A tensile strength apparatus with the facility to monitor negative pore-water pressure

This paper presents a new testing method for investigating the behaviour of clayey geomaterials subjected to a tensile (negative) total stress. The method includes the use of high capacity tensiometers to measure the pore-water pressure of the test specimen, an aspect which has not been demonstrated in any other direct tensile testing method. This addition allows interpretation of failure data in terms of effective stress rather than total stress, which is the approach that should be pursued in the saturated range. The test specimen shape and loading method have been modified from those commonly seen in existing literature to ensure that the direction of the major principal stress in the failure zone coincides with the direction of the externally applied tensile force, allowing for a more accurate analysis of tensile failure. Results are shown for saturated specimens and compared to results obtained for the same soil in uniaxial compression, using a modified version of the presented uniaxial tensile method, and a triaxial compression test. It is demonstrated that crack initiation occurs by shear failure if the data is interpreted in terms of effective stress rather than total stress, and that the failure mechanisms under tension do not differ from compression

Therapeutic Targets in Amyotrophic Lateral Sclerosis: Focus on Ion Channels and Skeletal Muscle

Amyotrophic Lateral Sclerosis is a neurodegenerative disease caused by progressive loss of motor neurons, which severely compromises skeletal muscle function. Evidence shows that muscle may act as a molecular powerhouse, whose final signals generate in patients a progressive loss of voluntary muscle function and weakness leading to paralysis. This pathology is the result of a complex cascade of events that involves a crosstalk among motor neurons, glia, and muscles, and evolves through the action of converging toxic mechanisms. In fact, mitochondrial dysfunction, which leads to oxidative stress, is one of the mechanisms causing cell death. It is a common denominator for the two existing forms of the disease: sporadic and familial. Other factors include excitotoxicity, inflammation, and protein aggregation. Currently, there are limited cures. The only approved drug for therapy is riluzole, that modestly prolongs survival, with edaravone now waiting for new clinical trial aimed to clarify its efficacy. Thus, there is a need of effective treatments to reverse the damage in this devastating pathology. Many drugs have been already tested in clinical trials and are currently under investigation. This review summarizes the already tested drugs aimed at restoring muscle-nerve cross-talk and on new treatment options targeting this tissue

A distributed bio-inspired method for multisite grid mapping

Computational grids assemble multisite and multiowner resources and represent the most promising solutions for processing distributed computationally intensive applications, each composed by a collection of communicating tasks. The execution of an application on a grid presumes three successive steps: the localization of the available resources together with their characteristics and status; the mapping which selects the resources that, during the estimated running time, better support this execution and, at last, the scheduling of the tasks. These operations are very difficult both because the availability and workload of grid resources change dynamically and because, in many cases, multisite mapping must be adopted to exploit all the possible benefits. As the mapping problem in parallel systems, already known as NP-complete, becomes even harder in distributed heterogeneous environments as in grids, evolutionary techniques can be adopted to find near-optimal solutions. In this paper an effective and efficient multisite mapping, based on a distributed Differential Evolution algorithm, is proposed. The aim is to minimize the time required to complete the execution of the application, selecting from among all the potential ones the solution which reduces the use of the grid resources. The proposed mapper is tested on different scenarios

Antisense reduction of thylakoidal ascorbate peroxidase in Arabidopsis enhances Paraquat-induced photooxidative stress and Nitric Oxide-induced cell death

The production and characterization of Arabidopsis plants containing a transgene in which the Arabidopsis tAPX is inserted in antisense orientation, is described. tAPX activity in these transgenic tAPX plants is around 50% of control level. The tAPX antisense plants are phenotypically indistinguishable from control plants under normal growth conditions; they show, however, enhanced sensitivity to the O 2- -generating herbicide, Paraquat. Interestingly, the tAPX antisense plants show enhanced symptoms of damage when cell death is triggered through treatment with the nitric oxide-donor, SNP. These results are in accordance with the ones recently obtained with transgenic plants overexpressing tAPX; altogether, they suggest that tAPX, besides the known ROS scavenging role, is also involved in the fine changes of H 2O2 concentration during signaling events

Endoscopic guide wire gallbladder decompression in a critically ill, septic patient

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HLMC Fuel Pin Bundle characterization in CIRCE-ICE pool facility

Abstract. This work, carried out at the DICI of Pisa University, in collaboration with ENEA Brasimone R.C., deals with the analysis and a preliminary discussion of the experimental tests performed in the Integral Circulation Experiment (ICE) configuration of the Circulation Eutectic (CIRCE) facility aiming to investigate the heat transfer in fuel rod bundle. The facility test section basically consists of an electrical bundle (FPS) made up of 37 pins arranged in a hexagonal wrapped lattice with a pitch to diameter ratio of 1.8. Along the FPS active length, two sections were instrumented to monitor the heat transfer coefficient along the bundle as well as the cladding temperatures at different ranks of the sub-channels. In particular, forced circulation condition tests were performed imposing a temperature difference through the FPS and a LBE mass flow rate through the FPS. Nusselt number in the sub-channels was calculated as function of the Peclet number and obtained results were compared to Nusselt numbers computed from correlations available in Heavy Liquid Metals (HLM) literature. Results shown that the Nu is slightly lower in the middle section (section 1) if compared with the ones into the upper section (section 3), and that behaviour is probably due to the turbulence of the flow which seems to be fully developed only in the upper part of the fuel pin bundle. Anyway the Nu number, calculated as function of the Pe number in the range Pe~1500÷3000 (forced circulation condition), matches well the numerical correlation available for HLM fuel pin bundle, (i.e. Ushakov and Mikityuk)

Impact of perceived stress and immune status on decision-making abilities during COVID-19 pandemic lockdown

The ability to make risky decisions in stressful contexts has been largely investigated in experimental settings. We examined this ability during the first months of COVID-19 pandemic, when in Italy people were exposed to a prolonged stress condition, mainly caused by a rigid lockdown. Participants among the general population completed two cognitive tasks, an Iowa Gambling Task (IGT), which measures individual risk/reward decision-making tendencies, and a Go/No-Go task (GNG), to test impulsivity, together with two questionnaires, the Perceived Stress Scale and the Depression, Anxiety and Stress Scales. The Immune Status Questionnaire was additionally administered to explore the impact of the individual health status on decision making. The effect of the questionnaires scores on task performance was examined. The results showed that higher levels of perceived stress and a more self-reported vulnerable immune status were associated, separately, with less risky/more advantageous choices in the IGT in young male participants but with more risky/less advantageous choices in older male participants. These effects were not found in female participants. Impulsivity errors in the GNG were associated with more anxiety symptoms. These findings bring attention to the necessity of taking into account decision-making processes during stressful conditions, especially in the older and more physically vulnerable male population

Treatment of infected pancreatic pseudocysts using a novel, dedicated covered self-expandable metal stent (CSEMS) with an effective antimigration system

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