Klinkenberg effect for gas permeability and its comparison to water permeability for porous sedimentary rocks

International audienceThe difference between gas and water permeabilities is significant not only for solving gas-water two-phase flow problems, but also for quick measurements of permeability using gas as pore fluid. We have measured intrinsic permeability of sedimentary rocks from the Western Foothills of Taiwan, using nitrogen gas and distilled water as pore fluids, during several effective-pressure cycling tests at room temperature. The observed difference in gas and water permeabilities has been analyzed in view of the Klinkenberg effect. This effect is due to slip flow of gas at pore walls which enhances gas flow when pore sizes are very small. Experimental results show (1) that gas permeability is larger than water permeability by several times to one order of magnitude, (2) that gas permeability increases with increasing pore pressure, and (3) that water permeability slightly increases with increasing pore-pressure gradient across the specimen. The results (1) and (2) can be explained by Klinkenberg effect quantitatively with an empirical power law for Klinkenberg constant. Thus water permeability can be estimated from gas permeability. The Klinkenberg effect is important when permeability is lower than 10?18 m2 and at low differential pore pressures, and its correction is essential for estimating water permeability from the measurement of gas permeability. A simple Bingham-flow model of pore water can explain the overall trend of the result (3) above. More sophisticated models with a pore-size distribution and with realistic rheology of water film is needed to account for the observed deviation from Darcy's law

Effect in supralethally irradiated rats of granulocyte colony- stimulating factor and lisofylline on hematopoietic reconstitution by syngeneic bone marrow or whole organ passenger leukocytes

We have previously shown the existence of migratory hematopoietic stem cells in adult solid organs. This study demonstrates that granulocyte colony- stimulating factor (G-CSF) and lisofylline, a phosphatidic acid inhibitor that suppresses hematopoiesis-inhibiting cytokines, can enhance the engraftment of organ-based hematopoietic stem cells. When syngeneic heart grafts or liver nonparenchymal cells were transplanted into lethally irradiated (9.5 Gy) Lewis rats, complete hematopoietic reconstitution and animal survival were significantly improved by treating the recipient with G- CSF or, to a lesser extent, with lisofylline. Pretreatment of hepatic nonparenchymal cell donors with G-CSF, but not lisofylline, also resulted in striking improvement of recipient survival which was associated with an augmented subpopulation of donor stem cells. The results suggest that these drugs can be used to enhance the chimerism that we postulate to be the basis of organ allograft acceptance

Saari's homographic conjecture for planar equal-mass three-body problem in Newton gravity

Saari's homographic conjecture in N-body problem under the Newton gravity is the following; configurational measure \mu=\sqrt{I}U, which is the product of square root of the moment of inertia I=(\sum m_k)^{-1}\sum m_i m_j r_{ij}^2 and the potential function U=\sum m_i m_j/r_{ij}, is constant if and only if the motion is homographic. Where m_k represents mass of body k and r_{ij} represents distance between bodies i and j. We prove this conjecture for planar equal-mass three-body problem. In this work, we use three sets of shape variables. In the first step, we use \zeta=3q_3/(2(q_2-q_1)) where q_k \in \mathbb{C} represents position of body k. Using r_1=r_{23}/r_{12} and r_2=r_{31}/r_{12} in intermediate step, we finally use \mu itself and \rho=I^{3/2}/(r_{12}r_{23}r_{31}). The shape variables \mu and \rho make our proof simple

High Fluid‐Pressure Patches Beneath the Décollement: A Potential Source of Slow Earthquakes in the Nankai Trough off Cape Muroto

南海トラフのスロー地震震源域近傍に高圧の間隙水帯を確認 --スロー地震発生のメカニズム解明へ前進--. 京都大学プレスリリース. 2021-06-17.Pore pressure plays a key role in the generation of earthquakes in subduction zones. However, quantitative constraints for its determination are quite limited. Here, we estimate the subsurface pore pressure by analyzing the transient upwelling flow of drilling mud from borehole C0023A of the International Ocean Discovery Program (IODP) Expedition 370, in the Nankai Trough off Cape Muroto. This upward flow provided the first direct evidence of an overpressured aquifer in the underthrust sediments off Cape Muroto. To estimate the pre-drilling pore pressure in the overpressured aquifer around a depth of 950–1, 050 m below sea floor, we examined the measured porosities of core samples retrieved from nearby IODP wells; we then proceeded to explain the observed time evolution of the flow rate of the upwelling flow by modeling various sized aquifers through solving a radial diffusion equation. It was observed that for a permeability of 10⁻¹³ m², the aquifer possessed an initial excess pore pressure of ∼5–10 MPa above the hydrostatic pressure, with a lateral dimension of several hundred meters and thickness of several tens of meters. The overpressure estimates from the porosity-depth profile at Site C0023 differ from those at other drill sites in the region, suggesting the possible existence of multiple overpressured aquifers with a patchy distribution in the underthrust sediments of the Nankai Trough. As pore pressure is relevant in maintaining fault stability, the overpressured aquifers may be the source of slow earthquakes that have been observed around the drilling site

