16 research outputs found
Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein
Olopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H(1) receptor antagonistic activity. Recently, olopatadine has been shown to bind to S100A12 which is a member of the S100 family of calcium-binding proteins, and exerts multiple proinflammatory activities including chemotaxis for monocytes and neutrophils. In this study, we examined the possibility that the interaction of olopatadine with S100A12 inhibits the proinflammatory effects of S100A12. Pretreatment of olopatadine with S100A12 reduced migration of THP-1, a monocyte cell line, induced by S100A12 alone, but did not affect recombinant human regulated upon activation, normal T cell expressed and secreted (RANTES)-induced migration. Amlexanox, which also binds to S100A12, inhibited the THP-1 migration induced by S100A12. However, ketotifen, another histamine H(1) receptor antagonist, had little effect on the activity of S100A12. These results suggest that olopatadine has a new mechanism of action, that is, suppression of the function of S100A12, in addition to histamine H(1) receptor antagonistic activity
Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis
10.1186/ar2474Arthritis Research and Therapy104R9
Spatial correlation between submillimetre and Lyman-alpha galaxies in the SSA 22 protocluster
Lyman-alpha emitters are thought to be young, low-mass galaxies with ages of
~10^8 yr. An overdensity of them in one region of the sky (the SSA 22 field)
traces out a filamentary structure in the early Universe at a redshift of z =
3.1 (equivalent to 15 per cent of the age of the Universe) and is believed to
mark a forming protocluster. Galaxies that are bright at (sub)millimetre
wavelengths are undergoing violent episodes of star formation, and there is
evidence that they are preferentially associated with high-redshift radio
galaxies, so the question of whether they are also associated with the most
significant large-scale structure growing at high redshift (as outlined by
Lyman-alpha emitters) naturally arises. Here we report an imaging survey of
1,100-um emission in the SSA 22 region. We find an enhancement of submillimetre
galaxies near the core of the protocluster, and a large-scale correlation
between the submillimetre galaxies and the low-mass Lyman-alpha emitters,
suggesting synchronous formation of the two very different types of
star-forming galaxy within the same structure at high redshift. These results
are in general agreement with our understanding of the formation of cosmic
structure.Comment: Published in Nature (7th May 2009 issue). The astro-ph paper includes
the main text (10 pages, 2 figures, 1 table) and supplementary material (6
pages, 4 figures, 1 table
The Subaru-XMM-Newton Deep Survey (SXDS) VIII.: Multi-wavelength Identification, Optical/NIR Spectroscopic Properties, and Photometric Redshifts of X-ray Sources
We report the multi-wavelength identification of the X-ray sources found in
the Subaru-XMM-Newton Deep Survey (SXDS) using deep imaging data covering the
wavelength range between the far-UV to the mid-IR. We select a primary
counterpart of each X-ray source by applying the likelihood ratio method to
R-band, 3.6micron, near-UV, and 24micron source catalogs as well as matching
catalogs of AGN candidates selected in 1.4GHz radio and i'-band variability
surveys. Once candidates of Galactic stars, ultra-luminous X-ray sources in a
nearby galaxy, and clusters of galaxies are removed there are 896 AGN
candidates in the sample. We conduct spectroscopic observations of the primary
counterparts with multi-object spectrographs in the optical and NIR; 65\% of
the X-ray AGN candidates are spectroscopically-identified. For the remaining
X-ray AGN candidates, we evaluate their photometric redshift with photometric
data in 15 bands. Utilising the multi-wavelength photometric data of the large
sample of X-ray selected AGNs, we evaluate the stellar masses, M*, of the host
galaxies of the narrow-line AGNs. The distribution of the stellar mass is
remarkably constant from z=0.1 to 4.0. The relation between M* and 2--10 keV
luminosity can be explained with strong cosmological evolution of the
relationship between the black hole mass and M*. We also evaluate the scatter
of the UV-MIR spectral energy distribution (SED) of the X-ray AGNs as a
function of X-ray luminosity and absorption to the nucleus. The scatter is
compared with galaxies which have redshift and stellar mass distribution
matched with the X-ray AGN. The UV-NIR SEDs of obscured X-ray AGNs are similar
to those of the galaxies in the matched sample. In the NIR-MIR range, the
median SEDs of X-ray AGNs are redder, but the scatter of the SEDs of the X-ray
AGN broadly overlaps that of the galaxies in the matched sample.Comment: Accepted for publication in PASJ Subaru special issue. 42 pages, 22
figures. Entire contents of Tables 3, 8, 9, 10, and 11, and ASCII format
tables are available from
http://www.astr.tohoku.ac.jp/~akiyama/SXDS/index.htm
Current Performance and On-Going Improvements of the 8.2 m Subaru Telescope
An overview of the current status of the 8.2 m Subaru Telescope constructed
and operated at Mauna Kea, Hawaii, by the National Astronomical Observatory of
Japan is presented. The basic design concept and the verified performance of
the telescope system are described. Also given are the status of the instrument
package offered to the astronomical community, the status of operation, and
some of the future plans. The status of the telescope reported in a number of
SPIE papers as of the summer of 2002 are incorporated with some updates
included as of 2004 February. However, readers are encouraged to check the most
updated status of the telescope through the home page,
http://subarutelescope.org/index.html, and/or the direct contact with the
observatory staff.Comment: 18 pages (17 pages in published version), 29 figures (GIF format),
This is the version before the galley proo
The Hyper Suprime-Cam SSP survey: Overview and survey design
Hyper Suprime-Cam (HSC) is a wide-field imaging camera on the prime focus of the 8.2-m Subaru telescope on the summit of Mauna Kea in Hawaii. A team of scientists from Japan, Taiwan, and Princeton University is using HSC to carry out a 300-night multi-band imaging survey of the high-latitude sky. The survey includes three layers: the Wide layer will cover 1400 deg2 in five broad bands (grizy), with a 5 σ point-source depth of r ≈ 26. The Deep layer covers a total of 26 deg2 in four fields, going roughly a magnitude fainter, while the UltraDeep layer goes almost a magnitude fainter still in two pointings of HSC (a total of 3.5 deg2). Here we describe the instrument, the science goals of the survey, and the survey strategy and data processing. This paper serves as an introduction to a special issue of the Publications of the Astronomical Society of Japan, which includes a large number of technical and scientific papers describing results from the early phases of this survey