vascular endothelium with the development of endotheliitis, which entails a number of typical disorders of the blood coagulation system: coagulopathy with increased thrombin generation, D-dimer, decreased fibrinolysis and prolonged prothrombin time. The coagulation disorder in COVID-19 is called thromboinflammation. Hyperinflammation, increased blood levels of von Willebrand factor, coagulation factor VIII, neutrophil extracellular traps, platelet activation, microvesicles play a significant role in the pathogenesis of hypercoagulation in COVID-19. To date, it is known that cases of COVID-19 in children and adolescents constitute a small part of the total number of patients with diagnosed COVID-19, and disorders of the blood coagulation system are similar to those in adults. The degree of hypercoagulable syndrome and the risk of thrombosis depend on the severity of COVID-19. And for children they are most expressed with the development of a hyperinflammatory immune response, called multisystem inflammatory syndrome. At the same time, clinical studies of the pathogenesis of COVID-19 in adults and children and the search for optimal methods of therapy for thrombus inflammation, which underlies the pathogenesis of COVID-19, continue
Predicion of charge separation in GaAs/AlAs cylindrical Russian Doll nanostructures
We have contrasted the quantum confinement of (i) multiple quantum wells of
flat GaAs and AlAs layers, i.e. (\GaAs)_{m}/(\AlAs)_n/(\GaAs)_p/(\AlAs)_q,
with (ii) ``cylindrical Russian Dolls'' -- an equivalent sequence of wells and
barriers arranged as concentric wires. Using a pseudopotential plane-wave
calculation, we identified theoretically a set of numbers ( and )
such that charge separation can exist in ``cylindrical Russian Dolls'': the CBM
is localized in the inner GaAs layer, while the VBM is localized in the outer
GaAs layer.Comment: latex, 8 page
A Case of Successful Medical Treatment of Ventricular Tachycardia in a Patient With Ischemic Heart Disease and Heart Failure
The pathogenetic mechanisms of arrhythmias, including high-grade ventricular arrhythmias (including non-sustained ventricular tachycardia), in patients with coronary heart disease may be different. Therefore, the characteristics of ventricular arrhythmias must be considered based on the totality of data, taking into account all the available features. The importance of a personalized approach to the management of a patient with coronary heart disease who had extensive myocardial infarction 18.5 years ago, followed by mammary coronary artery bypass grafting, aneurysmectomy and the development of heart failure with a low ejection fraction, in whom ventricular arrhythmias occurred against the background of a stable course of coronary disease , but after emotional stress, is reflected in this work. An extended examination, as well as a detailed study of the nature of ventricular arrhythmias, made it possible to determine the main provoking factor and select an individualized pathogenetic treatment with a good antiarrhythmic result that persists for several years of observation. Conducting mental tests and psychological questioning can be recommended for patients with coronary heart disease and chronic heart failure as an additional examination to assess the contribution of the psycho-emotional factor to arrhythmogenesis after excluding the ischemic and sympathetic nature of ventricular ectopia. It is incorrect to consider that all ventricular arrhythmias in patients with coronary heart disease are ischemic in nature, and in some clinical situations this statement is even erroneous
THE PROCESS APPROACH TO EMPLOYEE ENGAGEMENT IN AN ORGANIZATION
It is proposed the view on engagement in an organization as engagement in the processes taking place in an organization. The authors describe Engagement in an organization Questionnaire development and results of validation and reliability control. The sample is consists of 84 employees.Предлагается взгляд на вовлеченность в организацию как вовлеченность сотрудника в процессы, протекающие в организации. Описывается путь разработки методики «Вовлеченность в организацию », а также результаты ее проверки на валидность и надежность на выборке из 84 человек
Theory of anyon excitons: Relation to excitons of nu=1/3 and nu=2/3 incompressible liquids
Elementary excitations of incompressible quantum liquids (IQL's) are anyons,
i.e., quasiparticles carrying fractional charges and obeying fractional
statistics. To find out how the properties of these quasiparticles manifest
themselves in the optical spectra, we have developed the anyon exciton model
(AEM) and compared the results with the finite-size data for excitons of nu=1/3