A pilgrimage to gravity on GPUs

In this short review we present the developments over the last 5 decades that have led to the use of Graphics Processing Units (GPUs) for astrophysical simulations. Since the introduction of NVIDIA's Compute Unified Device Architecture (CUDA) in 2007 the GPU has become a valuable tool for N-body simulations and is so popular these days that almost all papers about high precision N-body simulations use methods that are accelerated by GPUs. With the GPU hardware becoming more advanced and being used for more advanced algorithms like gravitational tree-codes we see a bright future for GPU like hardware in computational astrophysics.Comment: To appear in: European Physical Journal "Special Topics" : "Computer Simulations on Graphics Processing Units" . 18 pages, 8 figure

Serratamolide is a hemolytic factor produced by Serratia marcescens

Serratia marcescens is a common contaminant of contact lens cases and lenses. Hemolytic factors of S. marcescens contribute to the virulence of this opportunistic bacterial pathogen. We took advantage of an observed hyper-hemolytic phenotype of crp mutants to investigate mechanisms of hemolysis. A genetic screen revealed that swrW is necessary for the hyper-hemolysis phenotype of crp mutants. The swrW gene is required for biosynthesis of the biosurfactant serratamolide, previously shown to be a broad-spectrum antibiotic and to contribute to swarming motility. Multicopy expression of swrW or mutation of the hexS transcription factor gene, a known inhibitor of swrW expression, led to an increase in hemolysis. Surfactant zones and expression from an swrW-transcriptional reporter were elevated in a crp mutant compared to the wild type. Purified serratamolide was hemolytic to sheep and murine red blood cells and cytotoxic to human airway and corneal limbal epithelial cells in vitro. The swrW gene was found in the majority of contact lens isolates tested. Genetic and biochemical analysis implicate the biosurfactant serratamolide as a hemolysin. This novel hemolysin may contribute to irritation and infections associated with contact lens use. © 2012 Shanks et al

Dynamical Processes in Globular Clusters

Globular clusters are among the most congested stellar systems in the Universe. Internal dynamical evolution drives them toward states of high central density, while simultaneously concentrating the most massive stars and binary systems in their cores. As a result, these clusters are expected to be sites of frequent close encounters and physical collisions between stars and binaries, making them efficient factories for the production of interesting and observable astrophysical exotica. I describe some elements of the competition among stellar dynamics, stellar evolution, and other processes that control globular cluster dynamics, with particular emphasis on pathways that may lead to the formation of blue stragglers.Comment: Chapter 10, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G. Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe

N-body simulations of gravitational dynamics

We describe the astrophysical and numerical basis of N-body simulations, both of collisional stellar systems (dense star clusters and galactic centres) and collisionless stellar dynamics (galaxies and large-scale structure). We explain and discuss the state-of-the-art algorithms used for these quite different regimes, attempt to give a fair critique, and point out possible directions of future improvement and development. We briefly touch upon the history of N-body simulations and their most important results.Comment: invited review (28 pages), to appear in European Physics Journal Plu

A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection

There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous recombination. Here we identify and characterize novel factors involved in choosing between these pathways; in this study we took advantage of the SeeSaw Reporter, in which the repair of double-strand breaks by homology-independent or -dependent mechanisms is distinguished by the accumulation of green or red fluorescence, respectively. Using a genome-wide human esiRNA (endoribonuclease- prepared siRNA) library, we isolate genes that control the recombination/endjoining ratio. Here we report that two distinct sets of genes are involved in the control of the balance between NHEJ and HR: those that are required to facilitate recombination and those that favour NHEJ. This last category includes CCAR2/DBC1, which we show inhibits recombination by limiting the initiation and the extent of DNA end resection, thereby acting as an antagonist of CtIP