and nu=2/3 IQL's. The model considers an exciton as a neutral composite
consisting of three quasielectrons and a single hole. The AEM works well when
the separation between electron and hole confinement planes, h, is larger than
the magnetic length l. In the framework of the AEM an exciton possesses
momentum k and two internal quantum numbers, one of which can be chosen as the
angular momentum, L, of the k=0 state. Existence of the internal degrees of
freedom results in the multiple branch energy spectrum, crater-like electron
density shape and 120 degrees density correlations for k=0 excitons, and the
splitting of the electron shell into bunches for non-zero k excitons. For h
larger than 2l the bottom states obey the superselection rule L=3m (m are
integers starting from 2), all of them are hard core states. For h nearly 2l
there is one-to-one correspondence between the low-energy spectra found for the
AEM and the many- electron exciton spectra of the nu=2/3 IQL, whereas some
states are absent from the many-electron spectra of the nu=1/3 IQL. We argue
that this striking difference in the spectra originates from the different
populational statistics of the quasielectrons of charge conjugate IQL's and
show that the proper account of the statistical requirements eliminates
excessive states from the spectrum. Apparently, this phenomenon is the first
manifestation of the exclusion statistics in the anyon bound states.Comment: 26 pages with 9 figures, typos correcte
Theory of Photoluminescence of the Quantum Hall State: Excitons, Spin-Waves and Spin-Textures
We study the theory of intrinsic photoluminescence of two-dimensional
electron systems in the vicinity of the quantum Hall state. We focus
predominantly on the recombination of a band of initial ``excitonic states''
that are the low-lying energy states of our model at . It is shown that
the recombination of excitonic states can account for recent observations of
the polarization-resolved spectra of a high-mobility GaAs quantum well. The
asymmetric broadening of the spectral line in the polarization is
explained to be the result of the ``shake-up'' of spin-waves upon radiative
recombination of excitonic states. We derive line shapes for the recombination
of excitonic states in the presence of long-range disorder that compare
favourably with the experimental observations. We also discuss the stabilities
and recombination spectra of other (``charged'') initial states of our model.
An additional high-energy line observed in experiment is shown to be consistent
with the recombination of a positively-charged state. The recombination
spectrum of a negatively-charged initial state, predicted by our model but not
observed in the present experiments, is shown to provide a direct measure of
the formation energy of the smallest ``charged spin-texture'' of the
state.Comment: 23 pages, 7 postscript figures included. Revtex with epsf.tex and
multicol.sty. The revised version contains slightly improved numerical
results and a few additional discussions of the result
Seqping: gene prediction pipeline for plant genomes using self-training gene models and transcriptomic data
Modern Geodynamics of South Yenisei Ridge to Result of the GPS/GLONASS Observations
Yenisei Ridge is located at the junction of major tectonic structures - Siberian Platform and West Siberian Plate. Its southern part is characterized by stable tectonic regime, the average speed of uplift according to geological data is 0.2-0.3 mm per year with the total amplitude of 400-500 m. However, the speed of modern movements of the Earth's crust is by more than an order of magnitude higher due to the temporary effect of large-scale geodynamic movements. The Yenisei river divides the area into two parts. The left bank is characterized by predominantly negative vertical movements and the right bank by positive ones. The major tectonic disturbances occur in the areas of the Muratovsky, Atamanovsky, Pravoberezhny and Bolshetelsky submeridional faults. It was investigated the dynamics of changes in the lengths of ΔL baselines for separate epochs of observations. In 2010-2013 the absolute values of ΔL were significantly lower than for the periods 2013-2014 and 2014-2015. For the entire observation period the average value of the differences of the line lengths is 3.8 mm. This suggests that in general the area experienced strain during the period 2010-2015. Maps of the Earth's surface dilatation zones (deformation rate) showed that the maximum deformations were recorded in the area of Muratovsky and Atamanovsky faults located at the junction of Siberian Platform and West Siberian plate. © Published under licence by IOP Publishing Ltd
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